[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Bursa City Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":627},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,48,78,106,131,155,178,201,226,249,279,300,318,345,371,396,419,446,463,488,510,532,556,579,603],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644243","i-fabp-as-a-predictor-of-gastrointestinal-involvement-in-pediatric-iga-vasculitis-100644243",false,"NCT07664228","I-FABP as a Predictor of Gastrointestinal Involvement in Pediatric IgA Vasculitis","The Role of Intestinal Fatty Acid Binding Protein in Predicting Gastrointestinal Involvement in Pediatric IgA Vasculitis","IFABP-IgAV","Inclusion Criteria:\n\n* Diagnosis of IgA vasculitis (Henoch-Schönlein purpura) according to EULAR\u002FPRINTO\u002FPRES classification criteria.\n* Age between 2 and 18 years.\n* Availability for blood sample collection at diagnosis (baseline visit).\n* Ability to attend a routine follow-up visit approximately 2-4 weeks after diagnosis.\n* Parent or legal guardian able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Refusal of informed consent by the parent\u002Flegal guardian.\n* Inability to obtain a baseline blood sample.\n* Inability to complete study follow-up procedures.","ALL","2 Years","18 Years",{"count":22,"type":23},100,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate plasma intestinal fatty acid-binding protein (I-FABP) levels in children with IgA vasculitis and investigate their association with gastrointestinal involvement. Blood samples will be collected at diagnosis and during follow-up 2-4 weeks later. The study will assess the potential value of plasma I-FABP as a biomarker for gastrointestinal involvement in pediatric IgA vasculitis.",[27,28],"IgA Vasculitis","Gastrointestinal Involvement",[27,30,31,32,28,33,34],"Henoch-Schönlein Purpura","I-FABP","Intestinal Fatty Acid Binding Protein","Children","Pediatric Rheumatology","RECRUITING","2026-06-17",{"date":38,"type":39},"2026-06-24","ACTUAL",{"date":41,"type":39},"2026-05-15",{"date":43,"type":23},"2027-05-15",{"name":45,"class":46},"Bursa City Hospital","OTHER_GOV",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100637429","individualized-peep-and-pulmonary-complications-in-on-pump-cabg-100637429","NCT07623109","Individualized PEEP and Pulmonary Complications in On-Pump CABG","Effect of Individualized PEEP Guided by Driving Pressure and Mechanical Power on Postoperative Pulmonary Complications in On-Pump CABG: A Randomized Controlled Trial","Patients with ASA physical status II-III who are scheduled to undergo elective open-heart surgery via on-pump median sternotomy will be included in the study.\n\nPatients scheduled for emergency surgery, those planned to undergo off-pump cardiac surgery, patients with a history of myocardial infarction within the last 3 months, patients with advanced COPD, patients with an ARISCAT score of 44 or higher, patients with a BMI of 35 kg\u002Fm² or higher, patients with NYHA class IV status, patients receiving preoperative immunotherapy, and patients with severe hepatic or renal failure will be excluded from the study.","80 Years",{"count":57,"type":23},80,"INTERVENTIONAL",[60],"NA","Postoperative pulmonary complications (PPCs) are an important cause of morbidity and mortality after major surgery and are frequently observed in cardiac surgery patients undergoing cardiopulmonary bypass (CPB). These complications are associated with prolonged mechanical ventilation, longer intensive care unit and hospital stays, increased healthcare costs, and higher mortality (1,2).\n\nIntraoperative lung-protective ventilation strategies have traditionally focused on individual parameters such as low tidal volume, positive end-expiratory pressure (PEEP), plateau pressure, and driving pressure. However, the effects of these parameters on postoperative pulmonary outcomes in cardiac surgery patients remain unclear. In particular, PEEP- and driving pressure-guided approaches are controversial in terms of feasibility and safety in patients undergoing CPB, who may be hemodynamically vulnerable.\n\nMechanical power is a comprehensive parameter that reflects the total energy delivered to the respiratory system per unit of time by integrating ventilatory variables such as tidal volume, airway pressures, respiratory rate, and flow. Therefore, mechanical power may provide a more comprehensive assessment of the mechanical load applied to the lungs compared with individual ventilatory parameters. Previous studies have reported that higher mechanical power values may be associated with lung injury, postoperative pulmonary complications, and mortality (3).\n\nThe aim of this study is to evaluate the effect of monitoring mechanical power during perioperative mechanical ventilation on postoperative pulmonary complications in patients undergoing cardiac surgery with cardiopulmonary bypass. The study hypothesis is that a mechanical power-based ventilation approach may reduce the incidence of PPCs compared with strategies based on conventional ventilation parameters.",[63,64,65],"Cardiac Surgery","Mechanical Power","Postoperative Pulmonary Complications (PPCs)",[67,68,69],"cardica surgery","mechanical power","postoperative pulmonary complications","NOT_YET_RECRUITING","2026-06-01",{"date":73,"type":39},"2026-06-03",{"date":41,"type":23},{"date":76,"type":23},"2026-07-15",{"name":45,"class":46},{"id":79,"slug":80,"hasResults":12,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":58,"phases":88,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":105,"locationsCount":47},"100627309","minimum-effective-volume-of-bupivacaine-for-serratus-posterior-superior-intercostal-plane-block-in-video-assisted-thoracoscopic-surgery-100627309","NCT07446959","Minimum Effective Volume of Bupivacaine for Serratus Posterior Superior Intercostal Plane Block in Video-Assisted Thoracoscopic Surgery","Determination of the Median Effective Volume (ED50) of Bupivacaine for Serratus Posterior Superior Intercostal Plane Block in Patients Undergoing Video-Assisted Thoracoscopic Surgery Using the Dixon Up-and-Down Method","SPSIP-EV50","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective video-assisted thoracoscopic surgery (VATS)\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Planned to receive ultrasound-guided serratus posterior superior intercostal plane block for postoperative analgesia\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy or contraindication to local anesthetics\n* Infection at the block injection site\n* Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia\n* Severe respiratory insufficiency\n* Chronic opioid use or chronic pain syndrome\n* Pregnancy\n* Inability to cooperate or communicate postoperative pain scores",{"count":87,"type":23},27,[60],"This study aims to determine the minimum effective volume of bupivacaine required for the serratus posterior superior intercostal plane (SPSIP) block in patients undergoing video-assisted thoracoscopic surgery (VATS). The SPSIP block is an ultrasound-guided regional anesthesia technique used to provide postoperative pain relief after thoracic surgery.