[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Benjamin T. Miller\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":61},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100582007","the-management-of-necrotizing-soft-tissue-infection-wounds-with-cytal-wound-matrix-and-micromatrix-100582007",false,"NCT06857708","The Management of Necrotizing Soft Tissue Infection Wounds With Cytal® Wound Matrix and MicroMatrix®","Inclusion Criteria:\n\n1. Adults (≥ 18 years) with a diagnosis of necrotizing fasciitis\n2. Wound ≥ 30 cm2\n3. The participant is willing and able to adhere to protocol requirements and agrees to participate in the study program and comply with the study follow-up regimen.\n\nExclusion Criteria:\n\n1. Burn as etiology of wound\n2. Acute osteomyelitis requiring active treatment\n3. Known allergy, hypersensitivity, or objection to porcine materials\n4. Pregnant participants\n5. Lack of English language fluency\n6. Participant report of concurrent participation in another clinical trial that would interfere with this study\n7. Inability to consent","ALL","18 Years",{"count":18,"type":19},50,"ESTIMATED","INTERVENTIONAL",[22],"NA","This is a prospective, pilot, parallel group, randomized controlled trial with 1:1 allocation. This will be a single center study coordinated at the Cleveland Clinic Foundation (CCF) Main Campus in Cleveland, Ohio. Data will be collected in a secure manner using REDCap housed at CCF. The study will consist of 2 arms: treatment with Cytal® Wound Matrix 2-Layer and MicroMatrix® (Integra LifeSciences, Plainsboro Township, NJ, U.S.A.) versus standard of care dressings. Wound debridement procedures will be performed by surgical staff at CCF. A co-investigator trained in the application of Cytal® Wound Matrix and MicroMatrix® will apply these treatments as outlined in section 6.1.2 Administration. This study will be conducted with IRB approval and written informed consent of each participant enrolled. The trial will be registered at ClinicalTrials.gov before the first participant is enrolled.",[25,26],"Necrotizing Fascitis","Necrotizing Soft Tissue Infection","RECRUITING","2026-03-30",{"date":30,"type":31},"2026-04-03","ACTUAL",{"date":33,"type":31},"2025-03-05",{"date":35,"type":19},"2026-12-31",{"name":37,"class":38},"Benjamin T. Miller","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":20,"phases":49,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":5},"100510401","preoperative-weight-loss-for-open-abdominal-wall-reconstruction-100510401","NCT05925959","Preoperative Weight Loss for Open Abdominal Wall Reconstruction","Inclusion criteria\n\n* Adults having open retromuscular ventral hernia repair with an anticipated posterior component separation with transversus abdominis release and synthetic mesh\n* BMI 40-55 kg\u002Fm2 and who are not planning to pursue weight loss surgery for any of the following reasons: they are not a candidate for weight loss surgery, cannot pursue weight loss surgery for insurance reasons, or are not interested in pursuing weight loss surgery.\n\nExclusion criteria\n\n* Lack of English language fluency\n* Urgent need for repair as determined by surgeon judgement\n* Pregnant patients\n* Permanent stoma in place\n* Isolated flank hernia\n* Anticipated need for staged operation; for example, patients who will undergo a mesh excision separate from definitive reconstruction.\n* BMI \\\u003C40 or \\>55 kg\u002Fm2\n* Inability to participate in the Obesity Management Program due to lack of insurance coverage or history of mental illness (including eating disorders, schizophrenia, etc.).\n* Obstructive symptoms",true,{"count":48,"type":19},258,[22],"The goal of this randomized controlled trial is to compare preoperative intensive weight management to upfront surgery in obese patients undergoing complex abdominal wall reconstruction. The main question is will abdominal wall specific quality of life (using the HerQLes survey) for the group undergoing upfront surgery be non-inferior compared to the group in the weight management program.",[52],"Abdominal Wall Hernia","2026-03-19",{"date":55,"type":31},"2026-03-23",{"date":57,"type":31},"2023-06-19",{"date":59,"type":19},"2027-06-01",{"name":37,"class":38},""]