[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"CMC Ambroise Paré\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":206},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,48,77,108,138,162,186],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644703","phase-3-efficacy-of-intravenous-dexamethasone-in-prolonging-the-duration-of-spinal-anesthesia-with-chloroprocaine-in-knee-arthroscopy-100644703",false,"NCT07674576","Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy","Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy: a Double-blind, Randomized, Controlled Trial","CHLORODEX","Inclusion Criteria:\n\n* Undergoing knee arthroscopy lasting ≤ 40 minutes requiring spinal anesthesia (diagnostic arthroscopy or meniscal surgery),\n* Signed written informed consent form,\n* Affiliation to a social security system,\n* Negative pregnancy test on the day of procedure for non-menopausal patients.\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia with intrathecal chloroprocaine\n* History of diabetes,\n* Pre-existing peripheral neuropathy,\n* American Society of Anesthesiologists (ASA) physical status IV,\n* Contraindication to dexamethasone,\n* Hypersensitivity of any drug used in this study,\n* Long-term oral corticosteroid therapy,\n* Chronic opioid use,\n* Chronic pain syndromes,\n* Contraindications to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (Ketoprofen, Celecoxib)\n* Need for a peripheral nerve block in addition to spinal anesthesia (e.g. knee ligamentoplasty),\n* Mental or linguistic inability to understand the study,\n* Patients under legal protection (guardianship, curatorship or safeguard of justice),\n* Patients currently included or planning to be included in another interventional study,\n* Pregnant or breastfeeding women,\n* Women of childbearing potential not using effective contraception.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Chloroprocaine is a short-acting local anesthetic that allows rapid recovery and early ambulation but is currently recommended for procedures lasting 40 minutes or less.\n\nDexamethasone is commonly used during anesthesia for the prevention of postoperative nausea and vomiting and has also been shown to prolong the duration of analgesia and sensory block after regional anesthesia.\n\nDexamethasone may therefore extend the duration of chloroprocaine spinal anesthesia, potentially allowing its use for longer surgical procedures while maintaining the benefits of rapid postoperative recovery.\n\nThis study aims to evaluate whether intravenous dexamethasone can prolong the effects of spinal anesthesia performed with chloroprocaine in adults undergoing knee arthroscopy.",[27],"Knee Arthroscopy",[29,30,31,32,33,34],"Knee arthroscopy","dexamethasone","chloroprocaine","spinal anesthesia","sensory block","motor block","NOT_YET_RECRUITING","2026-06-25",{"date":38,"type":39},"2026-06-29","ACTUAL",{"date":41,"type":21},"2026-09-01",{"date":43,"type":21},"2028-09-01",{"name":45,"class":46},"CMC Ambroise Paré","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":55,"targetDuration":57,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100301866","registry-for-the-improvement-of-postoperative-outcomes-in-cardiac-and-thoracic-surgery-100301866","NCT03209674","Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry","RIPOSTE","Inclusion Criteria:\n\n* all patients eligible for cardiac or thoracic surgery\n\nExclusion Criteria:\n\n* non applicable",{"count":56,"type":21},8000,"2 Months","OBSERVATIONAL","The registry for the improvement of postoperative outcomes in cardiac and thoracic surgery aims to prospectively collect data in order to test the association between various preoperative and per-operative variables ; and several postoperative outcomes such as mortality, shock, redo surgery, sepsis and extracorporeal life-support.",[61,62,63,64],"Heart Diseases","Death","Postoperative Complications","Cardiac Complication",[66,67],"Cardiac surgery","Thoracic surgery","RECRUITING","2026-04-02",{"date":71,"type":39},"2026-04-03",{"date":73,"type":39},"2012-01-01",{"date":75,"type":21},"2030-12-31",{"name":45,"class":46},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},"100619510","personalisation-of-mean-arterial-pressure-in-adult-patients-with-cardiogenic-shock-100619510","NCT07345559","Personalisation of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock","Prospective, Randomized, Multicenter, Controlled Trial Assessing the Personalization of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock","CARDIOPAM","Inclusion Criteria:\n\n* Aged ≥18 years\n* Cardiogenic shock state, according to the consensus definition,\n* SCAI (Society for Cardiovascular Angiography and Interventions) classification ≥ C\n* Consent from the patient or close relative \u002F trusted person