[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Bahria University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":236},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,80,110,135,163,188,210],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100612610","phase-4-dual-vs-triple-lipid-lowering-therapy-in-type-2-diabetes-mellitus-patients-with-elevated-ldl-cholesterol-100612610",false,"NCT07255820","Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol","Comparative Efficacy and Safety of Dual Versus Triple Lipid-Lowering Therapies (Rosuvastatin\u002FEzetimibe, Bempedoic Acid\u002FEzetimibe, and Rosuvastatin\u002FEzetimibe\u002FBempedoic Acid ) in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol","Inclusion Criteria:\n\n* Males and females\n* Age 35-60 years\n* HbA1c ≥ 7.0 (≥ 48 mmol\u002Fmol)\n* On stable anti-diabetic therapy for at least 3 months\n* LDL-C \\> 100 mg\u002FdL on at least two occasions\n* Diagnosed with hypercholesterolemia\n* Establish high cardiovascular risk (e.g, previous MI, stroke or atherosclerosis) or\n* ≥2 cardiovascular risk factors (hypertension, smoking, obesity, family history)\n* BMI \\>23 - \\\u003C32(WHO Asian Criteria)\n* No prior statin side effects\n\nExclusion Criteria:\n\n* HbA1c \\>10 % (86 mmol\u002Fmol)\n* BMI \\> 32\n* Type 1 Diabetes, gestational diabetes\n* Pregnancy or lactation\n* Acute liver disease or ALT\u002FAST levels \\> 3× the upper limit of normal\n* Renal failure (GFR \\\u003C 30 mL\u002Fmin)\n* Uncontrolled hypothyroidism or nephrotic syndrome\n* Recent cancer diagnosis (last 6 months)\n* Current use of other lipid-lowering agents (e.g., fibrates or PCSK9 inhibitors)\n* Known allergy to any component\n* Statin intolerance with severe adverse effects (e.g., rhabdomyolysis)","ALL","35 Years","60 Years",{"count":20,"type":21},126,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This Open-label, randomized clinical trial evaluates the comparative efficacy and safety of dual versus triple lipid-lowering therapy using rosuvastatin, ezetimibe, and bempedoic acid in patients with type 2 diabetes mellitus and elevated LDL cholesterol. The study aims to determine whether adding bempedoic acid to standard dual therapy provides superior lipid control without compromising safety. The 126 participants, aged 35 - 60 years will be randomly assigned to one of three treatment groups for 12 weeks, and their lipid profiles, glycemic control, and adverse effects will be monitored.The total duration of study will be 6 months, with a 3 months individual treatment period.",[27,28],"Type 2 Diabetes Mellitus","Hypercholesterolemia \u002F Elevated LDL Cholesterol",[30,31,32,33,34,35],"Lipid-lowering therapy,","Rosuvastatin, Ezetimibe, Bempedoic Acid","Dual therapy vs Triple therapy","LDL-C","Dyslipidemia","Type 2 Diabetes","RECRUITING","2026-06-23",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":40},"2026-01-01",{"date":44,"type":21},"2026-06-30",{"name":46,"class":47},"Bahria University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":17,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100643580","comparison-of-acupressure-ibuprofen-and-chewing-gum-for-the-management-of-post-archwire-orthodontic-pain-100643580","NCT07638644","Comparison of Acupressure, Ibuprofen, and Chewing Gum for the Management of Post-Archwire Orthodontic Pain","Comparative Efficacy of Acupressure, Ibuprofen, and Chewing Gum in Managing Post-Archwire Orthodontic Pain: A Three-Arm Randomized Clinical Trial","Inclusion Criteria:\n\n* Age 15 to 35 years\n* Complete permanent dentition\n* Undergoing comprehensive fixed orthodontic treatment\n* Scheduled for initial archwire placement\n* Ability to comply with study procedures\n* Written informed consent provided (or parental\u002Fguardian consent for participants younger than 18 years)\n\nExclusion Criteria:\n\n* Pregnant or lactating\n* Systemic disorders that may affect pain perception\n* Periodontal disease\n* Neurological abnormalities that may affect pain perception\n* Known sensitivity to chewing gum\n* Documented allergy to ibuprofen\n* Use of adjunctive orthodontic appliances\n* Use of analgesics, anti-inflammatory medications, or other medications that may affect pain perception within 24 hours before enrollment",true,"15 Years",{"count":59,"type":21},105,[61],"NA","The goal of this clinical trial is to find out which method works best to reduce pain after braces are adjusted for the first time (when the first archwire is placed). The study will compare three approaches: acupressure (applying pressure on a specific point on the hand), ibuprofen (a pain-relief medicine), and chewing sugar-free gum. It will also check how safe these methods are and whether patients need extra pain medicine.