[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Bispebjerg Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":574},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,53,77,109,139,162,184,213,237,264,295,318,351,380,410,440,465,491,511,532,554],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100645302","a-synergistic-approach-to-remodeling-of-photodamaegd-skin-exploring-laser-assisted-biostimulator-delivery-100645302",false,"NCT07680426","A Synergistic Approach to Remodeling of Photodamaegd Skin: Exploring Laser-Assisted Biostimulator Delivery","A Synergistic Approach to Remodeling of Photodamaegd Skin: Exploring Laser-Assisted Biostimulator Delivery Through AI-Assisted In Vivo Imaging and Transcriptomics","SYNTROMICS","Inclusion Criteria:\n\n* Age ≥18 years\n* Clinical signs of photodamage. Signs will include low-grade actinic keratoses (Olsen grade I-II), solar lentigines, telangiectasia, or other visible markers of chronic photodamage.\n\nExclusion Criteria:\n\n* Active skin diseases in the treatment site\n* Laser treatment, PLLA, or other treatments in the treatment area within the past 24 months\n* Pregnancy or breastfeeding\n* Contraindications to AFL or Sculptra","ALL","18 Years",{"count":20,"type":21},33,"ESTIMATED","INTERVENTIONAL",[24],"NA","Photodamaged skin increases the risk of skin cancer, highlighting the need for preventive treatments. Laser-assisted drug delivery (LADD) using ablative fractional lasers (AFL) enhances topical drug delivery and has proven safe and effective. Integrating non-invasive optical imaging techniques with transcriptomic gene expression profiling enables evaluation of the response of different skin layers to such interventions.\n\nIt is hypothesized that AFL-assisted delivery of biostimulators exerts synergistic regenerative effects on photodamaged skin, resulting in superior clinical, molecular, and morphological improvements, as well as enhanced epidermal and dermal remodeling, compared with either monotherapy alone. The study aims to provide an in-depth understanding of the individual and combined effects of AFL and biostimulators on the regeneration of photodamaged skin through clinical assessments, non-invasive imaging, and transcriptomic analysis.",[27,28],"Photodamaged Skin","Skin Cancer Prevention",[30,31,32,33,34,35,36,37,38,39],"laser-assisted drug delivery","optical coherence tomography","poly-l-lactic acid","transcriptomics","ablative fractional laser","Photodamaged skin","skin cancer prevention","sculptra","skin diseases","non-invasive imaging","NOT_YET_RECRUITING","2026-06-25",{"date":43,"type":44},"2026-07-02","ACTUAL",{"date":46,"type":21},"2026-09-01",{"date":48,"type":21},"2027-12",{"name":50,"class":51},"Bispebjerg Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100330636","physiotherapy-or-fasciotomy-as-treatment-for-chronic-exertional-compartment-syndrome-in-the-lower-leg-100330636","NCT03584815","Physiotherapy or Fasciotomy as Treatment for Chronic Exertional Compartment Syndrome in the Lower Leg?","Is Physiotherapy or Fasciotomy the Best Treatment Option for Chronic Exertional Compartment Syndrome in the Anterior Compartment of the Lower Leg? A Randomized Controlled Trial.","Inclusion criteria:\n\n* Age between 18 and 50 years\n* Symptoms for more than 3 months\n* Symptoms from both legs. Pain (cramp like, tight, burning or pressure) in the anterior part of the lower leg starting after approximately 10 minutes of exercise\n* Pain worsened with prolonged lower extremity exertion\n* Majority of pain relieved within 30 minutes of rest.\n\nExclusion criteria:\n\n* Previous fasciotomy in the lower leg\n* History of serious trauma involving the lower leg (fracture, muscle\u002Ftendon rupture)\n* ASA (America Association of Anaesthesiologists Classification of Physical Health) \\> 2\n* Clinical symptoms consistent with unilateral anterior CECS or lateral and posterior CECS\n* Clinical symptoms consistent with lumbar spine radiculopathy, periostit\u002Fshin-splint, stress fracture, popliteal artery entrapment syndrome, isolated peroneal nerve entrapment, with isolated muscle fascia herniation.","50 Years",{"count":62,"type":21},72,[24],"It is hypothesized that physiotherapy including a change in running landing pattern and surgical fasciotomy are equally good as treatment options for chronic exertional compartment syndrome (CECS) of the anterior compartment of the lower leg.\n\nThe endpoints\u002Foutcomes are:\n\nChange from week 0 (start of study) to week 12 (completion of intervention) in: patient reported outcome measure (PROM) (Exercise induced leg pain Questionnaire (EILP)).\n\nSecondary outcomes are: Visual Analogue Scale (VAS) score after an \"exercise provocation test\": Change in intracompartmental pressure (ICP)Change in muscle compartment compliance. Change in Global Rating of Change Score\u002FScale (GRC). Change in Single Assessment Numeric Evaluation (SANE)\n\nThe study is important because:\n\n1. Results from recent studies suggest that physiotherapy represents a valid alternative to surgery for the treatment of CECS. Surgery is currently standard treatment and a change towards physiotherapy as primary treatment could potentially reduce both complication rates and costs.\n2. Intracompartmental pressure (ICP) is gold standard for diagnosing CECS. However, the association between ICP and symptoms of CECS, both before and after physiotherapeutic and surgical treatment, muscle compartment compliance and intracompartmental perfusion, has not been thoroughly investigated.",[66],"Compartment Syndrome Nontraumatic Lower Leg","RECRUITING","2026-03-31",{"date":70,"type":44},"2026-04-06",{"date":72,"type":44},"2019-05-05",{"date":74,"type":21},"2027-08",{"name":50,"class":51},2,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":95,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":52},"100621666","preventing-hospital-associated-disability-in-older-patients-individualized-nutrition-and-exercise-strategy-100621666","NCT07373587","Preventing Hospital Associated Disability in Older Patients: Individualized Nutrition and Exercise Strategy","Preventing Hospital Associated Disability in Older Patients: Individualized Nutrition and Exercise Strategy, a Randomized Controlled Trial","PrevHAD RCT","Inclusion Criteria:\n\n* Hospitalized at the geriatric ward\n* Speak Danish or English\n* Ability to give informed consent\n\nExclusion Criteria:\n\n* Moderate to severe Dementia\n* Manifest delirium","65 Years",{"count":87,"type":21},360,[24],"Aproximately a third of persons older than 70 years lose physical function and ability to take care of themselves during a stay at a hospital. This is associated to an increased risk of readmission and