[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Birmingham Women's NHS Foundation Trust\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":99},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100620981","measuring-heart-health-in-both-term-preterm-and-unwell-newborn-babies-with-an-advanced-ultrasound-method-speckle-tracking-echocardiography-100620981",false,"NCT07364682","Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography","Assessment of Cardiac Function Using 2D Speckle Tracking Echocardiography (STE) in Neonates.","Inclusion Criteria:\n\n* Neonates who are inpatient at the Birmingham Women's Hospital\n* Confirmed diagnosis of acute pulmonary hypertension, congenital diaphragmatic hernia, hypoxic ischaemic encephalopathy, or bronchopulmonary dysplasia\u002Fchronic lung disease (defined by oxygen\u002Frespiratory support requirement at 36 weeks post menstrual\u002Fcorrected gestational age).\n\nOR\n\n* Health control (\\>36 weeks - well and on the postnatal ward)\n* Well preterm neonate (\\\u003C36 weeks) admitted to the NICU, transitional care or post-natal wards.\n* Informed consent obtained from parent(s) or legal guardian(s)\n\nExclusion Criteria:\n\n* Presence of major congenital heart disease (other than patent foramen ovale or patent ductus arteriosus).\n* Presence of other life-limiting congenital anomalies (other than CDH) or syndromes that could independently affect cardiac function.\n* Inability to obtain adequate echocardiographic images for STE analysis after reasonable attempts.\n* If the neonatal consultant or neonatal nurse caring for the neonate feels that the neonate is too unstable for inclusion in the study or that consent should not be sought from parents.",true,"ALL","0 Minutes","8 Weeks",{"count":21,"type":22},190,"ESTIMATED","OBSERVATIONAL","This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle tracking echocardiography (STE) can detect subtle problems with how the heart muscle squeezes and relaxes. This may allow doctors to spot potential issues earlier.\n\nOur research will take place at Birmingham Women's Hospital. The investigators will perform these advanced, non-invasive heart scans on several groups of babies:\n\n1. Healthy term and premature babies, to establish a \"normal\" range of heart function.\n2. Babies who are unwell with specific conditions, including those with brain injury due to lack of oxygen at birth (HIE), chronic lung disease of prematurity (BPD), a hole in the diaphragm (CDH), or high blood pressure in their lungs (aPHN).\n\nThe heart scan is a standard, painless procedure. Using STE does not require any extra scanning time or cause any additional discomfort to the baby; the special images are taken during the routine scan. For many of the sick babies, these scans are already part of their normal clinical care.\n\nThe main goals of this observational study are to see if STE is a feasible and reliable tool in newborns, to establish normal values for healthy babies, and to track how heart function changes in sick babies during their illness and recovery.\n\nUltimately, the investigators hope this research will provide doctors with a better tool to assess heart health in newborns. This could lead to earlier, more accurate detection of heart problems and help guide treatment decisions to improve outcomes for these vulnerable infants.",[26,27,28,29,30],"Premature Baby","Pulmonary Hypertension of Newborn","Hypoxic Ischaemic Encephalopathy (HIE)","Congenital Diaphragmatic Hernia","Chronic Lung DIsease",[32,33,34,35],"Speckle Tracking Echocardiography","STE","Functional echocardiography","Neonatal Performed Echocardiography","NOT_YET_RECRUITING","2026-01-23",{"date":39,"type":40},"2026-01-26","ACTUAL",{"date":42,"type":22},"2026-02-01",{"date":44,"type":22},"2028-03-01",{"name":46,"class":47},"Birmingham Women's NHS Foundation Trust","OTHER_GOV",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":56,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":48},"100602500","placental-characteristics-within-monochorionic-twin-pregnancies-100602500","NCT07124312","Placental Characteristics Within Monochorionic Twin Pregnancies","Placental Characteristics Within Monochorionic Twin Pregnancies: a Prospective Cohort Study.","Inclusion Criteria:\n\n• All consecutive placentas of monochorionic twin pregnancies whereby the placenta is transferred to the pathology department for analysis.\n\nExclusion Criteria:\n\n* Singleton, dichorionic and higher order pregnancies (e.g. triplet).\n* Fetus with known major congenital anomalies or aneuploidy","FEMALE",{"count":58,"type":22},65,"This prospective study aims to collate a comprehensive database of all main monochorionic twin groups to enable comparisons to be made within each twin group and additionally between each group with regards to several placental characteristics, whilst understanding their impact on several fetal outcomes. This study aims to provide new insights in to how the placental architecture influences pregnancy care within the UK pregnancy cohort. Results of this study may impact how clinicians conduct antenatal surveillance for these anatomical placental factors.\n\nPatients of both uncomplicated and complication monochorionic twin groups will be consented at a single site and recruited during the antenatal period. Following delivery the placenta will then be analysed macroscopically and assessed for several anatomical features. This will be compared with the antenatal complications and perinatal outcomes for the respective twin.",[61,62,63],"Placenta","Monochorionic Twins","Anatomy","RECRUITING","2025-08-08",{"date":67,"type":40},"2025-08-15",{"date":69,"type":40},"2024-12-12",{"date":71,"type":22},"2027-02-01",{"name":46,"class":47},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":16,"sex":56,"minAge":80,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":48},"100602501","remote-cardiotocography-telemonitoring-within-high-risk-pregnancy-care-100602501","NCT07124325","Remote Cardiotocography Telemonitoring Within High-risk Pregnancy Care","The Use of Remote Cardiotocography Telemonitoring Within High-risk Pregnancy Care.","Inclusion Criteria:\n\n* Women aged ≥18 years\n* Gestational age 32+0 weeks onwards.\n* Singleton pregnancy.\n* Able to speak English\n* Receiving antenatal care which includes routine antenatal fetal monitoring for one of the 6 index conditions (hypertensive disease in pregnancy, reduced fetal growth (small for gestational age and fetal growth restriction) obstetric cholestasis, PPROM, previous history of stillbirth and recurrent reduced fetal movements )\n* Able to give written informed consent.\n* Willing to attend hospital immediately in the event of an unexpected finding whilst using the home devices.\n\nExclusion Criteria:\n\n* Multiple pregnancy.\n* Fetal abnormalities or a non-viable fetus.\n* Body mass index (BMI) ≥35\n* Women with internal cardiac devices such as pacemaker and implantable cardioverter defibrillator.\n* History of allergic reaction to skin adhesives and\u002For latex.\n* Acute or chronic skin lesions and wounds in areas in contact with the device.","18 Years",{"count":82,"type":22},50,"INTERVENTIONAL",[85],"NA","The overall aim of this research proposal is to explore the feasibility and acceptability of home antenatal maternal-fetal monitoring technology within a high-risk pregnancy group. The investigators hypothesise that home monitoring is feasible and acceptable to both pregnant women and HCPs.\n\n50 women from a single site will be recruited to use a home cardiotocography (CTG) device alongside routine antenatal care. Participants will use this device once a week, for an hour at a time, for up to 6 weeks or until delivery. The primary outcome is 20 minutes of continuous monitoring. Additional outcomes assess acceptability, adherence and safety.",[88,89,90,91,92],"Pregnancy","High Risk","Telemonitoring","Telemedicine","Cardiotocography",{"date":67,"type":40},{"date":95,"type":40},"2025-06-11",{"date":97,"type":22},"2026-04-01",{"name":46,"class":47},""]