\n\nThe main questions the researchers want to answer are:\n\nWhich method reduces orthodontic pain the most after the first archwire is placed? Do patients need extra painkillers in any of the groups? Are there any problems with braces (such as loose brackets or wire issues) within the first week?\n\nResearchers will compare the three groups to see which option gives the best pain relief during the first few days after braces are activated.\n\nParticipants will:\n\nBe placed into one of three groups: acupressure, ibuprofen, or chewing gum Use their assigned method after their first orthodontic wire is placed Rate their pain at different time points using a simple pain scale (VAS) Report if they take any extra pain medicine Be checked for any brace-related problems for up to 7 days\n\nThis study may help improve comfort and pain management for patients starting orthodontic treatment.",[64],"Malocclusion",[66,67,68,69,70],"Post-archwire orthodontic pain","Fixed orthodontic treatment","Chewing gum pain relief","Ibuprofen analgesia","Acupressure LI4 Hegu point","NOT_YET_RECRUITING","2026-06-09",{"date":74,"type":40},"2026-06-11",{"date":76,"type":21},"2026-07-01",{"date":78,"type":21},"2027-07-01",{"name":46,"class":47},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":56,"sex":16,"minAge":88,"maxAge":18,"enrollmentInfo":89,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":48},"100622604","psychosomatic-symptoms-in-patients-with-myofascial-pain-and-temporomandibular-joint-dysfunction-100622604","NCT07385781","Psychosomatic Symptoms in Patients With Myofascial Pain and Temporomandibular Joint Dysfunction","Psychosomatic Symptoms in Patients With Myofascial Pain and Temporomandibular Joint Dysfunction- A Case Control Study","Psychosomatic","Inclusion Criteria:\n\ndiagnosed patients with myofascial pain and TMD for at least six months based on Research Diagnostic Criteria for Temporomandibular Disorders (RDC\u002FTMD), Axis I, age between 20 and 60 years, literate and able to comprehend the questionnaire no prior psychological treatment for pain.\n\nExclusion Criteria:\n\nage \\\u003C20 or \\>60 years, low literacy (less than five years of formal education), history of major psychiatric or neurological disorders, diagnosed joint pathologies (e.g., arthritis, disc displacement with reduction), history of migraine or facial trauma, drug dependency and pregnancy or current use of psychotropic medication.","20 Years",{"count":90,"type":21},300,"OBSERVATIONAL","Temporomandibular joint disorder poses an intricate etiology. Biomechanical, neuromuscular and psychosocial factors may contribute to the disorder among which psychological and psychosocial disturbances have shown strong direct or indirect contribution to the disease especially when the pain is of muscular origin.",[94,95],"Psychosomatic Symptoms","Temporomandibular Disorder (TMD)",[97,98,99,100,101],"Anxiety","Depression","myofascial facial pain","Perceived stress","Somatization","2026-03-16",{"date":104,"type":40},"2026-03-18",{"date":106,"type":21},"2026-03-01",{"date":108,"type":21},"2026-08-30",{"name":46,"class":47},{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":121,"studyType":91,"phases":4,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":48},"100619002","validating-and-assessing-reliability-100619002","NCT07338955","Validating and Assessing Reliability","Validating and Assessing Reliability of the Urdu Version of the Disabilities of the Arm, Shoulder, and Hand (DASH) Questionnaire.","Inclusion Criteria:\n\nDiagnosed with any upper limb disability or deformity . Able to read, understand and speak Urdu. Individuals with symptoms enduring for at least one week .\n\nExclusion Criteria:\n\nCognitive impairment or psychiatric illness that hinders understanding of the questionnaire.