[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Banner Health\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":117},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,39,68,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100606688","phase-2-phase-ii-evaluation-of-cytoreduction-surgery-and-hyperthermic-intraperitoneal-chemotherapy-crshipec-in-gastric-cancer-100606688",false,"NCT07178808","PHASE II EVALUATION OF CYTOREDUCTION SURGERY AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (CRS\u002FHIPEC) IN GASTRIC CANCER","Inclusion Criteria:\n\n* 1\\) Age 18 years and above. There will be no upper age restriction. 2)ECOG performance status ≤ 2. (See Appendix A -ECOG Performance Status Scale). 3)Cytologic or histologic proof of adenocarcinoma of the stomach or gastroesophageal junction.\n\n  4)Adequate renal, and bone marrow function:\n  1. Leukocytes \\>= 3,000\u002FuL\n  2. Absolute neutrophil count \\>= 1,500\u002FuL\n  3. Platelets \\>= 60,000\u002FUl\n  4. Serum creatinine \\\u003C= 1.5 mg\u002FdL 5)Distant metastatic disease of peritoneum may be visualized on imaging:\n\n  \u003C!-- -->\n\n  1. Positive peritoneal cytology only\n  2. Carcinomatosis on diagnostic laparoscopy or laparotomy.\n\n     Exclusion Criteria:\n* 1)Distant metastatic disease not limited to peritoneum:\n\n  1. Solid organ metastases (liver, central nervous system, lung). 2) Infections such as pneumonia or wound infections that would preclude protocol therapy.\n\n     3\\) Women with a positive urine or serum pregnancy test are excluded from this study; women ofchildbearing potential (defined as those who have not undergone a hysterectomy or who have not been postmenopausal for at least 24 consecutive months) must agree to refrain from breast feeding and practice adequate contraception as specified in the informed consent. Adequate contraception consists of oral contraceptive, implantable contraceptives, injectable contraceptives, a double barrier method, or abstinence.\n\n     4)Participants with unstable angina or New York Heart Association Grade II or greater congestive heart failure.\n\n     5\\) Participants deemed unable to comply with study and\u002For follow-up procedures. 6)Participants with a known hypersensitivity to protocol systemic chemotherapy that was life-threatening, required hospitalization or prolongation of existing hospitalization, or resulted in persistent or significant disability or incapacity.","ALL","18 Years",{"count":18,"type":19},30,"ESTIMATED","INTERVENTIONAL",[22],"PHASE2","This is a Phase II treatment study analyzing the role of preoperative chemotherapy, preoperative laparoscopic HIPEC, and gastrectomy with CRS\u002FHIPEC in gastric adenocarcinoma patients with cytology-positive only carcinomatosis, radiologically-occult carcinomatosis, or radiology apparent peritoneal-surface only metastatic disease.",[25],"Gastric Adenocarcinoma","RECRUITING","2026-04-29",{"date":29,"type":30},"2026-05-01","ACTUAL",{"date":32,"type":30},"2021-04-16",{"date":34,"type":19},"2031-02-22",{"name":36,"class":37},"Banner Health","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":15,"minAge":16,"maxAge":48,"enrollmentInfo":49,"targetDuration":51,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":38},"100210942","alzheimers-prevention-registry-a-program-to-accelerate-enrollment-into-studies-100210942","NCT02022943","Alzheimer's Prevention Registry: A Program to Accelerate Enrollment Into Studies","Alzheimer's Prevention Registry","APR","Inclusion Criteria:\n\n* Must be able to accept the Alzheimer's Prevention Registry website terms and conditions\n\nExclusion Criteria:\n\n* None",true,"110 Years",{"count":50,"type":19},500000,"20 Years","OBSERVATIONAL","The Alzheimer's Prevention Registry (www.endALZnow.org) will collect contact and demographic information on individuals. The objective is to provide information the latest news and advances in Alzheimer's prevention research, and to inform enrollees about research studies in their community. Enrolled individuals will receive regular email communications. As research studies become available, individuals will be notified via email with information as to how proceed should they be interested. Registry enrollees are under no obligation to participate in a research study. Study opportunities may include surveys, healthy lifestyle interventions (e.g., diet, exercise), memory \\& thinking tests, brain scans, and investigational drug trials. To join the Registry, please visit www.endALZnow.org",[55,56],"Alzheimer's Disease","Dementia",[58,59],"Alzheimer's","prevention","2025-12-08",{"date":62,"type":30},"2025-12-16",{"date":64,"type":4},"2012-05",{"date":66,"type":19},"2030-01",{"name":36,"class":37},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":47,"sex":15,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":20,"phases":79,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":38},"100592692","phase-2-a-study-of-donanemab-rg6289-or-the-combination-of-donanemab-and-rg6289-in-presenilin-1-psen1-e280a-mutation-carriers-for-the-treatment-of-autosomal-dominant-alzheimers-disease-100592692","NCT06996730","A