[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"BDH-Klinik Hessisch Oldendorf\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":169},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,71,99,125,149],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100449441","magnesium-and-cognition-after-stroke-100449441",false,"NCT05132517","Magnesium and Cognition After Stroke","Relationship Between Magnesium Concentration in Blood and Kognitive Functions After Stroke","Inclusion Criteria:\n\n* ischemic\u002Fhemmorhagic stroke\n* written consent form\n\nExclusion Criteria:\n\n* pre-existing dementia or cognitive impairment before stroke onset\n* pre-existing mental disorder (depression) or present\u002Fprior long-term treatment (\\> 6 months) with psychotropic drugs\n* pre-existing malign tumor disease\n* participation in another clinical trial within the past 30 days\n* pregnancy or breastfeeding","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","OBSERVATIONAL","Cognitive impairments such as memory impairments, word-finding difficulties, compromised orientation and perception are often observed in stroke patients.\n\nLow serum-mg-concentrations are associated with cognitive impairments in ischemic stroke patients one month after stroke onset. It is not clear, if cognitive impairments after stroke is caused by the mg-deficiency or by the stroke itself. Until now, no studies investigating the relationship between mg-concentration, stroke severity and cognition during treatment course are available. Thus, this study aimed to investigate the relationship between mg-concentration and cognition of stroke patients.",[24,25,26,27],"Stroke","Cognition","Magnesium","Neurologic Disorder","RECRUITING","2026-04-16",{"date":31,"type":32},"2026-04-20","ACTUAL",{"date":34,"type":32},"2022-10-26",{"date":36,"type":20},"2027-09-30",{"name":38,"class":39},"BDH-Klinik Hessisch Oldendorf","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":56,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":40},"100628006","assessment-of-consciousness-with-crs-r-and-seconds-100628006","NCT07456020","Assessment of Consciousness With CRS-R and SECONDs","Assessment of Consciousness After Severe Brain Injury: Comparison of CRS-R and SECONDs","AssessConsc","Inclusion Criteria:\n\n* Admission to an intensive care unit (ICU) or intermediate\u002Fhigh-dependency care unit\n* Underlying etiology of brain injury: anoxic, traumatic, or vascular\n* Time since index event \\\u003C 90 days\n* Early Rehabilitation Barthel Index (ERBI) score \\\u003C 30 points\n\nExclusion Criteria:\n\n* History of prior brain injury\n* Pre-existing major psychiatric disorder\n* Impaired language comprehension (e.g., insufficient German language proficiency or aphasia)\n* Ongoing sedation at the time of assessment\n* Interruption of rehabilitation treatment (transfer to an acute care hospital) for more than 14 days\n* isolation precautions due to multidrug-resistant organisms",{"count":50,"type":20},110,"Accurately determining the level of consciousness in patients with severe brain injury is essential for treatment planning, prognosis, and ethical decision-making. Clinically, levels of consciousness are differentiated into coma, Unresponsive Wakefulness Syndrome (UWS), and Minimally Conscious State (MCS) based on behavioral signs. Although behavioral assessment is considered the clinical gold standard, it is prone to misclassification. Research has shown that a substantial proportion of patients initially diagnosed with UWS may actually show signs of minimal consciousness, which is associated with better cognitive abilities and a more favorable prognosis.\n\nThe Coma Recovery Scale-Revised (CRS-R) is internationally recommended for diagnosing disorders of consciousness, but it is time-consuming and not free from diagnostic error. Repeated assessments can significantly improve diagnostic accuracy. To enhance feasibility in routine clinical practice, a shorter and more time-efficient assessment tool, the Simplified Evaluation of CONsciousness Disorders (SECONDs), was developed. This scale focuses on the behavioral signs most strongly associated with MCS and uses optimized testing procedures while maintaining high diagnostic accuracy.