[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"CMH Kharian Medical College\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":94},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100622121","endometrial-response-in-polycystic-ovarian-syndrome-treated-with-letrozole-alone-or-with-added-estradiol-valerate-100622121",false,"NCT07379502","Endometrial Response in Polycystic Ovarian Syndrome Treated With Letrozole Alone or With Added Estradiol Valerate","Endometrial Response in Women With Poorly Primed Endometrial Lining in Diagnosed Polycystic Ovarian Syndrome Treated With Letrozole Alone or With Added Estradiol Valerate","Inclusion Criteria:\n\n* Women aged 20-35 years\n* Clinical diagnosis of PCOS (Rotterdam criteria)\n\nExclusion Criteria:\n\n* Endocrine disorders other than PCOS\n* Endometrial pathology or uterine malformations\n* Allergy to letrozole or estradiol\n* Hormonal therapy within last 3 months","FEMALE","20 Years","35 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age, characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology. Letrozole, an aromatase inhibitor, has emerged as a first-line ovulation induction agent due to its superior ovulation and pregnancy rates compared to clomiphene citrate. Estradiol valerate, a synthetic estrogen, can be co-administered with letrozole to improve endometrial receptivity by enhancing endometrial thickness, vascularity, and pattern. This study aims to evaluate the effect of letrozole alone versus letrozole with estradiol valerate on endometrial development in these patients.",[27],"PCOS (Polycystic Ovary Syndrome)",[27,29,30,31,32],"Letrozole","Estradiol Valerate","Endometrial response","Endometrial thickness","NOT_YET_RECRUITING","2026-01-27",{"date":36,"type":37},"2026-01-30","ACTUAL",{"date":39,"type":21},"2026-03-05",{"date":41,"type":21},"2026-08-31",{"name":43,"class":44},"CMH Kharian Medical College","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":45},"100592649","comparative-efficacy-of-magnesium-supplement-and-melatonin-congener-in-young-adults-with-primary-insomnia-100592649","NCT06996171","Comparative Efficacy of Magnesium Supplement and Melatonin Congener in Young Adults With Primary Insomnia","Inclusion Criteria:\n\n* Age 18-40 years\n* Gender: Male and Females (Non-pregnant \\& Non lactating)\n* Diagnosed cases of primary insomnia according to following criteria:\n\n  * Difficulty falling asleep, staying asleep or nonrestorative sleep\n  * This difficulty is present despite adequate opportunity \\& circumstance to sleep\n  * This impairment in sleep is associated with daytime impairment or distress\n  * This sleep difficulty occurs at least 3 times per week and has been a problem for at least 1 month\n\nExclusion Criteria:\n\n* Insomnia due to a known underlying cause\n* Any psychiatric illness\n* Active use of sedative hypnotics","ALL","18 Years","40 Years",{"count":20,"type":21},[24],"Sleep is essential for our overall health and well-being, much like food and water. It plays a vital role in numerous bodily functions. Many studies have been conducted to determine the efficacy of melatonin congeners and Mg supplements in patients with insomnia separately. This study aims to compare the efficacy of melatonin and magnesium supplements in young adults with primary insomnia. Most insomnia studies focus on older adults or individuals with comorbidities. Targeting otherwise healthy young adults brings age-specific relevance and novel insight.",[59],"Primary Insomnia",[59,61,62],"Magnesium supplement","Melatonin congener","RECRUITING","2025-05-21",{"date":66,"type":37},"2025-05-30",{"date":68,"type":37},"2025-05-05",{"date":70,"type":21},"2025-10-30",{"name":43,"class":44},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":45},"100590592","comparative-efficacy-of-pregabalin-and-lacosamide-in-patients-with-herpes-zoster-and-post-herpetic-neuralgia-100590592","NCT06969417","Comparative Efficacy of Pregabalin and Lacosamide in Patients With Herpes Zoster and Post Herpetic Neuralgia","Inclusion Criteria:\n\n* Diagnosed cases of herpes zoster suffering from postherpetic neuralgia\n* Ages: 18 to 50\n* Both male and female\n\nExclusion Criteria:\n\n* Lack of consent\n* Patient already taking pain killers for post herpetic neuralgia\n* Patients suffering from other systemic illness","50 Years",{"count":80,"type":21},50,[24],"Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). PHN is characterized by neuropathic pain lasting beyond the resolution of the rashes. Post herpetic neuralgia (PHN) represents a potentially debilitating and often undertreated form of neuropathic pain that disproportionately affects vulnerable populations, including the elderly and the immunocompromised. PHN pain is typically localized, unilateral and chronic, but may be constant, intermittent, spontaneous and\u002For evoked. PHN is likely to interfere with sleep and daily activities.\n\nPregabalin is a gabapentinoid licenced for treatment of neurological disorders. It is one of the earlier drugs approved by the US Food and Drug Administration (2004) for the treatment of painful diabetic neuropathy and postherpetic neuralgia (PHN). Lacosamide (LCM) was approved in 2008 in the European Union and in the United States as adjunctive therapy for the treatment of focal-onset seizures with or without secondary generalization in adults and adolescents with epilepsy. Its efficacy has also been proven in neuropathic pain.\n\nAlthough Pregabalin and Lacosamide have proven effective in various neuropathic pain disorder, comparative studies specifically for PHN remain scarce. This study aims to compare the efficacy of Pregabalin and Lacosamide in PHN patients, addressing the current gap in literature and providing clinically relevant insights to optimize treatment selection.",[84,85],"Herpes Zoster (HZ)","Post Herpetic Neuralgia (PHN)","2025-05-13",{"date":88,"type":37},"2025-05-14",{"date":90,"type":37},"2025-04-10",{"date":92,"type":21},"2025-09-30",{"name":43,"class":44},""]