[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Banaras Hindu University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":88},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100503327","phase-2-addition-of-everolimus-to-standard-of-care-in-carcinoma-gallbladder-100503327",false,"NCT05833815","Addition of Everolimus to Standard of Care in Carcinoma Gallbladder","A Randomized Controlled, Open Labeled, Two Arm, Study of Addition of Everolimus to Standard of Care in Carcinoma Gallbladder","Inclusion Criteria:\n\n* Histological proof of cancer with stage III inoperable or Stage IV metastatic disease without any prior treatment.\n* Patients with histologic proof of metastatic gallbladder carcinoma who have not had previous treatment for metastatic disease or who received gemcitabine\u002Fcapecitabine with or without platinum\\>= 6 months ago as part of adjuvant therapy\n* Absolute neutrophil count (ANC) \\>= 1500\u002FuL\n* Platelet (PLT) \\>= 100,000\u002FuL\n* Total bilirubin =\\\u003C 3mg\u002Fdl for gemcitabine and any value for Capecitabine\n* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =\\\u003C 2.5 x upper limit of normal (ULN) (=\\\u003C 5x ULN in patients with liver metastases)\n* Creatinine =\\\u003C 1.5 x Institutional ULN\n* Alkaline phosphatase =\\\u003C 5 x Institutional ULN\n* Haemoglobin (Hgb) \\>= 8.0 g\u002FdL\n* International normalized ratio (INR) and Partial thromboplastin time (PTT) =\\\u003C 3.0 x ULN (anticoagulation is allowed if target INR =\\\u003C 3.0 x ULN on a stable dose of warfarin or on a stable dose of low-molecular-weight \\[LMW\\] heparin for \\> 2 weeks at time of registration)\n* Fasting serum glucose \\\u003C 1.5 x ULN\n* Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0, 1 or 2\n* Ability to provide informed consent\n* Willingness to return for follow up\n* Life expectancy \\>= 12 weeks\n* Women of childbearing potential only: Negative serum pregnancy test done =\\\u003C 7 days prior to registration.\n\nExclusion Criteria:\n\n* Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness\u002Fsocial situations that would limit compliance with study requirements\n* Clinically significant cardiac disease, especially history of myocardial infarction =\\\u003C 6 months, or congestive heart failure (New York Heart Association \\[NYHA\\] classification III or IV) requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias\n* Patients taking strong inhibitors or inducers of CYP3A4\n* Prior therapy with everolimus\n* Any of the following prior therapies:\n\n  * Chemotherapy =\\\u003C 4 weeks prior to registration\n  * Immunotherapy =\\\u003C 4 weeks prior to registration\n  * Biological therapy =\\\u003C 4 weeks prior to registration\n  * Radiation therapy =\\\u003C 4 weeks prior to registration\n  * Radiation to \\> 25% of bone marrow prior to registration\n* Failure to fully recover from acute, reversible effects of prior chemotherapy regardless of interval since last treatment\n* CNS metastases brain or leptomeningeal metastases that are not stable for at least 4 weeks prior to registration based on imaging, clinical assessment, and use of steroids\n* Pregnant women\n* Nursing women\n* Men or women of childbearing potential who are unwilling to employ adequate contraception\n* Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens\n* Immunocompromised patients (other than that related to the use of corticosteroids) including patients known to be human immunodeficiency virus (HIV) positive\n* Current active other malignancy, Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of everolimus (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection)\n* Severely impaired lung function (i.e., forced expiratory volume in one second \\[FEV1\\] \\\u003C 1 liter)\n* Received immunization with attenuated live vaccines =\\\u003C 7 days prior to study entry or during study period; close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus; examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, BCG, yellow fever, varicella and TY21a typhoid, SARS CoV2 vaccines\n* Liver disease such as cirrhosis or severe hepatic impairment (Child-Pugh class C); A detailed assessment