[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Baskent University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":641},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,52,79,107,133,167,196,218,241,263,288,309,326,350,373,402,430,455,477,504,531,552,573,594,618],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100641287","periodization-based-strength-exercise-training-in-ndividuals-with-type-2-diabetes-100641287",false,"NCT07659925","Periodization-Based Strength Exercise Training in İndividuals With Type 2 Diabetes","A Comparison of the Effects of Different Periodization-Based Strength Training Programs in Individuals With Type 2 Diabetes Mellitus","T2DM_NLP","Inclusion Criteria:\n\n* Adults aged between 18 to 65 years\n* Diagnosis of Type 2 Diabetes Mellitus (T2DM)\n* Not having participated in any structured exercise program within the last 6 months\n* Willingness to participate in the study and provide written informed consent\n\nExclusion Criteria:\n\n* Presence of nephropathy, retinopathy, or peripheral neuropathy\n* Presence of neurological, cognitive, or orthopedic disorders that may affect outcome measurements\n* Severe respiratory disease (Forced Expiratory Volume in the first second \\[FEV1\\] \\\u003C35% or Forced Vital Capacity \\[FVC\\] \\\u003C50%)\n* Presence of ischemic heart disease or peripheral arterial disease\n* History of any cardiovascular event within the last 6 months\n* Current malignancy","ALL","18 Years","65 Years",{"count":22,"type":23},48,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized controlled study aims to compare the effects of different periodization-based strength training approaches in individuals with type 2 diabetes mellitus. Participants will be allocated to non-linear periodization, linear periodization, or control groups. The intervention program will be conducted for 8 weeks and will evaluate exercise capacity, muscle strength, quality of life, body composition, and metabolic parameters.",[29],"Type 2 Diabetes",[31,32,33,34,35,36,37,38],"Type 2 Diabetes Mellitus","Strength Training","Non-linear Periodization","Exercise Capacity","Muscle Strength","Quality of Life","Linear Periodization","Resistance Training","RECRUITING","2026-06-17",{"date":42,"type":43},"2026-06-22","ACTUAL",{"date":45,"type":43},"2026-05-01",{"date":47,"type":23},"2026-12",{"name":49,"class":50},"Baskent University","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":51},"100642195","relationship-between-balance-arm-function-and-body-awareness-in-people-with-stroke-100642195","NCT07652710","Relationship Between Balance, Arm Function and Body Awareness in People With Stroke","Investigation of Balance, Upper Extremity and Body Awareness in Individuals With Stroke","Inclusion Criteria:\n\n* Individuals who experienced a cerebrovascular event at least 6 months previously\n* Individuals between 18 and 75 years of age\n* Individuals who have experienced stroke for the first time\n* Individuals with shoulder, elbow, wrist, and finger muscle tone graded as 2 or 3 according to the Modified Ashworth Scale (MAS)\n* Individuals scoring 24 points or higher on the Standardized Mini Mental State Examination\n* Individuals with at least 120° of shoulder range of motion\n* Individuals who are able to walk independently or with a walking aid\n\nExclusion Criteria:\n\n* Presence of communication problems such as difficulties in reading, writing, or speaking\n* Botulinum toxin injection within the last 3 months\n* Presence of hemispatial neglect syndrome\n* Presence of ataxia due to posterior circulation ischemia\n* Bilateral involvement (bilateral hemiparesis)\n* Having received physiotherapy within the last 6 months\n* Presence of orthopedic problems such as shoulder subluxation, shoulder pain, contracture of the hand and wrist\n* History of upper extremity or thoracic surgery\n* Presence of stroke-related visual impairments (hemianopia)\n* Presence of color blindness\n* Use of antiepileptic medication\n* History of convulsions","75 Years",{"count":61,"type":23},53,"OBSERVATIONAL","Stroke is one of the leading causes of long-term disability worldwide and is frequently associated with impairments in balance, upper extremity function, and body awareness. These impairments may negatively affect independence in activities of daily living and overall quality of life. Although previous studies have investigated the relationships between balance and upper extremity function after stroke, body awareness has received relatively limited attention.\n\nThe aim of this observational cross-sectional study is to investigate the relationship between balance, upper extremity skills, and body awareness in individuals with chronic stroke. Fifty-three individuals with chronic stroke will be recruited from the Department of Physical Medicine and Rehabilitation at Baskent University Hospital.\n\nBalance will be assessed using the Berg Balance Scale and the Tetrax computerized posturography system. Upper extremity motor impairment and functional performance will be evaluated using the Fugl-Meyer Upper Extremity Assessment and the Wolf Motor Function Test. Body awareness will be assessed using the Body Awareness Questionnaire. Additional assessments will include lower extremity motor function, muscle tone, cognitive status, shoulder range of motion, and upper extremity reaction time.\n\nThe study is expected to provide a better understanding of the relationships among balance, upper extremity function, and body awareness in individuals with chronic stroke. The findings may contribute to the development of individualized rehabilitation strategies and improve clinical assessment approaches in stroke rehabilitation.",[65],"Chronic Stroke Patient",[67,68,69,70],"stroke","postural balance","upper extremity","body image","NOT_YET_RECRUITING","2026-06-11",{"date":40,"type":43},{"date":75,"type":23},"2026-06-20",{"date":77,"type":23},"2026-10-20",{"name":49,"class":50},{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":18,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":51},"100643379","upper-extremity-skills-trunk-control-and-body-awareness-in-parkinsons-disease-100643379","NCT07639463","Upper Extremity Skills, Trunk Control, and Body Awareness in Parkinson's Disease","Investigation of Upper Extremity Skills, Trunk Control, and Body Awareness in Individuals With Parkinson's Disease","Inclusion Criteria:\n\n* Diagnosis of idiopathic Parkinson's disease\n* Age between 50 and 80 years\n* Montreal Cognitive Assessment (MoCA) score ≥21\n* Modified Hoehn and Yahr Stage 2-3\n* Stable medication regimen with no medication or dosage changes within the previous month\n* Ability to understand and follow instructions\n* Voluntary agreement to participate\n\nExclusion Criteria:\n\n* Presence of another chronic neurological disorder\n* Orthopedic or rheumatologic conditions limiting upper extremity movement\n* Previous upper extremity or trunk surgery\n* Severe tremor or dyskinesia preventing participation in assessments\n* Significant visual or communication impairments interfering with testing",true,"50 Years","80 Years",{"count":90,"type":23},118,"Parkinson's disease is associated with impairments in upper extremity function, postural control, and sensory-motor processing that may negatively affect daily activities and quality of life. While upper extremity dysfunction has been extensively investigated, the potential contributions of trunk control and body awareness have received less attention. This cross-sectional observational study aims to compare upper extremity skills, trunk control, and body awareness between individuals with Parkinson's disease and healthy adults, and to examine the relationships among these variables within the Parkinson's disease group. The findings may improve understanding of factors associated with upper extremity performance and support the development of more comprehensive rehabilitation approaches for individuals with Parkinson's disease.",[93],"Parkinson Disease",[95,96,97,98],"Functionality","Body","Parkinson's Disease","Upper Extremity","2026-06-06",{"date":101,"type":43},"2026-06-10",{"date":103,"type":23},"2026-06-15",{"date":105,"type":23},"2026-10-10",{"name":49,"class":50},{"id":108,"slug":109,"hasResults":12,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":12,"sex":114,"minAge":115,"maxAge":20,"enrollmentInfo":116,"targetDuration":4,"studyType":24,"phases":117,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":127,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":51},"100616218","ai-assisted-relaxation-and-breathing-training-in-postmenopausal-women-100616218","NCT07302750","AI-Assisted Relaxation and Breathing Training in Postmenopausal Women","The Effectiveness of Artificial Intelligence-Assisted Relaxation and Breathing Training on Pain Intensity and Quality of Life in Postmenopausal Women","Inclusion Criteria:\n\n* Women aged 45 to 65 years\n* Being in natural menopause (no menstrual bleeding for at least 12 months)\n* Having non-specific chronic musculoskeletal pain for at least 3 months (reporting a pain intensity of at least 4 cm on the VAS)\n* Using only standard analgesic medications for pain management\n* Being literate\n* Owning a smartphone or tablet, having the ability