or emergency inclusion procedure\n* Benefiting fromciary of a social security scheme\n\nExclusion Criteria:\n\n* Catecholamine infusion for more than 24 consecutive hours;\n* CVP \\\u003C 5 mm Hg at inclusion;\n* MAP \\> 70 mmHg at inclusion;\n* Chronic kidney disease stage G4 (defined by an eGFR between 15-29 ml\u002Fmin\u002F1.73 m²) or G5 (defined by an eGFR less than 15 ml\u002Fmin\u002F1.73 m²) according to the KDIGO CKD classification at inclusion;\n* Chronic dialysis or presence of renal replacement therapy criteria at inclusion ;\n* Recovered cardiopulmonary arrest within 7 days prior to inclusion;\n* Patient already on mechanical circulatory support at inclusion before enrollment (patients who receive support after inclusion will not be excluded);\n* Primary diagnosis of tamponade, pulmonary embolism, or septic shock;\n* Hypersensitivity to norepinephrine tartrate or to any of the following excipients: sodium chloride, hydrochloric acid or sodium hydroxide water for injectable preparations;\n* Absence of central venous access;\n* Known pregnancy or current breastfeeding;\n* Under legal guardianship, curatorship, or judicial protection.",{"count":86,"type":21},406,[88],"NA","Cardiogenic shock is a life-threatening condition characterized by inadequate cardiac output, leading to organ hypoperfusion and high mortality. Maintaining mean arterial pressure (MAP) is crucial, but standard targets may be insufficient due to venous congestion. Central venous pressure (CVP) can help assess effective perfusion pressure. This study investigates whether a personalized MAP target adjusted by CVP improves organ function and survival compared to standard MAP management.",[91],"Cardiogenic Shock",[93,94,95,96,97,98,99],"Cardiogenic shock","Inotropes","vasopressors","Mean arterial pressure","Central Venous Pressure","Organ dysfunction","Mortality","2026-04-01",{"date":69,"type":39},{"date":103,"type":39},"2026-03-26",{"date":105,"type":21},"2029-07-25",{"name":45,"class":46},11,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":47},"100629673","local-infiltration-analgesia-versus-quadruple-nerve-blocks-in-total-knee-arthroplasty-100629673","NCT07477730","Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty.","Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty: a Randomized Controlled Trial.","LIAQ","Inclusion Criteria:\n\n* Patients undergoing primary total knee arthroplasty under general anesthesia (laryngeal mask airway)\n* Fully autonomous at home\n* Planned discharge to home\n* Consent for participation\n* Affiliation to a social security system\n\nExclusion Criteria:\n\n* Preoperative opioid use\n* Chronic pain syndrome\n* Valgus contraindicating sciatic nerve block\n* Contraindication to any drugs used in the protocol\n* Contraindication to laryngeal mask airway\n* Pregnant or breastfeeding women\n* Patients under protection of the adults (guardianship, curators or safeguard of justice)",{"count":117,"type":21},80,[88],"Total knee arthroplasty (TKA) is one of the most common orthopedic surgical procedures and is associated with severe pain in the immediate postoperative period, thus limiting early recovery.\n\nOptimal postoperative pain management after TKA is not fully defined. While multimodal analgesia is standard, the choice of associated regional anesthesia techniques is debated.\n\nLocal infiltration analgesia (LIA) is widely used and provides effective pain relief without impairing early mobilization.\n\nPeripheral nerve blocks have been discussed due to the risk of motor blockade, but low-concentration local anesthetics, such as 0.1% ropivacaine, allow sensory blockade while preserving motor function. Preliminary studies suggest that this concentration is effective and safe.\n\nThe main objective of this monocenter, prospective, randomized, open-label, controlled trial is to compare the analgesic efficacy of a quadruple nerve blocks (femoral, sciatic, obturator, and lateral femoral cutaneous nerves) using 0.1% ropivacaine versus standard LIA in patients undergoing TKA.",[121],"Total Knee Arthroplasty",[123,124,125,126,127,128,129],"Knee arthroplasty","Local Infiltration Analgesia","Regional anesthesia","Ropivacaine","Postoperative analgesia","Pain management","Opioids","2026-03-13",{"date":132,"type":39},"2026-03-17",{"date":134,"type":21},"2026-06-01",{"date":136,"type":21},"2028-02-01",{"name":45,"class":46},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":47},"100618540","impact-of-dialysis-on-sexuality-100618540","NCT07332949","Impact of Dialysis on Sexuality.","SEXODIA","Inclusion Criteria:\n\n* Patient \\> 18 years,\n* Treated with chronic dialysis (hemodialysis or peritoneal dialysis) for at least 6 months.\n\nExclusion Criteria:\n\n* Major cognitive or psychiatric disorders that make understanding or completing the questionnaire difficult.