Study of Donanemab, RG6289, or the Combination of Donanemab and RG6289 in Presenilin 1 (PSEN1) E280A Mutation Carriers for the Treatment of Autosomal-Dominant Alzheimer's Disease","A Double-Blind, Placebo-Controlled, Double-Dummy Study of Donanemab and RG6289 in PSEN1 E280A Mutation Carriers, and in Non-Randomized, Placebo-Treated Non-Carriers From the Same Kindred, to Evaluate the Efficacy and Safety of Donanemab, RG6289, or the Combination of Donanemab and RG6289, in the Treatment of Autosomal-Dominant Alzheimer's Disease","Inclusion Criteria:\n\n* Membership in PSEN1 E280A mutation carrier kindred.\n* Agrees to conditions of, and is willing to undergo, genetic testing (e.g., APOE, PSEN1 E280A, and other genetic testing allowed by local regulatory requirements).\n* Males and females aged 25-65 inclusive.\n* Must meet one of the following criteria:\n\n  a. Determined to be cognitively normal as defined by an MMSE of ≥24 for participants with less than 9 years of education or MMSE of ≥26 for participants with 9 or more years of education. b. Or determined to have MCI with amnestic presentation as defined by:\n\n  1\\. Cognitive concern in the judgment of the Investigator, based in part on the: i. CERAD Word List: Recall \\\u003C3 for participants with less than 9 years of education. ii. CERAD Word List: Recall \\\u003C5 for participants with 9 or more years of education. iii. Preservation of independence in functional activities in the judgment of the Investigator. c. Or determined to have mild AD dementia as defined by:\n  1. Meets the 2011 National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria for probable AD, and\n  2. Has a CDR-GS of 0.5 or 1, with the memory box score ≥0.5.\n\n     Exclusion Criteria:\n* Significant medical, psychiatric, or other neurological condition or disorder documented by history, physical, neurological, laboratory examinations that would place the participant at undue risk in the Investigator's judgment or impact the interpretation of efficacy.\n* History of stroke.\n* History of severe, clinically significant (persistent neurological deficit or structural brain damage) CNS trauma (e.g., cerebral contusion).\n* Current presence of bipolar disorder or other clinically significant major psychiatric disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) or symptom (e.g., hallucinations, agitation, paranoia) that could affect the participant's ability to complete evaluations.\n* History of seizures (excluding febrile seizures of childhood, or other isolated seizure episodes that were not due to epilepsy in the judgment of the Investigator, and required at most time-limited anticonvulsant treatment, and which occurred more than 7 years prior to the screening visit).\n* Women who are pregnant or intend to become pregnant during the conduct of this study.\n* Women who are nursing infants or intend to nurse infants during the conduct of this study.\n* Known (or prior) hypersensitivity to donanemab, RG6289, or any excipients of RG6289.\n* History of or active inflammatory bowel disease (e.g., Crohn disease or ulcerative colitis).\n* Medical history of malignancy in the past 5 years, with the following exceptions:\n\n  1. If considered to be cured or,\n  2. If not being actively treated with anti-cancer therapy or radiotherapy and, in the opinion of the Investigator, is not likely to require treatment in the ensuing 5 years and,\n  3. For prostate cancer or basal cell carcinoma, no significant progression over the previous 2 years.\n  4. In-situ cervix carcinoma that has been successfully treated.\n  5. Fully excised non-melanoma skin cancers or in-situ melanoma.\n* Any surgery or hospitalization during the 4 weeks prior to screening or pre-planned\u002Fscheduled during the study period that, in the opinion of the Investigator, may compromise eligibility to the study. The Medical Monitor is available to the Investigator to advise and answer any questions.\n* Inability to tolerate MRI procedures or contraindication to MRI, including, but not limited to, presence of pacemakers not compatible with MRI, aneurysm clips, artificial heart valves, ear implants, or foreign metal objects in the eyes, skin, or body that would contraindicate an MRI scan, or any other clinical history or examination finding that, in the judgment of the Investigator, would pose a potential hazard in combination with MRI\n* Prior participation in an anti-amyloid therapy trial is allowed if it has been at least 1 year since the last study dose.