[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Blekinge Institute of Technology\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":192},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,55,92,121,143,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":35,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100613193","effect-of-hydrogen-gas-on-hyperbaric-oxygen-toxicity-100613193",false,"NCT07263399","Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity","Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity - A Randomized Controlled Cross-Over Trial","Inclusion Criteria:\n\n* Military divers actively serving, aged 20-64 years\n* Meeting the Swedish Armed Forces physical standards for diving\n\nExclusion Criteria:\n\n* Ongoing infection or illness that may impact pulmonary function\n* Use of alcohol or smoking cigarettes within 48 hours\n* Diving with any breathing gas within 48 hours\n* Diving with oxygen-enriched gas (100% O₂) within 2 weeks\n* Use of medications that could affect oxidative stress, lung function, or neurological status\n* Medical history of serious diving-related injuries or long-term complications",true,"ALL","20 Years","64 Years",{"count":21,"type":22},32,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed Forces. The main questions it aims to answer are:\n\n* Does hydrogen gas reduce oxidative stress and changes in pulmonary function associated with prolonged hyperbaric oxygen exposure?\n* What are the underlying pathophysiological mechanisms of pulmonary oxygen toxicity?\n\nResearchers will compare oxygen-enriched breathing gas with 1-2% hydrogen to oxygen-enriched gas with 1-2% nitrogen (control) to see if hydrogen provides protective effects against POT during hyperbaric exposure.\n\nParticipants will:\n\n* Complete two hyperbaric exposure sessions (hydrogen vs. nitrogen), each lasting 240 minutes at 1.75 ATA\n* Undergo pulmonary function tests and sampling of blod and urin before and after each session\n* Serve as their own controls in a double-blind, randomized, crossover study design",[28,29,30,31,32,33,34],"Oxygen Toxicity","Oxidative Stress","Hyperoxia","Hyperbaric Oxygen","Healthy Subjects (HS)","Diving Medicine","Hydrogen-oxygen Gas",[36,37,38,39,31,40,41],"Pulmonary Oxygen Toxicity","Hydrogen Gas","Diving Physiology","Lung Function","Human Study","Military Divers","NOT_YET_RECRUITING","2025-12-01",{"date":45,"type":46},"2025-12-04","ACTUAL",{"date":48,"type":22},"2026-01",{"date":50,"type":22},"2030-12",{"name":52,"class":53},"Blekinge Institute of Technology","OTHER",2,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":16,"sex":17,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100608442","non-invasive-diagnosis-of-parkinsons-disease-100608442","NCT07201610","Non-invasive Diagnosis of Parkinson's Disease","Non-invasive Diagnosis of Parkinson's Disease Using Hyperspectral Retinal Imaging, Optical Coherence Tomography, Computerized Cognitive Testing, and Voice Analysis","Inclusion criteria for Parkinson's group:\n\n* Age 60-80 years\n* Diagnosis of idiopathic Parkinson's disease\n* Ability to understand spoken and written Swedish\n* Ability to personally provide consent to participate in the study\n* At least one healthy eye for retinal photography\n\nInclusion criteria for control group:\n\n* Age 60-80 years\n* Ability to understand spoken and written Swedish\n* Ability to personally provide consent to participate in the study\n* At least one healthy eye for retinal photography\n* Healthy as defined below\n\nExclusion criteria:\n\n* At least one eye must not have retinal disease, glaucoma, or vascular eye disease (such as embolism)\n* Angle-closure glaucoma or other contraindication to mydriatic drops\n* Low functional ability that makes participation in examinations impossible\n* Diagnosed dementia\n* Specifically for the control group: Not healthy according to the definition below\n\nDefinition of healthy:\n\n* No diagnosed or suspected Parkinson's disease\n* No diagnosed or suspected cognitive disease\n* No psychiatric disease affecting cognition (e.g., psychotic disorder or major depression)\n* Cognitive testing with MMSE ≥ 26 points (out of a maximum of 30) and ≥ 8 points on the clock-drawing test","60 Years","80 Years",{"count":65,"type":22},60,"OBSERVATIONAL","This study will investigate new, non-invasive methods to help diagnose Parkinson's disease. Researchers will use advanced eye imaging (hyperspectral retinal photography and OCT), computerized memory and thinking tests, and voice analysis to identify patterns linked to Parkinson's. The goal is to improve early and accurate diagnosis of Parkinson's disease without the need for spinal taps or invasive