[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Baylor University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":314},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,47,75,104,152,180,207,231,260,290],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100577620","home-based-self-sampling-for-cervical-cancer-prevention-education-intervention-in-ghana-100577620",false,"NCT06800664","Home-based Self-sampling for Cervical Cancer Prevention Education Intervention in Ghana","The Impact of an Evidence-Based, Behavioral Cervical Cancer Screening Intervention Among Women Living With HIV in Ghana (HOPE-inG): A Type 2 Hybrid Effectiveness Implementation Trial","HOPE-inG","Inclusion Criteria:\n\nGeneral criteria\n\n* ability to give consent per Institutional Review Board stipulations\n* residing in the Central Region\n* having no medical characteristics that would interfere with the ability to participate fully\n* the willingness to participate in this study.\n\n  (a) Healthcare provider eligibility: Inclusion criteria include an individual (no gender restrictions) who\n* possesses healthcare qualifications (i.e., patient navigators, physicians, nurses, health facility management),\n* works at the HIV health facility at study sites,\n* is ≥18 years old. (b) Eligibility for women living with HIV (Patients)\n* identified female at birth) who\n* are living with HIV between 25 and 65 years old (age consistent with WHO CC screening guidelines)\n* have never had CC screening (Pap or HPV test),\n* have not had a screening for the past 5 years\n\nExclusion Criteria:\n\n* Women will be excluded if they are pregnant or have had a hysterectomy.\n* WLWH who have a cervix are the main target population to develop the HOPE toolkit.\n* Women who are below 25 and those who are above 65 years will be excluded.","ALL","25 Years","65 Years",{"count":21,"type":22},1500,"ESTIMATED","INTERVENTIONAL",[25],"NA","The investigators propose to develop and\u002For adapt implementation strategies and a structured implementation plan to translate the HOPE intervention into existing healthcare practice in Ghana.\n\nThese \"implementation support strategies (ISS)\" are implementation strategies relevant to implementation support, which is concerned with moving (implementation) research into (implementation) practice.\n\nThe ultimate goal is to facilitate health system adoption and sustainment.",[28,29,30,31,32,33],"Cervical Cancer Screening","HIV","Self-sampling","Implementation Science","Intervention (Training) Condition","Implementation Strategies","RECRUITING","2026-06-30",{"date":37,"type":38},"2026-07-01","ACTUAL",{"date":40,"type":38},"2025-11-11",{"date":42,"type":22},"2029-05",{"name":44,"class":45},"Baylor University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100639813","mystical-experiences-without-psychedelics-and-how-integration-improves-well-being-in-adults-100639813","NCT07584070","Mystical Experiences Without Psychedelics and How Integration Improves Well-Being in Adults","Mystical Experiences Without Psychedelics: The Nature of Peak Spiritual Experiences and How Integration Leads to Human Flourishing","Inclusion Criteria:\n\n* age 18 years or older;\n* active Christian faith;\n* willing to experience hypnosis;\n* English-speaking; able to complete one in-person session and 1- and 2-month follow-up assessments.\n\nExclusion Criteria:\n\n* prior psychedelic use;\n* severe mental illness (e.g., schizophrenia, bipolar disorder, psychosis, borderline personality disorder);\n* unwillingness to experience hypnosis;\n* inability to complete study procedures","18 Years",{"count":56,"type":22},120,[25],"The goal of this clinical trial is to evaluate whether a guided, non-drug spiritual intervention can facilitate mystical-type experiences and improve well-being in Christian adults.\n\nThe main questions it aims to answer are:\n\n* Does the guided spiritual intervention produce measurable mystical experiences?\n* Does participation in the intervention and assigned integration program lead to improvements in well-being over time?\n\nResearchers will compare a Christian-based integration program to a structured control integration program to determine whether Christian-based integration leads to greater improvements in well-being.