\n\nPatients with congenital deformities. Refusal to give informed consent.","18 Years","45 Years",{"count":120,"type":21},385,"385 Weeks","This study aims to translate, culturally adapt, and validate the Urdu version of the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire for individuals with upper limb disabilities. Since no validated Urdu version currently exists, Urdu-speaking patients face communication barriers that may lead to inaccurate assessment and limited clinical decision-making. By ensuring semantic equivalence through forward-backward translation and expert review, the study seeks to develop a version that is both linguistically accurate and culturally appropriate.",[124],"Upper Limb Disability",[126],"Validation and Reliability of DASH Questionnaire","2026-01-07",{"date":129,"type":40},"2026-01-14",{"date":131,"type":40},"2025-11-03",{"date":133,"type":21},"2026-01-20",{"name":46,"class":47},{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":56,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":22,"phases":144,"briefSummary":145,"conditions":146,"keywords":149,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":48},"100609146","gingival-cleft-development-at-two-time-points-of-canine-retraction-100609146","NCT07210762","Gingival Cleft Development at Two Time Points of Canine Retraction","Gingival Cleft Development at Two Time Points of Canine Retraction: a Split-mouth Randomized Controlled Trial","Inclusion Criteria:\n\n1. Extraction advised of both first premolars from either maxilla, mandible or both.\n2. All permanent dentition present apart from third molars.\n\nExclusion Criteria:\n\n1. Severe crowding\n2. Smokers\n3. Patients with systemic diseases that could interfere with bone remodeling.\n4. Patients with periodontitis or poor periodontal health.\n5. Patients who have previously undergone periodontal surgery in the area of interest.\n6. Patients with other oral health conditions that could complicate the treatment or healing process.",{"count":143,"type":21},19,[61],"The goal of this split-mouth randomized controlled trial is to assess whether the timing of extraction space closure-early vs. delayed initiation-affects the incidence of gingival cleft development in orthodontic patients. The main question it aims to answer is:\n\nDoes the incidence of gingival cleft development get influenced by the specific time point at which orthodontic space closure is initiated following extraction?\n\nQuadrants will be assigned to the early movement group and the other to the delayed movement group and extractions will be performed accordingly. These will be assessed for the effect on development of gingival cleft development.",[147,148],"Gingival Cleft","Orthodontic Space Closure",[150,148,151,152,153,154],"gingival cleft","gingiva","gingival disease","tooth extraction","tooth socket","2025-10-02",{"date":157,"type":40},"2025-10-07",{"date":159,"type":21},"2025-10-15",{"date":161,"type":21},"2026-07-19",{"name":46,"class":47},{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":16,"minAge":170,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":48},"100580807","relationship-between-hemodynamic-changes-and-cardiopulmonary-fitness-in-type-2-diabetes-mellitus-patients-100580807","NCT06842108","Relationship Between Hemodynamic Changes and Cardiopulmonary Fitness in Type 2 Diabetes Mellitus Patients","diabetes","Inclusion Criteria:\n\n* Subjects who agreed to sign the informed consent form.\n* Subject with an age group 30-50yrs.\n* Female and male.\n* Controlled type 2 Diabetes Mellitus patients.\n\nExclusion Criteria:\n\n* Patient performing any exercise.\n* cardiovascular diseases.\n* Patients with Cerebrovascular diseases.\n* Patients with Peripheral artery diseases.\n* Patients with pulmonary dysfunction.","30 Years","50 Years",{"count":173,"type":21},162,"Diabetes mellitus being metabolic disorder, chronic in nature, is characterized by high levels of glucose in our blood, which often lead to organ dysfunction. Approximately 10.5 % of adult (20-79 years) have diabetes according to international Diabetes federation. Cardiorespiratory fitness (CRF) is the capability of our cardiopulmonary system to make oxygen available to our skeletal muscles during physical activities for prolonged time, and is known to be decreased with diabetes. Hemodynamic parameters are correlated with various cardiovascular disorders but little evidence of hemodynamic changes in diabetes patients is present and more studies must be done. This study aims to establish the link between hemodynamic changes and cardiopulmonary fitness in T2DM patients, which could inform clinical practices and interventions to improve management, reduce cardiovascular risks, and enhance the quality of life for these patients.",[176],"Diabetes Mellitus Type 2 (T2DM)",[178,179],"Diabetes Mellitus","Hemodynamic changes","2025-02-19",{"date":182,"type":40},"2025-02-24",{"date":184,"type":40},"2024-10-01",{"date":186,"type":21},"2025-04-15",{"name":46,"class":47},{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":16,"minAge":196,"maxAge":18,"enrollmentInfo":197,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":199,"conditions":200,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":4},"100579839","barriers-towards-physical-activity-100579839","NCT06829511","BARRIERS TOWARDS PHYSICAL ACTIVITY","BARRIERS TOWARDS PHYSICAL ACTIVITY IN CARDIAC PATIENTS","CARDIAC PATIEN","Inclusion Criteria:\n\n* 1\\. Heart patients who have been diagnosed with a cardiovascular condition for more than six months.