[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Bangrak STIs Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100623497","phase-4-the-efficacy-of-doxycycline-post-exposure-prophylaxis-for-preventing-stis-among-msm-in-bangkok-thailand-100623497",false,"NCT07397403","The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.","The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing Sexually Transmitted Diseases (Gonorrhea, Chlamydia, Syphilis) Among Men Who Have Sex With Men in Bangkok, Thailand.","ThaiDoxyPEP","Inclusion Criteria:\n\nBiological male, aged not over 60 years\n\nThai nationality\n\nAble to read, communicate, and understand the Thai language\n\nMen who have sex with men (MSM), aged 18 years or older and not over 60 years\n\nHaving at least one of the following risk factors:\n\nA history of condomless sex, or condom failure (breakage, leakage, or slippage), via any sexual route with at least two sexual partners within the past 3 months\n\nA diagnosis of gonorrhea, chlamydia, or syphilis within the past 6 months\n\nCurrent use of HIV pre-exposure prophylaxis (PrEP)\n\nWilling and able to participate in study procedures (e.g., able to return to the clinic for scheduled testing for gonorrhea, chlamydia, and syphilis; able to complete doxycycline use records; and able to receive follow-up phone calls from the research team)\n\nWilling and able to provide written informed consent to participate in the study\n\n\\-\n\nExclusion Criteria:\n\n* History of allergy to tetracycline-class antibiotics\n\nDiagnosed with syphilis and not yet treated, or currently receiving treatment with benzathine penicillin G or doxycycline\n\nReceipt of benzathine penicillin G within the past 12 weeks\n\nPrior receipt of a gonorrhea vaccine\n\nCurrent use of medications or products that may interact with doxycycline, including:\n\nVitamin A derivatives (e.g., isotretinoin, acitretin)\n\nAntiepileptic drugs (e.g., phenytoin, carbamazepine, phenobarbital)\n\nImmunosuppressive agents (e.g., methotrexate)\n\nMedications for heart failure or cardiac arrhythmias (e.g., digoxin)\n\nAnticoagulants (e.g., warfarin)\n\nUse of oral or injectable medications that affect blood cells, such as anticancer drugs, chemotherapy, systemic corticosteroids, or targeted therapies\n\nHistory of renal impairment (eGFR \\\u003C 60 mL\u002Fmin\u002F1.73 m²) or hepatic impairment (AST or ALT \\> 3 times the upper limit of normal)\n\nUncontrolled or unstable underlying diseases, such as hematologic disorders, cancer, autoimmune diseases, or neurological disorders\n\nSevere medical or psychiatric conditions that, in the investigator's judgment, may increase study-related risk or impair the participant's ability to provide informed consent\n\nAlcohol dependence (inability to control alcohol consumption, withdrawal symptoms upon reduction or cessation, or continued use despite harm) or illicit drug dependence (regular, uncontrolled use) within the past 12 months prior to enrollment, which may affect doxycycline use for STI prevention\n\nPrevious participation in this study with prior randomization",true,"MALE","18 Days","60 Days",{"count":22,"type":23},400,"ESTIMATED","INTERVENTIONAL",[26],"PHASE4","The objective of this research is to evaluate the efficacy and safety of doxycycline in MSM for preventing sexually transmitted infections (gonorrhea, chlamydia, and syphilis) in Thailand\n\nParticipation in this study will last approximately 12 weeks and will include 2-3 clinic visits, along with 10-11 follow-up phone contacts over a period of 11 weeks.",[29,30,31],"Syphilis Infection","Gonorrhea","Chlamydia",[33,34,35,36,31,37],"DoxyPEP","MSM","Syphilis","gonorrhea","Prevention","RECRUITING","2026-02-02",{"date":41,"type":42},"2026-02-09","ACTUAL",{"date":44,"type":42},"2025-10-06",{"date":46,"type":23},"2027-05-31",{"name":48,"class":49},"Bangrak STIs Center","OTHER_GOV",""]