mortality. Earlier research has shown that insufficient nutrition and physical activity during hospital stay, leading to a loss in muscle mass and strength, plays an important role in this fall in functionality. This study aims to examine if a structured and supervised resistance and mobility exercise intervention, can prevent this fall in functional ability during hospital stay among older patients. The Impact of nutritional status will be investigated by registrering caloric, protein and hydtrational intake during the study period.",[91,92,93,94],"Sarcopenia in Elderly","Hospital Associated Disability","Malnutrition Elderly","Physical Function",[96,97,98,99,100],"Older","Hospitalized","Sarcopenia","Malnutrition","Exercise intervention","2026-01-28",{"date":103,"type":44},"2026-01-30",{"date":105,"type":21},"2026-02-03",{"date":107,"type":21},"2028-02-29",{"name":50,"class":51},{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":117,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":120,"phases":4,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":52},"100610826","energy-availability-and-its-impact-in-elite-triathletes-100610826","NCT07232628","Energy Availability and Its Impact in Elite Triathletes","Energy Availability in Elite Triathletes: Impact on Performance and Injury Risk","TriatLEA","Inclusion Criteria:\n\n* Age ≥18 years\n* Healthy individuals\n* Training ≥15 hours\u002Fweek in triathlon\n\nExclusion Criteria:\n\n* Smokers\n* Use of prohibited substances (WADA list) without medical justification\n* Existing injuries or illnesses that could worsen due to participation",true,{"count":119,"type":21},40,"OBSERVATIONAL","This study investigates how energy availability affects performance, injury risk, and training outcomes in elite triathletes. Over two competitive seasons (2026-2027), 40 elite and sub-elite triathletes will be monitored through physiological tests, blood samples, and questionnaires. The goal is to identify markers of low energy availability and understand its impact on health and athletic performance. The study is observational and does not involve experimental treatments. Participants continue their regular training and diet while undergoing periodic assessments.",[123,124],"Low Energy Availability","Relative Energy Deficiency in Sport",[126,127,128,129,130],"RED-S","injury risk","performance","triathlon","biomarker","2025-11-14",{"date":133,"type":44},"2025-11-18",{"date":135,"type":44},"2025-10-01",{"date":137,"type":21},"2028-06",{"name":50,"class":51},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":117,"sex":145,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":4},"100583110","the-effects-of-glucagon-on-renal-regional-blood-flow-in-humans-measured-by-magnetic-resonance-100583110","NCT06872060","The Effects of Glucagon on Renal Regional Blood Flow in Humans Measured by Magnetic Resonance.","Inclusion Criteria:\n\n* Normal health confirmed through; Interview and Medical examination\n* Normal values with respect to blood concentrations of fasting plasma glucose, fasting plasma total cholesterol, fasting triglycerides, HDL, LDL, creatinine, liver function tests, and electrolytes\n* Informed consent\n\nExclusion Criteria:\n\n* Immunosuppressive treatment in the previous 12 months\n* Alcohol abuse\n* Medical treatment with oral glucocorticoids, dipeptidyl peptidase-4 (DPP-4) inhibitors, or GLP-1 receptor agonists, which, in the opinion of the principal investigator, may interfere with glucose metabolism\n* Use of lithium\n* Medical treatment that affects insulin secretion or the renin-angiotensin-aldosterone system\n* Liver disease (ALT \\> 2x normal value)\n* Renal impairment (serum creatinine \\> 130 µM and\u002For albuminuria)\n* Individuals with severe claustrophobia\n* Individuals with MR-incompatible foreign bodies\n* Individuals with hypertension","MALE","20 Years","60 Years",{"count":149,"type":21},10,[24],"This study will investigating the effects of glucagon on renal blood flow in humans using MRI technology. Glucagon, a hormone produced by the pancreas, plays a key role in regulating blood sugar levels. It has been shown to affect renal function, including electrolyte balance and blood flow, especially in conditions like type 2 diabetes where abnormal glucagon levels are common. The study aims to understand how glucagon affects regional blood flow in the kidneys, specifically the cortex and medulla, and whether these effects are mediated by glucagon receptors.\n\nThe study will be conducted on 10 healthy male participants aged 20-60 years. It involves three test days where participants will receive either glucagon, glucagon with a GLP-1 receptor antagonist, or placebo. Blood flow, glomerular filtration rate, and other renal functions will be measured using MRI. The study seeks to clarify whether glucagon's effects on the kidneys are linked to changes in regional blood flow and to determine if these effects are mediated solely by glucagon receptors.",[153],"Kidney Diseases","2025-09-29",{"date":156,"type":44},"2025-10-03",{"date":158,"type":21},"2026-06-01",{"date":160,"type":21},"2027-11-01",{"name":50,"class":51},{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":117,"sex":17,"minAge":18,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":52},"100496624","improving-tissue-repair-after-injury-in-the-muscle-tendon-interface-muscle-tissue-injury-100496624","NCT05746650","Improving Tissue Repair After Injury in the Muscle-tendon Interface Muscle Tissue Injury","Regulation of Protein Turnover in Connective Tissue From Muscle and Tendon Following Muscle Tissue Injury","GH-MTJ","Inclusion Criteria:\n\n* Healthy men and women scheduled to undergo reconstructive knee surgery\n* BMI 18-35\n\nExclusion Criteria:\n\n* Former or current use of growth hormone or anabolic steroids\n* Use of corticosteroids in the past 3 months\n* Use of any medication known to affect muscle or tendon turnover\n* Former participation in a study using deuterated water\n* Chronic diseases","35 Years",{"count":119,"type":21},[24],"The study is a 2-week human study where 40 patients who are scheduled to undergo reconstructive knee surgery are randomized to administration of GH or placebo following or without neuromuscular electrical stimulation of hamstring muscles.The overall aim is to determine, the role of muscle connective tissue protein synthesis in muscle injury and repair.",[175],"Muscle Injury","2025-09-19",{"date":178,"type":44},"2025-09-24",{"date":180,"type":44},"2023-02-24",{"date":182,"type":21},"2027-09-01",{"name":50,"class":51},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":117,"sex":145,"minAge":170,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":200,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":4},"100602442","anal-cancer-prevention-in-high-risk-categories-of-men-who-have-sex-with-men-100602442","NCT07123558","Anal