to listen to audio recordings, and having adequate skills to participate in online sessions\n* Being willing to participate in the study and providing written informed consent\n\nExclusion Criteria:\n\n* Surgical or medication-induced menopause\n* Regular use of opioid analgesics, anticonvulsants, antidepressants, or similar medications\n* Uncontrolled advanced cardiovascular, oncological, metabolic, rheumatologic, or neurological diseases\n* Body Mass Index (BMI) of 40 kg\u002Fm² or higher\n* History of major surgery or severe trauma within the past 3 months","FEMALE","45 Years",{"count":22,"type":23},[26],"This study aims to evaluate the effectiveness of relaxation and breathing training delivered by a physiotherapist and by an artificial intelligence-assisted system in postmenopausal women with non-specific chronic musculoskeletal pain. Menopause and the postmenopausal period are associated with decreased estrogen levels, structural and functional changes in the musculoskeletal system, increased pain prevalence, reduced muscle function, and impaired quality of life. Relaxation techniques, breathing-focused exercises, and mind-body practices have been shown to reduce pain, improve psychological well-being, and enhance sleep quality. With the growing use of digital health technologies, AI-supported relaxation training may offer personalized guidance, easy accessibility, and sustainable home-based practice, although its effectiveness in postmenopausal women has not yet been demonstrated.\n\nIn this three-arm randomized controlled trial, participants will be assigned to physiotherapist-led relaxation and breathing training, AI-assisted relaxation and breathing training, or a control group. Interventions will last eight weeks and include sessions three days per week, each approximately 30 minutes. The physiotherapist-guided group will perform sessions face-to-face, while the AI-assisted group will complete prerecorded relaxation and breathing exercises created with AI-generated scripts and voice recordings. The control group will continue daily routines without structured training during the study period.\n\nAssessments will be conducted at baseline and at the end of eight weeks. Outcome measures will include pain severity, pressure pain threshold, musculoskeletal symptoms, menopause-specific quality of life, psychological status, sleep quality, dyspnea, and participant satisfaction. The study aims to compare the effects of physiotherapist-led and AI-assisted training modalities on pain, musculoskeletal health, sleep, psychological well-being, and quality of life. Findings are expected to contribute to the development of accessible and cost-effective interventions that support symptom management and improve the daily functioning of postmenopausal women.",[120,121],"Postmenopausal Period","Postmenopausal Women",[123,124,125,126],"postmenopausal","artificial intelligence","pain management","quality of life",{"date":101,"type":43},{"date":129,"type":43},"2026-04-01",{"date":131,"type":23},"2027-02",{"name":49,"class":50},{"id":134,"slug":135,"hasResults":12,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":86,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":24,"phases":143,"briefSummary":144,"conditions":145,"keywords":152,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":4},"100638527","developing-disability-awareness-attitude-and-empathy-in-nursing-students-100638527","NCT07609238","Developing Disability Awareness, Attitude, and Empathy in Nursing Students","A Randomized Controlled Trial Comparing Training Programs Designed to Improve Awareness, Attitudes, and Empathy Toward Individuals With Disabilities in Nursing Students","Disability","Inclusion Criteria:\n\n* Must be a 3rd or 4th-year student in the Department of Nursing at Başkent University.\n* Must be willing to participate in the study.\n\nExclusion Criteria:\n\n* Any kind of disability.\n* A visually-related problem",{"count":142,"type":23},66,[26],"Abstract\n\nIndividuals with disabilities frequently face barriers to accessing healthcare services due to physical, social, economic, and policy-related factors. As essential members of the healthcare workforce, nurses play a critical role in addressing these inequities. Previous studies focusing on disability awareness, attitudes, and empathy highlight the need for high-quality research employing mixed-method, simulation-based interventions aimed at enhancing awareness and empathy, fostering positive attitudes, and supporting learning outcomes. However, the existing literature lacks studies that simultaneously compare different simulation methods and comprehensively evaluate awareness, attitudes, and empathy using a multidimensional approach.\n\nThis study aims to examine the effectiveness of simulation-based interventions-standardized patient encounters and virtual reality training-in improving nursing students' awareness, strengthening positive attitudes, and increasing sensitivity in the delivery of healthcare services to individuals with disabilities. The findings are expected to support the integration and expansion of disability-focused simulation practices in nursing curricula and contribute to the development of evidence-based nursing education programs.\n\nKeywords: nursing students; disability; attitude; simulation; virtual reality",[146,147,148,149,150,151],"Simulation Training","Students, Nursing","Attitude","Empathy Skills","Disabled People","Awareness and Knowledge Level",[153,154,155,156,157,158],"simulation training","nursing students","attitude","empathy","disabled people","awareness","2026-05-31",{"date":161,"type":43},"2026-06-03",{"date":163,"type":23},"2026-09-15",{"date":165,"type":23},"2027-06",{"name":49,"class":50},{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":12,"sex":18,"minAge":175,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":24,"phases":179,"briefSummary":180,"conditions":181,"keywords":184,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":4},"100636376","the-effect-of-music-and-musical-mobile-interventions-on-pain-and-physiological-parameters-100636376","NCT07564882","The Effect of Music and Musical Mobile Interventions on Pain and Physiological Parameters","The Effect of Music and Musical Mobile Interventions on Pain and Physiological Parameters During Chest Tube Removal in Infants Undergoing Congenital Heart Surgery","Music Pain Inf","Inclusion Criteria:\n\n* Infants aged 2 to 12 months\n* Undergoing surgery due to congenital heart disease\n* Having a single chest tube\n* Not receiving mechanical ventilation support\n* Parent(s) voluntarily agree to participate in the study\n\nExclusion Criteria:\n\n* Receiving mechanical ventilation support\n* Administration of analgesics within 2 hours prior to chest tube removal\n* Presence of a neurodevelopmental disorder\n* Parent(s) do not consent to participate in the study","2 Months","12 Months",{"count":178,"type":23},54,[26],"Chest tube removal in infants undergoing surgery for congenital heart disease is an invasive procedure associated with significant pain and physiological stress responses. This randomized controlled trial evaluates the effects of music and musical mobile interventions on pain and physiological parameters during chest tube removal. A total of 54 infants aged 2-12 months are randomly assigned to music, musical mobile, or control groups. Pain is assessed using the FLACC scale, and physiological parameters (heart rate and oxygen saturation \\[SpO₂\\]) are monitored. Measurements are obtained at predefined time points: periprocedural (10 minutes before chest tube removal, immediately after removal, and 5 minutes post-removal). The findings aim to support evidence-based non-pharmacological pain management in pediatric intensive care settings.",[182,183],"Congenital Heart Disease (CHD)","Chest Tube Removal",[183,185,186,187],"Nursing","Congenital Heart Disease","Multisensory Distraction","2026-05-05",{"date":190,"type":43},"2026-05-08",{"date":192,"type":23},"2026-04-30",{"date":194,"type":23},"2027-06-30",{"name":49,"class":50},{"id":197,"slug":198,"hasResults":12,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":86,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":24,"phases":205,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":51},"100636179","ai-supported-flipped-learning-in-breast-self-examination-training-100636179","NCT07562321","AI-SUPPORTED FLIPPED LEARNING IN BREAST SELF-EXAMINATION TRAINING","IMPACT OF AN AI-SUPPORTED FLIPPED LEARNING MODEL ON NURSING STUDENTS' BREAST SELF-EXAMINATION KNOWLEDGE AND PERFORMANCE: A RANDOMIZED CONTROLLED TRIAL","Inclusion Criteria:\n\n* Being a second-year student in a nursing undergraduate program\n* Not having previously received breast examination training\n* Having signed the voluntary consent form\n\nExclusion Criteria:\n\n* Having any health problem that would prevent continuing to work\n* Requesting to withdraw from work voluntarily",{"count":204,"type":23},80,[26],"The global increase in cancer cases has made breast cancer the second most common cancer after lung cancer and a primary health problem among women. Early diagnosis is the most critical factor in improving survival rates and quality of life in breast cancer. Breast self-examination (BSE), which enables individuals to notice changes in their own breast tissue during the early diagnosis process, is a low-cost and effective awareness method. It is essential that nurses, who play a key role in raising public awareness on this issue, and nursing students, who are the future healthcare professionals, have sufficient knowledge and practical skills in BSE. However, the literature shows that even if students have theoretical knowledge, their application rates are low. In this context, the \"AI-Supported Flipped Learning\" model, which goes beyond traditional methods and supports active learning, personalized feedback, and digital literacy, has the potential to be an innovative solution in nursing education. Objective: This study aims to evaluate the effect of AI-supported flipped learning model and traditional education on the knowledge levels and performance skills of nursing students regarding BSE knowledge and skills.",[208,209,210],"Artifical Intelligence","Nursing Education","Breast Self-Examination",{"date":212,"type":43},"2026-05-06",{"date":214,"type":43},"2026-03-20",{"date":216,"type":23},"2026-05-10",{"name":49,"class":50},{"id":219,"slug":220,"hasResults":12,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":86,"sex":114,"minAge":4,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":24,"phases":226,"briefSummary":227,"conditions":228,"keywords":231,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":235,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":51},"100608522","the-effect-of-guded-imagery-on-premenstrual-syndrome-100608522","NCT07202650","THE EFFECT OF GUİDED IMAGERY ON PREMENSTRUAL SYNDROME","EFFECT OF GUİDED IMAGERY ON PREMENSİVE SYNDROME İN UNİVERSİTY STUDENTS","Inclusion Criteria:\n\n* Regular menstrual cycles (21-35 days over the last three cycles)\n* Age 18 years or older\n* No medical treatment for PMS\n* Ability to communicate effectively in Turkish\n* No psychiatric diagnosis or gynecological disorder (e.g., abnormal uterine bleeding, myoma, ovarian cysts)\n* A score \\>89 on the Premenstrual Syndrome Scale (PMSS)\n* No prior participation in guided imagery training\n\nExclusion Criteria:\n\n* Failure to perform guided imagery at the correct time or in the prescribed manner\n* Irregular menstruation during the last three months\n* Use of contraceptives\n* Use of analgesics during menstruation while participating in the study",{"count":22,"type":23},[26],"EFFECT OF GUIDED IMAGERY ON PREMENSTRUAL SYNDROME IN UNIVERSITY STUDENTS\n\nPremenstrual Syndrome (PMS) is a condition characterized by physical, behavioral, and emotional symptoms that appear at the end of the luteal phase, 7-10 days before menstruation, and resolve with the onset of menstruation. Symptoms include irritability, loss of control, anxiety, depression, sleep disturbances, decreased concentration, unexplained crying, fatigue, weakness, changes in appetite, edema, headaches, joint and muscle pain, breast tenderness, altered sexual activity, and social withdrawal. In young women, PMS can negatively affect self-confidence, social relationships, quality of life, and academic performance.\n\nPMS treatment aims to relieve both physical and psychological symptoms and may include dietary supplements and complementary-alternative therapies. Approaches such as reflexology, pilates, acupressure, music, exercise, and guided imagery have shown promising results in reducing premenstrual symptoms. Mind-body-based approaches in complementary therapies are known to support psychological well-being. Guided imagery, a form of mind-body communication, involves the flow of thoughts and the way the mind encodes, stores, and expresses sensory information. It is based on the understanding that the mind and body are interconnected and that mental processes can influence physical responses. Guided imagery has been shown to reduce stress, improve mood, enhance sleep quality, strengthen the immune system, reduce fatigue, and minimize nausea and vomiting.\n\nAlthough effective, research on the use of guided imagery to reduce PMS symptoms in university students is limited. This study aims to investigate the effect of guided imagery on premenstrual syndrome in this population.",[229,230,185],"Guided Imagery","Premenstrual Syndrome",[232,233,234,126],"premenstrual syndrome","guided imagery","university students",{"date":45,"type":43},{"date":237,"type":23},"2026-05-15",{"date":239,"type":23},"2026-12-15",{"name":49,"class":50},{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":12,"sex":18,"minAge":248,"maxAge":19,"enrollmentInfo":249,"targetDuration":4,"studyType":24,"phases":251,"briefSummary":252,"conditions":253,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":51},"100525363","effect-of-guided-imagery-on-chemotherapy-related-nausea-and-vomiting-100525363","NCT06120764","Effect of Guided Imagery on Chemotherapy-related Nausea and Vomiting","Effect of Guided Imagery on Chemotherapy-related Nausea and Vomiting in Pediatric Oncology Patients: a Randomized Controlled Trial","Inclusion Criteria:\n\n* 7 to 18 years old,\n* who will receive intravenous chemotherapy,\n* no cognitive or neurological disease that would prevent communication,\n* receiving a chemotherapy protocol with a high or moderate emetogenic effect according to the MASCC\u002FESMO Antiemetic Guideline Classification,\n* no verbal, visual and auditory communication disabilities (ability to speak Turkish, no mental deficiency),\n* children whose parents and themselves volunteered to participate in the study\n\nExclusion Criteria:\n\n* Children receiving radiotherapy,\n* taking ginger powder or vitamins to reduce nausea,\n* children who did not want to participate in the study","7 Years",{"count":250,"type":23},40,[26],"The goal of this randomized controlled study is to assess the effect of guided imagery on chemotherapy-related nausea and vomiting in pediatric oncology patients.\n\nParticipants will receive either guided imagery+routine care or routine care. The researchers will compare nausea and vomiting and vital signs between groups.",[254,255],"Chemotherapy-induced Nausea and Vomiting","Pediatric Cancer","2026-04-27",{"date":45,"type":43},{"date":259,"type":43},"2023-11-10",{"date":261,"type":23},"2026-10-30",{"name":49,"class":50},{"id":264,"slug":265,"hasResults":12,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":24,"phases":272,"briefSummary":273,"conditions":274,"keywords":278,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":4},"100636221","ai-supported-gamified-training-for-sharps-injury-prevention-in-nurses-100636221","NCT07562867","AI-Supported Gamified Training for Sharps Injury Prevention in Nurses","The Effect of An Artifıcial Intelligence-Supported Gamifıed Training Program on Nurses' Knowledge and Attitudes Toward The Prevention of Sharps Injuries","Inclusion Criteria:\n\n* Registered nurses working in the participating hospitals\n* Working in the institution for at least 2 months (Phase 1) or newly employed within the last 1 month (Phase 2)\n* Willing to participate in the study\n* Able to use smartphone-based technologies\n* Providing written informed consent\n\nExclusion Criteria:\n\n* Having received prior training based on the Health Belief Model for sharps injury prevention\n* Previous professional nursing experience before current employment (for newly recruited nurses in Phase 2)\n* Being on leave during the data collection period\n* Failure to attend training sessions (intervention group)\n* Incomplete data collection forms\n* Withdrawal from the study at any stage",{"count":271,"type":23},36,[26],"This study aims to evaluate the effect of a Health Belief Model (HBM)-based, artificial intelligence (AI)-supported gamified training program on nurses' knowledge and attitudes toward the prevention of sharps injuries. Sharps injuries remain a significant occupational risk for healthcare workers, particularly nurses, despite existing standard precautions.\n\nThe study will be conducted in two phases. In the first phase, the validity and reliability of the Sharps Injury Prediction Scale will be tested in a nurse population. In the second phase, a quasi-experimental pretest-posttest control group design will be used to assess the effectiveness of the intervention.\n\nThe study will be carried out in two hospitals from the same healthcare group located in different cities to prevent interaction between groups. A total of 36 nurses will be included, with 18 participants in the intervention group and 18 in the control group.\n\nThe intervention group will receive a structured, HBM-based training program consisting of seven sessions incorporating AI-supported content, gamified scenarios, interactive materials, and feedback mechanisms to enhance engagement and promote behavior change. The control group will receive routine institutional training on sharps injury prevention.\n\nData will be collected at baseline, immediately after the intervention, and two months later. Outcome measures include nurses' knowledge, attitudes toward safe sharps use, and sharps injury risk perception.