[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Bursa Yuksek Ihtisas Training and Research Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":215},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,71,106,138,164,194],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100644915","hfnc-for-postoperative-atelectasis-after-laparoscopic-surgery-100644915",false,"NCT07676760","HFNC for Postoperative Atelectasis After Laparoscopic Surgery","The Role of High-Flow Nasal Cannula in Monitoring Postoperative Atelectasis With Lung Ultrasonography After Laparoscopic Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Adult patients aged 18 years and older\n* Patients scheduled for elective laparoscopic surgery (general surgery, urology, gynecology)\n* Patients undergoing mechanical ventilation under general anesthesia\n* ASA physical status I-III\n* Patients providing written informed consent\n\nExclusion Criteria:\n\n* Severe or uncontrolled chronic obstructive pulmonary disease, asthma, or other chronic pulmonary diseases\n* Patients with atelectasis or pleural effusion detected on preoperative lung ultrasonography\n* Patients requiring intraoperative recruitment maneuver\n* ASA physical status IV or above\n* Patients receiving spinal or epidural anesthesia\n* Cases requiring conversion to laparoscopy or laparotomy\n* Patients refusing to participate","ALL","18 Years",{"count":19,"type":20},90,"ESTIMATED","OBSERVATIONAL","Pneumoperitoneum and Trendelenburg positioning during laparoscopic surgery promote atelectasis development, which has been reported in up to 90% of patients under general anesthesia and increases the risk of postoperative pulmonary complications. High-flow nasal cannula (HFNC) oxygen therapy may reduce post-extubation atelectasis through alveolar recruitment. This prospective observational cohort study aims to evaluate the role of HFNC in postoperative atelectasis monitored by lung ultrasonography (LUS) in patients undergoing elective laparoscopic surgery.",[24,25],"Postoperative Atelectasis","Postoperative Pulmonary Complications",[27,28,24,29,30],"High-Flow Nasal Cannula","Lung Ultrasonography","Laparoscopic Surgery","Pneumoperitoneum","NOT_YET_RECRUITING","2026-06-27",{"date":34,"type":35},"2026-06-30","ACTUAL",{"date":37,"type":20},"2026-07",{"date":39,"type":20},"2027-07",{"name":41,"class":42},"Bursa Yuksek Ihtisas Training and Research Hospital","OTHER_GOV",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":50,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},"100643852","vnotes-vs-laparoscopy-respiratory-mechanics-and-hemodynamics-100643852","NCT07667907","vNOTES vs Laparoscopy: Respiratory Mechanics and Hemodynamics","Comparison of the Effects of vNOTES and Laparoscopic Gynecological Surgery on Intraoperative Respiratory Mechanics and Hemodynamics: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Female patients aged 18 to 75 years\n* Patients scheduled for elective gynecological surgery\n* Patients undergoing mechanical ventilation under general anesthesia\n* ASA physical status I-III\n* Patients providing written informed consent\n\nExclusion Criteria:\n\n* Severe or uncontrolled chronic obstructive pulmonary disease, asthma, or other chronic pulmonary diseases\n* Cardiac arrhythmia\n* ASA physical status IV or above\n* Patients developing intraoperative hemodynamic instability\n* Patients receiving spinal or epidural anesthesia\n* Cases requiring conversion to laparoscopy or laparotomy\n* Patients refusing to participate","FEMALE","75 Years",{"count":53,"type":20},30,"Pneumoperitoneum and Trendelenburg position are unavoidable in laparoscopic surgery and are known to have adverse effects on intraoperative respiratory mechanics and hemodynamics. These conditions increase the risk of ventilator-induced lung injury (VILI) and highlight the importance of lung-protective ventilation strategies.\n\nvNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) is a minimally invasive technique that requires less Trendelenburg tilt and lower insufflation pressures compared to conventional laparoscopic surgery, and may therefore offer a more favorable intraoperative profile.