\n\nUsing a stepwise dose-adjustment method, the volume of local anesthetic will be increased or decreased based on the effectiveness of the block in each patient. The main outcome of the study is to identify the volume that provides effective pain control in 50% of patients. The results may help optimize pain management while minimizing drug exposure.",[91,92],"Postoperative Pain Management","Video-assisted Thoracoscopic Surgery (VATS)",[94,95,96,97,98],"SPSIP Block","Regional Anesthesia","Dose-Finding Study","Dixon Up-and-Down Method","Thoracic Analgesia","2026-05-11",{"date":101,"type":39},"2026-05-12",{"date":103,"type":39},"2026-03-15",{"date":76,"type":23},{"name":45,"class":46},{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":129,"leadSponsor":130,"locationsCount":47},"100635073","tmh-and-ultrasound-for-difficult-airway-prediction-100635073","NCT07547943","TMH And Ultrasound For Difficult Airway Prediction","Comparative Evaluation Of Thyromental Height And Ultrasonographic Airway Measurements In Predicting Difficult Airway: A Prospective Observational Study","TMH-USG","Inclusion Criteria:\n\nAdult patients aged 18 years and older Patients scheduled for elective surgery under general anesthesia Patients requiring endotracheal intubation Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients with known upper airway pathology (e.g., tumor, trauma, infection) Patients with previous head and neck surgery or anatomical deformity affecting airway evaluation Patients with limited mouth opening (\\\u003C3 cm) or severe cervical spine restriction Patients with contraindications to ultrasonographic examination Patients requiring rapid sequence induction or emergency surgery Patients who refuse to participate",{"count":115,"type":23},240,"This prospective observational study aims to evaluate the predictive value of thyromental height (TMH) and ultrasonographic airway measurements in predicting difficult airway in adult patients undergoing elective surgery under general anesthesia.\n\nPreoperative airway assessment will include standard clinical evaluation, TMH measurement, and ultrasonographic measurements of anterior neck soft tissue. Perioperative airway management data, including intubation difficulty, number of attempts, and Cormack-Lehane classification, will be recorded.\n\nThe relationship between preoperative measurements and difficult airway will be analyzed to determine their predictive accuracy and clinical usefulness.",[118,119],"Difficult Airway","Airway Management",[121,122,123,124],"Thyromental Height","Airway Ultrasound","Difficult Intubation","Cormack-Lehane","2026-04-17",{"date":127,"type":39},"2026-04-23",{"date":41,"type":23},{"date":43,"type":23},{"name":45,"class":46},{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":55,"enrollmentInfo":138,"targetDuration":4,"studyType":58,"phases":139,"briefSummary":140,"conditions":141,"keywords":144,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":47},"100624466","ultrasound-guided-quadro-iliac-plane-block-for-pain-management-after-total-hip-arthroplasty-100624466","NCT07410000","Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty","Effectiveness of Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty: A Prospective Randomized Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) classification I-III\n* Age between 18 and 80 years\n* Patients scheduled for elective primary total hip arthroplasty\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Allergy to local anesthetics or opioids\n* Known or suspected coagulopathy\n* Infection at the injection site\n* History of previous hip surgery\n* Severe cardiovascular disease\n* Liver or kidney failure\n* Pregnancy, suspected pregnancy, or breastfeeding\n* Severe neurological or psychiatric disorder\n* Chronic opioid use",{"count":22,"type":23},[60],"This prospective, randomized, double-blind study evaluates the analgesic effectiveness of the ultrasound-guided Quadro-Iliac Plane (QIP) block in patients undergoing primary total hip arthroplasty. The QIP block is a recently described fascial plane block. Patients will be randomized to receive either a QIP block with local anesthetic or a sham block with saline. The primary outcome is 24-hour opioid consumption. Secondary outcomes include motor block, dermatomal sensory assessment, pain scores, rescue analgesic requirement, quality of recovery (QoR-15), and opioid-related side effects.",[142,143],"Pain Management","Total Hip Arthroplasty",[143,145,146],"Postoperative Analgesia","Quadro-Iliac Plane Block","2026-03-26",{"date":149,"type":39},"2026-03-27",{"date":151,"type":39},"2026-03-16",{"date":153,"type":23},"2027-03-15",{"name":45,"class":46},{"id":156,"slug":157,"hasResults":12,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":58,"phases":164,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":172,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":47},"100629869","mtlip-vs-qipb-for-postoperative-analgesia-in-lumbar-microdiscectomy-surgery-100629869","NCT07480278","mTLIP vs QIPB for Postoperative Analgesia in Lumbar Microdiscectomy Surgery","Comparison of Ultrasound-Guided Modified Thoracolumbar Interfascial Plane Block Versus Quadro-Iliac Plane Block for Postoperative Analgesia in Patients Undergoing Lumbar Microdiscectomy","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Classified as American Society of Anesthesiologists physical status I-III\n* Scheduled for elective lumbar microdiscectomy surgery under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Use of anticoagulant medications or presence of bleeding diathesis\n* Known allergy or hypersensitivity to local anesthetics or opioid drugs\n* Infection at the planned block site\n* Alcohol or drug dependence\n* Cognitive impairment preventing reliable pain assessment\n* Pregnancy or lactation\n* History of previous lumbar spine surgery\n* Diabetes mellitus\n* Renal or hepatic insufficiency","65 Years",{"count":57,"type":23},[60],"The aim of this prospective randomized clinical study is to compare the analgesic efficacy and side effects of modified thoracolumbar interfascial plane block and quadroiliac plane block applied preoperatively in patients undergoing lumbar microdiscectomy surgery.The study will include a total of 80 patients aged 18-65 years with ASA I-III, with 40 patients in each group( Group mTLIP and Group QIPB) undergoing lumbar microdiscectomy surgery.\n\nThe primary objective of the study is to compare groups in terms of PCA opioid consumption during the 48-hour postoperative period. Secondary objectives are to compare groups in terms of QoR-15 recovery score, dynamic and static numerical rating scale scores, total rescue analgesic use, time to first request for rescue analgesia, length of hospital stay, block and opioid-related side effects and complications, and perioperative remifentanil infusion dose.",[91],[168,169,170,171],"Postoperative pain","Quadro-iliac plane block","Lumbar Microdiscectomy","Modified thoracolumbar interfascial plane block",{"date":149,"type":39},{"date":174,"type":39},"2026-03-25",{"date":176,"type":23},"2026-09-01",{"name":45,"class":46},{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":162,"enrollmentInfo":185,"targetDuration":4,"studyType":58,"phases":186,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":47},"100620204","erector-spinae-plane-block-vs-quadro-iliac-plane-block-after-lumbar-instrumentation-surgery-100620204","NCT07354581","Erector Spinae Plane Block vs Quadro-Iliac Plane Block After Lumbar Instrumentation Surgery","Comparison of Ultrasound-Guided Erector Spinae Plane Block and Quadro-Iliac Plane Block for Postoperative Analgesia Management Following Lumbar Instrumentation Surgery","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Classified as American Society of Anesthesiologists physical status I-III\n* Scheduled for elective lumbar instrumentation surgery under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Use of anticoagulant medications or presence of bleeding diathesis\n* Known allergy or hypersensitivity to local anesthetics or opioid drugs\n* Infection at the planned block site\n* Alcohol or drug dependence\n* Cognitive impairment preventing reliable pain assessment\n* Pregnancy or lactation\n* History of previous lumbar spine surgery\n* Diabetes mellitus\n* Renal or hepatic insufficiency",{"count":57,"type":23},[60],"Lumbar instrumentation surgery is associated with significant postoperative pain. This study compares the postoperative analgesic effectiveness of ultrasound-guided Erector Spinae Plane Block and Quadro-Iliac Plane Block in patients undergoing lumbar instrumentation surgery.",[189],"Pain, Postoperative",[191,192,193,146],"Lumbar instrumentation","Postoperative pain management","Erector Spinae