\n\nIt is expected that the AI-supported gamified training program will significantly improve knowledge, attitudes, and risk awareness compared to routine training. The findings may support the integration of innovative, theory-based educational interventions into institutional training programs to enhance occupational safety.",[275,276,277],"Sharps Injuries","Needlestick Injuries","Occupational Exposure",[279,280],"Sharps injuries","Nursing education","2026-04-26",{"date":45,"type":43},{"date":284,"type":23},"2026-06-01",{"date":286,"type":23},"2027-06-01",{"name":49,"class":50},{"id":289,"slug":290,"hasResults":12,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":86,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":24,"phases":297,"briefSummary":298,"conditions":299,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":305,"completionDateStruct":306,"leadSponsor":308,"locationsCount":51},"100623334","the-effect-of-gamified-metaverse-based-training-on-nursing-students-self-efficacy-and-metaverse-perception-regarding-pressure-injury-management-100623334","NCT07395284","The Effect of Gamified Metaverse-Based Training on Nursing Students' Self-Efficacy and Metaverse Perception Regarding Pressure Injury Management","The Effect of Gamified Metaverse-Based Training on Nursing Students' Self-Efficacy and Metaverse Perception Regarding Pressure Injury Management: A Randomized Controlled Study","Inclusion Criteria:\n\n* Voluntarily agree to participate in the research,\n* Be a second-year undergraduate nursing student,\n* Be able to understand and speak Turkish,\n* Have healthy hearing, vision, and speech.\n\nExclusion Criteria:\n\n* The student voluntarily requesting to withdraw from the study\n* The student ceasing to use the metaverse domain during the study period\n* Completing the survey form incompletely.",{"count":296,"type":23},60,[26],"Introduction: Pressure ulcers are a largely preventable clinical problem that negatively impacts the quality of patient care and constitutes a significant economic burden for healthcare systems. The prevention and effective management of these ulcers are closely related to nurses' knowledge, skills, and self-efficacy levels. However, current nursing education programs show a limited number of practice-based and interactive training approaches for the prevention and management of pressure ulcers. In recent years, innovative and technology-supported training methods such as gamification and metaverse have emerged as promising approaches for improving students' knowledge and self-efficacy levels by increasing their active participation in learning processes. Aim: The aim of this research is to evaluate the effect of gamified metaverse-based training developed for nursing students on their knowledge level, academic self-efficacy, and metaverse perception regarding pressure ulcer management.\n\nMethod: The research was planned as a randomized controlled experimental design. The population of the study will consist of students studying in the nursing department. The sample size was calculated using G\\*Power based on PUKAT 2.0-T scores; Assuming a two-way α=0.05 and power=0.80, at least 26 participants were selected for each group, and the total sample size was planned as 60 students, taking into account possible losses. Participants will be administered a Demographic Information Form, the Pressure Ulcer Knowledge Level Assessment Tool 2.0-Updated Version (PUKAT 2.0-T), and the Nursing Students Academic Self-Efficacy Scale. Participants will be randomly assigned to intervention and control groups based on their pre-test scores. The intervention group will receive traditional classroom theoretical training and gamified metaverse-based training for two weeks, while the control group will receive traditional classroom theoretical training. Post-tests will be administered immediately after the intervention and one month later. In addition, the Metaverse Perception Scale will be administered to the intervention group. Data will be collected using the Pressure Ulcer Knowledge Assessment Tool 2.0-Updated Version (PUKAT 2.0-T), the Nursing Students Academic Self-Efficacy Scale, and the Metaverse Perception Scale for Nursing Students.\n\nResults: The obtained data will be analyzed using appropriate statistical methods.\n\nConclusion: This research is expected to provide evidence regarding the effectiveness of innovative digital education models in nursing education and contribute to the development of educational strategies for the prevention of pressure ulcers.",[300,209,301,302],"Pressure Ulcers, Bedsores, Decubitus Ulcer","Gamification","Self-Efficacy","2026-04-25",{"date":192,"type":43},{"date":192,"type":23},{"date":307,"type":23},"2026-06-30",{"name":49,"class":50},{"id":310,"slug":311,"hasResults":12,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":86,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":316,"targetDuration":4,"studyType":24,"phases":317,"briefSummary":318,"conditions":319,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":322,"startDateStruct":323,"completionDateStruct":324,"leadSponsor":325,"locationsCount":51},"100623305","the-effectiveness-of-gamified-metaverse-based-training-on-patient-safety-for-nursing-students-100623305","NCT07394907","The Effectiveness of Gamified Metaverse-Based Training on Patient Safety for Nursing Students","The Effectiveness of Gamified Metaverse-Based Training on Patient Safety for Nursing Students: A Mixed Methods Study","Inclusion Criteria:\n\n* Voluntarily agreeing to participate in the research,\n* Being a second-year undergraduate nursing student,\n* Being able to understand and speak Turkish,\n* Having healthy hearing, vision, and speech.\n\nExclusion Criteria:\n\n* The student voluntarily wishing to withdraw from the study\n* The student ceasing to use the metaverse space during the study period\n* Filling out the survey form incompletely.",{"count":296,"type":23},[26],"Introduction: Patient safety issues, such as medication errors, healthcare-associated infections, unsafe surgical procedures, and diagnostic errors, can negatively impact the quality of healthcare and patient outcomes due to preventable risks. There is a need for innovative, interactive educational approaches to ensure the lasting acquisition of patient safety competencies in nursing students and to strengthen their transfer to the clinical environment. Aim: This study aims to evaluate the effect of gamified metaverse-based training on patient safety competencies in nursing students and to assess student opinions regarding metaverse-based training. Method: The research will be conducted using a mixed-methods design. The quantitative phase will be an experimental design including intervention and control groups, pre-test-post-test, and a one-month follow-up (retention test). The research will be conducted between February 2026 and May 2026 with second-year students studying in the Spring semester of 2025-2026 at Başkent University Nursing Department in Ankara. According to G\\*Power calculations, a minimum sample size of 52 was found; considering a possible 10% loss, the total sample size was planned as 60 students (intervention=30, control=30). All participants will take the Patient Safety Knowledge Level Test (pre-test) and the Patient Safety Competency Self-Assessment Tool before the training. This will be followed by 2 hours of traditional theoretical training on patient safety; the intervention group will also receive gamified metaverse-based training via Spatial.io for two weeks. Post-tests will be administered after the training and one month later. Data collection tools include the Demographic Information Form, the Patient Safety Knowledge Level Test, the Patient Safety Competency Self-Assessment Tool (PSCS), and focus group interviews to be conducted in the intervention group. Quantitative data will be analyzed through within-group and between-group comparisons; qualitative data will be analyzed using thematic analysis, and the findings will be interpreted holistically. Findings (Expected): Gamified metaverse-based training is expected to provide a greater increase in mean scores on the Patient Safety Knowledge Level Test (PSL) and total and sub-dimension scores (knowledge-skills-attitudes) of nursing students compared to the control group, and to support the retention of these results.