\n\nThis prospective, observational, single-center, parallel-group cohort study aims to compare respiratory mechanics parameters (Ppeak, Pplateau, DP, MPtot, MPdyn, Crs) and hemodynamic parameters (MAP, HR, vasopressor requirement) between vNOTES (n=15) and laparoscopic gynecological surgery (n=15) groups at four intraoperative time points.",[56,57],"Respiratory Mechanics","Hemodynamics",[59,60,56,57,30,61],"vNOTES","Laparoscopy","Trendelenburg","2026-06-19",{"date":64,"type":35},"2026-06-25",{"date":66,"type":20},"2026-07-01",{"date":68,"type":20},"2027-07-01",{"name":41,"class":42},1,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":70},"100641311","socio-cultural-level-health-literacy-and-parental-ct-demand-in-paediatric-minor-head-trauma-100641311","NCT07655310","Socio-Cultural Level, Health Literacy, and Parental CT Demand in Paediatric Minor Head Trauma","The Relationship Between Family Socio-Cultural Level, Health Literacy, and Parental Demand for Computed Tomography in PECARN-Stratified Children Presenting With Minor Head Trauma: A Single-Centre Prospective Observational Cohort Study","Inclusion Criteria:\n\n1. Age less than 18 years at time of emergency department presentation\n2. Presenting complaint of head trauma sustained within the preceding 24 hours\n3. Classified as minor head trauma at triage, defined as a Glasgow Coma Scale (GCS) score of 14 or 15 at initial assessment\n4. Accompanied by a parent or legal guardian with capacity to provide written informed consent\n\nExclusion Criteria:\n\n1. GCS score 13 or less at presentation (moderate or severe head injury)\n2. Transfer from another medical facility\n3. Head trauma sustained more than 24 hours before emergency department presentation\n4. Known coagulopathy, anticoagulant therapy, or bleeding disorder\n5. Ventriculoperitoneal shunt in situ\n6. Previous intracranial neurosurgery\n7. Pre-existing neurological disorder affecting GCS interpretation (e.g., cerebral palsy, developmental delay)\n8. Clinical suspicion of abusive head trauma (non-accidental injury) identified by the treating physician\n9. Concurrent multi-system trauma\n10. No accompanying parent or guardian available for consent and socio-cultural assessment","17 Years",{"count":80,"type":20},200,"Minor head trauma is one of the most frequent reasons for paediatric emergency department visits worldwide. The PECARN (Paediatric Emergency Care Applied Research Network) clinical decision rule stratifies children with minor head trauma into low-, intermediate-, and high-risk categories for clinically important traumatic brain injury (ciTBI) and provides evidence-based guidance on computed tomography (CT) ordering. Despite its high diagnostic accuracy, real-world CT utilisation frequently diverges from PECARN recommendations. Non-clinical family-level factors - including socio-cultural characteristics and health literacy - may drive part of this divergence, particularly through their influence on whether families explicitly request CT imaging.\n\nThis prospective observational cohort study will enrol 200 children with minor head trauma presenting to the emergency department of SBU Bursa Yuksek Ihtisas EAH, Bursa, Turkey. The primary aim is to determine whether family socio-cultural level (composite index incorporating education, occupation, income, and housing; scored 0-10) and health literacy (Newest Vital Sign-Turkish, NVS-TR) independently predict parental demand for CT imaging. Secondary aims include determining whether parental CT demand and family socio-cultural characteristics predict CT ordering by the treating physician, describing PECARN algorithm adherence patterns in this setting, and examining parental health-seeking behaviour at 7-day telephone follow-up.",[83,84,85],"Craniocerebral Trauma","Brain Injuries, Traumatic","Head Injuries, Closed",[87,88,89,90,91,92,93,94,95,96],"PECARN","paediatric head trauma","minor head trauma","computed tomography","health literacy","socio-cultural level","clinical decision rule","parental CT demand","emergency