Block",{"date":195,"type":39},"2026-03-31",{"date":197,"type":39},"2026-01-20",{"date":199,"type":23},"2026-07-01",{"name":45,"class":46},{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":162,"enrollmentInfo":209,"targetDuration":4,"studyType":58,"phases":210,"briefSummary":211,"conditions":212,"keywords":216,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":220,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":47},"100623287","ultrasound-guided-serratus-posterior-superior-intercostal-plane-block-for-analgesia-in-arthroscopic-shoulder-surgery-100623287","NCT07394673","Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Analgesia in Arthroscopic Shoulder Surgery","Postoperative Analgesic Efficacy of Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block in Arthroscopic Shoulder Surgery","SPSIP","Inclusion Criteria:\n\n* Classified as American Society of Anesthesiologists (ASA) physical status I-II-III\n* Scheduled for elective shoulder arthroscopy surgery\n* Surgery performed under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Use of anticoagulant or antiplatelet medications\n* Presence of bleeding diathesis or coagulation disorders\n* Known allergy or hypersensitivity to local anesthetics or opioid medications\n* Infection or history of previous surgery at the planned block site\n* Alcohol or drug dependence\n* Cognitive impairment preventing reliable pain assessment using the NRS\n* Pregnancy or lactation\n* Diabetes mellitus\n* Renal or hepatic impairment",{"count":57,"type":23},[60],"This study aimed to evaluate the effectiveness of serratus posterior superior intercostal plane (SPSIP) block in managing postoperative pain in patients undergoing arthroscopic shoulder surgery.",[213,214,215],"Postoperative Pain, Acute","Shoulder Pain","Serratus Posterior Superior Intercostal Plane Block",[217,218,219],"postoperative analgesia","shoulder arthroscopy","serratus posterior superior intercostal plane block",{"date":149,"type":39},{"date":222,"type":39},"2026-02-20",{"date":224,"type":23},"2026-07-20",{"name":45,"class":46},{"id":227,"slug":228,"hasResults":12,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":233,"enrollmentInfo":234,"targetDuration":4,"studyType":58,"phases":236,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":246,"leadSponsor":248,"locationsCount":47},"100630028","impact-of-different-fasting-strategies-on-gastric-ultrasound-and-anxiety-levels-in-children-100630028","NCT07482345","Impact of Different Fasting Strategies on Gastric Ultrasound and Anxiety Levels in Children","Impact of Three Different Preoperative Fasting Strategies on Gastric Ultrasound Findings and Anxiety Levels in Children Undergoing Inguinoscrotal Surgery: A Prospective Randomized Trial","Inclusion Criteria:\n\n* Patients scheduled to undergo elective surgery under general anesthesia for circumcision, undescended testis, inguinal hernia, and\u002For hypospadias (inguinoscrotal surgery)\n* Patients with an ASA physical status classification of I-II\n* Patients able to tolerate oral intake in the preoperative period and comply with the assigned fasting protocol\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Patients with ASA physical status III or higher\n* Patients requiring emergency surgery\n* History of gastroesophageal reflux disease, gastrointestinal motility disorders, or metabolic\u002Fneurological diseases affecting gastric emptying\n* History of upper gastrointestinal surgery\n* Active upper respiratory tract infection or lower respiratory tract infection within the previous 2-4 weeks\n* Severe pulmonary disease, including uncontrolled or moderate-to-severe persistent asthma, bronchopulmonary dysplasia, cystic fibrosis, interstitial lung disease, or other chronic lung diseases\n* Diabetes mellitus or endocrine\u002Fmetabolic disorders that may affect perioperative glucose metabolism\n* Obese patients with high aspiration risk (\\>95th percentile for age)\n* Cognitive or communication impairments that may interfere with compliance with the study protocol\n* Grade 2 or Grade 3 gastric fullness detected on preoperative gastric ultrasonography\n* Lack of written informed consent from parents or legal guardians for participation in the study","12 Years",{"count":235,"type":23},90,[60],"Children who undergo surgery are usually asked to stop eating and drinking for several hours before anesthesia to reduce the risk of stomach contents entering the lungs. However, long fasting times may cause discomfort, dehydration, low blood sugar, and increased anxiety in children. Recent guidelines suggest that clear liquids can safely be allowed closer to the time of surgery, and some enhanced recovery protocols even recommend giving carbohydrate-containing drinks before anesthesia.\n\nThis study will compare three different preoperative fasting approaches in children undergoing elective inguinoscrotal surgery: traditional fasting, preoperative carbohydrate drinks, and the \"Sip-Til-Send\" approach, which allows clear fluids until the child is called to the operating room.\n\nThe children's anxiety levels will be evaluated before surgery using a validated anxiety scale and assess stomach content and volume using gastric ultrasound. The secondary outcomes such as nausea, vomiting, pain, emergence delirium, and blood glucose levels will be evaluated.\n\nThe results may help determine safer and more comfortable fasting strategies for children undergoing surgery.",[239,240,241],"Preoperative Fasting","Enhanced Recovery After Surgery (ERAS) Protocol","Pediatric Surgery","2026-03-19",{"date":244,"type":39},"2026-03-23",{"date":174,"type":23},{"date":247,"type":23},"2027-04-30",{"name":45,"class":46},{"id":250,"slug":251,"hasResults":12,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":55,"enrollmentInfo":256,"targetDuration":4,"studyType":58,"phases":257,"briefSummary":258,"conditions":259,"keywords":266,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":47},"100630652","intraoperative-ketamine-for-chronic-postoperative-pain-after-open-heart-surgery-100630652","NCT07490457","Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery","Effect of Intraoperative Ketamine Administration on Postoperative Chronic Pain in Patients Undergoing Open Cardiac Surgery","Inclusion Criteria:\n\n* ASA II-III,\n* Patients scheduled for elective on-pump open cardiac surgery via median sternotomy.\n\nExclusion Criteria:\n\n* Emergency surgery requirement\n* Need for reoperation\n* Requirement for postoperative re-intubation\n* History of opioid use\n* Preoperative diabetic neuropathy or autonomic dysfunction\n* Hepatic or renal dysfunction\n* History of neuropathic pain\n* Neurocognitive disorders such as psychosis or dementia\n* Use of antidepressants or antipsychotics\n* Body mass index (BMI) \\> 40",{"count":22,"type":23},[60],"The goal of this interventional study is to determine whether a single intraoperative IV dose of ketamine can reduce postoperative chronic and acute pain and postoperative opioid requirements in adult patients undergoing open-heart surgery under general anesthesia. The main questions it aims to answer are:\n\nPrimary outcome: Does a single-dose intraoperative IV ketamine reduce the presence and severity of pain at 3 and 6 months after surgery ? Secondary outcomes: Does it reduce acute postoperative pain scores, opioid consumption, and other recovery-related outcomes in the early postoperative period ? Researchers will compare a single-dose IV ketamine arm to a placebo arm to see if ketamine decreases chronic pain incidence at 3 and 6 months and improves acute pain\u002Fopioid-related outcomes.\n\nParticipants will:\n\nBe randomized to receive either a single IV bolus of ketamine or placebo during surgery.\n\nUndergo standard general anesthesia and open cardiac surgery per protocol. Have postoperative pain assessed using Numeric Rating Scale (NRS) at extubation, 0, 3, 6, 12, 24, and 48 hours.\n\nHave opioid and additional analgesic use recorded, time to first rescue analgesic noted, and ICU\u002Fhospital length of stay tracked.\n\nBe evaluated for ICU delirium (CAM-ICU) and complete Quality of Recovery-15, Brief Pain Inventory-Short Form, and Pain Self-Efficacy questionnaires.