[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Baris Gencer\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100509991","moderate-alcohol-consumption-and-heart-function-in-patients-with-a-recent-myocardial-infarction-100509991",false,"NCT05920629","Moderate Alcohol Consumption and Heart Function in Patients With a Recent Myocardial Infarction","Moderate Alcohol Consumption and Heart Function in Patients With a Recent Myocardial Infarction: a Multicentre Randomized Controlled Trial","Moderate","Inclusion Criteria:\n\n* Hospitalization for acute ST-elevation MI (STEMI) or non ST-elevation MI (NSTEMI) within 365 days prior to screening\n* Men and women aged ≥18 years who are capable and willing to provide consent\n* ECG ischemic changes, such as persistent or dynamic ST-segment deviation\n* Evidence of positive high-sensitive troponin\n* Confirmation of coronary heart disease aetiology by angiography\n* Capacity to complete study visits with strict adherence to the protocol assignment\n* Self-reported average alcohol consumption of between 1 and 28 standard units per week in the 12 months prior to the index hospitalization.\n\nExclusion Criteria:\n\n* High alcohol consumption, defined as an average of \\>28 alcoholic standard units\u002Fweek in the 12 months prior to the index hospitalization\n* Alcohol use disorder (AUDIT score \\>20 at screening)\n* History of alcohol or substance abuse\n* Naïve to alcohol consumption\n* Light alcohol consumption (\\\u003C1 standard units by week)\n* Prior severe heart failure (NYHA III-IV)\n* Severe LV dysfunction at screening (\\\u003C30%)\n* History of gastric ulcer or gastro-intestinal bleeding\n* Serious chronic liver disease or liver test elevation (\\> 3 times upper limit normal range)\n* Personal history of any colon or liver cancer\n* Any active malignancy (less than 5 years or ongoing treatment)\n* Estimated glomerular filtration rate 15 ml\u002Fmin\u002F1.73m² or end-stage renal disease\n* Any medication (investigator's discretion) making study participation impractical or precluding required follow-up\n* History of organ transplant\n* Participation in another trial testing intervention on similar CV outcomes (investigator's discretion)\n* Any medical, geographic, or social factor making study participation impractical or precluding required follow-up.\n* Pregnant, breastfeeding or planning to become pregnant within 12 months.","ALL","18 Years",{"count":20,"type":21},220,"ESTIMATED","INTERVENTIONAL",[24],"NA","A total of 220 patients (110 per arm) who report moderate alcohol consumption between 1 and 28 standard units (1 standard unit = \\~10 grams) per week in the 12 months prior to hospital admission will be planned for randomization, using a 1:1 ratio to pursue moderate alcohol consumption (1 standard unit per day for women and 2 standard units per day for men) or abstinence (except for one drink on predefined\u002Fagreed special occasions) for a total duration of 3 months. An echocardiography will be performed at baseline and 3 months to assess changes in systolic cardiac function (LVEF) for the primary endpoint. A core laboratory team blinded to assignment will perform data interpretation.",[27],"Myocardial Infarction","RECRUITING","2026-04-22",{"date":31,"type":32},"2026-04-28","ACTUAL",{"date":34,"type":32},"2023-06-01",{"date":36,"type":21},"2026-04-30",{"name":38,"class":39},"Baris Gencer","OTHER",4,""]