[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Babes-Bolyai University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":303},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,50,79,105,126,151,180,203,226,259,277],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100596679","brief-trial-of-act-i-for-adults-with-chronic-insomnia-100596679",false,"NCT07048600","Brief Trial of ACT-i for Adults With Chronic Insomnia","Brief Group Acceptance and Commitment Therapy for Insomnia: Study Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n* clinical\u002F subclinical diagnosis of chronic insomnia either already diagnosed by a professional, or identified with SCISD-R by our team of clinicians\n* age over 18 and older, but not over 59 years old;\n* minimal\u002F mild symptomatology of depression (scores ≤ 9 on PHQ-9) and\u002F or anxiety (scores ≤ 9 on GAD-7) or as diagnosed with SCID-5-CV;\n\nExclusion Criteria:\n\n* diagnosed with a neurological degenerative disorder, or any moderate\u002F severe psychiatric disorder;\n* diagnosed with other sleep disorder (e.g., sleep apnea, restless legs\u002F periodic limb movements, circadian-based sleep disorder);\n* diagnosed with cognitive impairments;\n* unable to understand Romanian;\n* unable to attend to online-sessions (e.g., no laptop, microphone, camera);","ALL","18 Years","59 Years",{"count":20,"type":21},76,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a prospective, randomized-controlled trial that assesses the efficacy of a brief Acceptance and Commitment Therapy (ACT-i), compared to an attentional control group, in adults with chronic insomnia. The interventions will be evaluated for their impact on insomnia severity, cognitive function, depression, anxiety, psychological flexibility, and sleep beliefs - measured before treatment, two weeks after and at a three-month follow-up.",[27,28,29],"Chronic Insomnia","Depression - Major Depressive Disorder","Anxiety",[31,32,33,34,35,36],"acceptance and commitment therapy","chronic insomnia","cognitive functions","depression","anxiety","randomized controlled trial","RECRUITING","2026-04-03",{"date":40,"type":41},"2026-04-07","ACTUAL",{"date":43,"type":41},"2025-05-23",{"date":45,"type":21},"2026-06",{"name":47,"class":48},"Babes-Bolyai University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":49},"100623668","phase-1-adaptation-and-validation-of-the-hypomanic-personality-scale-hps-6-to-romanian-100623668","NCT07399626","Adaptation and Validation of the Hypomanic Personality Scale (HPS-6) to Romanian","Adaptation and Validation of the Hypomanic Personality Scale (HPS-6) to Romanian.","Inclusion Criteria:\n\n* 18-50 years of age\n* Not at high risk of suicide (current)\n* Not high SUDs \u002F AUDs (current)\n* Native Romanian speaker\n* Cognitive abilities intact (reading comprehension of items)\n\nExclusion Criteria:\n\n* High risk of suicide (current)\n* High SUDs \u002F AUDs (current)",true,"50 Years",{"count":60,"type":21},50,[62,63],"PHASE1","PHASE2","The HPS-6 (Hypomanic Personality Scale, 6 item version) could prove to be a valuable candidate for screening measures of high risk individuals. In the following study, we aim to validate and adapt the HPS-6 for the Romanian population.",[66],"Bipolar Disorder (BD)",[68,69,70],"bipolar disorder","manic-depression","cyclothymia","2026-02-03",{"date":73,"type":41},"2026-02-10",{"date":75,"type":41},"2025-09-22",{"date":77,"type":21},"2026-07",{"name":47,"class":48},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":57,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":49},"100620418","rethink-for-mental-health-of-youths-in-romania-100620418","NCT07357363","REThink for Mental Health of Youths in Romania","REThink for Mental Health of the Youths in Romania","Inclusion Criteria:\n\n* internet and PC access to complete the scales and game\n\nExclusion Criteria:\n\n* no internet of PC access","10 Years","24 Years",{"count":89,"type":21},1000,[24],"In order to test the effect of the intervention, a multi-center randomized control trial (RCT) will be conducted to test the efficacy of the REThink interventions on improving bullying (both victimization and aggression) and mental health compared with a care as usual group. A minimum of 1000 students from the participating institutions (schools will be able to join based on a recruitment call), will be recruited and randomly assigned to either the experimental or control group.",[93,94,95],"Bullying Victimisation","Bullying of Child","Bullying Behavior","NOT_YET_RECRUITING","2026-01-15",{"date":99,"type":41},"2026-01-22",{"date":101,"type":21},"2027-01",{"date":103,"type":21},"2028-01",{"name":47,"class":48},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":49},"100616378","the-effects-of-the-psypills-app-on-emotion-regulation-and-risk-behaviors-in-emerging-adults-a-randomized-clinical-trial-100616378","NCT07304830","The Effects of the PsyPills App on Emotion Regulation and Risk Behaviors in Emerging Adults: A Randomized Clinical Trial","Inclusion Criteria:\n\n* High emotional