\n\nParticipants will:\n\n* Complete baseline questionnaires assessing spiritual experiences, religiosity, and well-being\n* Complete one in-person session of the \"guided invocation for mystical experience\"\n* Be randomly assigned to complete either a Christian-based or control integration program for 4 weeks\n* Complete follow-up assessments at 1 month and 2 months",[60],"Healthy Adult Participants",[62,63,64,65],"mystical experience","peak spiritual experience","integration","hypnosis","NOT_YET_RECRUITING","2026-05-07",{"date":69,"type":38},"2026-05-13",{"date":71,"type":22},"2026-04",{"date":73,"type":22},"2027-08-01",{"name":44,"class":45},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},"100585725","validating-a-clinical-prediction-rule-to-guide-manual-therapy-and-exercise-for-neck-pain-relief-100585725","NCT06906107","Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief","Validation of a Clinical Prediction Rule to Identify Patients With Neck Pain Likely to Benefit From Cervical Spinal Manipulation: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Ages 18 to 70\n* Primary complaint of neck pain with or without unilateral upper extremity symptoms\n* Neck Disability Index (NDI) score of 10 or greater\n* Numeric Pain Rating Scale score of 2 or greater\n\nExclusion Criteria:\n\n* History of whiplash injury within the past 6 weeks\n* Diagnosis of cervical spinal stenosis\n* Bilateral upper extremity symptoms\n* Red flags noted in the patient's Neck Medical Screening Questionnaire (i.e. tumor, fracture, rheumatoid arthritis, osteoporosis, severe atherosclerosis, dizziness, diplopia, drop attacks, bilateral numbness, nausea, prolonged history of steroid use)\n* Evidence of central nervous system involvement, to include hyperreflexia, sensory disturbances in the hand, intrinsic muscle wasting of the hands, unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of the face, altered taste, the presence of pathological reflexes (i.e. positive Hoffman's and\u002For Babinski reflexes)\n* Two or more positive neurological signs consistent with significant nerve root compression, including any two of the following:\n\n  1. Muscle weakness involving a major muscle group of the upper extremity\n  2. Diminished upper extremity muscle stretch reflex (biceps, triceps, or brachioradialis)\n  3. Diminished or absent sensation to pinprick or light touch in any upper extremity dermatome\n* Prior neck surgery\n* Current pregnancy, pregnancy within 6 months, or currently lactating\n* Pending legal action pertaining to their neck pain\n* Currently receiving manual therapy treatment for neck pain through chiropractic or physical therapy care\n* Inability to read English at the 8th grade reading level\n* Inability to legally provide informed consent for any other reason\n* Inability to comply with the treatment and follow-up schedule","70 Years",{"count":84,"type":22},160,[25],"Neck pain is a common issue that can lead to long-term disability and lost work time for many individuals. Despite numerous studies, finding effective treatment strategies has been challenging. One possible reason for this is that treatments may not have been tested on the specific groups of people who would benefit most. A method was developed to identify people with neck pain who are likely to see significant improvements from a manipulation technique used by physical therapists, called cervical spine thrust joint manipulation. The investigators believe that patients identified as likely responders to cervical spine manipulation will show greater improvements in disability. The investigators aim to test whether this method works with different patients and therapists across the country through a multicenter randomized clinical trial. In this study, 160 patients with primary complaints of neck pain will be enrolled from 9 clinical sites. Designed with stringent criteria for inclusion, this study is a testament to our commitment to participant safety and the effectiveness of the treatment. Participants will be randomly assigned to one of two groups: (1) one group will receive 2 sessions of cervical spine manipulation followed by 3 sessions of exercise, and (2) the other group will receive 2 sessions of gentle hands-on treatment followed by 3 sessions of exercise. The primary goal is to measure changes in disability 4 weeks after starting treatment, with follow-ups after one week, 4 weeks, 3 months, and 6 months to assess both immediate and long-term effects. By providing crucial data on the reliability of our method in identifying patients who will benefit most from cervical spine manipulation, this study has the potential to significantly enhance