[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Cairo University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":633},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,1034,0,25,[9,42,68,91,109,138,160,184,206,226,244,273,297,332,355,380,417,446,470,498,529,545,567,586,609],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100053251","core-based-movement-and-nutritional-counselling-for-stress-and-metabolic-outcomes-in-overweight-women-with-functional-constipation-100053251",false,"NCT07694830","Core-Based Movement and Nutritional Counselling for Stress and Metabolic Outcomes in Overweight Women With Functional Constipation","Effects of Core-Based Movement and Nutritional Counselling on Stress, Cortisol, and Lipid Profiles in Overweight Women With Functional Constipation","Inclusion Criteria:\n\n* Female participants diagnosed with functional constipation according to Rome IV diagnostic criteria.\n* Age between 18 and 45 years.\n* Body mass index between 25 and 29.9 kg\u002Fm².\n* Ability to participate safely in the core-based movement exercise program.\n* Willingness to follow the nutritional counselling program and study procedures.\n\nExclusion Criteria:\n\n* Participants will be excluded if they have any organic gastrointestinal disorder or any disease that may affect gastrointestinal transit or colonic function.\n* Participants with inflammatory bowel disease, concurrent infectious enteritis, malignant tumors, or a history of gastrointestinal surgery, including resection of the stomach, small intestine, or large intestine, will be excluded.\n* Participants receiving steroids, antibiotics, immunosuppressive medications, or routinely using laxatives will be excluded.\n* Participants with hyperthyroidism, hypothyroidism, or other endocrine or metabolic disorders that may affect gastrointestinal function will be excluded.\n* Participants with serious cardiovascular, respiratory, renal, hepatic, hematological, neurological, or psychiatric disorders will be excluded.\n* Participants with a history or current evidence of alcohol abuse within the previous year will be excluded.\n* Participants currently engaged in an intense workout regimen will be excluded.\n* Participants with a musculoskeletal disability that may interfere with exercise applicability, such as cervical or lumbar radiculopathy, will be excluded.","FEMALE","18 Years","45 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will investigate the effect of core-based movement and nutritional counselling on stress, serum cortisol, and lipid profile in overweight women with functional constipation.\n\nSixty overweight women with functional constipation will be randomly assigned into two equal groups. The study group will include 30 participants who will receive a core-based movement exercise program for 8 weeks, two sessions per week, in addition to guideline-based nutritional counselling. The control group will include 30 participants who will receive guideline-based nutritional counselling only for 8 weeks.\n\nThe outcomes will include perceived stress, serum cortisol level, lipid profile, stool form, sleep quality, and quality of life.",[28],"Functional Constipation","NOT_YET_RECRUITING","2026-07-09",{"date":32,"type":33},"2026-07-13","ACTUAL",{"date":35,"type":22},"2026-08-25",{"date":37,"type":22},"2027-03-30",{"name":39,"class":40},"Cairo University","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":12,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":41},"100054154","dynamic-neuromuscular-stabilization-versus-corrective-exercises-in-upper-cross-syndrome-100054154","NCT07698392","Dynamic Neuromuscular Stabilization Versus Corrective Exercises in Upper Cross Syndrome","Effect of Dynamic Neuromuscular Stabilization Versus Corrective Exercises on Pain, Functional Disability, and Postural Alignment in Upper Crossed Syndrome.","DNS\u002FNASM","Inclusion Criteria:\n\n1. Having non-specfic neck Pain.\n2. Patients having a CVA of \\\u003C 52 .\n3. Forward shoulder angle \\> 52 degrees.\n\nExclusion Criteria:\n\n* Participants having conditions such as osteoporosis, blood disease, congestive heart disease, cancer, severe skin sensitization, major mental disease, and frozen shoulder, will be excluded from the study. Neck pain has a specific underlying pathology such as fractures, rheumatoid arthritis, osteoporosis, or whiplash injuries as well as neck pain associated with radiculopathy.","ALL","20 Years","40 Years",{"count":54,"type":22},45,[25],"The purpose of the study will be to investigate dynamic neuromuscular stabilization versus National American Academy of Sports Medicine (NASM) corrective exercises on pain, functional disability, cranio-vertebral angle, forward shoulder angle, and thoracic kyphosis in upper cross syndrome.",[58,59,60],"Upper Crossed Syndrome","Upper Cross Syndrome","Upper Crossed Syndorme","2026-07-08",{"date":32,"type":33},{"date":64,"type":22},"2026-11-01",{"date":66,"type":22},"2028-09-30",{"name":39,"class":40},{"id":69,"slug":70,"hasResults":12,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":12,"sex":50,"minAge":18,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":23,"phases":78,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":90,"locationsCount":4},"100053307","popliteus-muscle-release-versus-patellofemoral-mobilization-in-patellofemoral-pain-syndrome-100053307","NCT07698704","Popliteus Muscle Release Versus Patellofemoral Mobilization in Patellofemoral Pain Syndrome","PFPS","Inclusion Criteria:\n\n* Male and female participants aged 18-30 years.\n* minimum history of 3 months of unilateral PFP.\n* pain intensity score of ≥3 on a 10-cm Visual Analog Scale (VAS) for worst pain experienced during the previous week.\n* Pain reproduced during at least two of the following functional activities: stair ascent or descent, running, hopping, prolonged sitting, squatting, or kneeling.\n* Presence of pain on at least one of the following clinical tests: patellar compression test or palpation of the patellar facets.