\n\nBe followed up at 3 and 6 months for assessment of chronic postoperative pain.",[260,261,262,263,264,265],"Cardiac Anaesthesia","Chronic Pain","Post Operative Pain, Chronic","Post Operative Pain, Acute","Ketamine","Pain",[267,268,269,270],"Postoperative chronic pain","ketamine","Open-heart surgery","Intraoperative ketamine","2026-03-18",{"date":273,"type":39},"2026-03-24",{"date":275,"type":23},"2026-04-15",{"date":277,"type":23},"2027-05",{"name":45,"class":46},{"id":280,"slug":281,"hasResults":12,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":162,"enrollmentInfo":287,"targetDuration":4,"studyType":58,"phases":288,"briefSummary":289,"conditions":290,"keywords":292,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":298,"leadSponsor":299,"locationsCount":47},"100621423","us-guided-quadro-iliac-plane-block-for-postoperative-analgesia-after-lumbar-instrumentation-100621423","NCT07370428","US-Guided Quadro-Iliac Plane Block for Postoperative Analgesia After Lumbar Instrumentation","Evaluation of the Effectiveness of Ultrasound-Guided Quadro-Iliac Plane Block in Postoperative Analgesia Management Following Lumbar Instrumentation Surgery","QIPB","Inclusion Criteria:\n\n* Classified as American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective lumbar instrumentation surgery\n* Surgery performed under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Use of anticoagulant or antiplatelet medications\n* Presence of bleeding diathesis or coagulation disorders\n* Known allergy or hypersensitivity to local anesthetics or opioid medications\n* Infection at the planned block site\n* Alcohol or drug dependence\n* Cognitive impairment preventing reliable pain assessment using the NRS\n* Pregnancy or lactation\n* History of previous lumbar spine surgery\n* Diabetes mellitus\n* Renal or hepatic impairment",{"count":57,"type":23},[60],"Lumbar instrumentation surgery is associated with significant postoperative pain. This study evaluates the analgesic effectiveness of the ultrasound-guided Quadro-Iliac Plane Block in patients undergoing lumbar instrumentation surgery, aiming to assess the efficacy of this newly developed technique for postoperative pain management.",[291],"Postoperative Pain",[146,293,142],"Lumbar Instrumentation Surgery","2026-03-05",{"date":296,"type":39},"2026-03-06",{"date":197,"type":39},{"date":199,"type":23},{"name":45,"class":46},{"id":301,"slug":302,"hasResults":12,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":162,"enrollmentInfo":306,"targetDuration":4,"studyType":58,"phases":307,"briefSummary":308,"conditions":309,"keywords":310,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":312,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":47},"100621422","mtlip-vs-qipb-for-postoperative-analgesia-after-lumbar-instrumentation-surgery-100621422","NCT07370415","mTLIP vs QIPB for Postoperative Analgesia After Lumbar Instrumentation Surgery","Comparison of Ultrasound-Guided Modified Thoracolumbar Interfascial Plane Block Versus Quadro-Iliac Plane Block for Postoperative Analgesia After Lumbar Instrumentation Surgery",{"count":57,"type":23},[60],"Lumbar instrumentation surgery is associated with severe postoperative pain due to extensive tissue dissection and prolonged muscle retraction during the procedure. Inadequate postoperative pain control may result in delayed mobilization, increased cardiopulmonary complications, and prolonged hospital stay. Ultrasound-guided regional analgesia techniques are increasingly used to improve postoperative pain management after lumbar spine surgery. The thoracolumbar interfascial plane (TLIP) block has been shown to provide effective analgesia for lumbar instrumentation surgery, and its modified technique (mTLIP) has been reported to enhance postoperative pain control. The quadro-iliac plane (QIP) block is a newly described fascial plane block with promising results in lumbar spine surgery. This randomized controlled trial aims to compare the postoperative analgesic effectiveness of the modified thoracolumbar interfascial plane block and the quadro-iliac plane block in patients undergoing lumbar instrumentation surgery.",[189],[311,291,171,169],"Lumbar instrumentation surgery",{"date":296,"type":39},{"date":314,"type":23},"2026-03-20",{"date":316,"type":23},"2026-09-30",{"name":45,"class":46},{"id":319,"slug":320,"hasResults":12,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":325,"sex":18,"minAge":20,"maxAge":162,"enrollmentInfo":326,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":328,"conditions":329,"keywords":331,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":4},"100626723","age-and-cally-index-in-familial-mediterranean-fever-100626723","NCT07439341","AGE and CALLY Index in Familial Mediterranean Fever","Association Between Skin Autofluorescence-Measured Advanced Glycation End Products and the CALLY Index in Patients With Familial Mediterranean Fever: A Cross-Sectional Controlled Study","Inclusion Criteria:\n\nFor FMF Patients:\n\n* Age between 18 and 65 years\n* Diagnosis of Familial Mediterranean Fever according to Tel-Hashomer criteria\n* At least 6 months of clinical follow-up\n* Available routine laboratory data (CRP, albumin, lymphocyte count)\n* Not in an acute FMF attack at the time of assessment\n* Ability to provide written informed consent\n\nFor Healthy Controls:\n\n* Age between 18 and 65 years\n* No history of chronic inflammatory, autoimmune, metabolic, or renal disease\n* Ability to provide written informed consent\n\nExclusion Criteria :\n\n* Diagnosis of diabetes mellitus\n* Chronic kidney disease stage 3 or higher\n* Active infection\n* Malignancy within the past 5 years\n* Dermatologic condition affecting the forearm measurement site\n* Use of high-dose antioxidant or vitamin supplementation within the past 3 months\n* Any condition that, in the opinion of the investigators, may interfere with study participation",true,{"count":327,"type":23},150,"Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent inflammatory attacks and persistent low-grade inflammation. Even during attack-free periods, subclinical inflammation may continue and contribute to long-term complications.\n\nAdvanced glycation end products (AGEs) are molecules that accumulate under chronic inflammatory and oxidative stress conditions. AGEs can be measured non-invasively using skin autofluorescence (SAF). The C-reactive protein-albumin-lymphocyte (CALLY) index is a composite marker derived from routine laboratory parameters and reflects systemic inflammation and nutritional status.\n\nThis observational cross-sectional study aims to evaluate the association between skin autofluorescence-measured AGE levels and the CALLY index in patients with FMF. The study will also compare AGE levels between FMF patients and age- and sex-matched healthy controls.\n\nThe study does not involve any intervention, treatment assignment, or randomization. All laboratory parameters will be obtained from routine clinical evaluations, and AGE measurement will be performed using a non-invasive device.",[330],"Familial Mediterranean Fever",[332,333,334,335,336],"Advanced Glycation End Products","Skin Autofluorescence","CALLY Index","Amyloidosis","Inflammatory Biomarkers","2026-02-23",{"date":339,"type":39},"2026-02-27",{"date":341,"type":23},"2026-02-01",{"date":343,"type":23},"2026-11-01",{"name":45,"class":46},{"id":346,"slug":347,"hasResults":12,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":351,"eligibilityCriteria":352,"healthyVolunteers":12,"sex":353,"minAge":20,"maxAge":354,"enrollmentInfo":355,"targetDuration":4,"studyType":58,"phases":356,"briefSummary":357,"conditions":358,"keywords":360,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":367,"completionDateStruct":368,"leadSponsor":370,"locationsCount":47},"100624583","comparison-of-combined-spinal-epidural-analgesia-and-erector-spinae-plane-block-after-elective-cesarean-section-100624583","NCT07411521","Comparison of Combined Spinal Epidural Analgesia and Erector Spinae Plane Block After Elective Cesarean Section","Comparison of the Postoperative Analgesic Effectiveness of Combined Spinal Epidural Analgesia and Erector Spinae Plane Block in Elective Cesarean Section","CSEA-ESP-CS","Inclusion Criteria:\n\nFemale patients aged 18-45 years\n\nScheduled for elective cesarean section under regional anesthesia\n\nAmerican Society of Anesthesiologists (ASA) physical status I-II\n\nSingleton pregnancy at term gestation\n\nAbility to understand the study protocol and provide written informed consent\n\nExclusion Criteria:\n\nRefusal to participate in the study\n\nContraindications to regional anesthesia (coagulopathy, infection at injection site, severe hypovolemia)\n\nKnown allergy to local anesthetics or study medications\n\nBody mass index (BMI) \\> 40 kg\u002Fm²\n\nChronic opioid use or chronic pain disorders\n\nNeurological disorders affecting sensory assessment\n\nSevere obstetric complications (e.g., preeclampsia, placenta previa, fetal distress)","FEMALE","45 Years",{"count":235,"type":23},[60],"Postoperative pain after cesarean section can significantly affect maternal recovery, early mobilization, and patient satisfaction. Regional anesthesia techniques are widely used to improve postoperative analgesia and reduce opioid consumption.