decision-making leading to rapid improvement. Results from this study will provide clearer guidelines on the optimal use of cervical spine manipulation, potentially revolutionizing the way patients recover from neck pain.",[88,89,90],"Neck Pain Musculoskeletal","Neck Pain Treatment","Cervicalgia",[92,93,94],"neck pain","manual therapy","physical therapy","2026-04-09",{"date":97,"type":38},"2026-04-14",{"date":99,"type":38},"2025-06-01",{"date":101,"type":22},"2026-12-31",{"name":44,"class":45},4,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":82,"enrollmentInfo":112,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":115,"conditions":116,"keywords":129,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":46},"100627766","using-integrated-care-and-wearable-technology-to-evaluate-outcomes-of-the-shields--stripes-program-for-veterans-and-first-responders-100627766","NCT07452900","Using Integrated Care and Wearable Technology to Evaluate Outcomes of the Shields & Stripes Program for Veterans and First Responders","Evaluating Integrated Care and Wearable Technology Outcomes in the Shields & Stripes Program for Veterans and First Responders: A Retrospective Mixed-Methods Study","S&S Wellness","Inclusion Criteria:\n\n* Adults aged 18-70 years\n* Current or former members of the U.S. Armed Forces or first responder professions (e.g., law enforcement, firefighting, EMS)\n* Participants who completed the Shields \\& Stripes holistic wellness program\n* Providers who worked within the Shields and Stripes program.\n\nExclusion Criteria:\n\n-None",{"count":113,"type":22},80,"OBSERVATIONAL","This study aims to evaluate outcomes from the Shields \\& Stripes (S\\&S) program - a 12-week, multidisciplinary wellness intervention designed for veterans and first responders. The S\\&S program integrates occupational therapy (OT), mental health (MH), physical therapy (PT), and registered dietitian (RD) services to promote recovery, resilience, and performance in individuals who have experienced cumulative stress, trauma exposure, or occupational burnout.\n\nThis research will use a retrospective mixed-methods observational design to analyze data collected from previous S\\&S participants who consent to research use of their de-identified information. No intervention or treatment changes will occur as part of this study.\n\nQuantitative data will include biometric information (e.g., sleep, activity, and heart rate variability via Oura Ring), standardized self-report measures (GAD-7, PHQ-9, PCL-5, RAND-36, PSQI, ISI), satisfaction surveys, and laboratory nutrition panels. Qualitative data will include semi-structured interviews with consenting participants and S\\&S providers following program completion.\n\nThe purpose of the study is to identify patterns of improvement in physical, psychological, and occupational functioning and to explore how integrated, team-based care supports holistic recovery. Findings may inform the development of future evidence-based wellness programs for military and first-responder populations.\n\nParticipation involves minimal risk, and all data will be de-identified before analysis.",[117,118,119,120,121,122,123,124,125,126,127,128],"Holistic Care","Mental Health","Sleep","PTSD","Depression - Major Depressive Disorder","Anxiety","Resilience","Recovery","Occupation","Biometrics Measurement","Veteran","Quality of Life",[130,131,132,133,118,134,135,136,137,138,119,139,120,122,140,128,141,142,143],"Shields & Stripes","Veterans","First Responders","Occupational Therapy","Physical Therapy","Registered Dietitian","Integrated Wellness","Biometric Data","Oura Ring","Heart Rate Variability","Depression","Holistic Health","Multidisciplinary Rehabilitation","Functional Outcomes","2026-03-06",{"date":146,"type":38},"2026-03-10",{"date":148,"type":22},"2026-04-01",{"date":150,"type":22},"2027-04-30",{"name":44,"class":45},{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":162,"conditions":163,"keywords":168,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":46},"100614540","reliability-and-validity-of-the-prefs-100614540","NCT07280923","Reliability and Validity of the PReFS","Reliability and Validity of the Pressure Relief Frequency Scale","PReFS","Inclusion Criteria:\n\n* primary wheelchair user\n* diagnosed with a neurologic disorder\n\nExclusion Criteria:\n\n* does not use a wheelchair for more than 50% of waking hours",{"count":161,"type":22},15,"This study is testing the psychometric properties of a new