regulation difficulties, but not severe (DERS total score 88-105)\n* At least one risky behavior with a frequency ≥ 2 on the RBQ Frequency Scale\n* Access to an Android or iOS smartphone\n\nExclusion Criteria:\n\n* Diagnosed psychiatric disorders\n* Suicide risk (score ≥ 7 on the Suicidal Behaviors Questionnaire-Revised, SBQ-R)","29 Years",{"count":113,"type":21},204,[24],"This study aims to investigate the effects of the PsyPills mobile application on improving emotion regulation and reducing risk behaviors among emerging adults. PsyPills is a self-guided psychological intervention based on Rational-Emotive and Behavioral Therapy (REBT) principles and the Just-in-Time Adaptive Intervention (JITAI) framework. The app provides short, contextually adaptive \"psychological pills,\" or cognitive restructuring exercises, designed to help users replace irrational beliefs with rational alternatives in moments of emotional distress. The study will compare PsyPills app with an active control condition using the MoodWheel app, which supports emotional monitoring without therapeutic content.",[117],"Emotion Regulation Difficulties; Risky Behaviors (Substance Use, Risky Sexual Behavior, Self-harm, Aggression, Disordered Eating)","2025-12-12",{"date":120,"type":41},"2025-12-26",{"date":122,"type":21},"2026-01",{"date":124,"type":21},"2026-05",{"name":47,"class":48},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":137,"conditions":138,"keywords":141,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":150,"locationsCount":49},"100608432","death-anxiety-depression-and-anxiety-an-experimental-study-100608432","NCT07201480","Death Anxiety, Depression and Anxiety: An Experimental Study","Death Anxiety: Implications for Depression and Anxiety - An Experimental Study","Inclusion Criteria:\n\n* Age over 18 years.\n* Living in Cluj-Napoca (or otherwise willing and able to participate in the lab task)\n\nExclusion Criteria:\n\n* Personality disorder diagnosis\n* Psychotic disorder diagnosis\n* Suicidal ideation","65 Years",{"count":135,"type":21},128,[24],"The goal of this experimental study is to investigate the transdiagnostic role of death anxiety in depression and anxiety symptoms in participants from the general population.\n\nThe main questions it aims to answer are:\n\n1. Does the mortality salience task induce death anxiety?\n2. Does the experimental group present an increase in depression and anxiety symptoms following the mortality salience task?\n\nThe investigators will compare the experimental condition to a control condition to see if the death anxiety induction is responsible for the expected increase in depression and anxiety symptoms.\n\nThe mortality salience prompt will be asking participants to elaborate on their thoughts and feelings surrounding death and dying, including what they think happens during death. The dental pain prompt will ask participants to do the same, only in regards to the thought of having dental pain.\n\nExperimental group: participants will undergo a pen-and-paper writing task where they will be asked to answer two questions:\n\n1. \"Please briefly describe the emotions that the thought of your own death arouses in you.\"\n2. \"Jot down, as specifically as you can, what you think will happen to you physically as you die and once you are physically dead.\"\n\nControl group:\n\n1. \"Please briefly describe the emotions that the thought of dental pain arouses in you.\"\n2. \"Jot down, as specifically as you can, what you think happens to you physically as you experience dental pain and once you have physically experienced dental pain.\"",[139,140,29],"Death Anxiety","Depression",[142,34,35,143],"death anxiety","transdiagnostic","2025-09-23",{"date":146,"type":41},"2025-10-01",{"date":148,"type":41},"2025-03-01",{"date":122,"type":21},{"name":47,"class":48},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":161,"briefSummary":162,"conditions":163,"keywords":166,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":4},"100589998","the-efficacy-of-a-mindfulness-based-virtual-reality-intervention-to-reduce-pain-in-postoperative-patients-100589998","NCT06961695","The Efficacy of a Mindfulness-Based Virtual Reality Intervention to Reduce Pain in Postoperative Patients","Assessing the Effectiveness of a Mindfulness-Based Virtual Reality Intervention to Reduce Pain in Postoperative Patients: A Controlled Clinical Study","VR-MindPain","Inclusion Criteria\n\n* The participant is scheduled for surgery and is currently hospitalized for hernia or varicose vein procedures.\n* The participant is on the hospital's surgical waiting list.\n* The participant is willing and able to provide informed consent.\n* The participant agrees to participate in the study and to complete all required assessments during hospitalization and at follow-up (either at home or during post-operative medical visits).\n\nExclusion Criteria\n\n* Inability to provide informed consent due to mental incompetence (e.g., intellectual disability, dementia); mild cognitive impairment does not constitute an exclusion criterion.