Cancer Prevention in High-Risk Categories of Men Who Have Sex With Men","Anal Cancer Prevention in High-Risk Categories of Men Who Have Sex With Men - A Danish Prospective Study","DACaP","Inclusion Criteria:\n\n* MSM with HIV\n* HIV-negative MSMonPrEP\n* Age \\>=35 years\n* Written and orally informed consent in English or Danish\n\nExclusion criteria\n\n* Previous anal cancer\n* Rectum extirpation (of any cause)\n* Unwilling to have HRA performed\n* Inflammatory bowel disease\n* Inability and unwillingness to give informed consent\n* Other known immunosuppressive disorder than HIV\n* No sex with men",{"count":193,"type":21},700,[24],"The incidence of anal cancer is increasing, particularly among high-risk groups such as men who have sex with men (MSM), especially those living with HIV. The lack of comprehensive screening programs results in delayed diagnosis and higher mortality.\n\nThis project aims to establish a screening program for anal cancer in high-risk populations, with a specific focus on those most at risk. Using a prospective study design, the project will assess the effectiveness of early detection and prevention strategies to potentially reduce cancer incidence and improve survival rates. If an HPV-based screening method proves effective, it would serve as a potential implemention for high-risk groups in Denmark, further enhancing early detection and prevention efforts.\n\nThis study represents the first large-scale, prospective screening initiative for anal cancer in Denmark,specifically targeting MSM. It introduces a novel approach to cancer prevention in this population by building on research in other cancers and adapting it to anal cancer and its specific risk factors.\n\nThe project is a collaboration between clinical practitioners and academic researchers, ensuring that practical clinical insights guide the research and that research findings are rapidly translated into clinical practice. This partnership will enhance both the quality of the research and its direct application in healthcare.\n\nThe project is expected to lead to earlier diagnosis of anal cancer, reduced morbidity and mortality among high-risk populations, and the establishment of a screening model that can be applied nationwide. This could significantly reduce the overall healthcare burden associated with late-stage anal cancer and improve patient outcomes across Denmark.",[197,198,199],"Anal HSIL","Anal AIN3","Anal HPV Infection",[201,202,203,204],"anal HSIL","HIV infection","MSM","anal HPV infection","2025-08-13",{"date":207,"type":44},"2025-08-14",{"date":209,"type":21},"2025-11-01",{"date":211,"type":21},"2027-10-31",{"name":50,"class":51},{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":22,"phases":223,"briefSummary":224,"conditions":225,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":235,"locationsCount":236},"100591711","increasing-physical-activity-among-medical-inpatients-by-digital-nudging-of-patients-and-staff-100591711","NCT06983977","Increasing Physical Activity Among Medical Inpatients by Digital Nudging of Patients and Staff","Increasing Physical Activity Among Medical Inpatients by Digital Nudging of Patients and Staff - A Cluster Randomised Multicentre Study","IPAMINA","Inclusion Criteria:\n\n* Admitted to one of the participating wards\n* Has understood and signed informed consent\n* Reads and understands Danish, Faroese, Greenlandic or English\n\nExclusion Criteria:\n\n* Has an expected hospitalisation less than 24 hours after potential recruitment\n* Is not able to give informed consent to participate in the study\n* Has allergy towards band aid\n* Not able to (shortly) stand in an upright position even with maximal assistance\n* There are contraindications for the patient to mobilise or be physically active due to unstabilized acute medical conditions, including, but not limited to, acute aortic dissection, -myocardial infarction, -pulmonary embolism, -sepsis.\n* There are ethical concerns regarding the patients' participation in the study, including, but not limited to, the patient being:\n\n  * In the terminal phase of life\n  * In a crisis state regarding their disease\u002Fsituation and deemed unfit for participation\n\nTo ensure medically responsible inclusion of patients, the project personnel will consult and confer with the treatment responsible medical doctor, or their delegate, before including a potential participant for the trial.",{"count":222,"type":21},400,[24],"Sedentary behaviour among medical inpatients is strongly associated with hospital-associated functional decline and poses a severe threat to patients' functional capacity and independency. High human and socioeconomic costs underline the urgency to find solutions to this world-wide problem.\n\nObjective: This multicentre study, including a total of 400 patients from Copenhagen, Aalborg, Tórshavn, and Nuuk, will assess the effect of a digital intervention that aims to reduce sedentary behaviour and increase physical activity in medical inpatients.\n\nIntervention: Digital feedback and nudging regarding the patients' physical activity levels to patients and healthcare staff Design: Stepped-wedge cluster randomised multicentre trial Primary outcome: Daily average time of patients' physical activity (minutes).",[226,227,228],"Physical Activity","Inpatients","Digital Health","2025-05-21",{"date":231,"type":44},"2025-05-25",{"date":233,"type":44},"2025-05-19",{"date":48,"type":21},{"name":50,"class":51},4,{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":120,"phases":4,"briefSummary":247,"conditions":248,"keywords":251,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":261,"leadSponsor":263,"locationsCount":52},"100588832","nutritional-status-and-patient-characteristics-upon-length-of-stay-clinical-outcome-and-survival-in-older-hospitalized-patients-100588832","NCT06946537","Nutritional Status and Patient Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Older Hospitalized Patients","The Influence of Nutritional Status and Phenotypic Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Hospitalized Patients","INSIGHT","Inclusion Criteria:\n\n* Acutely admitted adults aged 65 years and above.\n* Be able to comply with the study information, as assessed by the research personnel.\n* Be able to understand Danish.\n\nExclusion Criteria:\n\n* \\\u003C24 hours admission\n* Terminal illness in end stage of life\n* Patients with temporary civil person registration number (CPR)",{"count":246,"type":21},1500,"Disease-related malnutrition (DRM) describes undernutrition or imbalances in energy, protein, or other nutrient-needs, caused by a concomitant disease. Nutritional status plays a vital role in the fate of hospitalized patients, and DRM is associated with loss of function and decreased survival.