tests.",[69],"Parkinsons Disease (PD)",[71,72,73,74,75,76,77,78,79,80,81,82,83],"Parkinson's disease","Non-invasive diagnosis","Hyperspectral retinal imaging","Optical coherence tomography","OCT","Computerized cognitive testing","Voice analysis","Biomarkers","Lewy body disease","Retinal biomarkers","Diagnostic accuracy","Neuropsychology","Machine learning","2025-09-30",{"date":86,"type":46},"2025-10-01",{"date":88,"type":22},"2025-10-16",{"date":90,"type":22},"2025-12-16",{"name":52,"class":53},{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":23,"phases":102,"briefSummary":103,"conditions":104,"keywords":107,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},"100605723","the-effect-of-regular-home-use-of-dual-light-antibacterial-photodynamic-therapy-apdt-or-the-use-of-a-powered-toothbrush-in-older-individuals-with-periodontitis-and-mild-cognitive-impairment-100605723","NCT07166224","The Effect of Regular Home Use of Dual-light Antibacterial Photodynamic Therapy (aPDT) or the Use of a Powered Toothbrush in Older Individuals With Periodontitis and Mild Cognitive Impairment.","The Effect of Regular Home Use of Dual-light Antibacterial Photodynamic Therapy (aPDT) or the Use of a Powered Toothbrush in Older Individuals With Periodontitis and Mild Cognitive Impairment: a Randomized Controlled Trial.","e-DENT II","Inclusion Criteria:\n\n* Adults aged ≥60 years\n* ≥15 teeth\n* Diagnosed periodontitis stage I-III\n* MMSE score between 22-28\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Antibiotic use (within 3 months)\n* Lumoral use within 3 months\n* Bisphosphonate medication\n* Immunosuppressive drugs or radiation therapy",{"count":101,"type":22},90,[25],"Objective:\n\nTo compare three different oral hygiene regimens regarding plaque index (PI), bleeding on probing (BOP), the number of deepened periodontal pockets ≥4 mm (PPD), oral halitosis, and changes in oral health-related quality of life (OHRQoL) in an older population with periodontitis stage I-III and mild cognitive impairment.\n\n1. Are there improvements in plaque index (PI), number of bleeding on probing (BOP) sites, number of probing depths (PPD), and intraoral halitosis in the two test groups compared to the control group?\n2. Do the study interventions affect oral health-related quality of life in older adults with periodontitis and mild cognitive impairment?\n\nStudy design:\n\nType: Randomized controlled trial Duration: 6 months per participant, 2 years in total for data collection Participants: 90 participants divided into Intervention and Control groups\n\nIntervention Group A (Lumoral Dual-Light aPDT + Manual Toothbrush) Standardized oral hygiene instructions and the use of a manual toothbrush during the test period, with an adjunctive aPDT device (Lumoral®).\n\nIntervention Group B (Oral-B iO Powered Toothbrush) Standardized oral hygiene instructions and the use of an Oral-B iO powered toothbrush during the test period.\n\nControl Group Standardized oral hygiene instructions and the use of a manual TePe Select extra soft toothbrush during the test period.",[105,106],"Periodontal Diseases","Oral Halitosis",[108,109,110,111],"Mild Cognitive Impairment","Oral health","Quality of life","Powered toothbrush","2025-09-16",{"date":114,"type":46},"2025-09-19",{"date":116,"type":22},"2025-10",{"date":118,"type":22},"2028-12",{"name":52,"class":53},1,{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":16,"sex":17,"minAge":62,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":23,"phases":131,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":120},"100593059","evening-screen-content-and-sleep-architecture-in-older-adults-crossover-rct-100593059","NCT07001514","Evening Screen Content and Sleep Architecture in Older Adults: Crossover RCT","The Effect of Evening Technology Use With Calming vs. Exciting Content on Sleep Architecture in Older Adults: A Crossover Randomized Controlled Trial","Inclusion Criteria\n\n1. Age 60 - 75 years\n2. Regular evening use of digital devices (e.g., smartphones or tablets)\n3. Willing and able to wear an EEG headband for sleep monitoring throughout the intervention\n\nExclusion Criteria:\n\n1. Diagnosed sleep disorder\n2. Severe cognitive impairment\n3. Current use of medications that significantly influence sleep (e.g., melatonin, benzodiazepines)","75 Years",{"count":130,"type":22},50,[25],"Title\n\nThe Effect of Evening Technology Use with Calming vs. Exciting Content on Sleep Architecture in Older Adults: A Crossover Randomized Controlled Trial\n\nBackground\n\nThe study explores how evening use of digital devices with different types of content (calming vs. exciting) affects sleep in older adults. While technology's effects on sleep have been studied in younger populations, its specific impacts on older adults remain under-researched. This study fills that gap by focusing on subjective and objective sleep measures.