\n\nExclusion Criteria:\n\n* Clinical, x-ray, or MRI findings indicative of other specific pathology including osteoarthritis, meniscal, ligament or cartilage injury, apophysitis.\n* Recurrent patellar subluxation or dislocation.\n* Cortisone use over an extended period of time.\n* Previous surgery to the knee joint; trauma to the knee joint affecting the presenting clinical condition.\n* Lower limb deformities.","30 Years",{"count":77,"type":22},48,[25],"This study will be conducted to compare the effect of popliteus muscle release and patellofemoral mobilization on pain intensity, function, and quadriceps muscle strength in patients with patellofemoral pain syndrome?",[81],"Patellofemoral Pain Syndrome",[83,84,81],"Popliteus Muscle Release","Patellofemoral Mobilization","2026-07-07",{"date":32,"type":33},{"date":88,"type":22},"2026-07-15",{"date":64,"type":22},{"name":39,"class":40},{"id":92,"slug":93,"hasResults":12,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":12,"sex":50,"minAge":18,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":104,"startDateStruct":105,"completionDateStruct":106,"leadSponsor":108,"locationsCount":41},"100054016","impact-of-adding-integrated-neuromuscular-inhibition-technique-to-cervical-stabilization-exercise-in-chronic-mechanical-neck-pain-100054016","NCT07699458","Impact of Adding Integrated Neuromuscular Inhibition Technique to Cervical Stabilization Exercise in Chronic Mechanical Neck Pain","Inclusion Criteria:\n\n1. Age from 18-44 year\n2. Their body mass index will be ranging from (18-25) Kg\u002Fm2\n3. All patient has active cervical trigger point of the upper fiber of the Trapezius detected by pincer palpation\n4. Subjects must have characteristics of trigger points hardened, thickened taut bands in MPS patients.\n\nExclusion Criteria:\n\n1. Individuals with a recent history of neck or back surgery.\n2. Individuals with recent history of trauma or fracture.\n3. Individuals with congenital and pathological disorders of the cervical spine.\n4. Individuals with any psychiatric diseases","44 Years",{"count":99,"type":22},63,[25],"the goal of this clinical trial is to study the Impact of adding integrated neuromuscular inhibition technique to cervical stabilization exercise in chronic mechanical neck pain",[103],"Mechanical Neck Pain",{"date":32,"type":33},{"date":35,"type":22},{"date":107,"type":22},"2027-01-25",{"name":39,"class":40},{"id":110,"slug":111,"hasResults":12,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":116,"sex":50,"minAge":51,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":126,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},"100053656","ketamine-versus-dexmedetomidine-as-an-adjuvant-in-scalp-block-in-supratentorial-brain-tumor-excision-surgeries-100053656","NCT07698665","Ketamine Versus Dexmedetomidine as an Adjuvant in Scalp Block in Supratentorial Brain Tumor Excision Surgeries","Efficacy of Ketamine Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block in Adults Undergoing Supratentorial Brain Tumor Excision Surgeries for Hemodynamics and Pain Control, Double-blinded Randomized Study","Inclusion Criteria:\n\n* Age from 20 to 60 years, both sexes, American Society of Anesthesiologists (ASA) physical status II-III, Supratentorial tumor excision, Supine Position.\n\nand operation time: less than 6 hours.\n\nExclusion Criteria:\n\n* Patient refusal, disturbed consciousness level (Glasgow Coma Scale \\[GCS\\] \\\u003C 15). Patients who required reintubation during the study period, those not extubated. immediately after surgery, or those who awoke with neurological deficits impairing. pain assessments were excluded from the final analysis, history of psychotic disorders or previous surgeries, Poor cognitive function.\n\nPostictal state or uncontrolled\u002Frecurrent seizures, known allergy to dexmedetomidine or ketamine, difficult intubation (Mallampati score \\> III) or multiple intubation attempts, operation duration \\> 6 hours, renal dysfunction (creatinine \\> 1.2 mg\u002FdL, BUN \\> 20 mg\u002FdL), heart block and patients with chronic headache disorders or those receiving chronic analgesic therapy (for \\>3 months) were excluded.",true,"60 Years",{"count":119,"type":22},90,[25],"Supratentorial brain tumor surgeries are associated with significant nociceptive stimulation and postoperative pain, which may adversely affect patient outcomes. Scalp block has emerged as an effective regional anesthetic technique to improve analgesia and reduce opioid consumption.\n\nObjective: To compare efficacy of ketamine versus dexmedetomidine as adjuvants to bupivacaine in scalp blocks for supratentorial brain tumor surgeries, focusing on analgesia, opioid consumption, and hemodynamic stability.\n\nMethods:\n\nThis randomized double-blinded controlled trial included 80 patients undergoing supratentorial tumor excision, allocated equally into two groups: Group K received bupivacaine with ketamine (2 mg\u002Fkg), and Group D received bupivacaine with dexmedetomidine (1 µg\u002Fkg). Intraoperative hemodynamics, fentanyl consumption, postoperative pain scores (NRS), analgesic requirements, and complications were assessed.",[123,124,125],"Regional Anesthesia Morbidity","Supratentorial Brain Tumor","Acute Pain",[127,128,129],"Scalp block","Dexemetomedine","Supratentorial","RECRUITING",{"date":32,"type":33},{"date":133,"type":33},"2026-01-01",{"date":135,"type":22},"2026-07-30",{"name":39,"class":40},2,{"id":139,"slug":140,"hasResults":12,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":116,"sex":50,"minAge":18,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":23,"phases":148,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":154,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":41},"100053580","diaphragmatic-and-box-breathing-on-heart-rate-variability-and-perceived-stress-100053580","NCT07698652","Diaphragmatic and Box Breathing on Heart Rate Variability and Perceived Stress","Enhancing Physiological and Psychological Resilience: A Comparative Study of Diaphragmatic and Box Breathing in Physical Therapy Students.","HRV DB BB PSS","Inclusion Criteria:\n\n* Academic Status: Currently enrolled, full-time undergraduate Physical Therapy students\n* Age Range: 18-25 years\n* Health Status: Generally healthy individuals with no known chronic respiratory or cardiovascular diseases.