\n* General health condition not allowing participation without significant discomfort or excessive fatigue.\n* Opposition by the patient.",{"count":146,"type":21},100,"Sexuality is an essential dimension of quality of life and is frequently impaired in patients with end-stage chronic kidney disease undergoing hemodialysis. Sexual dysfunctions-including erectile dysfunction, reduced sexual desire, and difficulties with arousal or orgasm-are highly prevalent in this population. These disorders have multifactorial origins, involving hormonal disturbances, comorbidities, treatment-related side effects, chronic fatigue, and the psychological and relational impact of long-term illness.\n\nDespite their frequency, sexual health issues are rarely addressed in routine dialysis care. This is largely due to time constraints during consultations, insufficient training of healthcare professionals, and persistent social and cultural taboos. In addition, the existing scientific literature remains limited, often outdated, and predominantly focused on male patients. Data concerning women, sexual diversity, body image, and couple-related aspects are scarce. Standard kidney disease-specific quality-of-life instruments, such as the KDQOL questionnaire, provide only a minimal assessment of sexuality, with a single item related to sexual desire.\n\nThe aim of this study is to provide a contemporary and comprehensive assessment of the impact of dialysis on sexual quality of life. By documenting sexual function and sexual complaints in patients undergoing dialysis, this study seeks to improve understanding of patients' experiences and to facilitate communication between patients and healthcare professionals. Ultimately, the findings are intended to support better integration of sexual health into routine nephrology care and to contribute to improved clinical practices in the field of sexual health.\n\nThis study is designed as a cross-sectional survey conducted among patients undergoing dialysis at the Groupe Hospitalier Privé Ambroise Paré-Hartmann in the Paris area. Eligible patients are informed about the study during a dialysis session by a healthcare professional (dialysis nurse, nephrologist, or physiotherapist specialized in sexology). Participants complete a self-administered questionnaire during their dialysis session, including the Male Sexual Health Questionnaire (MSHQ) for men and the Female Sexual Function Index (FSFI) for women. Additional questions addressing medical history and body image perception are included. The estimated completion time for the questionnaire is approximately 20 minutes.",[149],"Chronic Kidney Disease Requiring Chronic Dialysis",[151,152,153],"Hemodialysis","Peritoneal dialysis","Sexuality","2026-02-03",{"date":156,"type":39},"2026-02-04",{"date":158,"type":39},"2026-01-30",{"date":160,"type":21},"2027-01-30",{"name":45,"class":46},{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":185},"100541244","brain-heart-interactions-in-cardiac-arrest-ancillary-study-of-the-heavenward-trial-100541244","NCT06327334","Brain Heart InterActioNs in Cardiac Arrest. Ancillary Study of the HEAVENwARd Trial","BHIANCA","Inclusion Criteria:\n\n* Admitted in intensive care unit (ICU) after resuscitation from cardiac arrest (in-hospital or out-of-hospital)\n* Coma (Glasgow score \\\u003C 8) after ROSC, requiring sedation and targeted temperature management for at least 24h\n* EEG with ECG lead performed in routine care\n\nExclusion Criteria:\n\n* Dying patient (Limitation of life support techniques at admission to the ICU)\n* Limitation of life sustaining treatment before EEG\n* Non-Sinus Rhythm\n* Pregnant or breastfeeding women\n* Patient under protection of the adults (guardianship, curators or safeguard of justice)\n* Opposition by the trusted person or by the patient",{"count":170,"type":21},200,"Despite advances in post-resuscitation care of patients with cardiac arrest (CA), the majority of survivors who are treated after restoration of spontaneous circulation (ROSC) will have sequelae of hypoxic-ischemic brain injury ranging from mild cognitive impairment to a vegetative state. Current recommendations suggest using a multimodal approach to predict poor prognosis, meaning combining markers together. Yet, a substantial proportion of patients do not have a clear prognostic evaluation even when applying the latest ESICM recommendations algorithm published in 2021. It is therefore important to identify new prognostic markers to predict both unfavorable and favorable outcomes. Data regarding the pathophysiological mechanisms of post-anoxic encephalopathy suggest a diffuse anoxo-ischemic injury. However, post-mortem neuropathology data suggest that these lesions do not uniformly affect neuroanatomical structures, with