[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Bavarian Nordic\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":77},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100628904","phase-3-an-efficacy-safety-and-immunogenicity-study-of-chikv-vlp-vaccine-for-the-prevention-of-chikungunya-disease-in-adolescents-and-adults-100628904",false,"NCT07467707","An Efficacy, Safety, and Immunogenicity Study of CHIKV VLP Vaccine for the Prevention of Chikungunya Disease in Adolescents and Adults","A Phase 3b Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of an Adjuvanted Chikungunya Virus Virus-like Particle (CHIKV VLP) Vaccine for the Prevention of Chikungunya Disease in Adolescents (12 to \u003C18 Years) and Adults (≥18 Years)","Inclusion Criteria:\n\n1. Able and willing to provide informed consent (and assent, as applicable) voluntarily signed by participant (and guardian, as applicable). Must verbalize understanding of the reason for and the procedures needed for the study and be willing to stay in the study for its entire duration.\n2. Male or nonpregnant female 12 years of age and older.\n3. In stable health per the investigator, and no hospital admission or major surgical procedure in the last 30 days before investigational product administration.\n4. Women who are either:\n\n   1. Not of CBP: premenarchal, surgically sterile (at least 6 weeks post bilateral tubal ligation, bilateral salpingectomy, bilateral oophorectomy, or hysterectomy); or postmenopausal (defined as a history of ≥12 consecutive months without menses prior to randomization in the absence of other pathologic or physiologic causes, following cessation of exogenous sex-hormonal treatment). or\n   2. Meeting all the below criteria:\n\n      * Negative urine pregnancy test at screening visit\n      * Negative urine pregnancy test immediately prior to dosing\n      * Using an acceptable form of contraception per local standards and agree to use this for at least 8 weeks after investigational product administration\n\nNote: Contraception requirements do not apply for participants in exclusively same-sex relationships and these participants should have no plans to become pregnant by any other means for at least 8 weeks after investigational product administration.\n\nExclusion Criteria:\n\n1. Currently pregnant or breastfeeding.\n2. Participation or planned participation in an investigational clinical study within 30 days of Day 1 (investigational product administration) and for the duration of the study. Note: Participation in an observational trial\u002Fstudy or follow-up phase of a trial\u002Fstudy may be eligible; however, participation in any other study should be discussed with the MM prior to enrollment.\n3. History of severe allergic reaction or anaphylaxis to any component of the investigational product.\n4. Prior receipt of any CHIKV vaccine (or therapeutic) or participation in a prior interventional CHIKV trial\u002Fstudy.\n5. Prior documented, laboratory confirmed CHIKV disease.\n6. History of any known congenital or acquired immunodeficiency or immunosuppressive condition that could impact response to investigational product administration (eg, leukemia, lymphoma, malignancy, functional or anatomic asplenia, alcoholic cirrhosis). Notes: i) history of basal cell and squamous cell carcinoma of the skin or carcinoma in situ of the cervix considered cured is not exclusionary; ii) history of malignancy considered cured from over 5 years from the date of screening with minimal risk of reoccurrence or relapse is not exclusionary; iii) documented controlled HIV infection (most recent tests show undetectable viral load and a CD4 cell count over 350 at the time of investigational product administration) is not exclusionary.\n7. Prior receipt or anticipated use of systemic immunomodulatory or immunosuppressive medications including hyperimmune products, monoclonal antibody therapies, systemic corticosteroids, and\u002For therapy with alkylating agents, antimetabolites, or radiation from 6 months prior to screening through Day 22 visit (21 days \\[-3\u002F+5\\] after investigational product administration). Note: i) for systemic corticosteroid uses at a dose or equivalent dose of 20 mg of prednisone daily for 14 days or more within 90 days of screening through Day 22 visit is exclusionary, and ii) use of inhaled, intranasal, topical, or ocular steroids is not exclusionary.\n8. Receipt or anticipated receipt of any vaccine from 30 days prior to Day 1 through Day 22 visit.\n9. Unstable medical condition in the last 30 days prior to Day 1.\n10. Acute illness with or without fever (oral temperatures ≥38.0 ºC \\[100.4 °F\\]) within 14 days prior to investigational product administration.\n11. Medical or social condition (eg, substance abuse) that could have an impact on the participant's ability to be compliant with study procedures\u002Fvisits, as determined by the investigator.\n12. Plans to travel outside the study area or move away for more than 3 consecutive months and will not be available for follow up at the site.\n13. Identified as an investigator or employee of an investigator or study center with direct involvement in the proposed study, or identified as an immediate family member (ie, parent, spouse) of the investigator or employee with direct involvement in the proposed study, or identified as an employee of Bavarian Nordic, their families, contractors, agents, business partners, or anyone with a financial interest in the outcome of the study.