\n* Informed Consent: Ability and willingness to provide written informed consent and commit to the 4-week protocol (6 sessions\u002Fweek).\n* Stress Level: A baseline score on the Perceived Stress Scale (PSS) indicating at least moderate stress.\n\nExclusion Criteria:\n\n* Pre-existing Breathing Expertise: Individuals with professional training in yoga (Pranayama), formal meditation, or advanced breath work that might bias the baseline results.\n* Medical Conditions: Diagnosed respiratory conditions (e.g., Asthma, COPD).\n* Cardiovascular issues (e.g., Arrhythmias, Hypertension).\n* Clinical psychological disorders (e.g., Generalized Anxiety Disorder or Panic Disorder) that may require medication.\n* Pharmacological Factors: Use of medications that influence the Autonomic Nervous System (e.g., Beta-blockers, antidepressants, or heavy use of stimulants\u002Fsedatives).\n* Substance Use: Smokers\u002FVapers\n* Excessive Caffeine \"Participants consuming more than 400 mg of caffeine per day (equivalent to approximately 4 standard cups of brewed coffee) will be excluded.\n* Recent Acute Illness: Any respiratory tract infection or fever within two weeks prior to the start of the study","25 Years",{"count":21,"type":22},[25],"The goal of this clinical trial is to learn if diaphragmatic breathing and box breathing work to enhance resilience and manage stress in physical therapy students. It will also learn about their effects on overall physiological and psychological parameters. The main questions it aims to answer are:\n\nDo these breathing techniques improve heart rate variability (HRV)?\n\nHow do these interventions affect participants' perceived stress levels, cognitive performance, and academic achievement?\n\nResearchers will compare diaphragmatic breathing and box breathing to a control group to see if these non-invasive methods work to improve physiological adaptation and manage stress.\n\nParticipants will:\n\nBe randomly assigned to practice diaphragmatic breathing, practice box breathing, or join a control group Have their heart rate variability (HRV) measured as a primary sign of physiological adaptation Complete assessments to evaluate their perceived stress, cognitive performance, and academic achievement",[151,152,153],"Stress","Psychological Resilience","Healthy Students",{"date":32,"type":33},{"date":156,"type":22},"2026-07-01",{"date":158,"type":22},"2027-03-01",{"name":39,"class":40},{"id":161,"slug":162,"hasResults":12,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":116,"sex":50,"minAge":117,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":23,"phases":170,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":179,"startDateStruct":180,"completionDateStruct":181,"leadSponsor":183,"locationsCount":41},"100053918","impairment-based-treatment-versus-modified-functional-restoration-program-in-chronic-low-back-pain-patients-100053918","NCT07699419","Impairment Based Treatment Versus Modified Functional Restoration Program in Chronic Low Back Pain Patients","FIRM-CLBP: a Randomized Controlled Feasibility Trial Comparing Impairment-based Treatment With a Modified Functional Restoration Program in Older Adults With Chronic Low Back Pain","FIRM-CLBP","Inclusion Criteria:\n\n* ≥ 60 years\n* Chronic Non-Specific Low Back Pain (CNSLBP)\n* Pain duration ≥ 12 weeks\n* No identifiable specific spinal pathology\n* Pain Location\n* Pain localized between the 12th rib and gluteal folds\n* With or without non-dermatomal referred pain not extending below the knee\n* Pain Intensity\n* Mean pain intensity ≥ 4\u002F10 on the Numeric Rating Scale (NRS) over the past 7 days\n* Functional Disability\n* Oswestry Disability Index (ODI) ≥ 20% (moderate disability or higher)\n* Mechanical Pain Characteristics\n* Presence of ≥ 2 of the following:\n* Pain aggravated by movement, loading, or prolonged postures\n* Pain relieved by rest or positional change\n* Morning stiffness \\\u003C 30 minutes\n* Absence of constant, non-mechanical night pain Functional Capacity\n* Able to ambulate independently (with or without assistive device)\n* Able to actively participate in an exercise-based rehabilitation program\n* Clinical Stability\n* Stable medication regimen (analgesics, anti-inflammatories, or related drugs) for ≥ 4 weeks\n* No planned changes in pharmacological treatment during the study period\n* Cognitive \\& Communication Ability\n* Able to understand study procedures and follow instructions\n* MMSE ≥ 24 (or equivalent cognitive screening)\n* Consent\n* Provides written informed consent\n\nExclusion Criteria:\n\n* 1\\. Specific Spinal Pathology (\"Red Flags\")\n\n  * Suspected or confirmed:\n  * Spinal fracture\n  * Malignancy\n  * Spinal infection\n  * Inflammatory spondyloarthropathy\n\nClinical indicators:\n\nUnexplained weight loss Fever or systemic illness History of significant trauma\n\n2\\. Radicular or Neurological Involvement\n\n* Radiculopathy defined by ANY of:\n* Dermatomal pain radiating below the knee\n* Progressive motor weakness\n* Objective neurological deficit (sensory, reflex, or motor)\n\n  3\\. Lumbar Spinal Stenosis (Severe)\n* Neurogenic claudication limiting walking to \\\u003C 100 meters, OR\n* Symptoms not relieved by rest or flexion\n\n  4\\. Prior Surgical or Structural Conditions Lumbar spine surgery within the past 12 months\n\n  5\\. Medical Contraindications to Exercise\n* Severe osteoporosis with high fracture risk\n* Uncontrolled cardiovascular, respiratory, or metabolic disease\n* Any condition precluding safe participation in rehabilitation\n\n  6\\. Cognitive or Behavioral Barriers\n* Severe cognitive impairment (MMSE \\\u003C 24)\n* Inability to comply with study procedures\n\n  7\\. Confounding Treatment Factors\n* Participation in structured physiotherapy or rehabilitation within the past 3 months\n* Planned concurrent rehabilitation during the study\n\n  8\\. Psychosocial Confounders Ongoing litigation or compensation claims related to low back pain",{"count":169,"type":22},18,[25],"The aim of this feasibility study is to evaluate the practicality of conducting a future randomized controlled trial comparing two rehabilitation approaches for older adults with degenerative chronic low back pain: impairment-based treatment (IBT) and a modified short Functional Restoration Program (FRP).