medicine","NVS-TR","RECRUITING","2026-06-17",{"date":100,"type":35},"2026-06-22",{"date":102,"type":35},"2024-04-10",{"date":104,"type":20},"2027-08",{"name":41,"class":42},{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":117,"briefSummary":119,"conditions":120,"keywords":126,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":70},"100640980","parasacral-ischial-plane-block-in-lower-extremity-surgery-100640980","NCT07594197","Parasacral Ischial Plane Block in Lower Extremity Surgery","Evaluation of Sensory and Motor Blockade of Ultrasound-Guided Parasacral Ischial Plane Block in Lower Extremity Surgery","Inclusion Criteria:\n\n1. Ages 18-80\n2. ASA I-III\n3. Patients operated on under regional anesthesia\n4. Patients who provided written informed consent\n5. Patients scheduled for elective lower extremity surgery -\n\nExclusion Criteria:\n\n1. Patients with a history of allergy to local anesthetic drugs\n2. Patients with coagulation disorders\n3. Patients with BMI \\> 40 kg\u002Fm²\n4. Presence of infection at the block application site\n5. Chronic pain syndrome (chronic opioid use)\n6. Pregnant women\n7. Patients who cannot be communicated with\n8. Patients requiring emergency surgery -","80 Years",{"count":115,"type":20},60,"INTERVENTIONAL",[118],"NA","The parasacral ischial plane block is a novel fascial plane approach targeting the sacral plexus. This technique is technically less challenging and eliminates the requirement for direct visualization of the sacral plexus. The aim of this prospective observational study is to evaluate the efficacy of the conventional sacral plexus block versus the parasacral ischial plane block in patients undergoing lower extremity surgery.",[121,122,123,124,125],"Patients Scheduled for Elective Lower Extremity Surgery","Ages 18-80","ASA I-III","Patients Operated on Under Regional Anesthesia","Patients Who Provided Written Informed Consent",[127,128,129],"Lumbosacral Plexus","Anesthesia, Conduction","Postoperative Pain","2026-05-14",{"date":132,"type":35},"2026-05-18",{"date":134,"type":20},"2026-05-01",{"date":136,"type":20},"2027-05-01",{"name":41,"class":42},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":146,"targetDuration":148,"studyType":21,"phases":4,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":70},"100627725","optic-nerve-sheath-diameter-and-cognitive-outcomes-in-bentall-surgery-100627725","NCT07452367","Optic Nerve Sheath Diameter and Cognitive Outcomes in Bentall Surgery","Evaluation of the Relationship Between Bilateral Optic Nerve Sheath Diameter (ONSD) Measurements and Postoperative Cognitive Functions in Bentall Surgeries: A Prospective Observational Study","ONCOB","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Scheduled for elective Bentall procedure\n* Requiring cardiopulmonary bypass (CPB)\n* Willing to participate and able to provide informed consent\n* Able to complete the MoCA cognitive assessment test\n\nExclusion Criteria:\n\n* Age below 18 or above 80 years\n* Emergency Bentall surgery\n* Pre-existing diagnosed cognitive impairment or dementia\n* History of prior stroke or neurological disease\n* Significant carotid artery stenosis\n* Inability to complete the MoCA test (language barrier, illiteracy, visual or hearing impairment)\n* Refusal to participate or inability to provide informed consent\n* Patients with known psychiatric disorders\n* Reoperation (redo surgery)\n* Patients with severe renal or hepatic failure",{"count":147,"type":20},100,"1 Month","Bentall surgery is a major cardiac procedure involving replacement of the ascending aorta, aortic root, and aortic valve, typically requiring cardiopulmonary bypass (CPB) and sometimes deep hypothermic circulatory arrest (DHCA). Due to its complexity, it carries a significant risk of postoperative neurological complications including stroke and postoperative cognitive dysfunction (POCD).\n\nThis prospective observational study aims to evaluate the relationship between perioperative bilateral optic nerve sheath diameter (ONSD) measurements obtained by ultrasound and postoperative cognitive functions in patients undergoing elective Bentall surgery. ONSD is a non-invasive surrogate marker of intracranial pressure that can be measured at the bedside using ultrasound.