\n\nConclusion: This study is expected to generate evidence regarding the effectiveness of gamified metaverse-based training in improving patient safety competencies in nursing education and to contribute to the structuring of patient safety training in a more integrated, student-centered, and sustainable manner.",[301,209,320,321],"Patient Safety","Mixed Method Implementation Study",{"date":192,"type":43},{"date":192,"type":23},{"date":307,"type":23},{"name":49,"class":50},{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":332,"targetDuration":4,"studyType":24,"phases":334,"briefSummary":335,"conditions":336,"keywords":338,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":346,"leadSponsor":348,"locationsCount":349},"100635275","effectiveness-of-high-intensity-laser-therapy-in-management-of-lumbar-disc-herniation-100635275","NCT07550569","Effectiveness of High Intensity Laser Therapy in Management of Lumbar Disc Herniation","Inclusion Criteria:\n\n* Males and females aged 18-65 years\n* Diagnosed with lumbar disc herniation via MRI and presenting with low back pain\n* No History of lumbar physical therapy in the last 3 months\n* No History of analgesic or muscle relaxant use since initial presentation\n* Willingness to participate and signed informed consent\n\nExclusion Criteria:\n\n* History of Fibromyalgia diagnosis\n* History of acute trauma\n* History of Lumbar instability\n* History of Rheumatologic disease\n* Motor deficits or myelopathy\n* History of Lumbar injections in the last 3 months\n* History of Previous lumbar surgery\n* Pregnancy\n* Pacemaker\n* Cognitive impairment or unwillingness to comply with treatment",{"count":333,"type":23},150,[26],"Chronic lumbar radiculopathy is a multifactorial condition typically caused by lumbar disc herniation, where degenerative changes lead to nerve root compression, resulting in radiating pain, sensory disturbances, and motor deficits. Management requires a multidisciplinary, primarily conservative approach centered on physical therapy, including exercise, electrotherapy, and other non-invasive modalities. Exercise plays a key role in improving spinal stability, mobility, posture, and neuromuscular coordination, while treatments like transcutaneous electrical nerve stimulation (TENS) and high-intensity laser therapy (HILT) provide pain relief through neuromodulation and tissue regeneration mechanisms. Recent evidence suggests that combining HILT with exercise may enhance functional outcomes more effectively than exercise alone. Accordingly, this study aims to compare the effectiveness of exercise alone, exercise combined with HILT, and exercise combined with conventional therapies (ultrasound, hot pack, and TENS) in patients with lumbar disc herniation. Patients aged 18-65 will be randomly assigned to three groups and undergo a 3-week treatment program, with outcomes assessed through measures of pain, disability, range of motion, and quality of life.",[337],"Lomber Disc Herniation",[339,340,341],"Intervertebral Disc Displacement","Back Pain","Laser Therapy","2026-04-20",{"date":344,"type":43},"2026-04-24",{"date":45,"type":23},{"date":347,"type":23},"2027-02-28",{"name":49,"class":50},3,{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":86,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":356,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":358,"conditions":359,"keywords":361,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":371,"leadSponsor":372,"locationsCount":51},"100633076","comparison-of-frailty-physical-fitness-parameters-and-irisin-levels-between-patients-with-multiple-sclerosis-and-healthy-volunteers-100633076","NCT07521982","Comparison of Frailty, Physical Fitness Parameters, and Irisin Levels Between Patients With Multiple Sclerosis and Healthy Volunteers","Inclusion Criteria:\n\n* Patients aged 18-65 evaluated by neurology and diagnosed with definitive MS via objective methods (MRI, lumbar puncture, etc.).\n* Healthy volunteers aged 18-65.\n* Being literate in Turkish.\n* Participants who provide a consent form to participate in the study.\n\nExclusion Criteria:\n\n* Being younger than 18 or older than 65.\n* Presence of any concomitant neurological disease other than MS.\n* Presence of an uncontrolled systemic disease at a level that would affect the evaluation.\n* Presence of cognitive impairment or psychiatric illness at a level that would affect the evaluation.\n* Having had an MS attack or received steroid treatment in the last month.\n* Presence of an orthopedic disability that prevents evaluations.",{"count":357,"type":23},782,"Multiple Sclerosis (MS) is a chronic immune-mediated and neurodegenerative disease of the central nervous system that often affects young adults and is more common in women. In addition to neurological disability, individuals with MS frequently experience frailty, a condition characterized by reduced physiological reserve, weakness, fatigue, decreased physical activity, and increased vulnerability to stressors. Frailty in MS is associated with poorer mobility, higher fall risk, reduced quality of life, and increased healthcare utilization. Irisin, a hormone released from skeletal muscles during exercise, is linked to energy metabolism and muscle function, and lower levels have been associated with reduced physical performance and sarcopenia. However, the relationship between frailty, physical fitness, and irisin levels in individuals with MS has not been sufficiently explored.\n\nThis study aims to compare frailty status, physical fitness parameters, and circulating irisin levels between patients with MS and healthy volunteers aged 18-65 years. Participants will undergo assessments including the Functional Independence Measure, Frailty Index, Berg Balance Scale, 6-Minute Walk Test, and handgrip strength measurement. Blood samples will also be collected to determine irisin levels using the ELISA method. Statistical analyses will evaluate differences between groups and correlations among frailty, functional performance, and irisin levels. The findings are expected to improve understanding of frailty mechanisms in MS and contribute to developing targeted rehabilitation and management strategies.",[360],"MULTIPL SCLEROSİS",[362,363,364,365,366],"biomarker","physical fitness","multiple sclerosis","muscle weakness","functional performance","2026-04-03",{"date":369,"type":43},"2026-04-13",{"date":129,"type":23},{"date":307,"type":23},{"name":49,"class":50},{"id":374,"slug":375,"hasResults":12,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":4,"eligibilityCriteria":379,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":380,"targetDuration":4,"studyType":24,"phases":382,"briefSummary":383,"conditions":384,"keywords":388,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":401,"locationsCount":4},"100622570","comfort-communication-model-intervention-for-burn-pain-and-pain-anxiety-100622570","NCT07385339","Comfort Communication Model Intervention for Burn Pain and Pain Anxiety","The Effect of a Nursing Intervention Based on the Comfort Communication Model on Pain and Pain Anxiety in Outpatient Burn Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Be 18 years of age or older,\n* Patients with at least three dressing experiences\n* Patients with 2nd and 3rd degree burns\n* No difficulty communicating in Turkish,\n* No hearing problems or cognitive impairment,\n* No additional mental disorders,\n* Willingness to cooperate,\n* No additional mental disorders,\n* Ability to perform self-care,\n* Patients who voluntarily agreed to participate in the study\n\nExclusion Criteria:\n\n* First-time burn care dressing\n* Having a first-degree burn\n* Actively receiving inpatient treatment\n* Having a neurological or psychiatric condition that prevents reading and understanding data collection tools\n* Having difficulty speaking\u002Funderstanding Turkish",{"count":381,"type":23},62,[26],"This single-center, randomized controlled trial will evaluate the effect of a nursing intervention based on the COMFORT Communication Model on procedural pain and burn-specific pain anxiety in adult outpatient burn patients undergoing routine dressing changes at the Adult Burn Center Outpatient Unit of Ankara Bilkent City Hospital. Burn dressing changes are frequently perceived as one of the most painful non-surgical procedures, and repeated exposure to wound care may contribute to anticipatory anxiety and stress, potentially creating a reinforcing cycle in which anxiety amplifies pain and pain increases anxiety. In outpatient burn care, effective nurse-patient communication may play a critical role in improving comfort, supporting coping, and enhancing engagement in ongoing treatment.\n\nEligible participants will be adults aged 18 years and older with second- or third-degree burns who have experienced at least three prior dressing changes, can communicate in Turkish, and have no major hearing or cognitive impairment or comorbid psychiatric\u002Fneurological condition that would prevent understanding of the study procedures. Participants who request withdrawal, require hospitalization during follow-up, or miss two consecutive intervention sessions will be withdrawn from the study. The required minimum sample size was estimated as 62 patients (31 per group) based on power analysis (effect size f=0.30; 80% power).\n\nAfter providing written and verbal informed consent, participants will be randomly assigned (simple randomization using Random Allocation Software) to either the COMFORT-based communication intervention group or the usual care control group. Data will be collected face-to-face in a quiet and private environment during dressing visits. At the initial visit, participants in both groups will complete a sociodemographic and burn-related information form and baseline assessments. Pain intensity will be evaluated using a Verbal Rating Scale and a Numeric Rating Scale, and pain anxiety will be assessed using the Burn-Specific Pain Anxiety Scale; perceived stress will also be measured.