\n\nDRM is a common condition in patients with acute illnesses, approximately 30% among medical inpatients are malnourished when admitteed to the hospital, and rise higher among the older or critically ill. Physiologically malnutrition is associated with a) poorer tissue healing and restitution after severe disease, b) suppressed immune function and resistance towards infections, c) poorer metabolic defense towards critical disease, d) delayed and poorer progress of chronic diseases. In addition, inadequate nutrition is coupled to a prolonged hospital stay, resulting in more readmissions, and overall higher mortality in hospital patients. Yet, nutritional status of patients upon hospital admittance is seldom systematically assessed and the consequences of DRM in older acutely admitted patients still needs to be understood.\n\nThis project will provide a detailed description of nutritional, physiolgical, and biochemical status of 1500 acutely admitted patients. In relation, the study will investigate the relation between patient characteristics and disease progression. The obtained data will also be coupled to patient registers to investigate the link between length of hospital stay, readmissions and acute contact, and mortality.",[249,99,250],"Geriatric","Length of Stay",[249,252,253,254,255,256],"Disease-related malnutrition","Physiology","Acute illness","Deep phenotyping","Nutritional status","2025-05-12",{"date":259,"type":44},"2025-05-14",{"date":257,"type":44},{"date":262,"type":21},"2028-11",{"name":50,"class":51},{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":22,"phases":275,"briefSummary":276,"conditions":277,"keywords":279,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":294},"100571698","restoring-anatomy-of-ruptured-achilles-tendon-100571698","NCT06723639","Restoring Anatomy of Ruptured Achilles Tendon","Effects of Restoring Achilles Tendon Anatomy After a Rupture: A Randomized Controlled Trial","RATAR","Inclusion Criteria:\n\n* Diagnosed with a complete mid-substance Achilles tendon rupture based on clinical exam, including Thompson\u002FMatles test, by an experienced physician.\n* Presented within 14 days from injury.\n* Understands and reads Danish.\n* No contraindications for MRI.\n\nExclusion Criteria:\n\n* Smoking\n* Diabetes\n* Other injuries affecting their lower limb function.\n* Contralateral Achilles tendon rupture.\n* Re-rupture.\n* Anticoagulation treatment.\n* Inability to follow rehabilitation or complete follow-up tests.\n* Immunosuppressive treatment, including systemic corticosteroid treatment.\n* Pregnant","67 Years",{"count":274,"type":21},120,[24],"The goal of this clinical trial is to investigate a new surgical approach to restore the anatomy of a ruptured Achilles tendon. We will use a new two-layer technique followed by rehabilitation and find out how it influence the patients clinical outcome, muscle and tendon structure, and function after one year and compare with a standard non-surgical approach followed by rehabilitation. Participants will be randomized to 1) NEWSUR: A new two-layer surgical technique followed by rehabilitation regime or 2) CONSER: A standard non-surgical treatment followed by rehabilitation .\n\nWe hypothesize that restoring the anatomy of the ruptured mid-substance Achilles tendon using a new two-layer surgery technique followed by rehabilitation will yield a more favorable patient reported outcome (ATRS) one year after rupture compared to standard non-surgical treatment followed by rehabilitation.",[278],"Achilles Tendon Rupture",[280,281,282,283,284,285],"Achilles tendon rupture","MRI","Surgery","Restore anatomy","Heel-rise test","Rehabilitation","2025-04-11",{"date":288,"type":44},"2025-04-15",{"date":290,"type":44},"2025-02-28",{"date":292,"type":21},"2027-07-01",{"name":50,"class":51},3,{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":22,"phases":305,"briefSummary":306,"conditions":307,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":76},"100556802","impact-of-exercise-training-on-ischemia-with-non-obstructive-coronary-arteries-inoca-the-exinoca-study-100556802","NCT06529848","Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study","Ischemia With No Obstruction of Coronary Arteries: Underlying Mechanisms and the Impact of Exercise Training (EXINOCA)","ExINOCA","Inclusion Criteria:\n\n* Coronary microvascular dysfunction, defined as myocardial bloodflow reserve (MBFR) \\\u003C 2.5 or hyperemic myocar-dial blood flow (hMBF)\\\u003C2.3 ml\u002Fg\u002Fmin using \\[15O\\]H2O-PET\n* No obstructive coronary artery disease\n\nExclusion Criteria:\n\n* Females of childbearing potential (defined as a premeno-pausal female capable of becoming pregnant). The female patient must either be postmenopausal, defined as amen-orrhea for at least 1 year, or surgically sterile\n* Heart failure, defined as left ventricular ejection fraction of less than 40%\n* Uncontrolled hypertension defined as blood pressure above target 140\u002F90 for all\n* Co-morbidity resulting in \\\u003C1 year expected survival\n* Considered by the investigator, for any reason, to be an un-suitable candidate for the study.\n* Unable or unwilling to exercise, e.g. due to arthritis or in-jury\\*\n* Already are regularly physically active and\u002For have a maxi-mal oxygen uptake \\>45 ml\u002Fkg\u002Fmin",{"count":304,"type":21},100,[24],"The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary microvascular function.\n\nHypotheses:\n\nThe first hypothesis is that in INOCA, with reduced function of microvasculature of the heart, this reduced function also occurs in other organs of the body.\n\nThe second hypothesis is that regular physical activity (aerobic exercise training) can improve coronary microvascular function, reduce symptoms, and that there is a parallel improvement in vascular function in other organs of the body.",[308,309],"Coronary Microvascular Disease","CMD","2025-02-20",{"date":312,"type":44},"2025-02-21",{"date":314,"type":44},"2024-11-01",{"date":316,"type":21},"2028-05-15",{"name":50,"class":51},{"id":319,"slug":320,"hasResults":11,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":324,"eligibilityCriteria":325,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":326,"enrollmentInfo":327,"targetDuration":4,"studyType":22,"phases":329,"briefSummary":330,"conditions":331,"keywords":337,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":76},"100380089","computer-assisted-self-training-to-improve-executive-function-100380089","NCT04229056","COMPuter-assisted Self-training to Improve EXecutive Function","Computer-Assisted Self-Training to Improve Executive Function Versus Unspecific Training in Patients After Stroke, Cardiac Arrest or in Parkinson's Disease: a Randomized Controlled Trial","COMPEX","Inclusion Criteria:\n\n* A diagnose of stroke, cardiac arrest or Parkinson's disease.