tool to determine recommendations for pressure relief frequency in wheelchair users.",[164,165,166,167],"Neurologic Disorders","Spinal Cord Injury","Stroke","Traumatic Brain Injury",[169,170,171],"wheelchair user","pressure relief","skin integrity","2025-12-17",{"date":174,"type":38},"2025-12-23",{"date":176,"type":22},"2025-12",{"date":178,"type":22},"2027-01",{"name":44,"class":45},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":17,"minAge":188,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":23,"phases":192,"briefSummary":193,"conditions":194,"keywords":196,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":46},"100607119","activities-based-locomotor-training-in-children-with-cerebral-palsy-100607119","NCT07184411","Activities-based Locomotor Training in Children With Cerebral Palsy","Efficacy of Activities-based Locomotor Training in Children With Cerebral Palsy.","ENGAGE-CP","Inclusion Criteria: To be eligible for this study, the child must be:\n\n* • Able to hold their head upright for 5 seconds when supported at the trunk in sitting (the minimal amount of head control necessary for safe walking on the partial body weight support system during the AB-LT intervention);\n\n  * Non-ambulatory or not walking as primary means of mobility;\n  * Willing to attend the AB-LT intervention at Fortis Therapy Center in Dripping Springs, Texas for 3 hours\u002F day, 5 days\u002Fweek, for 3 weeks; and\n  * Willing to commit to a total of 7 weeks of the study, and to continue their usual care during the time period in which they are not enrolled in the AB-LT intervention.\n\nExclusion Criteria: The child must not have:\n\n* • Surgery or botulinum toxin injections in the previous 6 months;\n\n  * Uncontrolled epilepsy; and\n  * Uncontrolled cardiovascular disease","2 Years","6 Years",{"count":191,"type":22},19,[25],"This project aims to improve the quality of life and functional outcomes for young non-ambulatory children with Cerebral Palsy (CP) by investigating the efficacy of an Activities-Based Locomotor Training (AB-LT) program compared to usual care. By targeting the body structures, activities, and participation components of the World Health Organization's International Classification of Functioning, Disability, and Health (ICF) framework, this study seeks to enhance our understanding of neuroplasticity and motor learning in this population, offering a novel approach to rehabilitation. Results from this research will lead to more effective, individualized therapies that improve motor function, reduce disability, and ultimately lower the long-term healthcare needs associated with CP.",[195],"Cerebral Palsy (CP)",[197,198,134],"Cerebral Palsy","Locomotor Training","2025-12-01",{"date":201,"type":38},"2025-12-03",{"date":203,"type":22},"2026-01-11",{"date":205,"type":22},"2028-08-31",{"name":44,"class":45},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":23,"phases":216,"briefSummary":217,"conditions":218,"keywords":220,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":230,"locationsCount":46},"100607221","culturally-adapted-rubi-t-for-spanish-speaking-families-in-texas-and-mexico-100607221","NCT07185737","Culturally Adapted RUBI-T for Spanish-Speaking Families in Texas and Mexico","Cultural Adaptation of Parent Training Intervention for Spanish-Speaking Families","SS RUBI-T","Inclusion Criteria:\n\n* Caregiver of a child aged 2 to 9 years.\n* Caregiver of a child diagnosed with autism or suspected of being autistic.\n* Child exhibits challenging behaviors in naturalistic environments (e.g., home, school, community).\n* Caregiver is willing to complete all aspects of the study, including assessments and intervention sessions.\n* Caregiver has access to electronic resources (e.g., high-speed internet and a device capable of participating in Zoom sessions).\n* Caregiver is fluent in Spanish (speaks and understands Spanish sufficiently to participate in the intervention and assessments).\n\nExclusion Criteria:\n\n* Prior participation in the Research Units in Behavioral Intervention (RUBI) program.\n* Caregiver does not speak Spanish.\n* Caregiver unable or unwilling to provide informed consent.",{"count":56,"type":22},[25],"Supporting young autistic children can sometimes be very stressful, especially when children show behaviors that are difficult to understand and\u002For manage in everyday life. Research has shown that teaching parents practical strategies through programs like the Research Units in Behavioral Intervention (RUBI) can reduce these behaviors and help parents feel more confident. However, most of these programs have only been studied with English-speaking families, which means Spanish-speaking caregivers often do not have access to support that feels relevant to their culture and language.