\n\nCombined spinal-epidural analgesia is commonly used for cesarean section and provides effective pain control but may be associated with technical difficulties and potential complications. The erector spinae plane block is a newer ultrasound-guided regional anesthesia technique that has shown promising results for postoperative pain management in various surgical procedures.\n\nThe aim of this study is to compare the postoperative analgesic effectiveness of combined spinal-epidural analgesia and the erector spinae plane block in patients undergoing elective cesarean section.\n\nPain intensity will be assessed using the visual analog scale at multiple postoperative time points. Maternal recovery will be evaluated using the Obstetric Quality of Recovery-11 questionnaire. Secondary outcomes will include postoperative nausea, pruritus, time to first analgesic request, mobilization time, and patient satisfaction.\n\nThis study will help determine whether the erector spinae plane block can provide comparable or improved postoperative pain control with fewer complications compared to combined spinal-epidural analgesia.",[359],"Postoperative Pain After Cesarean Section",[361,362,363,91,95],"Cesarean Section","Combined Spinal Epidural Analgesia","Erector Spinae Plane Block","2026-02-11",{"date":366,"type":39},"2026-02-17",{"date":103,"type":23},{"date":369,"type":23},"2026-08-15",{"name":45,"class":46},{"id":372,"slug":373,"hasResults":12,"nctId":374,"briefTitle":375,"officialTitle":376,"acronym":4,"eligibilityCriteria":377,"healthyVolunteers":12,"sex":18,"minAge":378,"maxAge":379,"enrollmentInfo":380,"targetDuration":4,"studyType":58,"phases":381,"briefSummary":382,"conditions":383,"keywords":385,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":390,"startDateStruct":392,"completionDateStruct":394,"leadSponsor":395,"locationsCount":4},"100587197","considering-peripheral-nerve-injury-is-it-safe-to-perform-transradial-angiography-100587197","NCT06925256","Considering Peripheral Nerve Injury, Is It Safe to Perform Transradial Angiography?","Considerin Peripheral Nerve Injury, Is It Safe to Perform Transradial Angiography?","Inclusion Criteria:\n\n20-60 years old patiens who applied trans angiograhy were included to study\n\nExclusion Criteria:\n\n* Having cognitive disorders\n* Patients who have story of cardiac pace \u002F ICD,\n* History of polyneuropathy,\n* Previous nerve damages,\n* Deformities on arm,\n* Plexopathy,\n* Radiculopathy,\n* Spinal surgery.\n* Having medical treatment for any kind of neuropathy\n* Having Cognitive disorders","20 Years","60 Years",{"count":22,"type":23},[60],"So far, apart from a limited number of case reports and small-scale studies, the frequency and severity of this complication have not been objectively evaluated using electromyography (EMG). In this study, presence, severity, and extent of nerve injury (one of the potential complications following the transradial approach (TRA)) were evaluated by EMG studies in patients managed at Bursa City Hospital.",[384],"Neuropathic Peripheral Pain",[386,387,388],"Nerve Conduction Studies","Nerve damage","Transradial angiography","2026-02-03",{"date":391,"type":39},"2026-02-04",{"date":393,"type":23},"2026-04-01",{"date":247,"type":23},{"name":45,"class":46},{"id":397,"slug":398,"hasResults":12,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":403,"targetDuration":4,"studyType":58,"phases":405,"briefSummary":406,"conditions":407,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":412,"startDateStruct":414,"completionDateStruct":416,"leadSponsor":418,"locationsCount":4},"100618672","postural-kinesio-taping-in-stroke-rehabilitation-100618672","NCT07334665","Postural Kinesio Taping in Stroke Rehabilitation","Effects of Posture-Oriented Kinesio Taping on Mobility, Balance, Coordination, and Activities of Daily Living in Patients With Stroke: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosis of ischemic or hemorrhagic stroke confirmed clinically and\u002For radiologically\n* In the subacute or chronic phase of stroke (≥1 month post-stroke) and clinically stable\n* Presence of postural control and\u002For trunk control impairment\n* Ability to participate in a standard neurological rehabilitation program\n* No severe cognitive impairment or communication disorder that would interfere with outcome assessments\n* Intact skin at the kinesio taping application sites\n* Willingness to participate and provision of written informed consent\n\nExclusion Criteria:\n\n* Acute stroke phase or clinical instability\n* Severe cognitive impairment, aphasia, or insufficient cooperation that would interfere with reliable outcome assessments\n* Known allergy or hypersensitivity to kinesio tape\n* Active dermatological conditions at taping sites (e.g., open wounds, dermatitis, infection)\n* Severe spasticity (Modified Ashworth Scale ≥3)\n* Presence of other neurological disorders affecting balance or mobility (e.g., Parkinson's disease, multiple sclerosis)\n* Severe orthopedic conditions or cardiopulmonary diseases limiting participation in rehabilitation\n* Receipt of posture-oriented kinesio taping within the previous 3 months\n* Concurrent participation in another interventional clinical study that could influence study outcomes",{"count":404,"type":23},60,[60],"Stroke often leads to postural asymmetry and impaired trunk control, which negatively affect mobility, balance, coordination, and activities of daily living. These impairments increase the risk of falls and reduce functional independence during the rehabilitation process.\n\nThe purpose of this randomized controlled trial is to investigate the effects of posture-oriented kinesio taping, applied in addition to standard neurological rehabilitation, on functional outcomes in patients with stroke. Participants will be randomly assigned to either an intervention group receiving kinesio taping plus standard rehabilitation or a control group receiving standard rehabilitation alone.