[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Bozok University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":219},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,48,77,113,136,164,192],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100636562","common-pain-mechanisms-in-migraine-migraine-related-neck-pain-and-lower-back-pain-a-cross-sectional-study-100636562",false,"NCT07567300","Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cross Sectional Study","From Mechanisms to Clinical Evidence: A Cross-Sectional Study of Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain","Inclusion Criteria:\n\n* Being between 18 and 65 years of age,\n* Being able to read and understand Turkish,\n* Agreeing to participate voluntarily,\n* Having an episodic or chronic migraine diagnosis according to the International Classification of Headache Disorders Edition 3 criteria;\n* Having neck pain and\u002For lower back pain without any underlying diagnosis accompanying the migraine diagnosis.\n\nExclusion Criteria:\n\n* A history of neurological disorder (e.g., Multiple Sclerosis),\n* Inflammatory rheumatic disorders (e.g., Rheumatoid Arthritis), generalized chronic pain syndromes (e.g., Fibromyalgia),\n* Any other headache disease, any other systemic disease,\n* Acute fracture and infection,\n* Spinal surgery or spinal disease diagnosis within the last 6 months,\n* Serious musculoskeletal trauma within the last 6 months,\n* Pregnancy,\n* A cognitive or psychiatric condition that would prevent completion of the questionnaires,\n* In the control group without a migraine diagnosis,\n* A history of recurrent headaches within the last year.","ALL","18 Years","65 Years",{"count":20,"type":21},179,"ESTIMATED","1 Day","OBSERVATIONAL","Migraine is one of the primary headache disorders with a high prevalence worldwide, leading to significant disability and reduced quality of life. Trigeminal nerve activation and alterations in central pain processing mechanisms play a crucial role in the pathophysiology of migraine. Recent studies suggest that migraine may not only be a headache disorder but also a systemic pain disorder associated with changes in central pain processing mechanisms. Central sensitization is defined as increased sensitivity of nociceptive neurons in the central nervous system to afferent stimuli and is considered a key mechanism in the development and maintenance of chronic pain conditions. This condition is characterized by pain hypersensitivity, allodynia, and generalized pain sensitivity.\n\nIn addition to headaches, other musculoskeletal pains are also frequently reported in migraine patients. Spinal pain, particularly neck and lower back pain, can occur in migraine sufferers, with central sensitization contributing to the condition, considering the spine as a chain. Large population-based studies have shown a significant association between primary headaches and persistent low back pain, and a higher prevalence of concomitant low back pain has been reported in individuals with chronic migraine and chronic tension-type headaches. This association is suggested to be explained by the shared nociceptive pathways of the head and spinal structures and the changes in central pain processing seen in chronic pain conditions.\n\nThis relationship between migraine and musculoskeletal pain is also explained by the presence of shared neuroanatomical structures such as the trigemino-cervical complex. Nociceptive afferents from the upper cervical spine and cranial structures converge at the trigemino-cervical complex level in the brainstem, creating a predisposition to the co-occurrence of head and neck pain. This mechanism suggests that pain or dysfunction in the cervical region in migraine patients may be related to headache symptoms. Studies have shown that neck pain is more common in individuals with migraine than in the general population, and research suggests this rate may be approximately 10-12 times higher compared to healthy individuals. Furthermore, it has been reported that individuals with migraine more frequently experience tenderness in cranio-cervical muscles such as the upper trapezius, sternocleidomastoid, and suboccipital muscles, myofascial trigger points, and increased muscle sensitivity. The literature also emphasizes that these cervical symptoms may be related to migraine frequency, attack severity, and headache-related disability.