\n\nThis study will test a version of RUBI that has been adapted for Spanish-speaking families in the U.S. and Mexico. We will invite 100 parents of autistic children between the ages of 2 and 9 to take part. Half will start the program right away, while the other half will wait and receive it later. Parents in the program will join eight online group sessions, use a Spanish handbook at home, and practice strategies with support from trained facilitators.\n\nWe will look at whether the program helps reduce children's challenging behaviors, lowers parent stress, and increases parents' confidence in managing behaviors. We will also ask parents to share their experiences and opinions about how well the program fits their culture and daily life.\n\nBy combining numbers (surveys) and stories (interviews), this project will show whether the adapted program works well for Spanish-speaking families. The results can help make autism services more fair, accessible, and supportive for families from diverse backgrounds.",[219],"Autism",[219,221,222,223],"Cultural Adaptation","RUBI-T","Behavior Parent Training","2025-09-18",{"date":226,"type":38},"2025-09-22",{"date":228,"type":22},"2025-09-25",{"date":101,"type":22},{"name":44,"class":45},{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":238,"sex":17,"minAge":54,"maxAge":82,"enrollmentInfo":239,"targetDuration":4,"studyType":23,"phases":241,"briefSummary":242,"conditions":243,"keywords":246,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":46},"100603586","influence-of-melatonin-on-cardiovascular-and-thermoregulatory-responses-to-stress-100603586","NCT07138443","Influence of Melatonin on Cardiovascular and Thermoregulatory Responses to Stress","Influence of Melatonin on Cardiovascular and Skin Temperature Responses to Stress: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Must be between the ages of 18-70 years old.\n* All subjects will be required to abstain from exercise and caffeine for 12 h, and alcohol for 24 h prior to the experiment.\n* BMI must be \\\u003C30 kg\u002Fm2.\n* Menstruating women will initially be tested during their early follicular phase (2-5 days after initiating menstruation) or during low hormone phase (2-5 days after initiating menstruation) if on oral contraceptives to control for potential impact of sex steroids. Post-menopausal females (\\>5 years) will also be included. Females must have an intact uterus and at least one ovary. Use of hormonal replacement therapy will be allowed.\n\nExclusion Criteria:\n\n* Circadian rhythm sleep disorders\n* High obstructive sleep apnea diagnosis determined by STOP-BANG.\n* History of meeting Diagnostic and Statistical Manual of Mental health (DSM-V) criteria of major psychiatric disorder\n* Unstable or serious medical conditions (heart failure, diabetes, cardiovascular disease, etc.)\n* Current, or use within past month, of psychoactive (other than stable treatment with antidepressant), hypnotic, stimulant or analgesic medication (except occasional non-narcotic analgesics), beta blockers, or alpha blockers\n* Shift work or other types of self-imposed irregular sleep schedules\n* Habitual smoking (6 or more cigarettes per week)\n* Habitual alcohol consumption (more than 2 alcoholic drinks per day)\n* Pregnancy or breast feeding",true,{"count":240,"type":22},20,[25],"This study aims to evaluate the influence of acute oral melatonin supplementation on cardiovascular and skin temperature responses to mental stress. The hypothesis is that acute melatonin will lead to reduced cardiovascular and skin temperature responsiveness to acute mental stress.",[244,245],"Stress","Mental Stress",[247,248,249,250,251],"Melatonin","Mental stress","Trier Social Stress Test","Cardiovascular","Skin temperature","2025-08-21",{"date":254,"type":38},"2025-08-22",{"date":256,"type":22},"2025-08",{"date":258,"type":22},"2026-08",{"name":44,"class":45},{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":267,"minAge":54,"maxAge":268,"enrollmentInfo":269,"targetDuration":4,"studyType":23,"phases":271,"briefSummary":272,"conditions":273,"keywords":275,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":289},"100569692","conservative-care-for-pelvic-pain-c2p2-in-women-service-members-100569692","NCT06697548","Conservative Care for Pelvic Pain (C2P2) in Women Service Members","Conservative Care for Pelvic Pain (C2P2) in Women Service Members: A Multisite, Multigroup Non-inferiority Randomized Clinical Trial With Development of Clinical Decision Tools","Inclusion Criteria:\n\n1\\. Pain of at least 3 months duration in the abdominal-lumbopelvic area, defined as below the umbilicus, between the two ilia, and above the pubic symphysis including the vulvar, perineal, and vaginal regions.