\n* Limited proficiency in the Romanian language.\n* Active substance use or alcohol use disorders that, in the opinion of the investigators, may interfere with participation.\n* History of motion sickness.\n* Severe visual impairment (e.g., inability to see clearly without glasses); patients who use contact lenses are not excluded.\n* Use of strong opioids (e.g., morphine).\n* Current suicide risk.",{"count":160,"type":21},64,[24],"The goal of this randomized clinical trial is to evaluate whether a virtual reality (VR) mindfulness intervention can reduce anxiety and postoperative pain in adults undergoing surgery, primarily hernia and varicose vein procedures.\n\nThe main research questions are:\n\n* Does a preoperative VR mindfulness intervention reduce anxiety before surgery?\n* Does this reduction in anxiety result in lower postoperative pain compared to usual care?\n* Does the intervention help prevent chronic pain two weeks after surgery? Researchers will compare a VR mindfulness intervention group with a treatment-as-usual (TAU) group to assess the intervention's effectiveness.\n\nParticipants will:\n\n* Be randomly assigned to one of two groups:\n\n  * Experimental group: Receive a VR mindfulness session on the first day of hospitalization (one day before surgery).\n  * Control group: Receive standard hospital care (no intervention).\n* Complete psychological and pain assessments at four time points:\n\n  1. Before the intervention (Day 1)\n  2. Immediately after the intervention (only the experimental group, Day 1)\n  3. After surgery (Day 2)\n  4. Two weeks after surgery (follow-up)\n* Report pain intensity using the Numeric Rating Scale (NRS) at four postoperative time points.\n\nBefore enrollment, participants will undergo a structured interview to assess eligibility.\n\nThis study aims to determine whether reducing preoperative anxiety through VR mindfulness contributes to improved pain management and a lower risk of developing chronic pain following surgery.",[164,165],"Pain, Postoperative","Anxiety Preoperative",[167,168,169,170,171],"Postoperative Pain","Mindfulness-Based Intervention","Pain Management","Chronic Pain Prevention","Virtual Reality","2025-05-06",{"date":174,"type":41},"2025-05-08",{"date":176,"type":21},"2025-05-12",{"date":178,"type":21},"2025-07-05",{"name":47,"class":48},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":133,"enrollmentInfo":187,"targetDuration":4,"studyType":22,"phases":189,"briefSummary":190,"conditions":191,"keywords":192,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":4},"100578415","from-fear-to-purpose-act-protocol-implications-of-death-anxiety-in-depression-and-anxiety-symptoms-100578415","NCT06810999","From Fear to Purpose ACT Protocol. Implications of Death Anxiety in Depression and Anxiety Symptoms.","From Fear to Purpose ACT Protocol: Testing Indirect, Transdiagnostic Implications of Death Anxiety Over Depression and Anxiety. A Randomized Placebo Controlled Trial.","Inclusion Criteria:\n\n* Moderate-high levels of death anxiety (score \\> or = 55) AND\n* Subclinical levels of depression (score \\> or = 9) AND\u002FOR\n* Subclinical levels of anxiety (score \\> or = 9)\n\nExclusion Criteria:\n\n* Minors\n* Suicidal ideation\n* Current psychological\u002Fpsychiatric diagnosis (except depression or anxiety diagnosis)\n* Active psychological\u002Fpsychiatric treatment",{"count":188,"type":21},175,[24],"The main purpose of this placebo controlled trial is to test the efficacy of a one-session From Fear to Purpose ACT intervention in reducing self-reported death anxiety levels. Another objective of this study is to investigate whether reductions in death anxiety levels are associated with reductions in depression and anxiety levels, thus testing if death anxiety is a transdiagnostic factor involved in psychopathology.",[139,140,29],[142,34,35,143,193,194],"indirect intervention","rct","2025-04-16",{"date":197,"type":41},"2025-04-18",{"date":199,"type":21},"2025-06-01",{"date":201,"type":21},"2025-12-30",{"name":47,"class":48},{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":133,"enrollmentInfo":211,"targetDuration":4,"studyType":22,"phases":213,"briefSummary":214,"conditions":215,"keywords":217,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":220,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":49},"100536256","an-ocd-prevention-programme-for-at-risk-adults-100536256","NCT06262464","An OCD Prevention Programme for at Risk Adults","The Efficacy of an OCD Prevention Programme for at Risk Adults: a Randomized Clinical Trial","ØCD","Inclusion Criteria:\n\n\\- age over 18\n\nExclusion Criteria:\n\n* clinically diagnosed OCD\n* current psychiatric\u002Fpsychotherapeutic treatment\n* personality disorder diagnosis\n* suicidal ideation",{"count":212,"type":21},200,[24],"The main purpose of this randomised clinical trial is to test the efficacy of a prevention program for adult who are at risk of developing OCD, thus constituting a form of tertiary prevention.",[216],"Obsessive-Compulsive