\n\nThese findings suggest that migraine should be considered not only as a primary headache disorder but also as a complex neurobiological condition associated with widespread pain sensitivity and musculoskeletal symptoms. A better understanding of the relationship between migraine and musculoskeletal pain could be important for developing multidisciplinary treatment approaches. However, clinical studies in the literature that evaluate migraine, accompanying neck pain, and lower back pain together in terms of common pain mechanisms are quite limited. Therefore, the rationale for this study is that examining factors such as central sensitization, pain threshold, pain catastrophizing, psychological factors, body awareness, and regional disability together in migraine patients can lead to a better understanding of the pathophysiology of migraine-related musculoskeletal pain. Based on all these reasons and evidence, the aim of this study is to investigate the possible common pain mechanisms and musculoskeletal pathophysiological processes of migraine-related neck and back pain in migraine patients with accompanying neck and\u002For back pain by evaluating factors such as central sensitization, pain threshold, pain catastrophizing, psychological factors, body awareness, and regional disability together.",[26,27,28],"Neck Pain","Migraine","Low Back Pain",[30,31,32,33,34],"migraine","neck pain","low back pain","central sensitization","pain threshold","RECRUITING","2026-05-16",{"date":38,"type":39},"2026-05-19","ACTUAL",{"date":41,"type":21},"2026-04-30",{"date":43,"type":21},"2026-06-30",{"name":45,"class":46},"Bozok University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":56,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100635590","central-sensitization-work-related-stress-and-musculoskeletal-symptoms-in-desk-based-workers-with-and-without-migraine-100635590","NCT07554664","Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine","Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine: A Cross-Sectional Study","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Having been employed in an office job for at least 6 months\n* Working at a desk for at least 4 hours a day\n* Being able to read and understand Turkish\n* Agreeing to participate voluntarily\n* For individuals with a migraine diagnosis, having an episodic or chronic migraine diagnosis according to the International Classification of Headache Disorders Edition 3 criteria\n* For individuals without a migraine diagnosis, not having a diagnosis of migraine or other primary headache.\n\nExclusion Criteria:\n\n* A history of neurological disorder (e.g., Multiple Sclerosis)\n* Inflammatory rheumatic disorders (e.g., Rheumatoid Arthritis)\n* Generalized chronic pain syndromes (e.g., Fibromyalgia)\n* Any other headache disease\n* Any other systemic disease\n* Acute fracture and infection\n* Neck or spinal surgery within the last 6 months\n* Serious musculoskeletal trauma within the last 6 months\n* Pregnancy\n* A cognitive or psychiatric condition that would prevent completion of the questionnaires\n* In the control group without a migraine diagnosis, a history of recurrent headaches within the last year.",true,{"count":57,"type":21},159,"Migraine is a common neurological disease causing significant disability worldwide, with an estimated global prevalence of 14.4%. It represents a significant individual and societal burden, particularly for working-age individuals, as it can significantly impact work performance, productivity, and daily living activities. Migraine is not merely a headache; it is characterized by increased excitability of neurons in the central nervous system, leading to hypersensitivity to pain. Central sensory mechanisms are thought to play a role in the pathophysiology and chronicity of migraine, causing increased pain sensitivity, allodynia, and potentially related to musculoskeletal pain. Furthermore, psychosocial factors and work stress have been identified as significant factors associated with both headaches and musculoskeletal pain. Literature indicates that neck pain is common in individuals with migraine headaches; in fact, neck pain is twice as frequent in patients with chronic migraine headaches compared to those with episodic migraine. While evidence regarding back pain is limited, it has been shown that individuals with chronic headaches report back pain more frequently.