\n\nExclusion Criteria:\n\n1. Sign that pelvic pain may be due to other serious medical issue (recent history of abdominal pelvic surgery, current infection, disrupted tissue integrity, neoplasm, or history of radiation to the pelvic floor tissue or the tissues being measured for stiffness).\n2. Chronic debilitating medical conditions (e.g., fibromyalgia, lupus, complex regional pain syndrome, multiple sclerosis or other progressive neurologic condition).\n3. Currently pregnant or pregnancy in the last 6 months.\n4. Body mass index over 33 (Waco participants only due to limitation of the instrumentation).\n5. Soldiers in an Advanced Individual Training (AIT) status.\n6. Previous intervention to address lumbopelvic muscle stiffness or pain such as dry needling, injections, or soft tissue intervention of any kind in the past 6 months.\n7. Inability to read English at an 8th grade reading level (any participant unable to read the informed consent form, which will be written at an 8th grade level).\n8. Inability to legally provide informed consent for any other reason.","FEMALE","50 Years",{"count":270,"type":22},300,[25],"This study will test the effectiveness of emerging conservative interventions for treatment of chronic pelvic pain (CPP) that can be performed without intravaginal specialization. Participants with CPP will be randomly assigned to one of three groups. The first group will receive treatment based on what they normally would receive, including medications, education, and exercise (Usual Care Group). The second group will receive contemporary non-vaginal treatment including manual therapy, dry needling, and specific breathing training (Emerging Field-expedient Care Group). The third group will receive intravaginal treatment by a pelvic health specialist (Gold-standard Intravaginal Specialist Care Group). Participants will be asked about their pain and symptoms and have measurements taken of their pelvic and back muscles after 1, 3, 6, and 12 months. In addition to seeing which treatments work best, clinical decision tools (using medical and trauma history along with clinical examination) will be developed to identify women with CPP likely to respond favorably to non-vaginal conservative interventions. This study will help determine the best non-vaginal treatment strategies for women with CPP and help clinicians quickly determine which patients are likely to benefit from treatment by non-pelvic health physical therapists (e.g., in theater), vs. patients who should be referred for pelvic health specialty care.",[274],"Chronic Pelvic Pain",[276,277,278,279,280],"Pelvic health","Chronic pelvic pain","Physical therapy","Military","womens health","2024-11-19",{"date":283,"type":38},"2024-11-20",{"date":285,"type":22},"2025-01",{"date":287,"type":22},"2028-06",{"name":44,"class":45},2,{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":268,"maxAge":4,"enrollmentInfo":297,"targetDuration":4,"studyType":23,"phases":299,"briefSummary":300,"conditions":301,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":313},"100550266","paper-based-and-smartphone-based-memory-supports-100550266","NCT06444841","Paper-Based and Smartphone-Based Memory Supports","Smartphone-Based Solutions for Prospective Memory in Mild Cognitive Impairment and Dementia","Inclusion Criteria:\n\n* Demonstrate capacity to consent via structured interview that involves reviewing core study features and probing for understanding of potential benefits\u002Fconsequences of participating, and understanding that one can withdraw consent at any point, or availability to obtain surrogate consent.\n* Clinical features consistent with a diagnosis of MCI or dementia. For clinic-referred participants, available records will be reviewed to ensure the clinical diagnosis meets published diagnostic guidelines. If there is not sufficient documentation for diagnostic purposes, then semi-structured clinical interview and cognitive screening (see below) will be reviewed by clinical staff.