Disorder",[218,219],"Risk","Prevention",{"date":197,"type":41},{"date":222,"type":41},"2024-02-09",{"date":224,"type":21},"2025-12-31",{"name":47,"class":48},{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":230,"acronym":231,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":16,"minAge":233,"maxAge":234,"enrollmentInfo":235,"targetDuration":4,"studyType":22,"phases":237,"briefSummary":238,"conditions":239,"keywords":246,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":258},"100571777","transdiagnostic-internet-delivered-intervention-for-adolescents-with-anxiety-and-depression-100571777","NCT06724666","Transdiagnostic Internet-delivered Intervention for Adolescents With Anxiety and Depression","NEURO4C","Inclusion Criteria:\n\n* elevated symptoms of anxiety or depression\u002F internalizing problems (T score\\> 60) at intake (based on Youth self-report completed by adolescents)\n* primary diagnosis of an anxiety\u002Fdepressive disorder based on DSM-5 criteria according to ADIS-5-C\u002FP interview\n* age 13-17\n* able to read and understand Romanian language\n* Currently unmedicated or on stable and adequate doses of medication for at least 6 weeks before treatment onset\n* Internet access\n\nExclusion Criteria:\n\n* severe mental disorder (psychosis, severe depression, bipolar disorder, based on clinical interview)\n* any condition that interferes with the protocol implementation (e.g., physical illness or sensory impairment that interferes with behavioral tasks such as exposure, behavioral activation, unavailable for the next 3 months),\n* active suicidal ideation (assessed by child psychiatrist during clinical interview) in the last month\n* currently following CBT\u002F psychotherapy for anxiety\u002Fdepression, in the last 6 months\n* fMRI incompatible (based on safety questionnaire)\n* Being diagnosed with an intellectual disability, pervasive developmental disorder, an alcohol and\u002For substance dependence disorder, reading disabilities (based on clinical interview).\n* Current treatment with benzodiazepines","13 Years","17 Years",{"count":236,"type":21},198,[24],"The goal of this clinical trial is to test the efficacy of a transdiagnostic Internet-delivered interventions for Romanian adolescents with anxiety and\u002F or depression. The main questions it aims to answer are:\n\n* What is the clinical efficacy of the Internet-delivered intervention?\n* How accurate is the prediction model in predicting who will respond to treatment? Participants will undergo non-invasive fMRI to measure variability in brain signal as a proxy of the neural systems' adaptability before receiving the intervention, then they will be allocated either to the Internet-delivered intervention or control group.",[240,241,242,243,244,245],"Anxiety Disorders","Depressive Disorder","Social Anxiety Disorder","Major Depressive Disorder","Dysthymia","Generalized Anxiety Disorder",[247,143,248,249,35,34],"Internet-delivered intervention","adolescents","internalizing","2025-04-02",{"date":252,"type":41},"2025-04-04",{"date":254,"type":41},"2025-04-01",{"date":256,"type":21},"2026-06-30",{"name":47,"class":48},2,{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":84,"officialTitle":84,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":57,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":265,"targetDuration":4,"studyType":22,"phases":266,"briefSummary":91,"conditions":267,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":49},"100565744","rethink-for-mental-health-of-the-youths-in-romania-100565744","NCT06646159","REThink","Inclusion Criteria:\n\n* internet and PC access to complete the scales and game\n\nExclusion Criteria:\n\n* no internet or PC access",{"count":89,"type":21},[24],[94,93,268],"Bullying","2024-10-17",{"date":271,"type":41},"2024-10-18",{"date":273,"type":21},"2025-09-01",{"date":275,"type":21},"2026-12-01",{"name":47,"class":48},{"id":278,"slug":279,"hasResults":11,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":283,"eligibilityCriteria":284,"healthyVolunteers":57,"sex":16,"minAge":285,"maxAge":234,"enrollmentInfo":286,"targetDuration":4,"studyType":22,"phases":288,"briefSummary":289,"conditions":290,"keywords":292,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":49},"100557161","the-effect-of-tomatis-auditory-stimulation-in-children-and-adolescents-with-ndds-100557161","NCT06534515","The Effect of Tomatis Auditory Stimulation in Children and Adolescents With NDDs","The Effect of Tomatis Auditory Stimulation in Children and Adolescent With Neurodevelopmental Disorders (TomatisOn)","TomatisOn","Inclusion Criteria:\n\n\\- neurodevelopmental disorder\n\nExclusion Criteria:\n\n* intellectual disability","4 Years",{"count":287,"type":21},40,[24],"The current study aims to explore the preliminary efficacy of the Tomatis method on auditory processing in children with NDDs.",[291],"Neurodevelopmental Disorders",[293,294,248],"Tomatis","children","2024-08-07",{"date":297,"type":41},"2024-08-09",{"date":299,"type":41},"2023-12-01",{"date":301,"type":21},"2024-09-30",{"name":47,"class":48},""]