\n\nThe aim of this study is to further evaluate diagnostic approaches for assessing consciousness in patients with severe brain injury and to improve the reliability and clinical applicability of these assessments.",[53,54,55],"Disorders of Consciousness Due to Severe Brain Injury","Minimally Conscious State","Unresponsive Wakefulness Syndrome",[57,58,59,60,61,62],"Disorders of consciousness","Coma Recovery Scale-Revised","SECONDs","Acquired Brain Injury","Neurological rehabilitation","Critical ill patients","2026-03-09",{"date":65,"type":32},"2026-03-11",{"date":67,"type":32},"2026-02-01",{"date":69,"type":20},"2028-03-31",{"name":38,"class":39},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":98,"locationsCount":40},"100627980","auditory-processing-in-doc-patients-100627980","NCT07455682","Auditory Processing in DOC Patients","Hierarchical Auditory Processing in Disorders of Consciousness: From Basic Deviance Detection to Semantic Integration","AUD-DOC","Inclusion Criteria:\n\n* Presence of a disorder of consciousness (Unresponsive Wakefulness Syndrome \\[UWS\\] or Minimally Conscious State \\[MCS\\]), classified using the Coma Recovery Scale-Revised (CRS-R) based on three assessments conducted on at least two separate days\n* Age between 18 and 80 years\n* Written informed consent provided by the patient's legal representative\n* Preserved brainstem auditory evoked potentials (BAEPs) on at least one side\n\nExclusion Criteria:\n\n* Ongoing sedation at the time of EEG assessment\n* Current treatment with medications known to significantly affect cortical functional state, including barbiturates, neuroleptics (antipsychotics), antiepileptic drugs, benzodiazepines, or comparable agents\n* Colonization with multidrug-resistant organisms requiring isolation precautions (e.g., 4MRGN)\n* Pregnancy\n* Impaired language comprehension (e.g., insufficient German language proficiency or aphasia)\n* Temporal bone fractures or severe infratentorial brain injury associated with unilateral or bilateral absence of auditory evoked potentials (AEPs)\n* Bilateral hearing impairment or deafness, or presence of a cochlear implant\n* Scalp wounds or conditions preventing placement of an EEG electrode cap","80 Years",{"count":81,"type":20},42,"This prospective observational study investigates whether electroencephalography (EEG) can improve the differentiation between unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) in patients with severe acquired brain injury. The study further examines the association between EEG markers of auditory processing and long-term functional outcome at 12 months.",[84,55,54],"Disorder of Consciousness",[86,87,88,89,60,90,61],"Disorders of Consciousness","Electroencephalography (EEG)","Event-related potential (ERP)","Coma Recovery Scale-Revised (CRS-R)","Critically ill patients","NOT_YET_RECRUITING","2026-03-03",{"date":94,"type":32},"2026-03-06",{"date":96,"type":20},"2026-04-15",{"date":69,"type":20},{"name":38,"class":39},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":40},"100396710","prognostic-factors-to-regain-consciousness-100396710","NCT04445649","Prognostic Factors to Regain Consciousness","Investigation of Prognostic Factors to Regain Consciousness in Neurological Early Rehabilitation","Inclusion Criteria:\n\n* early neurological rehabilitation (phase B)\n* stroke, traumatic brain injury, hypoxic-ischemic encephalopathy\n* disorder of consciousness (coma, UWS, MCS)\n* at minimum two weeks after disease onset\n* admission to intensive care unit\n* written consent from the patient's legal representative\n* exclusion of pregnancy\n\nExclusion Criteria:\n\n* insufficient cardiorespiratory stability\n* fractures or severe infratentorial brain injuries leading to impaired auditory evoked - potentials\n* previous brain damage\n* mental disorders (dementia, depression)\n* colonization with multi-resistant pathogens\n* MRI contraindications\n* claustrophobia\n* weight \\> 120 kg","85 Years",{"count":108,"type":20},130,"The study aims to identify factors that predict the medium and long-term outcome of patients with disorders of consciousness (DOC) undergoing early neurological rehabilitation.