\n\nImpairment-based treatment is an individualized approach in which interventions are tailored to the patient's specific physical deficits, such as limitations in mobility, strength, and motor control. In contrast, the Functional Restoration Program is a structured, standardized approach focusing on improving overall functional capacity through progressive exercise, movement retraining, and activity-based rehabilitation.\n\nParticipants will be randomly allocated to one of the two groups. Both interventions will be delivered by trained physiotherapists following standardized protocols over a 6-week period, with supervised sessions conducted according to a predefined rehabilitation schedule.",[173],"Chronic Low Back Pain (CLBP)",[175,176,177,178],"LBP","Old age","Impairment","Functional",{"date":32,"type":33},{"date":156,"type":22},{"date":182,"type":22},"2027-01-10",{"name":39,"class":40},{"id":185,"slug":186,"hasResults":12,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":12,"sex":50,"minAge":18,"maxAge":190,"enrollmentInfo":191,"targetDuration":4,"studyType":193,"phases":4,"briefSummary":194,"conditions":195,"keywords":197,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":200,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":41},"100053931","the-correlation-between-central-conduction-time-and-central-pain-syndrome-in-chronic-neck-pain-100053931","NCT07698691","The Correlation Between Central Conduction Time and Central Pain Syndrome in Chronic Neck Pain","Inclusion Criteria:\n\n* Participants aged 18-35 years.\n* Normal Body Mass Index (BMI) less than 25 kg\u002Fm2.\n* Both genders were included.\n* having chronic neck pain lasting for more than three months.\n\nExclusion Criteria:\n\n* signs of serious pathology (e.g., malignancy, inflammatory disorders, infection).\n* history of cervical spine surgery.\n* history of trauma or fractures in the cervical spine.\n* presence of vascular syndromes such as vertebrobasilar insufficiency.","35 Years",{"count":192,"type":22},120,"OBSERVATIONAL","To investigate the neurophysiological relationship between Central Conduction Time measured via Somatosensory evoked potentials and pain intensity in individuals suffering from chronic neck pain",[196],"Chronic Neck Pain",[198,199,196],"Central Conduction Time","Central Pain Syndrome",{"date":32,"type":33},{"date":202,"type":22},"2026-07-10",{"date":204,"type":22},"2026-09-01",{"name":39,"class":40},{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":12,"sex":50,"minAge":18,"maxAge":117,"enrollmentInfo":214,"targetDuration":4,"studyType":193,"phases":4,"briefSummary":216,"conditions":217,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":4},"100053510","deep-learning-framework-for-classification-3d-segmentation--visualization-of-c-shaped-canals-100053510","NCT07697378","Deep Learning Framework for Classification, 3D Segmentation & Visualization of C-shaped Canals","Diagnostic Accuracy of a Deep Learning Framework for Automated Classification, 3D Segmentation and Comprehensive Visualization of C-shaped Root Canal Architecture From Cone-Beam Computed Tomography","AI","Inclusion Criteria:\n\n* CBCT scans of C- shaped canals of patients aged 18 years or older, with satisfactory image quality, characterized by adequate sharpness, contrast and noise levels, enabling accurate delineation of pulp chambers and root canals. Additionally, the CBCT scans needed to have a field of view (FOV) covering the area of interest.\n\nExclusion Criteria:\n\n* Patients younger than 18 years. CBCT scans with poor image quality (e.g., motion artifacts, excessive noise, low contrast, or beam hardening artifacts).\n\nIncomplete field of view that does not include the tooth of interest.",{"count":215,"type":22},112,"The goal of this retrospective diagnostic accuracy study is to develop and validate a deep learning framework for the automated classification, three-dimensional (3D) segmentation, and visualization of C-shaped root canal anatomy using cone-beam computed tomography (CBCT) scans in adults with C-shaped root canals.\n\nThe main questions it aims to answer are:\n\nCan a deep learning model accurately classify C-shaped root canal configurations from CBCT images? Can the model precisely segment the complex 3D anatomy of C-shaped root canals, including fins, webs, and isthmuses, with accuracy comparable to expert endodontists? Can the automated framework improve the efficiency and clinical utility of diagnosing and visualizing C-shaped root canal anatomy?",[218],"C-shaped Root Canal","2026-07-05",{"date":32,"type":33},{"date":222,"type":22},"2026-09-05",{"date":224,"type":22},"2027-10-01",{"name":39,"class":40},{"id":227,"slug":228,"hasResults":12,"nctId":229,"briefTitle":230,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":12,"sex":50,"minAge":52,"maxAge":117,"enrollmentInfo":232,"targetDuration":4,"studyType":23,"phases":233,"briefSummary":234,"conditions":235,"keywords":4,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":41},"100641257","effect-of-high-power-laser-therapy-on-disc-morphology-and-functional-outcome-in-patients-with-cervical-radiculopathy-100641257","NCT07661290","Effect of High-Power Laser Therapy on Disc Morphology and Functional Outcome in Patients With Cervical Radiculopathy","Inclusion Criteria:\n\n\\- Adults aged between 40 to 60 years.\n\n• A Body Mass Index (BMI) range of 18.5-35 (normal to overweight) will be required.