[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"CHOSEOK YOON\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100591201","appropriateness-of-antibiotic-combination-therapy-for-severe-community-acquired-pneumonia-in-south-korea-100591201",false,"NCT06977347","Appropriateness of Antibiotic Combination Therapy for Severe Community-acquired Pneumonia in South Korea","Verification of Anti-pseudomonal Antibiotic Combination Therapy in Severe Community-acquired Pneumonia in South Korea: A Randomized-controlled Study","ACTSCAP","* Inclusion Criteria:\n\n  * Adult patients aged 19 years or older who visited the emergency department and were hospitalized.\n  * Findings consistent with pneumonia diagnosis, meeting all of the following criteria:\n  * Radiologic evidence of pulmonary infiltration on chest X-ray or chest CT.\n  * At least two or more of the following clinical signs:\n\n    i) Body temperature ≥38°C or \\\u003C36°C ii) White blood cell count ≥11,000\u002FµL or \\\u003C4,000\u002FµL iii) Presence of purulent sputum or bronchial secretions\n  * Within 24 hours of admission, the patient meets one major criterion or three minor criteria according to ATS\u002FIDSA classification:\n\n    * Major criteria:\n\n      i) Invasive mechanical ventilation ii) Use of vasopressors (vasopressor-dependent septic shock)\n    * Minor criteria:\n\n      i) Respiratory rate ≥30 breaths\u002Fmin ii) PaO2\u002FFiO2 ≤ 250 iii) Multilobar infiltrates iv) Confusion or disorientation v) BUN ≥20 mg\u002FdL vi) WBC \\\u003C4,000\u002Fmm³ vii) Platelet count \\\u003C100,000\u002Fmm³ viii) Hypothermia (temperature \\\u003C36°C) ix) Hypotension requiring aggressive fluid resuscitation\n* Exclusion Criteria:\n\n  * Transferred from another hospital after \\>48 hours of hospitalization\n  * Died within 72 hours of hospital admission\n  * Transferred to another hospital within 14 days of admission\n  * Pneumonia occurring after \\>48 hours of mechanical ventilation, including home ventilators\n  * Detection of influenza or SARS-CoV-2 virus within 7 days of hospitalization\n  * Identified non-pneumonia infection requiring antibiotics within 72 hours of admission\n  * Detection of piperacillin\u002Ftazobactam-resistant Enterobacterales, Pseudomonas spp., or Acinetobacter spp. in respiratory or blood cultures within the past 90 days\n  * Antibiotic-related adverse events observed within 72 hours of assigned treatment, requiring discontinuation or change of antibiotics","ALL","19 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to provide high-level evidence for appropriate empirical antibiotic use tailored to the clinical reality in Korea by conducting a randomized controlled trial comparing monotherapy with piperacillin\u002Ftazobactam and combination therapy with piperacillin\u002Ftazobactam plus a fluoroquinolone in patients with severe community-acquired pneumonia.",[27],"Severe Community-acquired Pneumonia (sCAP)","NOT_YET_RECRUITING","2025-05-09",{"date":31,"type":32},"2025-05-18","ACTUAL",{"date":34,"type":21},"2025-06-15",{"date":36,"type":21},"2027-02-01",{"name":38,"class":39},"CHOSEOK YOON","OTHER",""]