\n14. Any other medical condition that, in the opinion of the investigator, could adversely impact the participant's participation or the conduct of the study.",true,"ALL","12 Years",{"count":20,"type":21},6144,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Study EBSI-CV-317-007 is a field study to evaluate the efficacy, immunogenicity, and safety of CHIKV VLP vaccine. The study was designed using infectious disease models and advanced analytics to guide region and clinical site prioritization, define the timing of study activities, and optimize the study parameters to local epidemiological conditions for CHIKV disease to overcome the challenges of assessing efficacy for CHIKV VLP vaccine.",[27],"Chikungunya Virus",[29,30,31,32,33,34,35,36,37,38],"Chikungunya","PXVX0317","CHIKV VLP","vaccine","immunogenicity","efficacy","safety","VIMKUNYA","adolescents","adults","RECRUITING","2026-06-25",{"date":42,"type":43},"2026-06-29","ACTUAL",{"date":45,"type":43},"2026-05-26",{"date":47,"type":21},"2030-05",{"name":49,"class":50},"Bavarian Nordic","INDUSTRY",3,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":16,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":66,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100593249","phase-3-a-safety-and-immunogenicity-study-of-chikv-vlp-vaccine-in-children-100593249","NCT07003984","A Safety and Immunogenicity Study of CHIKV VLP Vaccine in Children.","A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled, Safety and Immunogenicity Study of CHIKV VLP Vaccine in Children 1 to \u003C12 Years of Age","Inclusion Criteria:\n\n1. Males or females between 1 and \\\u003C12 years of age at Day 1 (day of vaccination). Note: Screening should only occur in the active\u002Fopen cohorts. Please see Section 6.1 for details\n2. Body weight ≥6.5 kg.\n3. In general good health, in the opinion of the investigator, based on medical history and physical examination.\n4. Able and willing to provide informed assent for study participation and primary caregiver is able and willing to provide informed consent for study participation, in accordance with the Institutional Review Board (IRB)\u002FIndependent Ethics Committee (IEC) determination and applicable federal and local regulations and guidelines.\n5. Able and willing to complete all scheduled visits and comply with all study procedures.\n\nExclusion Criteria:\n\n1. Participation or planned participation in an investigational clinical study (eg, vaccine, drug) within 30 days before Day 1 and for the duration of the study. Note: Participation in an observational study or follow-up phase of a study may be allowed; these instances should be discussed with the sponsor's medical monitor and written agreement obtained prior to enrollment.\n2. Current acute illness, with or without fever.\n3. Current or recent CHIKV infection indicated by positive immunoglobulin M (IgM) and negative immunoglobulin G (IgG) rapid diagnostic test (RDT) results at screening in the Philippines only; participants in the US will not be tested using the RDT.\n4. History of any known or suspected allergy or history of anaphylaxis to any component of the investigational product.\n5. History of any known congenital or acquired immunodeficiency or immunosuppressive condition that could impact response to vaccination.\n6. Prior receipt or anticipated use of systemic immunomodulatory or immunosuppressive medications from 180 days prior to screening through Day 22. Note: Systemic corticosteroid use at a dose or equivalent dose of 20 mg or greater (≥0.5 mg\u002Fkg for children \\\u003C40 kg) of prednisone for 14 consecutive days or more within 90 days of screening through Day 22 is exclusionary. The use of inhaled, intranasal, topical, or ocular steroids is allowed.\n7. Receipt or anticipated receipt of immunoglobulin from 180 days prior to screening through the duration of the study.\n8. Any administration or planned administration of:\n\n   * A licensed live attenuated vaccine within 28 days before administration of investigational product and until Visit 2 (Day 15 or 22, as applicable) has occurred.\n   * Other licensed (not live) vaccine within 14 days before administration of investigational product and until Visit 2 (Day 15 or 22, as applicable) has occurred.\n   * Another licensed or investigational CHIKV vaccine.\n9. Known infection with human immunodeficiency virus, hepatitis C virus (HCV), or hepatitis B virus. Note: Positive anti-HCV antibodies and negative HCV polymerase chain reaction would NOT be exclusionary. Polymerase chain reaction testing will not be performed as part of this protocol.\n10. Bleeding disorder or receipt of anticoagulants in the 21 days before Day 1, contraindicating intramuscular vaccination, as judged by the investigator.\n11. Receipt or anticipated receipt of blood products from 90 days before Day 1 through the duration of the study.\n12. Onset of menarche prior to study vaccination.\n13. Planned medical or surgical procedure that could adversely impact the participant's participation or the conduct of the study.\n14. Identified as an immediate family member of the investigator or employee with direct involvement in the study. Bavarian Nordic staff members and their families, contractors, agents, business partners, and anyone with a financial interest in the outcome of the study.\n15. Any other medical condition, including severe malnutrition, that, in the opinion of the investigator, could adversely impact the participant's participation or conduct of the study.","1 Year","11 Years",{"count":62,"type":21},720,[24],"The goal of this multi-center, randomized, double-blind, placebo-controlled study is to evaluate the safety and immunogenicity of CHIKV VLP Vaccine in children 1 to \\\u003C12 years of age.",[27],[29,30,31,32,33,36,67],"children","2026-03-20",{"date":70,"type":43},"2026-03-24",{"date":72,"type":43},"2025-06-05",{"date":74,"type":21},"2028-12",{"name":49,"class":50},15,""]