\n\n• Diagnosed with cervical radiculopathy, confirmed by clinical examination and diagnostic imaging (e.g., MRI).\n\n• Pain intensity level of at least 4 on the Visual Analog Scale (VAS).\n\n• No previous history of surgery on the cervical spine.\n\n• Able to provide informed consent and participate in the study protocol.\n\nExclusion Criteria:\n\n* Pregnant women or those planning to become pregnant. • Individuals with severe comorbidities that could interfere with the study, such as uncontrolled diabetes, cancer, or systemic inflammatory diseases.\n\nIndividuals with severe cervical stenosis or spinal cord compression.\n\n• Individuals any form of malignancy, active infection, or dermatological issues on the neck.\n\n• Patients using opioid analgesics or other strong pain medications that could alter the results.\n\n• Previous treatment with high-power laser therapy within the last six months.",{"count":21,"type":22},[25],"The study aims to evaluate the effectiveness of high-power laser therapy (HPLT) in patients with cervical radiculopathy, focusing on its impact on disc morphology, and overall functional activity",[236],"Radiculopathy",{"date":238,"type":33},"2026-07-02",{"date":240,"type":33},"2026-06-30",{"date":242,"type":22},"2026-11-20",{"name":39,"class":40},{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":116,"sex":50,"minAge":251,"maxAge":252,"enrollmentInfo":253,"targetDuration":4,"studyType":23,"phases":255,"briefSummary":256,"conditions":257,"keywords":259,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":4},"100644806","evaluation-of-instrumentation-time-and-obturation-quality-using-two-different-pediatric-rotary-file-systems-in-primary-molar-pulpectomy-100644806","NCT07672990","Evaluation of Instrumentation Time and Obturation Quality Using Two Different Pediatric Rotary File Systems in Primary Molar Pulpectomy","Evaluation of Instrumentation Time and Obturation Quality Using Two Different Pediatric Rotary File Systems in Primary Molar Pulpectomy :(A Randomized Clinical Trial)","Inclusion Criteria:\n\n1. Healthy Cooperative children.\n2. Children between the ages of four and eight years.\n3. Restorable teeth with irreversible pulpitis.\n4. Continuous bleeding after amputation of coronal pulp tissue.\n\nExclusion Criteria:\n\n1. Molars that exhibit physiologic root resorption in excess of one-third.\n2. Internal and external root resorption.\n3. Presence of dental abscess, sinus tract or excessive mobility.\n4. Acute spreading infection\u002Fcellulitis not manageable with local treatment.\n5. Large periapical\u002Ffurcation lesion with poor prognosis.\n6. Teeth close to natural exfoliation.\n7. Children with known allergies to study materials or medications used.","4 Years","8 Years",{"count":254,"type":22},30,[25],"Preserving primary teeth is essential for maintaining normal chewing, speech development, and psychological well-being. Successful pulpectomy depends on effective chemomechanical preparation of the root canals while preserving their original anatomy. Although hand files are traditionally used for canal preparation in primary teeth, they are time-consuming and may increase the risk of procedural errors. Nickel-titanium (Ni-Ti) rotary systems have gained popularity because they improve canal shaping and reduce instrumentation time. Among these systems, Pediatric NiTi rotary files manufactured with AF-H Wire technology and Pediatric NiTi rotary files manufactured with blue Wire technology are specifically designed for pediatric use. However, evidence regarding their clinical performance remains limited, highlighting the need to compare their effectiveness, particularly in terms of instrumentation time and obturation quality",[258],"Pulpectomy",[260,261,262,263,264,265],"EndoArt Pedo Blue","fanta Baby","instrumentation time","obturation quality","pulpectomy using rotary files","rotary files in primary molars","2026-06-28",{"date":156,"type":33},{"date":269,"type":22},"2026-09",{"date":271,"type":22},"2027-09",{"name":39,"class":40},{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":12,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":280,"targetDuration":4,"studyType":23,"phases":282,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":41},"100645024","mulligan-mobilization-versus-pnf-technique-in-sis-100645024","NCT07675655","Mulligan Mobilization Versus PNF Technique in SIS","Shoulder Mulligan Mobilization Versus Proprioceptive Neuromuscular Facilitation Technique In Subacromial Impingement Syndrome","Inclusion Criteria:\n\n1. Sixty nine Males and females subjects with SIS, age between 20-40 years old and body mass index (BMI) 18-27.9 kg\u002Fm2\n2. The SIS group will be limited to patients who had history of shoulder pain of \\>1-week duration.\n3. Pain localized at the proximal anterolateral shoulder region.\n4. Patients with subacromial pain syndrome with positive results of 3 of 5 tests: painful arc, pain or weakness with resisted external rotation, Neer test, Hawkins Kennedy test, and Jobe\u002Fempty can test.\n\nExclusion Criteria:\n\n* Patients will be excluded if they had any of the following conditions:\n\n  1. Open wounds, infection, acute injuries, swelling, rheumatoid arthritis, reflex sympathetic syndrome, or adhesive capsulitis.\n  2. BMI greater than 28 kg\u002Fm².\n  3. History of shoulder girdle fractures and dislocation, shoulder surgery in the last 12 months or full thickness rotator cuff tear.\n  4. History of systemic or neurological disorder, cervical radiculopathy and subjects who had received physical therapy treatment for their shoulder within the past three months.