\n* Aged 18 years or older.\n* Impaired working memory measured with CABPad working memory test, cut off for inclusion: 5 symbols or less backwards\n* Computer and internet access at home.\n* Providing informed consent.\n\nInclusion criteria specific for stroke\n\n* Inclusion within 6 months post-stroke\n* Stroke confirmed by clinical findings and imaging, both AIS and ICH is allowed.\n* Initial stroke severity \\>\u002F= NIHSS 3.\n\nInclusion criteria specific for cardiac arrest\n\n• Inclusion within 6 months post ictus.\n\nInclusion criteria specific for Parkinson's disease\n\n* Clinical diagnosis of PD.\n* Anti-parkinsonian medical treatment (dopaminergic or other).\n\nExclusion Criteria:\n\n* Informed consent not provided\n* Other neurological or psychiatric disease which is expected to influence the patient's ability to participate in the trial according to the investigator\n* Not able to participate according to investigator\n\nExclusion criteria specific for stroke\n\n* Patients with massive anosognosia for executive dysfunction or patients with no subjective feeling of executive dysfunction (Patient sustains total denial of executive symptoms over time)\n* Patients with severe aphasia, in which it is unclear whether the patient's performance on a neuropsychological test-battery is due to aphasia and not executive dysfunction.\n\nExclusion criteria specific for cardiac arrest • None\n\nExclusion criteria specific for PD\n\n• Diagnosis of PD Dementia according to the MDS PD Dementia criteria","100 Years",{"count":328,"type":21},307,[24],"This project explores the effects of specialized computer-based cognitive rehabilitation (CBCR) targeting executive functions in three groups of patients: Stroke, Cardiac Arrest and Parkinson's Disease. The effect of specialized CBCR is compared to generally cognitively stimulating activities on a computer",[332,333,334,335,336],"Parkinson Disease","Stroke","Cardiac Arrest","Cognitive Dysfunction","Executive Dysfunction",[338,339,340,341,342,343],"parkinson disease","stroke","cardiac arrest","executive dysfunction","cognitive dysfunction","computer-based cognitive rehabilitation","2025-02-19",{"date":310,"type":44},{"date":347,"type":44},"2020-06-01",{"date":349,"type":21},"2026-06-30",{"name":50,"class":51},{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":357,"eligibilityCriteria":358,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":359,"targetDuration":361,"studyType":120,"phases":4,"briefSummary":362,"conditions":363,"keywords":365,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":76},"100566244","risk-factors-for-development-of-non-union-of-displaced-midshaft-clavicle-fractures-100566244","NCT06652659","Risk Factors for Development of Non-union of Displaced Midshaft Clavicle Fractures","Risk Factors for Development of Non-union of Displaced Midshaft Clavicle Fractures: A Prospective Double-center Cohort Study","RisC","Inclusion Criteria:\n\n* 18 years of age upon study enrollment\n* Admitted to the emergency room (ER) at BBH or HVH with a displaced midshaft clavicle fracture\n* Danish social security number\n* Understand Danish\n* Able to fill out questionnaire by hand or online.\n* Provides informed consent prior to initiation of any study-related activities\u002Fprocedures\n\nExclusion Criteria:\n\n* Subject incapable of understanding the patient information or unable to provide informed consent\n* Open fracture or fracture with risk of skin penetration\n* Pathological fracture\n* Clavicle fracture due to polytrauma\n* Floating shoulder injury\n* Vascular injury at fracture site\n* Pregnancy",{"count":360,"type":21},250,"12 Months","Clavicle fractures are common and usually heal well without surgery. Most patients recover full shoulder function within a few weeks with conservative treatment, which is the standard in Denmark. However, in cases where the broken ends of the bone do not touch (displaced fractures), there is a higher risk of complications like non-healing (non-union), affecting 11-18% of such cases. Non-union can lead to long-term pain, reduced shoulder function, and a longer recovery time, often requiring multiple follow-up visits.\n\nWhile surgery might prevent these complications for some patients, operating on all displaced fractures would lead to overtreatment. The current challenge is identifying which patients are at risk for non-union and would benefit most from surgery. This study aims to investigate the risk factors for non-union in patients with displaced clavicle fractures by examining both patient characteristics and fracture-related factors.\n\nThe goal is to use multiple data points to develop a score that can support clinicians and patients in shared decision-making regarding the optimal and individualized treatment for clavicle fractures.\n\nThis research is important not only for clavicle fractures but also for understanding and treating non-union in other bones like the ulna and tibia, which face similar challenges.",[364],"Non-union of Fractures",[366,367,368,369,370,371],"Non-union","Midshaft Clavicle Fracture","Clavicle","Midshaft","Midshaft Clavicle","Risc Factors for Non-union","2025-02-03",{"date":374,"type":44},"2025-02-04",{"date":376,"type":44},"2024-10-21",{"date":378,"type":21},"2028-12-31",{"name":50,"class":51},{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":386,"eligibilityCriteria":387,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":22,"phases":389,"briefSummary":390,"conditions":391,"keywords":397,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":402,"lastUpdatePostDateStruct":403,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":409,"locationsCount":294},"100563076","strong-for-surgery--strong-for-life---intensive-prehabilitation-for-risk-reduction-in-ventral-hernia-repair-100563076","NCT06611462","STRONG for Surgery & Strong for Life - Intensive Prehabilitation for Risk Reduction in Ventral Hernia Repair","Effect of Tailored, Intensive Prehabilitation for Risky Lifestyles Before Ventral Hernia Repair on Postoperative Outcomes, Health, and Costs - a Randomised Controlled Trial (STRONG-Hernia)","STRONG-Hernia","Inclusion Criteria:\n\n* Participants ≥18 years scheduled for ventral hernia repair (defect smaller than 8cm)\n* Enough time for at least 4 weeks of prehabilitation\n* Screened positive for at least 1 risky SNAP factor\n* Signed informed consent\n\nExclusion Criteria:\n\n* Ventral hernia repairs with defect larger than 8 cm\n* Pregnancy\u002Fbreastfeeding\n* Allergy\u002Fother contradiction to pharmaceutical and\u002For nutritional support\n* Contradiction to exercise\n* Previous complicated alcohol withdrawal symptoms (delirium or seizures)\n* Not able to participate in intervention due to psychiatric ilness",{"count":222,"type":21},[24],"The five risky lifestyles Smoking, Nutrition (obesity and malnutrition), risky Alcohol intake, and Physical inactivity (SNAP) are common in surgical patients and associated with worse postoperative outcomes. Mono-factor interventions targeting and improving these risky lifestyles have been shown to reduce the risk at surgery, but there is a lack of systematic assessment of all five lifestyles of the patient before surgery and related optimization.