\n\nIn modern work environments, sedentary work and prolonged computer use are increasing. Prolonged sitting, improper ergonomics, and repetitive movements are considered significant risk factors for musculoskeletal problems. This can lead to pain and functional limitations, particularly in the neck, shoulders, and back. Although there has been an increase in working from home, especially after the pandemic, the time spent at a desk is still similar to that spent in the workplace. It is stated that static muscle activity and improper postures maintained during prolonged computer use can lead to increased strain on cervical and upper extremity muscles, exacerbating musculoskeletal symptoms. Literature reports that headaches and neck pain are common among individuals who work at desks; for example, a study of office workers reported that approximately 80% of individuals with headaches also experienced neck pain. Furthermore, high workload, time pressure, and psychosocial stress factors have been shown to be associated with both headaches and musculoskeletal pain in individuals who work at desks. Therefore, desk-based work conditions are considered a significant environmental factor that may play a role in the onset or exacerbation of migraine and musculoskeletal symptoms. Despite this, studies examining musculoskeletal symptoms, central sensitivity, and work stress together in desk-bound migraine patients are limited in the literature. Most studies have only examined individuals with headaches or evaluated musculoskeletal findings in limited areas. Therefore, studies comparing desk-bound migraine patients with non-migraine-bound desk-bound individuals could fill a significant gap in the literature. In this context, it is believed that the planned study will contribute to a better understanding of the possible relationships between migraine and musculoskeletal symptoms, help develop protective and rehabilitative approaches to the work environment, and benefit individuals exposed to musculoskeletal risks in desk-bound work, within the scope of Sustainable Development Goals 3: ensure healthy lives and promote well-being for all at all ages. The aim of this study is to compare central sensitization, work-related stress levels, and musculoskeletal symptoms in desk-based workers according to the presence of migraine and to examine the relationships among these variables.",[27,60,61,62,63],"Worker Health","Sensitization","Musculoskeletal Pain","Work Stress",[65,66,62,67,61,60,68,69,70],"Migraine Disorders","Workplace","Rehabilitation","Sustainable Development Goals","Disability","SDG 3",{"date":38,"type":39},{"date":73,"type":39},"2026-04-23",{"date":75,"type":21},"2026-05-11",{"name":45,"class":46},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":55,"sex":16,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":98,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":47},"100624315","preoperative-gamified-breathing-exercise-on-anxiety-and-delirium-in-children-100624315","NCT07408037","Preoperative Gamified Breathing Exercise on Anxiety and Delirium in Children.","Preoperative Anxiety and Postoperative Recovery Delirium Observation in Children Who Underwent Gamified Breathing Exercise","PED-ANX-DEL","Inclusion Criteria:\n\n* Children aged 3 to 7 years (preschool age).\n\nScheduled for elective (planned) surgery at Bursa Uludag University Hospital.\n\nPhysical status classified as ASA I or ASA II.\n\nChildren and parents who volunteer to participate and provide written informed consent.\n\nExclusion Criteria:\n\nChildren with chronic neurological or psychiatric disorders.\n\nChildren with existing respiratory system diseases that prevent breathing exercises.\n\nChildren or parents with communication barriers (e.g., severe hearing or speech impairment).\n\nChildren undergoing emergency (non-elective) surgery.