\n\nIn this prospective, observational study, 130 DOC patients are going to be included (36 months). At study entry, different routine data, disease severity and functional status are documented for each patient. In addition, MRI, EEG and evoked potentials are measured within the first week. The level of consciousness is recorded with the Coma-Recovery-Scale-Revised and serves as the primary outcome parameter. Complications, comorbidities, functional status and leve of consciousness are assessed weekly. After eight weeks, the measurement of the MRI, the EEG and the evoked potentials are repeated. After 3, 6 and 12 months, the Glasgow Outcome Scale-Revised is used to followed up the current status of the patients.",[27,84,111,24,112],"Traumatic Brain Injury","Hypoxic-Ischemic Encephalopathy",[61,114,115,116],"Prognosis","Outcome","Level of consciousness","2025-09-18",{"date":119,"type":32},"2025-09-19",{"date":121,"type":32},"2020-06-15",{"date":123,"type":20},"2027-12-15",{"name":38,"class":39},{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":106,"enrollmentInfo":132,"targetDuration":4,"studyType":134,"phases":135,"briefSummary":137,"conditions":138,"keywords":139,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":144,"startDateStruct":145,"completionDateStruct":146,"leadSponsor":148,"locationsCount":40},"100396505","effectiveness-of-music-therapy-on-level-of-consciousness-100396505","NCT04442971","Effectiveness of Music Therapy on Level of Consciousness","Investigation of the Effectiveness of Music Therapy on the Level of Consciousness of Neurological Early Rehabilitation Patients","Inclusion Criteria:\n\n* early neurological rehabilitation (phase B)\n* traumatic brain injury\n* disorder of consciousness (coma, UWS, MCS)\n* at minimum two weeks after disease onset\n* admission to intensive care unit\n* written consent from the patient's legal representative\n* Exclusion of pregnancy\n\nExclusion Criteria:\n\n* insufficient cardiorespiratory stability\n* fractures or severe infratentorial brain injuries leading to impaired auditory evoked potentials\n* previous brain damage\n* Known mental disorders (dementia, depression)\n* hearing loss or deafness in one or two ears\n* wounds that do not allow you to wear headphones\n* colonization with multi-resistant pathogens\n* MRI contraindications\n* claustrophobia\n* weight\\>120 kg",{"count":133,"type":20},66,"INTERVENTIONAL",[136],"NA","It is known that even in patients with severe disorders of consciousness (DOC), the perception of known stimuli triggers emotional reactions that can be interpreted as an expression of a residual function of consciousness. Music therapy has a long tradition in neurological rehabilitation. Frequently, active therapies with own music making and singing are implemented in clinical settings. In DOC patients, it is more likely to use passive music listening. However, findings on effectiveness are limited, as only a few studies have systematically investigated the effects of music therapy in this population. Therefore, the investigators want to investigate the effectiveness of passive listening to preferred music on the level of consciousness.",[27,111,84],[140,141,142,143],"neurological rehabilitation","music therapy","level of consciousness","default mode network",{"date":119,"type":32},{"date":121,"type":32},{"date":147,"type":20},"2026-12-15",{"name":38,"class":39},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":159,"conditions":160,"keywords":162,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":165,"startDateStruct":166,"completionDateStruct":167,"leadSponsor":168,"locationsCount":40},"100397018","hippocampal-volume-and-memory-functions-in-aneurysmal-subarachnoid-hemorrhage-100397018","NCT04449666","Hippocampal Volume and Memory Functions in Aneurysmal Subarachnoid Hemorrhage","Investigation of the Relationship Between Hippocampal Volume and Memory Functions in in Patients With Aneurysmal Subarachnoid Hemorrhage (aSAH)","Inclusion Criteria:\n\n* neurological rehabilitation patients in phase B - D\n* at minimum eight weeks after disease onset\n* aneurysmal subarachnoid hemorrhage (Hunt \\& Hess grade I or II)\n* written consent from the patient's legal representative\n* exclusion of pregnancy\n\nExclusion Criteria:\n\n* insufficient cardiorespiratory stability\n* previous brain damage\n* mental disorders (dementia, depression)\n* colonization with multi-resistant pathogens\n* MRI contraindications\n* claustrophobia\n* weight \\> 120 kg","70 Years",{"count":158,"type":20},30,"Neuropsychological and functional long-term consequences of subarachnoid hemorrhages (SAH) represent a great challenge, since sometimes considerable cognitive deficits occur without evidence of substantial brain damage. In this study, we want to examine if the frequently observed memory deficits are associated with hippocampal atrophy.",[27,161],"Subarachnoid Hemorrhage, Aneurysmal",[61,163,164],"Hippocampal volume","Memory deficits",{"date":119,"type":32},{"date":121,"type":32},{"date":147,"type":20},{"name":38,"class":39},""]