\n\nThis study aims to evaluate the effect of intensive combined lifestyle interventions (the STRONG programme) compared with treatment as usual in patients undergoing ventral hernia repair on postoperative complications, health, and costs on short and longer term.\n\nThe hypothesis is that the STRONG programme will halve the complication rates within 30 days.",[392,282,393,394,395,396],"Ventral Hernia","Risk Reduction","Lifestyle","Postoperative Complications","Prehabilitation",[392,282,393,395,396,398,399,400,99,401],"Smoking","Alcohol drinking","Obesity","Physical Inactivity","2024-09-20",{"date":404,"type":44},"2024-09-25",{"date":406,"type":44},"2024-03-04",{"date":408,"type":21},"2028-03-01",{"name":50,"class":51},{"id":411,"slug":412,"hasResults":11,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":4,"eligibilityCriteria":416,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":417,"targetDuration":419,"studyType":120,"phases":4,"briefSummary":420,"conditions":421,"keywords":424,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":4},"100560917","cementation-of-cup-and-the-risk-of-second-revision-100560917","NCT06583382","Cementation of Cup and the Risk of Second Revision","Risk for Second Revision in Patients With Cemented Versus Non-cemented Acetabular Component at Primary THA. A National Cohort Study From DHR","Inclusion Criteria:\n\n* Primary osteoarthritis as the indication for the primary THA.\n* Has experienced a first revision with exchange of the liner, femoral head and\u002For acetabular component either with or without exchange of the femoral component.\n* Femoral with a size of 28mm, 32mm or 36mm after the first revision\n* Surgery with the posterior approach.\n\nExclusion Criteria:\n\n* Isolated revision of the femoral component.\n* Constrained liner.\n* Metal-on-metal implant.",{"count":418,"type":21},60000,"15 Years","Background:\n\nThe fixation method of the acetabular component during the primary total hip arthroplasty (THA) affects the surgical techniques implemented in the revision surgery and may influence the risk of second revision.\n\nObjectives:\n\nThe objectives of this study are to investigate the risk of second revision of the cup alone or any component after first cup revision following cemented or non-cemented cup in the primary THA.\n\nMethods\u002Fdesign:\n\nThe study is a nationwide register-based cohort study and will follow the reporting of studies Conducted using Observational Routinely collected health Data (RECORD) guidelines. We will compare the risk of undergoing a second revision between cemented and uncemented revised acetabular component by reporting the absolute risk of second revision of 1) the acetabular component and 2) any other component. The cumulative incidence of revision will be estimated using Fine-Gray regression to model the cumulative incidence function, accounting for the competing risk of death. We will apply both a crude and a multivariable adjusted model adjusting for age, sex, Charlson Comorbidity Index (CCI) and the 5-year intervals during which the primary operation was performed.",[422,423],"Total Hip Arthroplasty (THA)","Revision Hip Arthroplasty",[425,426,427,428,429,430,431],"Cup cementation","total hip arthroplasty","THA","Revision","Second Revision","Re-revision","cement","2024-09-04",{"date":434,"type":44},"2024-09-19",{"date":436,"type":21},"2024-10-01",{"date":438,"type":21},"2026-10-01",{"name":50,"class":51},{"id":441,"slug":442,"hasResults":11,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":4,"eligibilityCriteria":446,"healthyVolunteers":117,"sex":145,"minAge":18,"maxAge":147,"enrollmentInfo":447,"targetDuration":4,"studyType":22,"phases":448,"briefSummary":449,"conditions":450,"keywords":452,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":52},"100558752","cardio-and-renovascular-effects-of-isometric-exercise-in-the-healthy-human-measured-by-petct-and-mri-100558752","NCT06555211","Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET\u002FCT and MRI","Cardio and Renovascular Effects of Static Muscle Work in the Healthy Human - Measured With Finapres® and Positron Emission Tomography (PET) Using 15-oxygen Labeled Water as Tracer Compared to Magnetic Resonance (MR)","Inclusion Criteria:\n\n* Normal health stated through medical questionnaire, examination and blood samples.\n\nExclusion Criteria:\n\n* Immunosuppressive treatment\n* Alcohol abuse\n* Treatment with glucocorticoids, Glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase 4 (DPP-4)-inhibitors\n* Medical treatment affecting insulin secretion or cardiovascular endpoints\n* Liver disease\n* Decreased kidney function\n* Severe claustrophobia\n* Elements incompatible with MR.",{"count":149,"type":21},[24],"This randomized crossover study aims to validate measurements of renal perfusion in healthy males with PET\u002FCT, using 15-oxygen labeled water as tracer, against the validated multiparametric MRI technique.\n\nThe study will determine:\n\n* Total renal blood flow and regional renal perfusion at baseline (rest) and during isometric muscle exercise of the upper arm, using PET\u002FCT (with 15-oxygen labeled water as a tracer) and MRI.\n* The coefficient of variation of renal blood flow and regional renal perfusion measurements at baseline and during isometric muscle exercise of the upper arm, using PET\u002FCT (with 15-oxygen labeled water as a tracer) and MRI.\n* Regional renal oxygenation and oxygen extraction at baseline and during isometric muscle exercise of the upper arm using MRI.