\n\n  2\\. People between the ages of forty and sixty. 3. It was acceptable to have both male and female participants. 4. Patients either already participating in a cardiac rehabilitation program or those who had yet to engage in one were included.\n\nExclusion Criteria:\n\n1. Existence of musculoskeletal disorders that might affect their physical activity levels.\n2. Neurological conditions that could hinder exercise participation or influence responses to surveys.\n3. Chronic illnesses such as diabetes or irritable bowel syndrome that could interfere with the barriers evaluated in the study.","40 Years",{"count":198,"type":21},323,"A cross-sectional study of 323 cardiac patients aged 40 to 60 will be carried out at PNS Shifa and the National Institute of Cardiovascular Diseases. Data will be gathered using surveys and evaluated with SPSS software. The results are likely to show considerable differences in barrier frequency across demographic groups, offering insights into targeted treatments.\n\nUnderstanding these limitations is critical for establishing successful physical activity regimens, improving heart health, and, eventually, lowering rehospitalization rates. The findings will help to develop specific approaches to overcome these challenges and encourage regular physical exercise among cardiac patients.\n\nObjectives:\n\n1. To identify and categorize the specific barriers to physical activity faced by cardiac patients.\n2. To analyze how these barriers differ among various demographic groups (e.g., age, gender).\n3. To examine how barriers to physical activity vary according to clinical characteristics.\n\nMethodology:\n\nUsing a cross sectional study design, data data was collected from NICVD hospital and PNS shifa hospital by providing questionnaires to patient having cardiac disease. The questionnaires comprises of close ended questions.",[201],"Cardiac Patients","2025-02-11",{"date":204,"type":40},"2025-02-17",{"date":206,"type":21},"2025-02-15",{"date":208,"type":21},"2025-03-30",{"name":46,"class":47},{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":56,"sex":16,"minAge":117,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":220,"conditions":221,"keywords":225,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":48},"100511769","hiccups-and-obstacles-of-e-learning-among-medical-sudents-100511769","NCT05943743","Hiccups and Obstacles Of E-Learning Among Medical Sudents","Hiccups and Obstacles Of E-Learning Among Medical Students; A Cross-sectional Survey From Pakistan","Inclusion Criteria:\n\nAll undergraduate medical students of Pakistan.\n\nExclusion Criteria:\n\nPostgraduate Medical students Teaching Faculty","25 Years",{"count":219,"type":21},600,"The COVID-19 Pandemic is the characterizing worldwide wellbeing emergency within recent memory. Since its development in Asia before the end of last year, the infection has spread to each mainland with the exception of Antarctica. Countries are dashing to moderate the spread of the illness by testing and treating patients, completing contact following, restricting travel, isolating residents, and dropping huge social occasions like games, shows, and educational institutes.\n\nAs almost every institution was closed for the safety of human kind. All educational institutes were also closed for any kind of education. Also, In Pakistan all educational institutes were closed since march 2020. It was impossible to keep educational activities closed for long. In order to keep educational activities in working e-learning was introduced through out the world. As many other countries Pakistan also started e-learning for all students.",[222,223,224],"Covid-19","E-learning","Medical Student",[222,226,227],"obstacles","Screen Time","2025-01-06",{"date":230,"type":40},"2025-01-07",{"date":232,"type":40},"2022-12-20",{"date":234,"type":21},"2025-12-15",{"name":46,"class":47},""]