of Hepatitis B\u002FC medical history and risk factors will be done at screening for all patients; hepatitis B virus (HBV) deoxyribonucleic acid (DNA) and hepatitis C virus (HCV) ribonucleic acid (RNA) polymerase chain reaction (PCR) testing are required at screening for all patients with a positive medical history based on risk factors and\u002For confirmation of prior HBV\u002FHCV infection.","ALL","18 Years","99 Years",{"count":20,"type":21},56,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","Gallbladder cancer (GBC) is the most common malignant tumour of the biliary tract. It is also the most aggressive cancer of the biliary tract with the shortest median survival from the time of diagnosis. Currently, radical resection is the most effective strategy to potentially cure GBC. Chemotherapy and radiotherapy have been employed as adjuvant and palliative setting, however, the overall survival is still dismal. This study aim to evaluate the addition of Everolimus in addition to standard of care in gallbladder cancer.",[28],"Gallbladder Cancer",[30,31,32],"everolimus","mToR inhibitors","chemotherapy","RECRUITING","2024-08-09",{"date":36,"type":37},"2024-08-13","ACTUAL",{"date":39,"type":37},"2022-11-01",{"date":41,"type":21},"2024-12-30",{"name":43,"class":44},"Banaras Hindu University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100468653","newer-therapeutic-targets-in-head-and-neck-cancers-100468653","NCT05382585","Newer Therapeutic Targets in Head and Neck Cancers","A Cohort Study to Identify Newer Therapeutic Targets in Head and Neck Cancers","Inclusion Criteria:\n\n* Histologically proven cases of primary head and neck cancers.\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Pregnant and lactating women\n* Multiple cancers or patients with cancer of other sites.","100 Years",{"count":55,"type":21},200,"OBSERVATIONAL","Based on the recently identified mutations in HNSCCs, the major pathologic pathways implicated in the tumorigenesis of HNSCC include dysregulation of four processes:\n\n1. cellular survival and proliferation (e.g., TP53, EGFR, MET, and PIK3CA);\n2. cell-cycle control (e.g., CDKN2A and CCND1);\n3. cellular differentiation (e.g., NOTCH1); and\n4. Adhesion and invasion signaling (e.g., FAT1).7 TP53, EGFR, PIK3CA, CDKN2A, CCND1, and MET participate in several common signaling pathways.\n\nAlterations of these genes are most frequently seen in alcohol and tobacco-related HNSCC. However their role in prognostication and selection of therapeutics is not known",[59,60],"Head Neck Cancer","Oral Cancer",[62,63],"Next generation sequencing","predictive biomarker",{"date":36,"type":37},{"date":66,"type":37},"2017-04-01",{"date":68,"type":21},"2027-12-31",{"name":43,"class":44},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":77,"targetDuration":79,"studyType":56,"phases":4,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":82,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":45},"100470322","ngs-in-gallbladder-cancer-and-response-to-treatment-100470322","NCT05404347","NGS in Gallbladder Cancer and Response to Treatment","Genetic Mutations and Response to Treatment in Gallbladder Cancer: A Hospital Based Cohort Study","Inclusion Criteria:\n\n* Treatment naïve patients with histologically proven carcinoma of the gallbladder.\n\nExclusion Criteria:\n\n* No histological evidence of malignancy\n* Pregnant and lactating women",{"count":78,"type":21},100,"5 Years","Evidence suggests distinct models of molecular and pathologic progression, and a growing body of genetics data points to a heterogeneous collection of underlying mutations in key oncogenes and tumor suppressor genes. Although tumor genetics have been used to tailor individual treatment regimens and guide clinical decision making in other cancers, these principles have not been applied in gallbladder malignancy. Recent clinical trials with targeted therapies seem promising, although the relationships between subsets of patients with positive responses to therapy and tumor genetics remain unexplored.",[28],{"date":36,"type":37},{"date":84,"type":37},"2018-01-01",{"date":86,"type":21},"2026-12-31",{"name":43,"class":44},""]