\n\n\\-","3 Years","7 Years",{"count":88,"type":21},80,"INTERVENTIONAL",[91],"NA","This study aims to evaluate the effect of preoperative gamified breathing exercises on preoperative anxiety and postoperative emergence delirium in children. The intervention includes games like ball blowing and bubble blowing. Anxiety is measured using the mYPAS-SF scale, and delirium is assessed with the PAED scale.",[94,95,96,97],"Preoperative Anxiety (Ameliyat Öncesi Anksiyete)","Emergence Delirium (Derlenme Deliryumu)","Postoperative Complications","Pediatric Patients",[99,100,101,102,103,104],"Preoperative Anxiety","Emergence Delirium","Gamification","Breathing Exercises","Pediatric Nursing","Postoperative Recovery","2026-02-10",{"date":107,"type":39},"2026-02-12",{"date":109,"type":39},"2024-03-03",{"date":111,"type":21},"2026-12-12",{"name":45,"class":46},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":89,"phases":123,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":47},"100620635","the-effect-of-laughter-yoga-on-primiparous-pregnant-women-100620635","NCT07360184","The Effect of Laughter Yoga on Primiparous Pregnant Women","The Effect of Laughter Yoga on Fear of Childbirth and Self-Efficacy During Childbirth in Primiparous Women: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Being 18 years of age or older,\n* never having given birth before\n* be a primiparous pregnant woman experiencing her first birth,\n* be pregnant with a single baby,\n* be approximately 28-34 weeks pregnant at the start of the intervention,\n* be planning a vaginal birth,\n* have the ability to read and speak Turkish,\n* volunteer to participate in the study\n\nExclusion Criteria:\n\n* A diagnosis of high-risk pregnancy or the presence of serious obstetric complications that prevent participation in exercise (e.g., placenta previa, uncontrolled gestational hypertension or preeclampsia, bed rest recommended due to threatened preterm labor, cervical insufficiency),\n* multiple pregnancy,\n* history of recurrent pregnancy loss (≥2 miscarriages) or pregnancy achieved through assisted reproductive techniques (e.g., IVF),\n* diagnosis of a known psychiatric disorder (major depression, anxiety disorder, psychosis, etc.),\n* history of alcohol or substance use during pregnancy,\n* Severe orthopedic problems or chronic respiratory system diseases that prevent participation in light exercise or laughter exercises,\n* Participation in other structured prenatal interventions (e.g., prenatal yoga, hypno-birth, intensive childbirth education programs) aimed at reducing fear or anxiety about childbirth during the study period.","40 Years",{"count":122,"type":21},110,[91],"Primiparous women constitute a special risk group who may experience higher levels of fear of childbirth and lower birth self-efficacy during pregnancy due to their lack of prior childbirth experience. Fear of childbirth is associated with increased anxiety, negative birth experiences, and unnecessary medical interventions, while birth self-efficacy is an important determinant of adaptation to the birth process and positive birth outcomes. In recent years, non-pharmacological and mind-body-based interventions have become increasingly important in the management of these psychological problems. Laughter yoga is a complementary method that combines conscious laughter exercises with breathing techniques to reduce stress and anxiety. This randomized controlled trial aims to evaluate the effect of laughter yoga on fear of childbirth and self-efficacy during childbirth in primiparous pregnant women. The study aims to provide scientific evidence for the use of laughter yoga as an effective, safe, and inexpensive psychosocial intervention that can be applied in prenatal care.",[126],"Laughter","NOT_YET_RECRUITING","2026-01-14",{"date":130,"type":39},"2026-01-22",{"date":132,"type":21},"2026-02-15",{"date":134,"type":21},"2026-03-22",{"name":45,"class":46},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":143,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":89,"phases":145,"briefSummary":146,"conditions":147,"keywords":151,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100613831","the-effect-of-laughter-yoga-in-type-2-diabetes-patients-100613831","NCT07271706","The Effect of Laughter Yoga in Type 2 Diabetes Patients","The Effect of Laughter Yoga on Self-management and Comfort in Type 2 Diabetes Patients","Inclusion Criteria\n\n* Diagnosis of Type 2 diabetes\n* Age 18 years or older\n* Willingness to participate in the Laughter Yoga intervention\n* Ability to read and comprehend Turkish\n\nExclusion Criteria\n\n* Diagnosis of Type 1 diabetes\n* Participation in individual psychotherapy or group-based psychological intervention programs\n* Experience of a recent loss within the past month (e.g., death, divorce)\n* Presence of any psychiatric diagnosis\n* Use of psychiatric medication\n* Severe visual or hearing impairment preventing active participation in the intervention\n* Pregnancy or breastfeeding\n* Limitations in reading or comprehending Turkish","18 Months",{"count":88,"type":21},[91],"The