\n\nThe intervention will be delivered by a wound care nurse during three consecutive dressing sessions. Each session is structured to last approximately 10 minutes and uses specific components of the COMFORT Communication Model tailored to the dressing-change context. In Session 1, the focus is on establishing trust, providing clear information, and supporting patient control through Connection\u002FCommunication, Orientation and opportunity, and Relating strategies (e.g., explaining the procedure step-by-step, checking understanding, offering supportive options, and inviting the patient to signal if they want pauses). In Session 2, the focus shifts to creating space for emotions and strengthening supportive openings using Mindful communication, Openings, and Family components (e.g., exploring how the prior session felt, inviting expression of concerns, and identifying supportive persons). In Session 3, communication emphasizes personalization, meaning-making, and teamwork by integrating Relating, Team, and Meaning-focused prompts (e.g., reflecting on what was most helpful, supporting adaptive coping, and, if appropriate, facilitating communication with the clinical team). Throughout all sessions, routine wound care will continue as standard practice in both groups.\n\nOutcomes will be assessed repeatedly across the three dressing sessions. Pain and pain anxiety will be assessed before each dressing, and follow-up assessments will be repeated approximately 30 minutes after the dressing procedure. The primary objective is to determine whether COMFORT model-based nursing communication reduces procedural pain intensity and burn-specific pain anxiety compared with usual care during outpatient dressing changes. A secondary objective is to evaluate whether the intervention reduces perceived stress across sessions. Statistical analyses will include appropriate descriptive and repeated-measures comparisons to examine group differences over time.",[385,386,387],"Burn Patients","Pain Management","Nursing Interventions",[389,390,391,392,393,394],"burn patients","dressing change","pain","pain anxiety","Comfort communication model","nursing intervention","2026-02-27",{"date":397,"type":43},"2026-03-02",{"date":399,"type":23},"2026-02-17",{"date":101,"type":23},{"name":49,"class":50},{"id":403,"slug":404,"hasResults":12,"nctId":405,"briefTitle":406,"officialTitle":407,"acronym":408,"eligibilityCriteria":409,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":410,"targetDuration":4,"studyType":24,"phases":412,"briefSummary":413,"conditions":414,"keywords":416,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":425,"completionDateStruct":427,"leadSponsor":429,"locationsCount":51},"100626947","tidal-model-based-act-for-depression-100626947","NCT07442253","Tidal Model-Based ACT for Depression","THE EFFECT OF ACCEPTANCE AND STABİLİTY BASED PSYCHOEDUCATİON ON MEANİNG OF LİFE AND CONSCİOUS SELF-CARE İN PATİENTS WİTH DEPRESSİON BASED ON TİDAL MODEL","TIDAL-ACT","Inclusion Criteria:\n\nAge between 18 and 65 years\n\nReceiving treatment for depression for at least 6 months\n\nWithin the 6-month period following TMS treatment\n\nAble to communicate in Turkish without difficulty\n\nNo hearing problems, cognitive impairments, or additional psychiatric disorders\n\nWilling to participate and has provided written informed consent\n\nExclusion Criteria:\n\nParticipant withdraws voluntarily from the study\n\nRelapse of depression during the study period requiring psychiatric hospitalization\n\n* Sİtuation in which participants do not attend two consecutive sessions\n\nStarting participants on other psychotropic medications (e.g., ANTIPSYCHOTIC, MOOD STABILIZER, etc.) IN ADDITION TO THEIR ongoing antidepressant or anxiolytic treatments, and additional psychotherapies other than the ACT intervention.",{"count":411,"type":23},46,[26],"The purpose of this randomized controlled clinical trial is to evaluate the effectiveness of an Acceptance and Commitment Therapy (ACT)-oriented psychoeducation program based on the Tidal Model in patients diagnosed with depression who are receiving transcranial magnetic stimulation (TMS) treatment at a university hospital psychiatry clinic.\n\nThe primary objective of this study is to determine whether participation in the psychoeducation program improves meaning in life and conscious self-care compared to usual treatment alone. The main questions this study aims to answer are:\n\n* Does the ACT-oriented psychoeducation program increase participants' level of meaning in life?\n* Does the program improve conscious self-care behaviors in individuals with depression?\n\nParticipants will be randomly assigned to either an intervention group or a control group. The intervention group will receive an 8-week structured psychoeducation program in addition to standard TMS treatment. The control group will continue to receive standard treatment without additional psychoeducation.\n\nParticipants in the intervention group will attend weekly psychoeducation sessions focusing on psychological flexibility, values clarification, coping strategies, and self-care practices. Outcome measures will be collected at baseline, immediately after the intervention, and one month after completion of the program.",[415],"Depression - Major Depressive Disorder",[417,418,419,420,421,422],"Acceptance and Commitment Therapy","Tidal Model Meaning in Life Conscious Self-Care","Nursing Intervention","Randomized Controlled Trial","depression","Transcranial Magnetic Stimulation","2026-02-24",{"date":397,"type":43},{"date":426,"type":23},"2026-02-26",{"date":428,"type":23},"2026-06",{"name":49,"class":50},{"id":431,"slug":432,"hasResults":12,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":436,"eligibilityCriteria":437,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":438,"enrollmentInfo":439,"targetDuration":4,"studyType":24,"phases":441,"briefSummary":442,"conditions":443,"keywords":445,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":51},"100626291","3d-printed-vs-conventional-acrylic-stabilization-splints-in-young-adults-with-bruxism-and-temporomandibular-disorders-a-randomized-trial-100626291","NCT07433725","3D-Printed vs Conventional Acrylic Stabilization Splints in Young Adults With Bruxism and Temporomandibular Disorders: A Randomized Trial","Clinical Performance of Stabilization Splints Produced With a 3D Printer in the Treatment of Bruxism and Temporomandibular Disorders","3D PRINTED","Inclusion Criteria:\n\n* Adults (≥18 years) diagnosed with bruxism (sleep and\u002For awake bruxism) based on clinical assessment and patient report.\n\nIndication for an occlusal splint and willingness to wear the splint during sleep for 3 months.\n\nAbility to provide written informed consent and to attend scheduled follow-up visits.\n\nExclusion Criteria:\n\n* Current or recent use of an occlusal splint within the last 6 months.\n\nOngoing orthodontic treatment or planned major dental treatment during the study period that could affect occlusion.\n\nSevere temporomandibular disorder requiring active treatment (e.g., acute pain, limited mouth opening) or other conditions that could contraindicate splint use.\n\nExtensive untreated dental disease requiring immediate care (e.g., severe periodontal disease, multiple untreated caries).\n\nSystemic\u002Fneurologic conditions or medications that may significantly affect bruxism or neuromuscular function (as judged by the investigator).","25 Years",{"count":440,"type":23},44,[26],"This randomized clinical study will compare two occlusal splint (night guard) fabrication methods in adults with bruxism (teeth grinding\u002Fclenching). Forty-four participants will be randomly allocated to receive either (1) a 3D-printed splint manufactured from a photopolymer resin (Voco V-Print) or (2) a conventional acrylic splint fabricated using standard techniques. Participants will wear the splint during sleep for 3 months and will follow standardized instructions for use and care. At the 3-month follow-up, patient-reported satisfaction and oral health-related quality of life will be assessed using an OHIP-derived questionnaire, and splint wear will be quantified as volumetric material loss (mm³) by 3D scanning and superimposition. The results will help determine whether 3D-printed splints provide comparable patient-centered outcomes and clinical durability to conventional acrylic splints.",[444],"Bruxism, Sleep",[446],"occlusal splint","2026-02-19",{"date":449,"type":43},"2026-02-25",{"date":451,"type":43},"2026-01-12",{"date":453,"type":23},"2026-08",{"name":49,"class":50},{"id":456,"slug":457,"hasResults":12,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":4,"eligibilityCriteria":461,"healthyVolunteers":12,"sex":114,"minAge":19,"maxAge":462,"enrollmentInfo":463,"targetDuration":4,"studyType":24,"phases":464,"briefSummary":465,"conditions":466,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":475,"locationsCount":476},"100624339","guided-imagery-of-the-gynecological-cancer-100624339","NCT07408349","Guided Imagery of the Gynecological Cancer","The Effect of Guided Imagery on Nausea, Vomiting, Anxiety and Quality of Life in Gynecologic Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Having a diagnosis of another type of cancer\n* An ECOG (Eastern Cooperative Oncology Group) performance score of ≥3 (PS 3: Confined to bed for more than half of the day, limited self-care; PS 4: Completely bedridden, unable to perform self-care)\n\nExclusion Criteria:\n\n* Choosing to withdraw from the study\n* Refusing to practice guided imagery before chemotherapy treatment","90 Years",{"count":411,"type":23},[26],"The goal of this randomized controlled trial is to evaluate the effectiveness of a guided imagery intervention in women receiving chemotherapy for gynecological cancers at Başkent University Ankara Hospital Outpatient Chemotherapy Unit.