\n\nObjectives and Research Questions\n\nObjective: Compare the effects of calming digital content, exciting digital content, and non-digital activities on sleep architecture.\n\nKey Questions:\n\nHow does content type impact sleep architecture and quality? Does calming content lead to better sleep outcomes than exciting content? Are there subjective differences in sleep quality across conditions?",[134],"Sleep","2025-05-31",{"date":137,"type":46},"2025-06-03",{"date":139,"type":22},"2025-08",{"date":141,"type":22},"2026-12",{"name":52,"class":53},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":16,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":151,"targetDuration":153,"studyType":66,"phases":4,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":120},"100591504","oral-health-parameter-based-diabetes-type-2-indication-using-machine-learning-100591504","NCT06981286","Oral Health Parameter-Based Diabetes Type 2 Indication Using Machine Learning","Oral Health Parameter-Based Diabetes Type 2 Indication Using Machine Learning in Older Individuals With Mild Cognitive Impairment","JFG","Inclusion Criteria:\n\n* Individuals aged 60 years or older.\n* Participants with recorded oral health parameters with or without Diabetes type2\n\nExclusion Criteria:\n\n• Individuals with Diabetes type1",{"count":152,"type":22},2000,"1 Day","This study aims to explore the potential of using machine learning (ML) algorithms to predict Diabetes type2, based on oral health and demographic data. The objective is to evaluate the effectiveness of various ML models and identify the most relevant oral health indicators for predicting type 2 diabetes in individuals with mild cognitive impairment aged 60 and above.",[156],"Type 2 Diabetes",[158,159,160],"Oral Health","Machine Learning","Diabetes Type 2","2025-05-19",{"date":163,"type":46},"2025-05-20",{"date":165,"type":22},"2025-08-30",{"date":167,"type":22},"2027-07",{"name":52,"class":53},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":16,"sex":17,"minAge":176,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":183,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":120},"100542002","a-digital-life-story-to-support-person-centred-care-for-older-adults-with-dementia-perspectives-100542002","NCT06337201","A Digital Life Story to Support Person-centred Care for Older Adults With Dementia Perspectives","A Digital Life Story to Support Person-centred Care for Older Adults With Dementia: Healthcare Professionals' Perspectives","Inclusion Criteria:\n\n* Healthcare professionals using a life story in daily care.\n\nExclusion Criteria:\n\n* N\u002FA","18 Years",{"count":178,"type":22},30,"Person-centred care can be supported when healthcare professionals access and actively use the information recorded in a life story. Active use of the life story can create security for a person with dementia and their carers. The written life story describes the person and their life experiences, which can define the person's identity. National guidelines for care and nursing in dementia and Blekinge's regional guidelines emphasise the importance of care and nursing for people with dementia, which should be given with a person-centred approach, where the life story becomes a tool for healthcare professionals. Research shows that a life story can be designed in several ways. For example, in book form, as a brochure, collage, memory box or electronically. The life story is also intended as a tool for healthcare professionals to create security and facilitate communication with the individual. As more and more older adults are using computers and tablets as assistive devices, and it is also becoming more common for healthcare professionals to use, for example, tablets as assistive devices in nursing care, the life story could be shared in digital form as an application and become a living document.\n\nOverall aim: To test an application for the life story with the intention of supporting person-centred care for older adults with dementia and to test whether the application can replace the written completion document. Study I: Exploring the research area of the life story in digital form. Study II: Focus group interviews with healthcare professionals. Study III: Test the application, Min Memoria. Study IV: Observations on the use of the application.",[181,182],"Cognitive Impairment","Dementia","RECRUITING","2024-03-22",{"date":186,"type":46},"2024-03-29",{"date":188,"type":46},"2022-08-15",{"date":190,"type":22},"2027-06",{"name":52,"class":53},""]