[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Berthold Langguth, MD, Ph.D.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":63},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100495524","intermittent-theta-burst-stimulation-for-maintenance-therapy-in-depression-100495524",false,"NCT05732311","Intermittent Theta Burst Stimulation for Maintenance Therapy in Depression","PROTECT","Inclusion Criteria:\n\n* adult women and men aged 18 to 70 years with an ICD-10 diagnosis of a depressive episode of depressive disorder (F32), recurrent depressive disorder (F33), or bipolar disorder (F31)\n* moderate or severe current episode prior to initial open iTBS treatment (HAMD-21 \\>16 points)\n* response to iTBS treatment (either reduction in HAMD score by 50% or score at the end of treatment \\\u003C11 points)\n* no concomitant psychotic symptoms.\n* no other relevant psychiatric disorder as assessed by the study physician\n* residence in Germany and German speaking that allows understanding of the information provided\n* patient is capable of giving consent\n\nExclusion Criteria:\n\n* fulfillment of the general contraindications for TMS (electrical implants or metallic objects in the body such as pacemakers or insulin pumps).\n* severe neurological diseases (e.g., cerebrovascular events, neurodegenerative diseases, epilepsy, malformations of the brain, severe head injury in the history)\n* current harmful use or dependence on alcohol, amphetamines, cocaine, benzodiazepines, anticonvulsants, or opiates\n* acute suicidality\n* pregnancy\n* current participation in another study","ALL","18 Years","70 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a randomized, multi-center, open-label study in which patients with depression who responded to an open-label treatment with intermittent theta burst stimulation (iTBS) will receive this procedure as maintenance therapy. The patients will be randomized to two study arms. The arms differ in the frequency of stimulation (standard iTBS (5 treatments every working day for one week) vs. accelerated iTBS (5 treatments in one day)). For purposes of effect size estimation an interim analysis will be done after half of the patients.",[27],"Depression","RECRUITING","2025-11-28",{"date":31,"type":32},"2025-12-01","ACTUAL",{"date":34,"type":32},"2023-04-25",{"date":36,"type":21},"2026-02-28",{"name":38,"class":39},"Berthold Langguth, MD, Ph.D.","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":62,"locationsCount":40},"100495974","high-dose-accelerated-theta-burst-stimulation-for-the-treatment-of-alcohol-addiction-100495974","NCT05738174","High-dose Accelerated Theta Burst Stimulation for the Treatment of Alcohol Addiction","Theta Burst Zur Behandlung Der Alkoholabhängigkeit","TBA","Inclusion Criteria:\n\n* alchohol dependence according to ICD-10 (F10.2)\n* desire to reduce or abstain from alcohol drinking\n* male or female\n* 18-65 years\n* residency in Germany, German speaking\n* written informed consent\n\nExclusion Criteria:\n\n* contraindications for transcranial magnetic stimulation (electric devices or metal parts in the body such as pacemaker)\n* relevant neurological or internistic diseases according to study investigator\n* treatment with TMS in the past\n* participation in other trials during treatment\n* pregnancy or breatfeeding\n* positive breath test for alcohol\n* legal care and placement in a psychiatric hospital\n* co-medication with disulfiram, acamprosate, topiramate, baclofen, naltrexone, or nalmefene\n* acute psychiatric comorbidity that requires inpatient treatment or medication readjustment (\\\u003C1 month)\n* severe chronic psychiatric illness (schizophrenia, schizoaffective disorder, bipolar disorder)\n* patients who are unable to complete study questionnaires or follow-up questionnaires (in the opinion of the investigators)","65 Years",{"count":51,"type":21},72,[24],"This is a two-arm randomized placebo-controlled trial in which 72 patients with alcohol addiction are treated with high-dose accelerated intermittent theta burst stimulation (TBS).",[55],"Alcohol Dependence","2025-09-18",{"date":58,"type":32},"2025-09-19",{"date":60,"type":32},"2023-03-01",{"date":36,"type":21},{"name":38,"class":39},""]