\n\nThe main questions it aims to answer are:\n\nDoes guided imagery improve psychological or physical outcomes during chemotherapy? How do outcomes differ between the intervention (guided imagery) and control (standard information) groups?\n\nResearchers will compare both groups to assess the effect of guided imagery across three repeated measurements.\n\nParticipants will:\n\n* Be randomly assigned (1:1) to intervention or control groups via an online randomization tool.\n* Complete outcome assessments at three time points.\n* Be part of a sample of 158 women (minimum 76 per group), based on power analysis for repeated measures ANOVA (effect size f = 0.25, 95% power, 95% confidence).\n\nThe study will follow the CONSORT-Outcomes 2022 guideline and be registered at ClinicalTrials.gov.",[467],"Gynecologic Cancer","2026-02-10",{"date":470,"type":43},"2026-02-13",{"date":472,"type":43},"2026-01-19",{"date":474,"type":23},"2026-12-31",{"name":49,"class":50},2,{"id":478,"slug":479,"hasResults":12,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":483,"eligibilityCriteria":484,"healthyVolunteers":86,"sex":18,"minAge":485,"maxAge":87,"enrollmentInfo":486,"targetDuration":4,"studyType":24,"phases":488,"briefSummary":489,"conditions":490,"keywords":493,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":51},"100580308","effects-of-schroth-based-exercise-on-kyphosis-angle-muscle-strength-balance-pain-and-quality-of-life-in-hyperkyphosis-with-chronic-neck-pain-100580308","NCT06835608","Effects of Schroth-Based Exercise on Kyphosis Angle, Muscle Strength, Balance, Pain, and Quality of Life in Hyperkyphosis With Chronic Neck Pain","Effects of Schroth-Based Three-Dimensional Exercise Program on Angle of Kyphosis, Muscle Strength, Balance, Pain, and Quality of Life in Patients With Postural Hyperkyphosis With Chronic Neck Pain","Kyphosis","Inclusion Criteria:\n\n* Thoracic kyphosis angle \\> 45 degrees,\n* Aged between 20 and 50 years,\n* Have neck pain for more than 3 months,\n* Neck pain visual analogue scale \\> 3,\n* Not being treated for postural kyphosis in the last 6 months,\n* Has no systemic disease\n\nExclusion Criteria:\n\n* History of trauma or surgery on spinal joints,\n* Participants with rheumatological and metabolic disorders,\n* Participants with congenital postural deformity and scoliosis","20 Years",{"count":487,"type":23},52,[26],"The normal thoracic kyphosis angle of the spine is 20-40°, however, an angle of more than 40° is referred to as postural kyphosis, increased kyphosis or hyperkyphosis. Although postural kyphosis negatively affects individuals' general health status, physical performance, and quality of life, there is still no standardized protocol for correcting the thoracic kyphosis angle. Conservative treatment approaches such as postural training and exercises, manual therapy, postural corrective kinesiotaping, and orthotic use have been recommended for managing increased thoracic kyphosis. While numerous studies have demonstrated the effectiveness of three-dimensional exercise programs in the treatment of scoliosis, research examining their impact on kyphosis remains considerably limited.Nevertheless, the potential of these exercises to promote neuromuscular reorganization suggests that they may be similarly effective in individuals with thoracic kyphosis. This randomized controlled trial aims to evaluate the effects of a Schroth-based three-dimensional exercise program on kyphosis angle, trunk muscle strength, balance, pain, and quality of life in individuals with postural hyperkyphosis and chronic neck pain.",[491,492],"Postural Kyphosis","Chronic Neck Pain",[494,495],"postural hyperkyphosis","chronic neck pain","2025-12-02",{"date":498,"type":43},"2025-12-03",{"date":500,"type":43},"2025-02-25",{"date":502,"type":23},"2026-08-23",{"name":49,"class":50},{"id":505,"slug":506,"hasResults":12,"nctId":507,"briefTitle":508,"officialTitle":509,"acronym":4,"eligibilityCriteria":510,"healthyVolunteers":86,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":511,"targetDuration":4,"studyType":24,"phases":513,"briefSummary":515,"conditions":516,"keywords":519,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":530,"locationsCount":51},"100605953","phase-4-lidocaine-paracetamol-and-dexmedetomidine-for-rocuronium-injection-pain-100605953","NCT07169227","Lidocaine, Paracetamol, and Dexmedetomidine for Rocuronium Injection Pain","The Comparison of the Efficacy of Lidocaine, Paracetamol, and Dexmedetomidine in Preventing Rocuronium Injection Pain","Inclusion Criteria:\n\nPatients who will receive propofol and rocuronium 18 - 65 years No psychiatric disorders Elective surgery Those who accept the research No history of allergy to any of the drugs used in the study Patients in American Society of Anesthesiologists (ASA) I and II class\n\nExclusion Criteria:\n\nPatients with chronic pain syndromes Patients with difficult intravenous access Patients with advanced heart block or heart failure Patients with uncontrolled hypertension (Systolic blood pressure \\>160 mmHg)",{"count":512,"type":23},170,[514],"PHASE4","Propofol and rocuronium may cause pain during intravenous injection. Various pharmacological agents are used to reduce the incidence and severity of injection pain. Among the most commonly used agents for this purpose are lidocaine, various opioids, ketamine, paracetamol, and dexmedetomidine. The aim of this study was to evaluate the comparative effect of intravenous dexmedetomidine and paracetamol versus lidocaine in preventing propofol- and rocuronium-induced pain during anesthesia induction.",[517,518],"Propofol Injection Pain","Rocuronium Injection Pain",[520,521,522],"lidocaine","dexmedetomidine","paracetamol","2025-09-05",{"date":525,"type":43},"2025-09-11",{"date":527,"type":23},"2025-09",{"date":529,"type":23},"2025-10",{"name":49,"class":50},{"id":532,"slug":533,"hasResults":12,"nctId":534,"briefTitle":535,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":537,"targetDuration":4,"studyType":24,"phases":539,"briefSummary":540,"conditions":541,"keywords":543,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":549,"leadSponsor":551,"locationsCount":51},"100597242","investigation-of-the-effects-of-visual-motor-based-training-on-upper-extremity-functions-in-individuals-with-stroke-100597242","NCT07055945","Investigation of the Effects of Visual-Motor Based Training on Upper Extremity Functions in Individuals With Stroke","Inclusion criteria:\n\n* At least 6 months have passed since the cerebrovascular event\n* Aged between 18 and 75 years\n* First-time stroke\n* Scoring 24 or higher on the Standardized Mini Mental Test (SMMT)\n* Upper extremity functioning at Stage 4 or above according to the Brunnstrom Staging\n* Shoulder, elbow, wrist, and finger muscle tone at or below a score of 2 on the Modified ---Ashworth Scale (MAS)\n* Shoulder joint range of motion of at least 120°\n* Ability to stand independently\n\nExclusion Criteria:\n\n* Presence of hemispatial neglect syndrome\n* Ataxia due to posterior circulatory ischemia\n* Bilateral involvement (bilateral hemiparesis)\n* Botulinum toxin injection in the last three months\n* Physiotherapy treatment within the last 6 months\n* Orthopedic problems such as shoulder subluxation, shoulder pain, or contractures in the hand or wrist\n* Previous upper extremity or thoracic surgery\n* Vision problems related to stroke (hemianopsia)\n* Color blindness",{"count":538,"type":23},38,[26],"The purpose of this study is to investigate the effects of visual-motor based training and physiotherapy program on upper extremity functions in individuals with stroke and to compare with physiotherapy program.",[542],"Stroke",[542,544,95],"Physiotherapy Rehabilitation","2025-08-28",{"date":547,"type":43},"2025-09-04",{"date":545,"type":43},{"date":550,"type":23},"2025-12-30",{"name":49,"class":50},{"id":553,"slug":554,"hasResults":12,"nctId":555,"briefTitle":556,"officialTitle":556,"acronym":557,"eligibilityCriteria":558,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":559,"targetDuration":4,"studyType":24,"phases":561,"briefSummary":562,"conditions":563,"keywords":564,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":567,"startDateStruct":569,"completionDateStruct":571,"leadSponsor":572,"locationsCount":4},"100600196","effects-of-intradialytic-inspiratory-muscle-training-on-functional-capacity-in-hemodialysis-patients-100600196","NCT07094347","Effects of Intradialytic Inspiratory Muscle Training on Functional Capacity in Hemodialysis Patients","Hemodialysis","Inclusion Criteria:\n\n* Being on hemodialysis for at least 6 months\n* Being on hemodialysis for 4 hours, 3 days a week\n* Not having had a transplant\n* Being able to continue sitting and standing\n* Being able to walk without assistance\n* Being willing to participate in the study\n\nExclusion Criteria:\n\n* Individuals with communication and\u002For cognitive problems that are unable to