\n\nFunctional outcomes including trunk control, postural stability, balance, mobility, and activities of daily living will be assessed using validated clinical scales at baseline and after the intervention period. The findings of this study are expected to provide evidence regarding the clinical effectiveness of posture-oriented kinesio taping as a non-invasive and easily applicable adjunct treatment in stroke rehabilitation.",[408,409,410],"Stroke","Hemiplegia","Postural Control","2026-01-10",{"date":413,"type":39},"2026-01-13",{"date":415,"type":23},"2026-01-30",{"date":417,"type":23},"2027-01-30",{"name":45,"class":46},{"id":420,"slug":421,"hasResults":12,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":325,"sex":18,"minAge":20,"maxAge":426,"enrollmentInfo":427,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":429,"conditions":430,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":445,"locationsCount":4},"100618279","skin-autofluorescence-assessment-of-advanced-glycation-end-products-in-rheumatic-diseases-100618279","NCT07329556","Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic Diseases","Evaluation of Advanced Glycation End Products Accumulation in Rheumatic Diseases Using Non-Invasive Skin Autofluorescence Measurements","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* Diagnosis of an inflammatory rheumatic disease (including rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, reactive arthritis, connective tissue diseases, Behçet disease, familial Mediterranean fever, or crystal arthropathies), confirmed by a rheumatologist\n* Healthy volunteers without a history of rheumatic or chronic inflammatory disease (for the control group)\n* Ability to undergo non-invasive skin autofluorescence measurement\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Diagnosis of diabetes mellitus (type 1 or type 2)\n* Chronic kidney disease with estimated glomerular filtration rate (eGFR) \\\u003C 60 mL\u002Fmin\u002F1.73 m²\n* Active malignancy or history of malignancy within the past 5 years\n* Presence of acute infection or acute inflammatory condition at the time of assessment\n* Secondary causes of systemic inflammation unrelated to the underlying rheumatic disease (e.g., uncontrolled endocrine disorders, chronic liver disease)\n* Use of medications known to markedly affect AGE accumulation or skin autofluorescence measurements (e.g., recent high-dose systemic glucocorticoids)\n* Pregnancy or breastfeeding\n* Presence of significant skin conditions (e.g., extensive dermatitis, scars, tattoos, or burns) at the measurement site that may interfere with skin autofluorescence assessment\n* Inability to comply with study procedures or to provide informed consent","75 Years",{"count":428,"type":23},300,"Rheumatic diseases are chronic inflammatory conditions that can lead to long-term tissue damage and increased cardiovascular and metabolic risk. Advanced glycation end products (AGEs) are harmful molecules that accumulate in the body over time and are known to promote inflammation and oxidative stress. Increased AGE burden has been implicated in several chronic diseases; however, its role in rheumatic diseases has not been fully clarified.\n\nThis observational, cross-sectional study aims to evaluate the accumulation of AGEs in patients with various rheumatic diseases compared with healthy individuals. AGE levels will be assessed non-invasively using skin autofluorescence measurements.\n\nBy comparing AGE burden between patients and healthy controls, this study seeks to improve understanding of the potential role of AGEs in the pathophysiology of rheumatic diseases and to explore their usefulness as a non-invasive biomarker in clinical practice.",[431,432,433,434,435,436,437],"Rheumatoid Arthritis (RA","Ankylosing Spondylitis","Psoriatic Arthritis","Reactive Arthritis (ReA)","Crystal Arthropathies","Connective Tissue Diseases","Familial Mediterranean Fever (FMF )","2026-01-08",{"date":440,"type":39},"2026-01-09",{"date":442,"type":23},"2026-01-15",{"date":444,"type":23},"2027-04-15",{"name":45,"class":46},{"id":447,"slug":448,"hasResults":12,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":12,"sex":18,"minAge":453,"maxAge":4,"enrollmentInfo":454,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":455,"conditions":456,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":459,"startDateStruct":460,"completionDateStruct":461,"leadSponsor":462,"locationsCount":4},"100618278","age-burden-and-response-to-antiresorptive-therapy-in-osteoporosis-100618278","NCT07329543","AGE Burden and Response to Antiresorptive Therapy in Osteoporosis","Association of Advanced Glycation End-Product Burden With Response to Antiresorptive Therapy and Residual Fracture Risk in Osteoporosis: A Prospective Cohort Study","Inclusion Criteria:\n\n* Age ≥ 50 years\n* Diagnosis of osteoporosis based on dual-energy X-ray absorptiometry (DXA) criteria (T-score ≤ -2.5 at the lumbar spine, total hip, or femoral neck) or presence of a prior fragility fracture\n* Planned initiation of antiresorptive therapy (denosumab or bisphosphonate) as part of routine clinical care\n* Ability to undergo DXA measurements at baseline and during follow-up\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Diagnosis of diabetes mellitus (type 1 or type 2)\n* Chronic kidney disease with estimated glomerular filtration rate (eGFR) \\\u003C 60 mL\u002Fmin\u002F1.73 m²\n* Active malignancy or history of malignancy within the past 5 years\n* Secondary causes of osteoporosis (including hyperparathyroidism, hyperthyroidism, Cushing's syndrome, malabsorption syndromes, or chronic liver disease)\n* Use of medications known to significantly affect bone metabolism other than antiresorptive therapy (e.g., long-term systemic glucocorticoids, anabolic osteoporosis agents)\n* Prior treatment with denosumab or bisphosphonates within the last 12 months\n* Inflammatory rheumatic diseases or chronic inflammatory conditions that may affect bone metabolism\n* Pregnancy or breastfeeding\n* Inability to comply with study procedures or follow-up visits","50 Years",{"count":115,"type":23},"Osteoporosis is a common condition that increases the risk of bone fractures. Although antiresorptive treatments such as bisphosphonates and denosumab are effective in increasing bone mineral density, some patients continue to experience fractures despite treatment.\n\nAdvanced glycation end-products (AGEs) accumulate in the body over time and can negatively affect bone quality by altering collagen structure and increasing inflammation. The role of AGE burden in predicting response to osteoporosis treatment has not been fully established.\n\nThis prospective cohort study aims to evaluate whether baseline AGE burden, measured non-invasively using skin autofluorescence, is associated with treatment response in patients receiving antiresorptive therapy for osteoporosis. Changes in bone mineral density, bone turnover markers, and fracture outcomes will be analyzed in relation to baseline AGE levels. The results of this study may help identify patients at risk for reduced treatment response and residual fracture risk.",[457,458],"Osteoporosis","Postmenopausal Osteoporosis",{"date":440,"type":39},{"date":442,"type":23},{"date":444,"type":23},{"name":45,"class":46},{"id":464,"slug":465,"hasResults":12,"nctId":466,"briefTitle":467,"officialTitle":468,"acronym":4,"eligibilityCriteria":469,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":162,"enrollmentInfo":470,"targetDuration":4,"studyType":58,"phases":471,"briefSummary":472,"conditions":473,"keywords":475,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":47},"100614088","analgesic-efficacy-of-spsip-block-versus-paravertebral-block-following-thoracotomy-100614088","NCT07275047","Analgesic Efficacy of SPSIP Block Versus Paravertebral Block Following Thoracotomy","Comparison of Ultrasound Guided Serratus Posterior Superior Intercostal Plane Block Versus Paravertebral Block for Postoperative Analgesia After Thoracotomy","Inclusion Criteria:\n\n* Scheduled to undergo thoracotomy\n* ASA physical status I-III according to the American Society of Anesthesiologists classification\n* Able to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Declines or is unable to provide informed consent\n* Allergy or hypersensitivity to local anesthetics or opioids\n* Known or suspected coagulopathy\n* Infection at the injection site\n* History of thoracic surgery\n* Severe cardiovascular disease\n* Hepatic or renal failure\n* Pregnant, suspected pregnancy, or breastfeeding\n\nSignificant neurological or psychiatric disorder that may interfere with study participatio",{"count":57,"type":23},[60],"Thoracotomy causes severe postoperative pain that may impair respiratory function and increase complications. This study compares the postoperative analgesic effectiveness of the serratus posterior superior intercostal plane (SPSIP) block and the paravertebral block in patients undergoing thoracotomy. The aim is to determine whether the newly described serratus posterior superior intercostal plane block can serve as a safe and effective alternative to established techniques.",[474],"Post-thoracotomy Pain",[476,477,478,479],"Post-thoracotomy pain","Serratus posterior superior intercostal plane block","Paravertebral Block","Pain management","2025-12-22",{"date":482,"type":39},"2025-12-23",{"date":484,"type":39},"2025-12-15",{"date":486,"type":23},"2026-12-15",{"name":45,"class":46},{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":162,"enrollmentInfo":495,"targetDuration":4,"studyType":58,"phases":496,"briefSummary":497,"conditions":498,"keywords":499,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":506,"completionDateStruct":508,"leadSponsor":509,"locationsCount":47},"100610850","esp-vs-spsip-block-in-vats-analgesia-100610850","NCT07232940","ESP vs SPSIP Block in VATS Analgesia","Comparison of the Effects of Ultrasound-Guided Erector Spinae Plane Block and Serratus Posterior Superior Intercostal Plane Block on Postoperative Analgesia Management in Patients Undergoing Video-Assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* Patients aged 18-65 years with ASA physical status I-III who will undergo elective video-assisted thoracoscopic surgery (VATS) will be included.