\n* Any other investigational treatment, including anti-amyloid small molecules (i.e., BACEi and GSIs, other GSMs) within five half-lives or 16 weeks prior to screening (calculated from the last safety follow-up visit of the previous study), whichever is longer. Note: The participant may be eligible for this study if it can be documented that he\u002Fshe was randomized to placebo","25 Years","65 Years",{"count":78,"type":19},240,[22,80],"PHASE3","The study will be conducted in 2 blinded parts (Part 1 and Part 2). In Part 1, study participants who are mutation carriers will receive active donanemab and non-mutation carriers will receive placebo-donanemab for up to 18 months (76 weeks), with a minimum treatment period of 9 months. Amyloid PET scans will be conducted at screening, 9, and 18 months in Part 1. Participants who are at or below 11 CL at screening or reach complete amyloid plaque clearance as measured by florbetapir F18 PET (defined as ≤11 CL) at 9 months will initiate Part 2. Participants who are ≤11 CL at screening may delay their entry into Part 2 for up to 6 months at the discretion of the Investigator. All remaining participants will start Part 2 after completing 18 months (76 weeks) in Part 1 independent of amyloid results. Non-carriers will receive placebo in both Parts 1 and 2.\n\nIn Part 2, study participants who are mutation carriers will be randomized 1:1:1:1 in a full factorial design to receive either RG6289 + placebo-donanemab (RG6289 alone group), donanemab + placebo-RG6289 (donanemab alone group), the combination of RG6289 and donanemab (combination group), or placebo-RG6289 and placebo-donanemab (placebo group). All non-carriers will be assigned to the placebo group. CDR-GS at the end of Part 1 and the amyloid level using the last completed amyloid PET scan in Part 1 will be used for stratification. All study participants will participate in a double-dummy design for the duration of Part 2 receiving both an intravenous (IV) infusion at the required interval for the donanemab or matching placebo as well as a daily oral treatment of RG6289 or matching placebo.\n\nAn exploratory outcome of Part 1 is a comparison of the amyloid clearance between this ADAD cohort and historical controls using propensity score matching. The primary outcome in Part 2 is change from the start of Part 2 through the end of Part 2 in brain amyloid load in PSEN1 E280A mutation carriers as measured by amyloid PET imaging. Other endpoints will include fluid and imaging biomarkers and measures of cognition and functioning. The maximum study duration for any individual participant will be 3 years, not including the screening or follow-up periods",[83,84,85],"Autosomal Dominant Alzheimers Disease","Early Onset Alzheimer Disease","Alzheimers Disease",[56],"NOT_YET_RECRUITING","2025-08-01",{"date":90,"type":30},"2025-08-03",{"date":92,"type":19},"2026-01-15",{"date":94,"type":19},"2030-06-01",{"name":36,"class":37},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":15,"minAge":102,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},"100470378","arizona-alzheimers-disease-research-center-adrc-100470378","NCT05405075","Arizona Alzheimer's Disease Research Center (ADRC)","Inclusion Criteria:\n\n* Cognitively normal persons, individuals with mild cognitive impairment or dementia who are at least 40 years of age.\n* Willing to undergo health and cognitive assessments, and collection and banking of blood with venipuncture for genetic research, biomarker research, and DNA banking.\n\nExclusion Criteria:\n\n* 1\\. Participants whose diagnosis is unclear and confounded by multiple possible factors are excluded. Participants with diagnoses of non-AD dementias are not excluded.\n\n  2\\. Participants whose primary diagnosis is cognitive impairment due to a penetrating or single severe closed head injury, multiple sclerosis, brain tumor, metabolic or toxic encephalopathy, post-infectious (e.g., viral encephalitis, bacterial meningitis), paraneoplastic, primary psychiatric illness, or otherwise not deemed relevant to the intent of the Alzheimer Disease Center program are excluded.\n\n  3\\. Procedure specific exclusion criteria also apply but this does not impact the participants ability to be included in the study.","40 Years",{"count":104,"type":19},550,"The Arizona Alzheimer's Disease Research Center (ADRC) is the National Institute on Aging's (NIA's) first statewide AD Center (ADC), the only ADC in the Southwestern United States, and a leading example of statewide collaboration in biomedical research. It capitalizes on Arizona's strengths in brain imaging, genomics, computer science and biomathematics, the basic, cognitive and behavioral neurosciences, clinical, and neuropathological studies of AD, the discovery and evaluation of investigational treatments, and the study of normal cognitive aging.",[107],"Alzheimer Disease","2024-08-16",{"date":110,"type":30},"2024-08-19",{"date":112,"type":30},"2021-10-01",{"date":114,"type":19},"2026-06-30",{"name":36,"class":37},5,""]