fulfill the assessment and treatment requirements\n* Patients with uncontrolled cardiac, pulmonary or other systemic diseases",{"count":560,"type":23},34,[26],"There is a need for long-term sustainable studies that will increase the potential health benefits in hemodialysis patients. Inspiratory muscle training, one of the recommended treatments to increase exercise capacity and quality of life during dialysis treatment in people with chronic renal failure, is a method that can be applied intradialytically, in addition to being easy to apply, cheap and sustainable. It improves functional capacity by increasing respiratory muscle strength. In this context, our study aims to investigate the effects of inspiratory muscle training on functional parameters and on hemodialysis patients with a personalized portable device and to add it to the literature.",[557],[565],"powerbreathe","2025-07-28",{"date":568,"type":43},"2025-07-30",{"date":570,"type":23},"2025-08-20",{"date":307,"type":23},{"name":49,"class":50},{"id":574,"slug":575,"hasResults":12,"nctId":576,"briefTitle":577,"officialTitle":578,"acronym":579,"eligibilityCriteria":580,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":581,"targetDuration":176,"studyType":62,"phases":4,"briefSummary":583,"conditions":584,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":586,"lastUpdatePostDateStruct":587,"startDateStruct":589,"completionDateStruct":591,"leadSponsor":593,"locationsCount":51},"100570436","the-trkiye-heart-failure-registry-100570436","NCT06707220","The Türkiye Heart Failure Registry","The Türkiye Heart Failure (TURK-HF) Registry","TURK-HF","Inclusion Criteria: Presence of heart failure -\n\nExclusion Criteria: Age \\\u003C18 years\n\n\\-",{"count":582,"type":23},5000,"A comprehensive understanding of the socio-demographic, clinical, and biological characteristics of patients with heart failure is essential to develop novel strategies for improving outcomes. The identification of the barriers to guideline-directed medical therapy implementation in a real-world setting is critical to decreasing the risk of heart failure hospitalization and mortality. A comprehensive and well-designed heart failure registry can determine the clinical characteristics of patients with heart failure, identify patient, physician, and healthcare system-related factors for the non-use of evidence-based therapies, and improve the implementation of guideline-directed medical therapy. It should be noted that the number of heart failure registries that enroll patients with de novo heart failure, chronic heart failure (outpatients), and worsening of heart failure (hospitalized or treated in the emergency department), with all three relevant ejection fraction categories (heart failure with reduced ejection fraction, heart failure with mildly-reduced ejection fraction, and heart failure with preserved ejection fraction), is limited. Furthermore, only a few registries assess detailed aspects of guideline adherence, treatment decisions, and both in-hospital and long-term outcomes. Therefore, the Türkiye Heart Failure (TURK-HF) registry has been designed to address this gap in knowledge about the identification, management, and long-term prognosis of patients with heart failure in a real-world setting.",[585],"Heart Failure","2025-02-27",{"date":588,"type":43},"2025-03-03",{"date":590,"type":43},"2025-01-08",{"date":592,"type":23},"2027-12",{"name":49,"class":50},{"id":595,"slug":596,"hasResults":12,"nctId":597,"briefTitle":598,"officialTitle":599,"acronym":4,"eligibilityCriteria":600,"healthyVolunteers":86,"sex":18,"minAge":601,"maxAge":602,"enrollmentInfo":603,"targetDuration":4,"studyType":24,"phases":605,"briefSummary":606,"conditions":607,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":610,"lastUpdatePostDateStruct":611,"startDateStruct":613,"completionDateStruct":615,"leadSponsor":617,"locationsCount":51},"100575760","clinical-evaluation-of-two-different-pit-and-fissure-sealants-100575760","NCT06776471","Clinical Evaluation of Two Different Pit and Fissure Sealants","Clinical Evaluation of Two Different Pit and Fissure Sealants Used in Teeth Affected by Molar Incisor Hypomineralization","Inclusion Criteria:\n\n* Healthy children aged 6-12 years with at least two fully erupted permanent first molars diagnosed with molar ıncisor hypomineralization according to the European Academy of Paediatric Dentistry criteria.\n* Hypomineralized first molars with enamel defects according to early lesions\n\nExclusion Criteria:\n\n* Ongoing orthodontic treatment\n* Uncooperative child during dental treatment\n* Teeth with advanced lesions, existing restorations, fluorosis, or enamel malformation due to syndromic causes\n* Presence of pulpal symptoms","6 Years","12 Years",{"count":604,"type":23},126,[26],"It is planned to include girls and boys between the ages of 6-12 who apply to Başkent University Faculty of Dentistry, Pediatric Dentistry Clinic for routine dental examination. Informed and written consent will be obtained from the parents of each participating child. In teeth planned to undergo treatment, molar ıncisor hypomineralization diagnosis will be made primarily in the presence of limited opacities\u002Fenamel fracture after eruption in at least one first permanent molar according to European Academy of Paediatric Dentistry criteria. In teeth diagnosed with molar ıncisor hypominerlization, tooth surfaces will be cleaned with a slow-speed rotary brush and dried with air before the evaluations to be made using the ICDAS II index. Early enamel caries lesions will be assessed by visual examination.\n\nThe decayed, missing, filled teeth of the patients will be assessed according to the World Health Organization assessment criteria. The groups will be double-blind randomized as conventional fissure sealant (n=63) and self-adhesive flowable composite (n=63): Group I (acid+resin-based fissure sealant) will be etched with 37% phosphoric acid for 30 seconds, the surface will be rinsed and air dried until an opaque appearance is achieved on the enamel. Low-viscosity fluoride containing resin based fissure sealant will be applied to the etched enamel surface. Group II (self-adhesive flowable composite); self adhesive flowable composite will be applied in one step. All applied fissure sealants will be polymerized using a light device. Finally, occlusion control will be performed on fissure sealants with articulation paper.The Schiff Cold Air Sensitivity Scale will be used to assess the presence of hypersensitivity in the affected teeth by applying the air-water spray perpendicular to the occlusal surface of the tooth from a distance of 1 cm for 1 second. Clinical evaluation of fissure sealants will be performed at 1, 3, 6 and 12 months using modified . Sealants that receive \"Alpha\" or \"Bravo\" scores for all criteria (anatomical form, marginal adaptation, surface texture, marginal color change, retention and secondary caries) will be classified as successful; while \"Charlie\" scores received from one or more of the United States Public Health Service criteria will be evaluated as failure.",[608,609],"Pit and Fissure Sealants","Molar Incisor Hypomineralization","2025-01-15",{"date":612,"type":43},"2025-01-17",{"date":614,"type":43},"2024-11-18",{"date":616,"type":23},"2025-12-18",{"name":49,"class":50},{"id":619,"slug":620,"hasResults":12,"nctId":621,"briefTitle":622,"officialTitle":623,"acronym":4,"eligibilityCriteria":624,"healthyVolunteers":86,"sex":18,"minAge":625,"maxAge":602,"enrollmentInfo":626,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":628,"conditions":629,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":633,"lastUpdatePostDateStruct":634,"startDateStruct":636,"completionDateStruct":638,"leadSponsor":640,"locationsCount":51},"100574634","postoperative-behavioral-changes-in-children-100574634","NCT06761833","Postoperative Behavioral Changes in Children.","The Effect of Preoperative Anxiety on Postoperative Behavioral Changes in Children Receiving Dental Treatment Under General Anesthesia","Inclusion Criteria:\n\n1. Patients categorized as American Society of Anesthesiologists (ASA) groups 1 and 2.\n2. Children aged 3 to 12 years who are scheduled to receive dental treatment under general anesthesia.\n\nExclusion Criteria:\n\n1. The child patient or parent has a diagnosed psychiatric disorder.\n2. There is a history of substance use that may affect cognitive function.\n3. The parent has declined to participate in the study.\n4. The child patient or parent does not speak Turkish.\n5. Patients categorized as American Society of Anesthesiologists (ASA) group 3 and 4.","3 Years",{"count":627,"type":23},260,"In children scheduled for dental treatment, negative thoughts can lead to anxiety and make them resistant to treatment techniques. In our prospective, single-center observational study, we aim to investigate preoperative anxiety and postoperative negative behaviors in children aged 3 to 12 years who are set to undergo general anesthesia for dental conditions and treatments.",[630,631,632],"Behavior Problems","Pediatrics","Pediatric Pain and Anxiety","2025-01-06",{"date":635,"type":43},"2025-01-07",{"date":637,"type":23},"2025-01",{"date":639,"type":23},"2026-02",{"name":49,"class":50},""]