\n\nExclusion Criteria:\n\n* Patients who do not consent to participate in the study\n\nPatients with coagulopathy\n\nPatients with a history of local anesthetic allergy or toxicity\n\nPatients with hepatic or renal failure\n\nPatients with uncontrolled diabetes\n\nPatients with uncontrolled hypertension\n\nMentally disabled patients\n\nPatients receiving chronic pain treatment (opioid users)\n\nPatients using antidepressant medication\n\nPatients with neuropathic pain\n\nMentally disabled patients\n\nPresence of infection at the injection site\n\nPregnant or breastfeeding women, or those with suspected pregnancy",{"count":235,"type":23},[60],"Video-assisted thoracoscopic surgery (VATS) is a minimally invasive procedure performed through small thoracic incisions, but postoperative pain remains significant due to tissue and rib trauma. Poorly controlled pain may lead to chronic postoperative pain; therefore, optimal analgesia is essential.\n\nAccording to PROSPECT guidelines, erector spinae plane block (ESPB) or paravertebral block (PVB) are recommended for VATS. The recently defined serratus posterior superior intercostal plane block (SPSIPB) provides analgesia between C3-T10 levels, but its efficacy compared with ESPB has not been studied.\n\nThis study aims to compare postoperative analgesic efficacy and patient satisfaction between ESPB and SPSIPB in VATS patients.",[92,215],[477,500,501,502],"erector spinae plane block","pain management","Video-assisted thoracoscopic surgery (VATS)","2025-12-14",{"date":505,"type":39},"2025-12-16",{"date":507,"type":39},"2025-11-15",{"date":41,"type":23},{"name":45,"class":46},{"id":511,"slug":512,"hasResults":12,"nctId":513,"briefTitle":514,"officialTitle":515,"acronym":4,"eligibilityCriteria":516,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":517,"enrollmentInfo":518,"targetDuration":4,"studyType":58,"phases":519,"briefSummary":520,"conditions":521,"keywords":523,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":530,"leadSponsor":531,"locationsCount":4},"100610853","m-tapa-block-for-analgesia-after-open-heart-surgery-100610853","NCT07232979","M-TAPA Block for Analgesia After Open-Heart Surgery","The Effectiveness of the Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) on Postoperative Analgesia and Recovery in Open-Heart Surgery: A Prospective, Double-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18 to 85 years with ASA physical status II-III who are scheduled to undergo elective open-heart surgery will be included.\n\nExclusion Criteria:\n\nPatients who refuse to participate in the study\n\nPatients with coagulopathy\n\nPatients with a history of allergy or toxicity to local anesthetics\n\nPatients with hepatic or renal failure\n\nPatients with uncontrolled diabetes mellitus\n\nPatients with uncontrolled hypertension\n\nMentally disabled patients\n\nPatients receiving chronic pain therapy (opioid use)\n\nPatients using antidepressant medications\n\nPatients with neuropathic pain\n\nPatients with infection at the injection site\n\nPregnant, suspected pregnant, or breastfeeding women","85 Years",{"count":57,"type":23},[60],"Postoperative pain following open-heart surgery is primarily caused by median sternotomy, although additional contributors include costovertebral joint stress related to sternal retraction and the presence of chest wall and mediastinal drains during the postoperative period. This pain is often severe, especially in the early postoperative hours, making effective management both challenging and essential. Insufficient pain control frequently necessitates high doses of opioids, which may lead to adverse effects such as nausea, vomiting, respiratory complications, and postoperative delirium. Excessive use of anesthetic agents or opioids can also delay extubation and prolong the process of weaning from mechanical ventilation.\n\nThe modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA) is a regional anesthesia technique performed beneath the costal margin between the internal oblique and transversus abdominis muscles. It provides broad dermatomal coverage, extending approximately from the upper thoracic to the lower thoracic and upper lumbar segments. This study aims to evaluate the postoperative analgesic effectiveness of combining the M-TAPA block with a parasternal block in patients undergoing open-heart surgery.",[291,522],"Acute Pain",[524,269,525,217],"M-TAPA block","parasternal block","2025-11-17",{"date":528,"type":39},"2025-11-19",{"date":442,"type":23},{"date":275,"type":23},{"name":45,"class":46},{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":4,"eligibilityCriteria":538,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":162,"enrollmentInfo":539,"targetDuration":4,"studyType":58,"phases":540,"briefSummary":541,"conditions":542,"keywords":544,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":548,"lastUpdatePostDateStruct":549,"startDateStruct":551,"completionDateStruct":553,"leadSponsor":555,"locationsCount":4},"100607608","effectiveness-of-kinesiologic-taping-and-dry-needling-in-the-treatment-of-subacromial-pain-syndrome-100607608","NCT07190768","Effectiveness of Kinesiologic Taping and Dry Needling in the Treatment of Subacromial Pain Syndrome","The Comparison of the Effectiveness of Kinesiologic Taping and Dry Needling in the Treatment of Subacromial Pain Syndrome: a Randomize Trial","Inclusion Criteria:\n\nAge 18-65 years\n\nPain in the upper, outer arm, especially during shoulder elevation\n\nShoulder pain lasting more than 6 weeks with or without partial rotator cuff tear\n\nAt least three of the following findings:\n\nPainful arc during flexion or abduction\n\nPositive Neer test\n\nPositive Hawkins-Kennedy test\n\nPainful resisted external rotation\n\nPositive Jobe's test\n\nDiagnosis confirmed by MRI evaluation when indicated\n\nExclusion Criteria:\n\nParticipation in a physical therapy program or receipt of injection therapy within the past 3 months\n\nPrevious shoulder surgery\n\nPresence of joint contracture\n\nComplete tendon rupture\n\nCervical radiculopathy\n\nSystemic inflammatory disease (e.g., rheumatoid arthritis, ankylosing spondylitis)\n\nKnown allergy to tape or materials used in interventions\n\nBleeding disorders\n\nLocal infection or open wound in the treatment area\n\nCognitive dysfunction that prevents cooperation\n\nHistory of malignancy",{"count":22,"type":23},[60],"This study aims to compare the effectiveness of two common physiotherapy methods, Kinesiologic Taping (KT) and Dry Needling (DN), in the treatment of Subacromial Pain Syndrome (SAPS), a frequent cause of shoulder pain. The trial also investigates whether using KT and DN together provides greater benefits than using them separately. The main goal is to determine which treatment approach is more effective in reducing pain and improving shoulder function in patients with SAPS.",[214,543],"Shoulder Impingement Syndrome",[545,546,547],"Kinesiologic