\n* The coefficient of variation on regional renal oxygenation and oxygen extraction measurements at baseline and during isometric muscle exercise of the upper arm using MRI.",[451],"Kidneys",[453,454,455,456],"Total renal blood flow","Regional renal perfusion","Regional renal oxygenation","Renal oxygen extraction","2024-08-12",{"date":459,"type":44},"2024-08-15",{"date":461,"type":44},"2024-05-07",{"date":463,"type":21},"2024-12",{"name":50,"class":51},{"id":466,"slug":467,"hasResults":11,"nctId":468,"briefTitle":469,"officialTitle":470,"acronym":471,"eligibilityCriteria":472,"healthyVolunteers":11,"sex":145,"minAge":146,"maxAge":147,"enrollmentInfo":473,"targetDuration":4,"studyType":22,"phases":475,"briefSummary":476,"conditions":477,"keywords":480,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":485,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":52},"100558747","semaglutides-effect-on-renal-hemodynamics-and-function-in-patients-with-type-2-diabetes-mellitus-and-nephropathy-100558747","NCT06555146","Semaglutide's Effect on Renal Hemodynamics and Function in Patients With Type 2 Diabetes Mellitus and Nephropathy","Glucagon-like Peptide-1's Effect on Renal Regional Blood Flow and the Renal Function in Patients With Type 2 Diabetes Mellitus","Sema-RMA","Inclusion Criteria:\n\n* Type 2 diabetes mellitus diagnosed through either HbA1c ≥6,5% but ≤8,5%, or \\\u003C6,5% combined with either fasting plasma glucose ≥7,0 mmol\u002FL or plasma glucose ≥11,1 mmol\u002FL two hours after an oral glucose tolerance test (OGTT).\n* Estimated glomerular filtration rate (eGFR, CKD-EPI) between 30-60 mL\u002Fmin\u002F1.73m2\n* Urine Albumin:Creatinine ratio (UACR) ≥30mg\u002Fg\n* Stable RAAS blockade (ACE inhibitors or angiotensin II receptor blocker (ARB) with stable dosis for 4 weeks prior to screening)\n* Discontinuation of treatment with selective sodium glucose transporter inhibitors (SGLT2i), dipeptidyl peptidase 4 inhibitors (DPP-4i), GLP-1R analogs, rapid-acting and mix insulin 30 days before screening.\n\nExclusion Criteria:\n\n* Immunosuppressive therapy within 30 days of screening\n* Alcohol abuse\n* Medical treatment with glucocorticoids\n* Kidney transplantation\n* Treatment for renal failure with dialysis\n* Myocardial infarction within 3 months of screening\n* Heart failure (NYHA 3-4)\n* Dysregulated arterial hypertension (systolic blood pressure ≥180 mm Hg or diastolic blood pressure ≥ 100 mm Hg)\n* Liver disease (ALAT \\>2 x normal value)\n* Conditions which may interfere with the glucose metabolism according to the PI\n* Severe claustrophobia\n* Elements incompatible with MRI\n* Abnormal kidney size and\u002For position\n* Venous and arterial anatomy hindering catheterization.",{"count":474,"type":21},15,[24],"The goal of this double-blinded, placebo-controlled, randomized, crossover study is to examine the effect of semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), on renal hemodynamics and function in patients with type 2 diabetes mellitus (T2DM) and moderate chronic kidney disease (CKD).\n\nThe study will determine the effects of semaglutide on:\n\n* Renal arterial blood flow, regional renal perfusion, and oxygenation\n* Activity of the renin-angiotensin-aldosterone system (RAAS)\n* The glomerular filtration rate (GFR)\n* Sodium excretion in urine\n* Blood pressure and heart rate",[478,479],"Diabetes Mellitus, Type 2","Kidney Disease, Chronic",[481,454,482,483,484],"Renal flow","Sodium excretion in urine","Renin angiotensin aldosterone system","Glomerular filtration rate",{"date":459,"type":44},{"date":487,"type":21},"2024-08",{"date":489,"type":21},"2025-03",{"name":50,"class":51},{"id":492,"slug":493,"hasResults":11,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":497,"eligibilityCriteria":498,"healthyVolunteers":117,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":499,"targetDuration":4,"studyType":120,"phases":4,"briefSummary":501,"conditions":502,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":509,"leadSponsor":510,"locationsCount":52},"100556803","mechanisms-behind-microvascular-dysfunction-in-inoca-100556803","NCT06529861","Mechanisms Behind Microvascular Dysfunction in INOCA","Identification of Mechanisms Behind Microvascular Dysfunction in Ischemia With No Obstructive Coronary Artery Disease","ExINOCA-P1","Inclusion Criteria:\n\nOnly for angina patients: Have CMD, defined as myocardial bloodflow re-serve (MBFR) \\\u003C 2.5 or hyperemic myocardial blood flow (hMBF) \\\u003C 2.3ml\u002Fg\u002Fmin\n\nExclusion Criteria:\n\n* Females of childbearing potential (defined as a premeno-pausal female capable of becoming pregnant). The female patient must either be postmenopausal, defined as amen-orrhea for at least 1 year, or surgically sterile\n* Heart failure, defined as left ventricular ejection fraction of less than 40%\n* Uncontrolled hypertension defined as blood pressure above target 140\u002F90 for all\n* Co-morbidity resulting in \\\u003C1 year expected survival\n* Considered by the investigator, for any reason, to be an unsuitable candidate for the study.\n* Unable or unwilling to exercise, e.g. due to arthritis or injury\\*\n* Already are regularly physically active and\u002For have a maximal oxygen uptake \\>45 ml\u002Fkg\u002Fmin\n* The subject has a known allergy to either: norepinephrine, adenosine, ketorolac, and or ascorbic acid (vitamin C).",{"count":500,"type":21},60,"The purpose of the study is to identify the causes of chest pain in patients experiencing chest pain with no signs of narrowing in the coronary arteries of the heart.",[503,504],"Coronary Microvascular Dysfunction","Ischaemia With Non Obstructed Coronary Arteries","2024-07-29",{"date":507,"type":44},"2024-07-31",{"date":436,"type":21},{"date":316,"type":21},{"name":50,"class":51},{"id":512,"slug":513,"hasResults":11,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":117,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":518,"targetDuration":4,"studyType":22,"phases":520,"briefSummary":521,"conditions":522,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":526,"startDateStruct":528,"completionDateStruct":529,"leadSponsor":531,"locationsCount":4},"100537155","optimal-treatment-of-acute-skeletal-muscle-injury-100537155","NCT06274151","Optimal Treatment of Acute Skeletal Muscle Injury","Optimal Treatment of Inflammation Following Acute Skeletal Muscle Injury","Inclusion Criteria:\n\n* Sports-active individuals with an acute muscle train injury in either the hamstrings or calf muscle caused by an explosive movement (during sprinting, jumping etc)\n* Age older than 18 years\n\nExclusion Criteria:\n\n* Lack of hypoechoic\u002F hyperechoic area on ultrasound\n* Diabetes type I and II\n* Connective tissue disorders, rheumatism or any other chronic disease affecting the musculoskeletal system\n* Anticoagulant medication\n* Needle phobia",{"count":519,"type":21},20,[24],"Acute muscle strain injuries occur both during sports, in leisure time activities and during manual occupation and represent a major clinical challenge and has societal economic costs. The recovery time is long and a substantial injury recurrence is observed. Despite current best evidence rehabilitation with early mechanical loading, a significant loss of muscle mass, fatty infiltration and formation of scar tissue is reported.