\n* Cognitive status for inclusion will be assessed by Montreal Cognitive Assessment (MoCA) scores of 17-25 (or 12-18 for the telephone version if in-clinic assessment is not feasible). While some studies suggested that these ranges are appropriate across diverse groups, recent work indicates that adjustment of 1-2 points for different demographics improves instrument sensitivity in disadvantaged groups. The latter approach will be taken.\n* Functional status will be assessed via semi-structured interview with the Global Deterioration Scale (GDS), with stage 3 or 4 indicating independence in basic self-maintenance activities.\n* Adequate sensory and motor abilities to utilize a smartphone with accommodation.\n* Availability of a co-participant who sees the participant at least once a month.\n\nCo-Participant Inclusion Criteria:\n\n* The co-participant will need to be over the age of 18, consent to participation, and see the participant at least once per month.\n\nExclusion Criteria:\n\n* History of serious mental illness including schizophrenia or bipolar disorder that is judged by the clinician to be the primary cause of cognitive decline.\n* Indication of moderate or severe dementia based on clinical documentation, MoCA score, and\u002For collateral\u002Finformant activities of daily living measure during the screening process (GDS score ≥5).\n* Language difficulties significant enough to interfere with the screening procedures.\n* Uncorrected hearing loss, vision loss, or motor dysfunction significant enough to interfere with training.\n* No study partner.\n* At the current time, individuals who do not identify as conversational in English will be excluded from participation.\n\nCo-Participant Exclusion Criteria:\n\n* Sees participant less than once per month.\n* At the current time, individuals who do not identify as conversational in English will be excluded from participation.",{"count":298,"type":22},200,[25],"Alzheimer's disease and related dementias lead to marked declines in daily functioning, independence, and quality of life. One of the earliest cognitive changes in these conditions is impairment in prospective memory, or the ability to remember future intentions such as taking medications at a given time. Prior intervention studies that targeted prospective memory used mnemonic strategies or cognitive training, but these approaches resulted in modest gains in clinical populations. By contrast, a Stage I pilot trial indicated that smartphone-based memory aids (reminder apps) can be accepted and used by persons with mild cognitive impairment and mild dementia to improve both subjective and objective prospective memory performance. The investigators will now test for efficacy, durability, and generalizability of benefits across diverse samples in a Stage II randomized controlled trial. Some 200 participants with mild cognitive impairment or mild dementia will be recruited, half of whom will be from digitally-disadvantaged backgrounds (low socioeconomic status, rural, or historically underrepresented groups). Participants will complete baseline assessments and then be randomly assigned to a smartphone reminder app intervention or an active control condition that uses a paper- based memory support system. Across a 4-week intervention period, participants will complete patient-selected and experimenter-assigned prospective memory assessments and receive booster training sessions to promote self-efficacy with the intervention\u002Fcontrol system. Durability of effects will be assessed at 3-month and 6-month follow-up sessions. As a secondary aim, study partners will be simultaneously enrolled to collect informant ratings, track how much study partners assist the participants, and determine whether improving prospective memory in patients improves quality of life in study partners (e.g., by reducing the double to-do list burden of remembering for themselves and for care recipients). As a third aim, the investigators will identify barriers and facilitators to smartphone interventions in digitally-disadvantaged individuals who have historically been underrepresented in technology and dementia research.",[302,303,304],"Alzheimer Disease","Dementia, Mild","Mild Cognitive Impairment","2024-07-08",{"date":307,"type":38},"2024-07-09",{"date":309,"type":38},"2024-06-27",{"date":311,"type":22},"2028-09-30",{"name":44,"class":45},3,""]