taping","shoulder pain","dry needling","2025-09-23",{"date":550,"type":39},"2025-09-24",{"date":552,"type":23},"2025-10-01",{"date":554,"type":23},"2026-10-01",{"name":45,"class":46},{"id":557,"slug":558,"hasResults":12,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":4,"eligibilityCriteria":562,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":55,"enrollmentInfo":563,"targetDuration":4,"studyType":58,"phases":564,"briefSummary":565,"conditions":566,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":578,"locationsCount":47},"100593794","rhomboid-intercostal-and-subserratus-plane-block-vs-erector-spinae-plane-block-in-video-assisted-thoracoscopic-surgery-100593794","NCT07011069","Rhomboid Intercostal and Subserratus Plane Block vs Erector Spinae Plane Block in Video-Assisted Thoracoscopic Surgery","Comparison of the Efficacy of Rhomboid Intercostal and Subserratus Plane Block (RISS) Versus Erector Spinae Plane (ESP) Blocks in Video-Assisted Thoracoscopic Surgery (VATS) for Postoperative Pain Management and Respiratory Function","Inclusion Criteria:\n\n* Patients who will undergo VATS\n* Who agrees to participate\n* American Society of Anesthesiologists (ASA) physical status I, II, and III\n* Elective surgery\n* Age between 18 and 80 years\n\nExclusion Criteria:\n\n* Local anesthetic allergy\n* Who disagrees to participate\n* ASA physical status IV and V\n* Emergency surgery\n* Hemorrhagic disease\n* Thoracic vertebrae deformity\n* Thoracic vertebrae surgery",{"count":235,"type":23},[60],"To compare the rhomboid intercostal subserratus plane block with the erector spinae plane block regarding their analgesic efficacy and effects on respiratory function for patients undergoing video-assisted thoracoscopic surgery.",[567,568,569,570],"Video Assisted Thoracoscopic Surgery","Regional Block for Pain Control","Regional Blocks","Pulmonary Functions","2025-06-04",{"date":573,"type":39},"2025-06-08",{"date":575,"type":39},"2024-11-15",{"date":577,"type":23},"2026-12-31",{"name":45,"class":46},{"id":580,"slug":581,"hasResults":12,"nctId":582,"briefTitle":583,"officialTitle":584,"acronym":4,"eligibilityCriteria":585,"healthyVolunteers":12,"sex":18,"minAge":453,"maxAge":426,"enrollmentInfo":586,"targetDuration":4,"studyType":58,"phases":587,"briefSummary":588,"conditions":589,"keywords":591,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":598,"completionDateStruct":600,"leadSponsor":602,"locationsCount":4},"100586164","the-effect-of-kinesio-taping-on-mobility-pain-balance-and-daily-activities-in-total-knee-replacement-patients-100586164","NCT06911814","The Effect of Kinesio Taping on Mobility, Pain, Balance and Daily Activities in Total Knee Replacement Patients","Does Kinesiotaping Really Effective on Mobility, Pain and Daily Activities After Total Knee Arthroplasty?","Inclusion Criteria:\n\n* Patients aged 50-75 who have undergone total knee arthroplasty (TKA)\n* Patients able to mobilize independently\n* Patients willing to participate in the treatment program\n* Patients without any secondary conditions that could cause immobilization\n\nExclusion Criteria:\n\n* Patients who have undergone surgery due to cancer\n* Renal insufficiency (GFR \\<30)\n* Patients with local infection in the kinesiology taping application area\n* Heart failure (Stage III-IV)\n* BMI \\>35\n* Cognitive impairment\n* COPD (GOLD Stage III-IV)",{"count":404,"type":23},[60],"Total knee arthroplasty (TKA) is a surgical procedure performed to relieve pain and functional limitations caused by advanced gonarthrosis that cannot be managed with conservative methods. It is known that the postoperative rehabilitation program plays a crucial role in functionality and mobility in the postoperative period. Pain and swelling are the most commonly reported minor complications that lead to functional limitations, often associated with decreased muscle strength. After TKA, various current methods such as compression therapy and electrotherapy are employed to treat postoperative edema. Typically, patients are discharged with a home exercise program once they are ambulatory. However, the return to daily living activities varies among patients, and some may experience prolonged recovery times. In our country and hospital, there is no standardized algorithm for postoperative care following TKA. Patients are often referred to rehabilitation clinics only when complications arise.\n\nDue to issues with patient ambulation, there may be a need for inpatient care following TKA. While traditional rehabilitation programs are used, alternative methods to facilitate early ambulation have emerged in recent years, one of which is kinesiology taping (KT). Developed by Kenso Kase in the 1970s, KT is an elastic, wave-textured, waterproof, breathable cotton tape applied directly to the skin. When applied with various techniques, it helps alleviate pain, reduce edema, and provides mechanical support and joint protection. KT does not restrict movement; instead, its elastic structure opens the space between the dermis and fascia, aiding lymphatic and blood flow, thereby reducing swelling in the extremities. There are studies on the use of KT in postoperative patients beyond musculoskeletal pain conditions, particularly regarding its effectiveness in managing pain, swelling, and joint range of motion after shoulder and anterior cruciate ligament surgeries.\n\nAlthough recent studies in the literature have explored the use of KT after TKA, there is still no consensus on its efficacy and application methods. This study aims to investigate the potential effects or complications of KT treatment on balance, pain, mobility, and quality of life in patients undergoing rehabilitation after TKA.",[590],"Total Knee Anthroplasty",[592,593,265,594],"Total knee arthroplasty","Kinesiotape","Edema","2025-04-03",{"date":597,"type":39},"2025-04-04",{"date":599,"type":23},"2025-06-01",{"date":601,"type":23},"2026-01-01",{"name":45,"class":46},{"id":604,"slug":605,"hasResults":12,"nctId":606,"briefTitle":607,"officialTitle":608,"acronym":4,"eligibilityCriteria":609,"healthyVolunteers":325,"sex":18,"minAge":610,"maxAge":611,"enrollmentInfo":612,"targetDuration":4,"studyType":58,"phases":613,"briefSummary":614,"conditions":615,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":619,"lastUpdatePostDateStruct":620,"startDateStruct":622,"completionDateStruct":624,"leadSponsor":626,"locationsCount":47},"100521671","enteral-feeding-of-premature-babies-and-olive-oil-supplementation-100521671","NCT06072625","Enteral Feeding of Premature Babies and Olive Oil Supplementation","The Effect of Enteral Organic Extra Virgin Olive Oil Supplementation in Premature Babies on Postnatal Growth and Premature Morbidities","Inclusion Criteria:\n\n* Premature babies born at 32 weeks or less\n* Babies who tolerate full enteral feeding at the before end of the second week\n* Babies given consent by their parents -\n\nExclusion Criteria:\n\n* Having a congenital or genetic anomaly","14 Days","40 Days",{"count":57,"type":23},[60],"It is a two-arm prospective interventional study. 40 babies in both groups will be enrolment in the study. In the intervention group, babies will take 1 ml\u002Fkg\u002Fday of the study product (ULTRA PREMIUM) after full enteral feeding.\n\nSupplementation will continue until discharge or the 36th week. Blood samples will be taken for serum Total antioxidant capacity and Malondialdehyde levels before the intervention and on the 14th day of the control group. At the end of the study, serum will be taken again for control values.\n\nDaily lipid intake amounts will be recorded through breast milk analysis. Lipid profile will be monitored weekly The growth parameters of babies will be monitored daily It will be evaluated at the end of the study in terms of ROP, BPD, and NEC. At the end of the study, the data of babies in both groups will be compared.",[616,617,618],"Premature","Olive Oil","Enteral Feeding","2024-07-12",{"date":621,"type":39},"2024-07-15",{"date":623,"type":39},"2023-10-01",{"date":625,"type":23},"2025-03-31",{"name":45,"class":46},""]