\n\nAnimal models and human in vitro experiments suggest that inflammation is vital in the early period after an injury, however an inhibition of inflammatory processes is beneficial for healing.\n\nWe investigate here whether a pharmacological inhibition of inflammatory pathways in the 2nd week following a muscle strain injury will provide a better clinical outcome and an advantageous cellular profile than rehabilitative training alone would.",[523,524],"Muscle Strain, Multiple Sites","Inflammation","2024-02-15",{"date":527,"type":44},"2024-02-23",{"date":525,"type":21},{"date":530,"type":21},"2029-12-31",{"name":50,"class":51},{"id":533,"slug":534,"hasResults":11,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":4,"eligibilityCriteria":538,"healthyVolunteers":117,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":539,"targetDuration":4,"studyType":120,"phases":4,"briefSummary":541,"conditions":542,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":550,"completionDateStruct":551,"leadSponsor":553,"locationsCount":52},"100500646","cellular-mechanisms-involved-in-muscle-pathology-100500646","NCT05798962","Cellular Mechanisms Involved in Muscle Pathology","Cellular Mechanisms Involved in Pathology Following Musculo-tendinous Injuries","Inclusion Criteria:\n\n* 18 years and older, male and female, with an acute muscle strain injury (\\\u003C14 days post injury) in the calf or hamstring muscles (group 1). Pathological changes visible on an ultrasound scan as hypoechoic areas.\n* 18 years and older, male and female, with a chronic muscle strain injury (\\> 6 months prior to inclusion) in the calf or hamstring muscles (group 2), sequela including recurrent strain injuries, pain and\u002F or decrease in muscle function. Pathological changes visible on an ultrasound scan as hypo-\u002F hyperechoic areas.\n* 18 years and older, male and female, with a full Achilles tendon rupture (\\> 1 year prior to inclusion) with pathological changes: Fatty degeneration visible on an ultrasound scan (group 3).\n\nExclusion Criteria:\n\n* Type I and II Diabetes, Connective tissue and\u002For rheumatic diseases, or any observed organ dysfunctions\n* Daily smoking\n* Persons with daily intake of non-steroidal anti-inflammatory drugs (NSAIDs) within three months prior to time of contact\n* Allergic reactions to local anesthesia\n* Use of anticoagulant treatment\n* Needle phobia\n* Any drug or alcohol abuse now or in the past\n* The absence of any pathological changes visible on an ultrasound scan as hypo-\u002F hyperechoic areas (group 1 and 2)\n* The absence of any pathological changes (fatty degeneration) in either the gastrocnemius or the soleus muscle visible on an ultrasound scan (Subject group 3)",{"count":540,"type":21},30,"The overall purpose of this proposed study is the understanding of cellular mechanisms involved in the pathologic fatty degeneration of muscle. Fatty infiltration in skeletal muscle is observed following sports injuries such as muscle strain injuries and Achilles tendon rupture. It is also observed in the degenerative state after rotator cuff tears as well as in the aging process. While fatty degeneration of skeletal muscle occurs in many different conditions and is known to decrease muscle function, the cellular processes involved in fatty infiltration have not been investigated in human muscle.\n\nHypotheses:\n\n1. There is a high amount of fibro-adipogenic progenitors (FAPs) with an adipogenic pattern in pathologic skeletal muscle following a muscle strain injury and a full Achilles tendon rupture. We hypothesize that there is an increased number of FAPs with an adipogenic signature already in the acute phase after a strain injury, but a significantly higher number in the chronic stage as well as in the muscle following an Achilles tendon rupture.\n2. Mechanical cues are a major driver of the phenotypic drift of FAPs. The lack of mechanical stimuli initiates the adoption of an adipogenic pathway in naïve FAPs, whereas naïve FAPs exposed to mechanical stimuli will maintain their undifferentiated phenotype.\n3. The adherence of FAPs to a soft material will activate the adoption of an adipogenic phenotype, whereas a stiff material will favor a more fibrotic phenotype in naïve FAP's isolated from healthy skeletal muscle.",[543,544,545,546],"Muscle Strain, Lower Leg","Muscle Strained Thigh","Achilles Tendon; Laceration","Fatty Degeneration","2023-04-05",{"date":549,"type":44},"2023-04-06",{"date":547,"type":44},{"date":552,"type":21},"2030-08-31",{"name":50,"class":51},{"id":555,"slug":556,"hasResults":11,"nctId":557,"briefTitle":558,"officialTitle":558,"acronym":4,"eligibilityCriteria":559,"healthyVolunteers":117,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":560,"targetDuration":4,"studyType":22,"phases":562,"briefSummary":563,"conditions":564,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":567,"startDateStruct":569,"completionDateStruct":571,"leadSponsor":573,"locationsCount":52},"100495855","learning-effect-of-onsite-vs-online-education-in-a-medical-context-100495855","NCT05736627","Learning Effect of Onsite vs. Online Education in a Medical Context","Inclusion Criteria:\n\n* All PhD students on the courses if they are able to give informed consent\n\nExclusion Criteria:\n\n* Declining to participate\n* Withdrawal of informed consent",{"count":561,"type":21},240,[24],"The goal of this clinical trial is to learn about the effects of online medical education in PhD students. The main question it aims to answer is:\n\nWhat is the effect of onsite compared to online research courses on theoretical knowledge of research methodology and motivation for young medical researchers? Participants will join 20 research courses which are computer randomised to be delivered online (intervention) or onsite (control group) with 10-12 PhD students of each course (200-240 participants). Participants will be followed for up to two years after their course. The outcomes are\n\n* theoretical learning (main)\n* academic achievements\n* motivation\n* self-efficacy\n\nResearchers will compare online and onsite research courses to see if there is a difference in theoretical learning, academic achievements, motivation and self-efficacy.",[565],"Online Learning","2023-02-10",{"date":568,"type":44},"2023-02-21",{"date":570,"type":44},"2022-01-01",{"date":572,"type":21},"2027-12-31",{"name":50,"class":51},""]