some regions (especially hippocampal and insular) appearing more sensitive to anoxia. Conversely, the brainstem appears less affected by anoxic lesions. Under physiological conditions, there are interactions between the heart and the brain, and between the brain and the heart mainly related to the autonomic nervous system, through interactions between central cortical control structures (especially insular) and brainstem structures (at the level of the bulb) and peripheral structures of the heart. Exploring the pathophysiological mechanisms of heart-brain interactions post-CA could thus help better understand the pathophysiology of anoxo-ischemic encephalopathy, before considering potential therapeutic targets. Furthermore, this heart-brain dysfunction could have prognostic value. Indeed, recent studies in healthy subjects and patients with consciousness disorders suggest that autonomic nervous system activity measured by brain-heart interactions could be a reliable marker of consciousness and cognitive processing. These coupled heart-brain interactions can be evaluated through synchronous electroencephalogram (EEG) and electrocardiogram (ECG) recordings, as there are coupled interactions between the signals of these two organs. The existence of abnormal brain-heart coupling could be associated, on the one hand, with the severity of post-anoxic encephalopathy, and on the other hand, with neurological prognosis in patients with persistent coma post-CA.\n\nThis ancillary study of a multicentre prospective cohort \"HEAVENwARd study\" (NCT06044922) will assess the prevalence and prognostic value of bilateral brain-heart interactions in comatose patients after CA.",[173],"Cardiac Arrest",[175,176],"Brain-heart interactions","Resuscitated cardiac arrest","2025-03-24",{"date":179,"type":39},"2025-03-27",{"date":181,"type":39},"2024-11-25",{"date":183,"type":21},"2027-12-15",{"name":45,"class":46},5,{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":194,"conditions":195,"keywords":196,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":205,"locationsCount":185},"100519544","heart-rate-variability-in-early-prediction-of-a-noxic-brain-injury-after-cardiac-arrest-100519544","NCT06044922","Heart Rate Variability in Early Prediction of a Noxic Brain Injury After Cardiac Arrest","HEAVENwARd","Inclusion Criteria:\n\n* Admitted in intensive care unit (ICU) after resuscitation from cardiac arrest (in-hospital or out-of-hospital)\n* Coma (Glasgow score \\\u003C 8) after ROSC, requiring sedation and targeted temperature management for at least 24h\n\nExclusion Criteria:\n\n* Dying patient (Limitation of life support techniques at admission to the ICU)\n* Non-Sinus Rhythm\n* Pregnant or breastfeeding women\n* Patient under protection of the adults (guardianship, curators or safeguard of justice)\n* Opposition by the trusted person or by the patient once he\u002Fshe wakes up",{"count":170,"type":21},"Despite advances in post-resuscitation care of patients with cardiac arrest (CA), the majority of survivors who are treated after restoration of spontaneous circulation (ROSC) will have sequelae of hypoxic-ischemic brain injury ranging from mild cognitive impairment to a vegetative state.\n\nEarly prognostication in comatose patients after ROSC remains challenging. Recent recommendations suggest carrying out clinical and paraclinical tests during the first 72 h after ROSC, to predict a poor neurological outcome with a specificity greater than 95% (no pupillary and corneal reflexes, bilaterally absent N20 somatosensory evoked potential wave, status myoclonus, highly malignant electroencephalography including suppressed background ± periodic discharges or burst-suppression, neuron-specific enolase (NSE) \\> 60 µg\u002FL, a diffuse and extensive anoxic injury on brain CT\u002FMRI), but with a low sensitivity due to frequent confounding factors.\n\nThe heart rate variability (HRV) is a simple and non-invasive technique for assessing the autonomic nervous system function. In patients with a recent myocardial infarction, reduced HRV is associated with an increased risk for malignant arrhythmias or death. In neurology, reduced HRV is associated with a poor outcome in severe brain injury patients and allows to predict early neurological deterioration and recurrent ischemic stroke after acute ischemic stroke.\n\nA reduced HRV could be a sensitive, specific and early indicator of diffuse anoxic brain injury after CA.\n\nThis multicenter prospective cohort study assesses the added value of early HRV (within 24h of ICU admission) for neuroprognostication after cardiac arrest.",[173],[197,198],"Heart rate variability","Neurologic prognosis","2024-12-11",{"date":201,"type":39},"2024-12-16",{"date":203,"type":39},"2024-10-23",{"date":183,"type":21},{"name":45,"class":46},""]