purpose of this study is to examine the effect of laughter yoga on self-management skills and comfort levels in patients with Type 2 diabetes.",[148,149,150],"Diabetic","Laughter Yoga","Comfort",[152,153,154,155],"laughter yoga","diabetic","comfort","self-governance","2025-12-06",{"date":158,"type":39},"2025-12-09",{"date":160,"type":21},"2025-12-15",{"date":162,"type":21},"2026-01-25",{"name":45,"class":46},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":55,"sex":171,"minAge":17,"maxAge":120,"enrollmentInfo":172,"targetDuration":4,"studyType":89,"phases":174,"briefSummary":175,"conditions":176,"keywords":178,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":4},"100605785","virtual-reality-enabled-digital-storytelling-100605785","NCT07167030","Virtual Reality-Enabled Digital Storytelling","Evaluation of the Effects of Digital Storytelling Applied to Primiparous Pregnant Women With Virtual Reality Glasses on Prenatal Attachment, Fear of Childbirth, Perception of Childbirth Self-Efficacy, and Non-Stress Test Results","Inclusion Criteria:\n\n* Primiparous women in their 28th week of pregnancy\n* Between the ages of 18 and 40\n* Experiencing a singleton pregnancy\n* Applied to the Yozgat City Hospital Gynecology and Obstetrics Clinic and agreed to participate in the study\n* Have a primary school education and can understand Turkish\n* Have no serious vision or balance problems that would prevent the use of VR glasses\n* Have not experienced any risky pregnancy problems (premature membrane rupture, preeclampsia, gestational diabetes, etc.)\n* Have no identified fetal anomalies\n* Have no psychiatric diagnosis\n\nExclusion Criteria:\n\n* Pregnant women who cannot obtain a work permit and who do not agree to participate in the study will not be included in the study.","FEMALE",{"count":173,"type":21},112,[91],"Current scientific literature on VR details primarily focuses on fear and anxiety during childbirth. Variables such as attachment, fear, and self-efficacy are often considered independently. Therefore, in addition to interventions focused on the prenatal period, a need arose for holistic audiovisual and technologically supported intervention models that simultaneously address multidimensional aspects of life, such as prenatal attachment, fear of childbirth, and perception of childbirth self-efficacy.",[177],"Primiparous Pregnant Women",[179,180,181,182,183],"Prenatal attachment","Fear of Childbirth","Birth Self-Efficacy","Virtual Reality","Digital Storytelling","2025-09-10",{"date":186,"type":39},"2025-09-16",{"date":188,"type":21},"2025-11-01",{"date":190,"type":21},"2026-12-30",{"name":45,"class":46},{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":89,"phases":202,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":218},"100542617","motivational-interviewing-applied-to-individuals-with-diabetes-100542617","NCT06345196","Motivational Interviewing Applied to Individuals With Diabetes","The Effect of Motivational Interviewing on Well-being, Stress and Difficulties in Individuals With Diabetes","Inclusion Criteria:\n\n* volunteering to participate in the study,\n* Having a diagnosis of Type 2 Diabetes,\n* HbA1C values outside the normal range for the last 2-3 months.\n\nExclusion Criteria:\n\n* Having a diagnosis of Type 1 Diabetes,\n* Having limitations in reading and understanding Turkish.","85 Years",{"count":201,"type":21},66,[91],"This study will be conducted using a randomized controlled trial design to evaluate the effect of online individual motivational interviewing on well-being, stress and difficulties in individuals with diabetes. The study will be conducted between March 2024 and March 2025 with individuals with Type 2 Diabetes who are followed up in Yozgat Bozok University Health Practice and Research Center Internal Medicine Polyclinic. The motivational interview group will receive a motivational interview once a week, lasting a maximum of 40 minutes, consisting of a total of four sessions. Chi-square (X2), t-test, repeated measures analysis of variance, Pearson correlation coefficient, partial eta-square and linear regression analysis will be used to evaluate the data.",[205,206,207,208,209],"Motivational Interviewing","Stress","Well-Being, Psychological","Diabetes Mellitus","Type2diabetes","2024-07-16",{"date":212,"type":39},"2024-07-17",{"date":214,"type":21},"2024-10-15",{"date":216,"type":21},"2024-12-15",{"name":45,"class":46},2,""]