[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Barron Associates, Inc.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":132},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,81,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100627588","virtual-activities-of-living-for-occupational-rehabilitation-100627588",false,"NCT07450586","Virtual Activities of Living for Occupational Rehabilitation","Virtual Activities of Living for Occupational Rehabilitation (VALOR)","VALOR","Criteria for inclusion:\n\n1. Participant has had a right or left hemispheric stroke affecting normal hand function.\n2. At least 3 months have passed since the last stroke.\n3. Participant has sufficient active finger flexion at the MCP joint in at least one finger to be detected by visual observation by a study therapist.\n4. Participant has visual acuity with corrective lenses of 20\u002F50 or better.\n5. Participant must have active movement against gravity of at least 30 degrees shoulder flexion, 45 degrees elbow flexion, elbow extension to within 30 degrees of full extension, and 15 degrees shoulder internal and external rotation.\n6. In the opinion of a study therapist, participant can independently and safely use the system at home or has an at-home caregiver who is willing and able to assist.\n7. In the opinion of a study therapist, participant has a suitable and safe space in their home for using the VALOR system.\n8. Participant is willing and able to provide informed consent.\n\nCriteria for exclusion:\n\n1. Withholding or withdrawal of consent by the participant.\n2. Inability to understand and follow verbal directions.\n3. Determination by the Principal Investigator that participation would result in overexertion or significant discomfort or pain.\n4. A psychological diagnosis that in the determination of the Principal Investigator could significantly impact subject's participation or that could be aggravated by study participation (Principal Investigator will consult with candidate's personal physician as appropriate).\n5. Determination by the Principal Investigator that participation would result in significant agitation or elevated stress.\n6. Visual field deficit in either eye that impairs the ability to view the VR display.\n7. Significant contractures of the muscles, joints, tendons, ligaments, or skin that restrict normal upper extremity movement.\n8. More than mild tone\u002Fspasticity (measured on modified Ashworth, 5-point scale);\n9. Severe pre-stroke co-morbidities, such as cardiovascular, neurological, orthopedic, or rheumatoid impairments before stroke that may interfere with task performance.\n10. Severe sensory deficits from the involved UE; or\n11. Hemispatial neglect that impairs the ability to process and perceive visual stimuli provided through the VR display.\n\nAs the system will be adaptable to a wide range of hand dexterity, no restriction will be made for fine control of digits. Patients will not be excluded due to inability to use the VR headset. If at any time the study therapist, in consultation with the Duke PI, determines the patient is not tolerating VR headset use, the patient will be given the option to use a non-immersive version of the VALOR system which employs a TV monitor and depth sensor in lieu of the headset. Please see Potential Risks section for additional details on controls and mitigations for potential cyber sickness.","ALL","18 Years",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","Duke University will serve as the clinical research site for the Phase II RCT of the VALOR system, which enables telehealth delivery of evidence-based upper extremity (UE) stroke therapy in a patient's home using immersive VR headset technology for guided practice of activities of daily living (ADLs) and instrumental ADLs (IADLs). The study compares VALOR Home Exercise Program (HEP) to Usual Care Treatment (UCT) in adults with stroke-related UE impairment.",[27,28,29,30,31],"Stroke","Occupational Therapy","Activities of Daily Living","Rehabilitation","Virtual Reality",[33,31,34,35,36,29,37,38,39,40,41,28],"Stroke Rehabilitation","Upper Extremity","Telehealth","Home Exercise Program","Fugl-Meyer Assessment","Wolf Motor Function Test","Motor Activity Log","Hand Function","Hemiplegia","NOT_YET_RECRUITING","2026-04-22",{"date":45,"type":46},"2026-04-27","ACTUAL",{"date":48,"type":21},"2026-06-15",{"date":50,"type":21},"2027-07-29",{"name":52,"class":53},"Barron Associates, Inc.","INDUSTRY",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":54},"100634673","a-system-to-help-with-freezing-of-gait-in-parkinsons-patients-100634673","NCT07542743","A System to Help With Freezing of Gait in Parkinson's Patients","A Novel Instrument to Address Freezing of Gait in Parkinson's Patients","Inclusion Criteria:\n\n* Confirmed diagnosis of idiopathic Parkinson's Disease\n* Prior identified presence of Freezing of Gait\n* Ability to ambulate;\n* Montreal Cognitive Assessment (MOCA) MOCA questionnaire score \\>=21.