\n  5. History of corticosteroid injection in the shoulder region less than 12 weeks previously.",{"count":281,"type":22},69,[25],"To investigate the differences between adding Mulligan mobilization and PNF to the conventional physical therapy program on shoulder pain, function, shoulder muscles strength, glenohumeral flexion, abduction, external rotation, and internal rotation ROM, scapular symmetry, and pectoralis minor length in patients with SIS.",[285],"Subacromial Impingement Syndrome",[287,288,289],"Rotator Cuff Impingement Syndrome","PROPRIOCEPTIVE NEUROMUSCLAR FACILITATION TECHNIQUE","mulligan mobilization","2026-06-27",{"date":240,"type":33},{"date":293,"type":33},"2025-09-02",{"date":295,"type":22},"2026-08-01",{"name":39,"class":40},{"id":298,"slug":299,"hasResults":12,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":303,"eligibilityCriteria":304,"healthyVolunteers":116,"sex":50,"minAge":18,"maxAge":19,"enrollmentInfo":305,"targetDuration":4,"studyType":193,"phases":4,"briefSummary":307,"conditions":308,"keywords":313,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":327,"startDateStruct":328,"completionDateStruct":329,"leadSponsor":331,"locationsCount":41},"100645326","hamstring-tightness-and-lumbar-lordosis-angle-across-functional-sitting-postures-100645326","NCT07682142","HAMSTRING TIGHTNESS AND LUMBAR LORDOSIS ANGLE ACROSS FUNCTIONAL SITTING POSTURES","CORRELATION BETWEEN HAMSTRING TIGHTNESS AND LUMBAR LORDOSIS ANGLE ACROSS FUNCTIONAL SITTING POSTURES IN SEDENTARY ADULTS.","LLA-HT","Inclusion Criteria:\n\n* Healthy adults aged 18-45 years.\n* Sedentary occupation requiring \\> 6 hours of sitting per day.\n* Active Knee Extension (AKE) angle \\>15°.\n* Bilateral hamstring tightness.\n* Sedentary individual as determined by IPAQ (MET≤ 600 min\u002Fweek).\n* Asymptomatic for low back pain at the time of testing.\n\nExclusion Criteria:\n\n* History of significant low back pain requiring medical treatment in the past 12 months.\n* Previous spinal surgery or structural spinal deformities.\n* Lower extremity injury or surgery within the past 6 months.\n* Neurological disorders affecting sensation or movement.\n* Pregnant female or get birth in the last year.\n* Body mass index (BMI) ≥ 30 kg\u002Fm².\n* postural deviations resulting from shortening of the iliopsoas and erector spinae or insufficiency of the core stabilizers and hip extensors",{"count":306,"type":22},110,"The goal of this observational study is to learn about the relationship between hamstring tightness and the lumbar lordosis angle in sedentary adults across different sitting postures. The main question it aims to answer is:\n\nIs hamstring tightness related to the lumbar lordosis angle across three functional sitting postures (upright, slumped, and forward-leaning)? It also asks whether hamstring tightness differs between men and women, whether it differs between the dominant and non-dominant leg, and whether the lumbar lordosis angle differs between men and women across the three postures.\n\nParticipants will have their hamstring tightness measured with the Active Knee Extension test and their lumbar lordosis angle measured with a bubble inclinometer while sitting in each of the three postures.",[309,310,311,312],"Hamstring Tightness","Lumbar Lordosis","Sedentary Behavior","Posture Sitting Position",[314,315,316,317,318,319,320,321,322,323,324,325,326],"Hamstring tightness","Lumbar lordosis","Sitting posture","Functional sitting postures","Sedentary adults","Active Knee Extension test","AKE test","bubble inclinometer","Pelvic tilt","Lumbopelvic rhythm","Limb dominance","Posterior pelvic tilt","Spinopelvic alignment",{"date":238,"type":33},{"date":295,"type":22},{"date":330,"type":22},"2026-12-01",{"name":39,"class":40},{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":12,"sex":50,"minAge":18,"maxAge":4,"enrollmentInfo":339,"targetDuration":4,"studyType":23,"phases":340,"briefSummary":341,"conditions":342,"keywords":4,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":350,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":354,"locationsCount":41},"100644957","hemodynamic-effect-of-dexmedetomidine-versus-magnesium-sulphate-as-an-adjuvant-to-lidocaine-in-preemptive-peribulbar-block-in-patients-undergoing-dacryocystorhinostomy-under-general-anesthesia-100644957","NCT07675616","Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia","Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Undergoing elective Dacryocystorhinostomy (DCR) surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Patients have local infection.\n* Allergic reaction or complications of the local anaesthesia (LA).\n* Coagulopathy defined as international normalized ratio (INR) \\> 1.5, platelet count \\\u003C 100,000\u002Fmm³, or ongoing anticoagulant therapy not adequately discontinued.\n* Uncontrolled systemic disease, defined as poorly controlled hypertension \\[systolic blood pressure (SBP) \\> 160 mmHg\\], uncontrolled diabetes mellitus (HbA1c \\> 8.5%), unstable ischemic heart disease, or decompensated hepatic or renal disease.\n* Uncooperative patients.",{"count":21,"type":22},[25],"This study aims to compare the hemodynamic effect of dexmedetomidine and magnesium sulphate as an adjuvant to lidocaine in preemptive peribulbar block in patients undergoing Dacryocystorhinostomy (DCR) under general anaesthesia (GA) .",[343,344,345,346,347,348,349],"Hemodynamic Effect","Dexmedetomidine","Magnesium Sulphate","Lidocaine","Peribulbar Block","Dacryocystorhinostomy","General Anesthesia",{"date":240,"type":33},{"date":352,"type":33},"2026-05-16",{"date":330,"type":22},{"name":39,"class":40},{"id":356,"slug":357,"hasResults":12,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":4,"eligibilityCriteria":361,"healthyVolunteers":12,"sex":50,"minAge":362,"maxAge":363,"enrollmentInfo":364,"targetDuration":4,"studyType":23,"phases":365,"briefSummary":366,"conditions":367,"keywords":369,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":376,"completionDateStruct":377,"leadSponsor":379,"locationsCount":4},"100644847","functional-progressive-resistive-training-and-cerebral-palsy-100644847","NCT07675343","Functional Progressive Resistive Training and Cerebral Palsy","Effect of Functional Progressive Resistance Training on Bone Mineral Density and Balance in Children With Cerebral Palsy","Inclusion Criteria:\n\n1. A diagnosis of spastic diplegic CP\n2. Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)\n3. The age of the selected children will range from 6 to 10 years old.\n4. Children are levels II and III according to GMFCS\n\nExclusion Criteria:\n\n1 - Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).","6 Years","10 Years",{"count":21,"type":22},[25],"Functional Progressive Resistive Exercise (FPRE) is a strengthening approach that combines functional movement activities with progressively increased resistance. It involves performing task-oriented exercises, such as sit-to-stand, stair climbing, and walking-related activities, while gradually increasing the load to enhance muscle strength, endurance, and functional performance. FPRE is widely used in rehabilitation programs to improve mobility and the ability to perform activities of daily living in various populations, including children with neurological and musculoskeletal disorders.",[368],"Cerebral Palsy",[370,371,372,373],"cerebral palsy","functional progressive resistive exercise","bone mineral density","balance","2026-06-26",{"date":240,"type":33},{"date":156,"type":22},{"date":378,"type":22},"2026-11-09",{"name":39,"class":40},{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":386,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":50,"minAge":251,"maxAge":252,"enrollmentInfo":388,"targetDuration":4,"studyType":23,"phases":390,"briefSummary":391,"conditions":392,"keywords":401,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":411,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":41},"100644947","oxymetazoline-versus-sodium-hypochlorite-as-hemostatic-agents-in-mta-pulpotomy-of-primary-molars-100644947","NCT07675330","Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars","Comparative Evaluation of Clinical and Radiographic Success of Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars in a Group of Egyptian Children: A Randomized Controlled Trial","OXY - MTA","Inclusion Criteria:\n\n• Patients: Egyptian children with carious mandibular primary molars aged 4-8 years.\n\n• Teeth: Restorable mandibular primary molars with no clinical signs or symptoms of irreversible pulpitis.\n\n• Pre-operative Radiograph: No radiographic signs of internal or external root resorption and no furcation or periapical radiolucencies.\n\n\\-\n\nExclusion Criteria:\n\n* • Patients:\n\n  1. Uncooperative children.\n  2. Medically compromised children.\n  3. Patients whose parents refuse to participate or refuse to sign the informed consent.\n\n     * Teeth:\n\n  \u003C!-- -->\n\n  1. Previously accessed molars.\n  2. Mobile primary molars.\n  3. Presence of sinus tract or pain on percussion.",{"count":389,"type":22},50,[25],"This study aims to evaluate clinical and radiographic success of oxymetazoline versus sodium hypochlorite as hemostatic agents in MTA pulpotomy of primary molars.",[393,394,395,396,397,398,399,400],"Pulp Disease, Dental","Pulp Therapy in Primary Molars","Pulpitis - Reversible","Pulp Inflammation","Vital Pulp Therapies","Carious Exposure of Pulp","Primary Molar Tooth","Primary Molar Pulpotomy",[402,403,404,405,406,407,408,409,410],"Pulp therapy in primary molars","pulpotomy","MTA pulpotomy for primary molars","Sodium hypochlorite","Oxymetazoline","Hemostatic agents","NaOCl","Oxy","Oxymetazoline nasal spray",{"date":240,"type":33},{"date":413,"type":22},"2026-08",{"date":415,"type":22},"2027-12",{"name":39,"class":40},{"id":418,"slug":419,"hasResults":12,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":423,"eligibilityCriteria":424,"healthyVolunteers":12,"sex":50,"minAge":18,"maxAge":4,"enrollmentInfo":425,"targetDuration":4,"studyType":23,"phases":427,"briefSummary":428,"conditions":429,"keywords":431,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":440,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":445,"locationsCount":41},"100641061","assessment-of-bone-density-following-application-of-bmac-around-zygomatic-implant-100641061","NCT07657026","Assessment of Bone Density Following Application of BMAC Around Zygomatic Implant","Assessment of Bone Density Following Application of Bone Marrow Aspirate Concentrate Around Zygomatic Implants (Via the Intrasinus Approach): A Case Series Study","BMAC","Inclusion Criteria:\n\n* Patients over 18 years old.\n* Patients requiring rehabilitation with zygomatic implants in the posterior maxilla.\n* Patients who are willing to participate and able to provide informed consent.\n\nExclusion Criteria:\n\n* Pregnant women.\n* Individuals with history of radiation therapy or other contraindications for surgery.\n* Patients with bone marrow diseases.\n* Patients with local infections at intraoral surgical site or bone marrow aspiration site.\n* Patients unwilling to sign the written informed consent.\n* Heavy smokers \\>20 cigarettes per day.\n* Patients taking contraindicated drugs such as bisphosphonates.\n* Patients with sinus pathology or acute sinusitis.\n* Patients with malignancy or pathology of maxilla.",{"count":426,"type":22},10,[25],"This prospective case series is designed to evaluate the effect of autologous bone marrow aspirate concentrate applied around zygomatic implants placed via the intrasinus approach. The study will include adult patients with severe maxillary atrophy requiring zygomatic implant rehabilitation. BMAC will be prepared from iliac crest aspirate and loaded on gelatin sponge at the implant site. Peri-implant bone density will be assessed using CBCT at baseline and 6 months postoperatively. Secondary implant stability will be measured using resonance frequency analysis. (Recruitment has not started yet)",[430],"Severe Maxillary Atrophy",[432,433,434,435,436,437,438,439],"zygomatic implants","Bone marrow aspirate concentrate","Bone density","CBCT","Intrasinus approach","Mesenchymal stem cells","Osseointegration","Secondary