\n\nIn addition to routine hemodynamic monitoring and cerebral oximetry (NIRS), bilateral ONSD will be measured at predefined intraoperative and postoperative time points. Cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA) test preoperatively and postoperatively, and delirium will be evaluated using the CAM-ICU scale during ICU stay. The association between perioperative ONSD values and postoperative cognitive outcomes, extubation time, ICU stay, and neurological complications will be analyzed.",[151],"Postoperative Cognitive Dysfunction",[153,154,155],"Bentall surgery","Optic nerve sheath diameter","Postoperative cognitive dysfunction","2026-03-05",{"date":158,"type":35},"2026-03-06",{"date":160,"type":35},"2025-08-30",{"date":162,"type":20},"2026-08-30",{"name":41,"class":42},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":172,"targetDuration":174,"studyType":21,"phases":4,"briefSummary":175,"conditions":176,"keywords":180,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":4},"100623517","ultrasound-based-prediction-of-hemodynamic-instability-during-cvvhdf-initiation-100623517","NCT07397663","Ultrasound-Based Prediction of Hemodynamic Instability During CVVHDF Initiation","Prediction of Intradialytic Hypotension at the Initiation of Continuous Venovenous Hemodiafiltration Using Multimodal Ultrasonographic and Hemodynamic Parameters in Intensive Care Unit Patients","US-CVVHDF","Inclusion Criteria:\n\n* Adult patients (≥18 years) admitted to the intensive care unit\n* Indication for continuous venovenous hemodiafiltration\n* Adequate transthoracic echocardiographic image quality\n* Written informed consent obtained from legal representatives\n\nExclusion Criteria:\n\n* Acute coronary syndrome\n* Severe valvular heart disease or pericardial effusion\n* Significant arrhythmias interfering with Doppler measurements\n* Presence of pacemaker, ICD, or ventricular assist device\n* Poor echocardiographic imaging window\n* Life expectancy less than 24 hours",{"count":173,"type":20},80,"1 Year","This prospective observational study aims to evaluate the ability of transthoracic echocardiographic and bedside ultrasonographic parameters to predict intradialytic hypotension and hemodynamic instability at the initiation of continuous venovenous hemodiafiltration (CVVHDF) in adult intensive care unit patients.",[177,178,179],"Renal Failure , Chronic","Intradialytic Hypotension","Critical Illness",[178,181,182,183,184,185],"LVOT VTI","CVVHD","Renal Resistive Index","Echocardiography","VExUS","2026-02-11",{"date":188,"type":35},"2026-02-13",{"date":190,"type":20},"2026-02-10",{"date":192,"type":20},"2027-02-10",{"name":41,"class":42},{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":116,"phases":203,"briefSummary":204,"conditions":205,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":70},"100600382","effect-of-injection-duration-of-fascial-plane-blocks-on-block-success-100600382","NCT07096765","Effect of Injection Duration of Fascial Plane Blocks on Block Success","Effect of Injection Duration of Fascial Plane Blocks on Block Success and Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Laparoscopic cholecystectomy surgery\n* Patients with ASA (American Society of Anaesthetists) scores I and III will be included.\n\nExclusion Criteria:\n\n* Uncontrolled Arterial Hypertension\n* Uncontrolled Diabetes Mellitus,\n* Mental retardation\n* Antidepressant use\n* Metabolic disorders\n* Bleeding diathesis\n* Patients with a body mass index above 30","65 Years",{"count":147,"type":20},[118],"This prospective observational study aims to evaluate the impact of injection duration during fascial plane blocks on block success and analgesic efficacy in patients undergoing laparoscopic cholecystectomy. The hypothesis is that shorter injection durations increase injection pressure, potentially limiting local anesthetic spread, while longer durations facilitate broader anesthetic distribution.",[206],"Nerve Block","2025-07-24",{"date":209,"type":35},"2025-07-31",{"date":211,"type":20},"2025-08-01",{"date":213,"type":20},"2026-02-01",{"name":41,"class":42},""]