[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Boston VA Research Institute, Inc.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":79},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100462291","real-time-fmri-neurofeedback-in-patients-with-schizophrenia-and-auditory-hallucinations-100462291",false,"NCT05299749","Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations","Real-time fMRI Neurofeedback as a Tool to Mitigate Auditory Hallucinations in Patients With Schizophrenia - R33 Phase","Inclusion Criteria:\n\n* patients diagnosed with SZ or schizoaffective disorder using DSM-5 criteria\n* auditory hallucinations not responsive to pharmacology as determined by chart review and a clinical interview of SCID.\n\nExclusion Criteria:\n\n* neurologic illness\n* major head trauma\n* electroconvulsive therapy\n* alcohol or drug dependence\n* alcohol or drug abuse within the past five years\n* verbal IQ below 70","ALL","18 Years","55 Years",{"count":20,"type":21},104,"ESTIMATED","INTERVENTIONAL",[24],"NA","Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.",[27,28,29],"Schizophrenia","Auditory Hallucination","Treatment-resistant Schizophrenia",[31,32,33,34,35,36,37],"Auditory-Hallucination","Connectivity","brain-activity","default-mode-network","superior temporal gyrus","Neurofeedback","MRI","RECRUITING","2025-09-12",{"date":41,"type":42},"2025-09-18","ACTUAL",{"date":44,"type":42},"2022-03-01",{"date":46,"type":21},"2026-06-30",{"name":48,"class":49},"Boston VA Research Institute, Inc.","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":16,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100553919","neurofeedback-in-clinical-high-risk-100553919","NCT06492343","Neurofeedback in Clinical High Risk","Real Time Neurofeedback, Its Neurotransmitter Underpinnings, and Therapeutic Effects, in Clinical High Risk Individuals","Inclusion Criteria:\n\n* For CHR Inclusion:\n\n  1. 12-30 years old\n  2. Native speaker or early learner (by age of 6) of English\n  3. COPS diagnostic criteria met For HC Inclusion\n\n  \u003C!-- -->\n\n  1. 12-30 years old\n  2. Native speaker or early learner (by age of 6) of English\n  3. Provides a match with CHR subject on demographic matching variables\n\n     Exclusion Criteria:\n\n     For CHR:\n\n     Exclusion:\n\n  \u003C!-- -->\n\n  1. Meeting DSM-5 criteria for lifetime psychotic disorder, including affective psychoses\n  2. WASI-II IQ \\\u003C 70\n  3. Psychosis risk symptoms caused by other psychiatric disorders (including substance use\u002Fmisuse)\n  4. Congenital or acquired CNS disorder that could account for psychosis-risk or cognitive symptoms\n  5. Medication that interferes with assessment \u002F presentation of psychosis risk or that could account for psychosis risk symptoms\n  6. Antipsychotic medication administered in the absence of evidence the individual was still in the CHR state when treatment began\n  7. Inability or refusal to provide informed consent\n\n     For HC:\n\n  \u003C!-- -->\n\n  1. Meets criteria for a psychosis-risk syndrome\n  2. Current or previous diagnosis for psychotic di sorder\n  3. DSM-5 Cluster A personality disorder\n  4. First degree biological relative with psychotic disorder or psychotic symptoms\n  5. Current use of psychotropic medication\n  6. WASI-II IQ \\\u003C70\n  7. Congenital or acquired CNS disorder that interferes with cognition or produces psychosis risk-like symptoms\n  8. Inability or refusal to provide informed consent",true,"12 Years","30 Years",{"count":62,"type":21},40,[24],"The goal of this trial is to test whether fMRI based neurofeedback from default mode network (DMN) will reduce DMN hyperconnectivity in clinical high risk individuals, which will lead to reductions in clinical symptoms and improve cognitive performance.",[66,67],"Real Neurofeedback From DMN","Sham Neurofeedback From Motor Cortex",[69],"fMRI, neurofeedback, DMN, functional connectivity","NOT_YET_RECRUITING","2024-07-01",{"date":73,"type":42},"2024-07-09",{"date":75,"type":21},"2024-09",{"date":77,"type":21},"2028-12",{"name":48,"class":49},""]