\n\nExclusion Criteria:\n\n* Peripheral neuropathy\n* Dementia\n* Severe gait abnormalities not related to Parkinson's Disease.","21 Years",{"count":64,"type":21},60,[24],"The goal of this clinical trial is to learn if the ParkinSense system, a customizable, multimodal, and adaptable cueing system, can assist with freezing of gait (FOG) in patients with Parkinson's disease. The main question it aims to answer is: is the percent of time spent frozen reduced when using the system compared to not using the system? Participants will be asked to take part in a single-visit laboratory study where they will wear the system in a controlled environment, followed by a two weeks of home use.",[68],"Freezing of Gait Symptoms in Parkinson Disease",[70,71,72],"FOG","Freezing of Gait","Parkinson's Disease","2026-04-20",{"date":75,"type":46},"2026-04-21",{"date":77,"type":21},"2026-06-01",{"date":79,"type":21},"2027-05-31",{"name":52,"class":53},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":54},"100523013","knee-biofeedback-rehabilitation-through-game-therapy-100523013","NCT06090097","Knee Biofeedback Rehabilitation Through Game Therapy","Knee-Biofeedback Rehabilitation Interface for Game-based Home Therapy","KneeBRIGHT","Inclusion Criteria:\n\n* diagnosis via x-ray, with a score of at least 2 (out of 4) on the Kellgren-Lawrence OA scoring system; independent ambulation without assistive device\n\nExclusion Criteria:\n\n* individuals who have psychiatric or cognitive impairment (e.g., dementia) that interferes with their ability to follow instructions or provide voluntary consent; symptomatic spine, hip, ankle, or foot disease other than OA that would interfere with assessment of the knee.","30 Years","75 Years",{"count":64,"type":21},[24],"The goal of this study is to learn about the effect of video-game based rehabilitation exercise for patients with knee osteoarthritis. The main question the study aims to answer is: do patients who exercise with the game have better functional outcomes and engagement compared to patients who do conventional exercise? Participants will complete 10 weeks of physical therapy exercise sessions that focus on quadriceps strengthening. Two sessions per week will be conducted in the clinic, and one session will be conducted at home each week. The interventional group will conduct all exercises using the KneeBRIGHT EMG sensors and game software. The control group will conduct all exercises following a standard physical therapy regimen. Researchers will compare knee function and engagement between the group who uses the game, and the group who does conventional exercise.",[95],"Knee Osteoarthritis",[97],"knee osteoarthritis, physical therapy, rehabilitation","RECRUITING","2025-12-01",{"date":101,"type":46},"2025-12-03",{"date":103,"type":46},"2024-09-04",{"date":105,"type":21},"2026-11-30",{"name":52,"class":53},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":54},"100583267","respiratory-oxygen-adherence-monitor-for-chronic-obstructive-pulmonary-disease-patients-100583267","NCT06874101","Respiratory Oxygen Adherence Monitor for Chronic Obstructive Pulmonary Disease Patients","Evaluating a Respiratory Oxygen Adherence Monitor for COPD Patients With Long-term Oxygen Therapy","ROAM","Inclusion Criteria:\n\n* Post-Bronchodilator FEV1\u002FFVC\\\u003C.80\n* Participants with medical history of COPD\n* Prescription for oxygen use via nasal cannula or mask at home\n* At baseline of health with no hospitalization\u002Fexacerbation within the past 6 weeks\n* Use of Continuous oxygen at baseline\n\nExclusion Criteria:\n\n* Post -Bronchodilator FEV1\u002FFVC ≤25%\n* Intermittent oxygen use at home\n* Inability to understand simple instructions\n* Respiratory exacerbation or infections within 6 weeks prior to screen visit\n* Not at baseline of medical health prior to screen visit",{"count":116,"type":21},100,[24],"The goal of this clinical trial is to test a device called \"ROAM\" that is being developed to see how patients with chronic obstructive pulmonary disease (COPD) use oxygen therapy over a long period of time. This study will focus on evaluating the ROAM device, which will be attached to your oxygen source. The question that the study aims to answer is: will patients who receive daily adherence feedback from the ROAM have increased adherence to their prescribed long term oxygen therapy regimens?\n\nResearchers will compare the amount of time using oxygen and attitudes about oxygen therapy observed in a group that receives feedback from ROAM, and a control group that does not receive feedback.\n\nParticipants will have their oxygen supplies fitted with the ROAM device and then use their oxygen as usual for the 5-week study duration. Participants in the study group will have access to information about their oxygen usage and pulse oximetry levels. All participants will attend two in-clinic sessions of about an hour each, and will complete questionnaires at the beginning and end of the study.",[120,121],"COPD","COPD - Chronic Obstructive Pulmonary Disease",[123,120],"oxygen therapy","2025-03-07",{"date":126,"type":46},"2025-03-13",{"date":128,"type":21},"2025-05-01",{"date":130,"type":21},"2026-04-30",{"name":52,"class":53},""]