stability",{"date":240,"type":33},{"date":442,"type":22},"2026-06-15",{"date":444,"type":22},"2027-06-15",{"name":39,"class":40},{"id":447,"slug":448,"hasResults":12,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":452,"eligibilityCriteria":453,"healthyVolunteers":12,"sex":50,"minAge":18,"maxAge":52,"enrollmentInfo":454,"targetDuration":4,"studyType":23,"phases":456,"briefSummary":457,"conditions":458,"keywords":460,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":464,"lastUpdatePostDateStruct":465,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":469,"locationsCount":4},"100645216","comparing-between-mulligan-technique-and-active-release-technique-in-treatment-of-chronic-mechanical-neck-pain-100645216","NCT07679438","Comparing Between Mulligan Technique and Active Release Technique in Treatment of Chronic Mechanical Neck Pain","Effect of Mulligan Mobilization Technique Versus Active Release Technique on Chronic Non-specific Neck Pain","MWM\u002FART","Inclusion Criteria:\n\n* Inclusion Criteria\n\nThe participants will be included in this study if they meet the following criteria:\n\n1. Have referred from orthopedic surgeon diagnosed with NSCNP that has been localized to the cervical and periscapular areas for at least three months\n2. Aged from 18-40 years\n3. Having a score more than 10 on the Neck disability index (NDI)\n4. BMI from 18.5 to 29.9 kg\u002Fm2.\n\nExclusion Criteria:\n\nThe Participants will be excluded from this study if they meet any of the following criteria\n\n1. History of previous neck surgery.\n2. Recent or old fractures.\n3. Cognitive impairment and inability to understand the scale.\n4. Systematic inflammatory disease e.g., rheumatoid arthritis and ankylosing spondylitis, neck pain with radiculopathy or neuropathy.\n5. A score of below 10 or above 40 points out of 50 on the NDI.",{"count":455,"type":22},36,[25],"This study will be conducted to compare between Mulligan mobilization technique and Active release technique in management of non-specific chronic neck pain as regard to neck pain, cervical range of motion and neck function.",[459],"Chronic Non-specific Neck Pain",[461,462,463],"Mulligan","Active release technique","neck pain","2026-06-25",{"date":156,"type":33},{"date":467,"type":22},"2026-07",{"date":413,"type":22},{"name":39,"class":40},{"id":471,"slug":472,"hasResults":12,"nctId":473,"briefTitle":474,"officialTitle":475,"acronym":4,"eligibilityCriteria":476,"healthyVolunteers":12,"sex":50,"minAge":18,"maxAge":52,"enrollmentInfo":477,"targetDuration":4,"studyType":23,"phases":479,"briefSummary":480,"conditions":481,"keywords":483,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":464,"lastUpdatePostDateStruct":492,"startDateStruct":494,"completionDateStruct":495,"leadSponsor":497,"locationsCount":4},"100644552","effect-of-adipose-tissue-derived-autologous-mesenchymal-stem-cell-concentrate-on-bone-quality-in-mandibular-fracture-healing-100644552","NCT07671183","Effect of Adipose Tissue Derived Autologous Mesenchymal Stem Cell Concentrate on Bone Quality in Mandibular Fracture Healing.","Bone Quality Assessment Following Application of Adipose Tissue Derived Autologous Mesenchymal Stem Cell Concentrate in the Management of Mandibular Fractures. A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients with mandibular fracture.\n* Patients who are willing to participate in the study\n\nExclusion Criteria:\n\n* Patients with systemic diseases influence bone healing\n* Patients with pathological fractures.\n* Infection located at the zone to be treated",{"count":478,"type":22},20,[25],"* The goal of study is to evaluate the effectiveness of adipose tissue derived-MSCs concentrate application in mandibular fractures. The main question it aims to answer is: Does intervention enhance bone quality, reduce complications and reduce bone regeneration time.\n* Researchers will compare the effectiveness of adipose tissue derived-MSCs concentrate application with ORIF to ORIF alone to see if MSCs improve healing in mandibular fractures.\n* Participants will:\n\n  * Be managed either by adipose tissue derived-MSCs concentrate application with ORIF or ORIF alone.\n  * Undergo CBCT immediately (T1) and 3 months (T4) postoperatively for bone density radiographic evaluation\n  * Visit the clinic postoperatively at one week (T2), one month (T3), three months (T4) for clinical examination",[482],"Mandible Fracture",[484,485,486,487,488,489,490,491],"bone quality","bone healing","mandibular fractures","mesenchymal stem cells","randomized clinical trial","fracture repair","bone regeneration","regenerative medicine",{"date":493,"type":33},"2026-06-29",{"date":467,"type":22},{"date":496,"type":22},"2027-02",{"name":39,"class":40},{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":73,"eligibilityCriteria":504,"healthyVolunteers":12,"sex":50,"minAge":18,"maxAge":505,"enrollmentInfo":506,"targetDuration":4,"studyType":23,"phases":508,"briefSummary":509,"conditions":510,"keywords":516,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":464,"lastUpdatePostDateStruct":523,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":41},"100644562","effects-of-kinesio-taping-versus-mcconnell-taping-on-clinical-outcomes-in-patients-with-patellofemoral-pain-syndrome-100644562","NCT07671482","Effects of Kinesio Taping Versus McConnell Taping on Clinical Outcomes in Patients With Patellofemoral Pain Syndrome.","Effects of Kinesio Taping Versus McConnell Taping on Clinical Outcomes in Patients With Patellofemoral Pain Syndrome. A Randomized Clinical Trial.","Inclusion Criteria:\n\n* Anterior or retropatellar pain for a minimum of 3 months during functional activities.\n* 18-50 years of age.\n* Minimum pain of 3\u002F10 on the VAS score.\n* No LL physical therapy in the past 3 months.\n\nExclusion Criteria:\n\n* Meniscal or ligamentous injury\n* Neurological or systemic conditions affecting proprioception, coordination and balance.\n* Spinal referred pain or rheumatoid arthritis.\n* Hip and ankle disorders.","50 Years",{"count":507,"type":22},80,[25],"The primary goal of this randomized clinical trial (RCT) is to evaluate whether Kinesio Taping versus McConnell Taping, when integrated into a standardized hip-knee strengthening and neuromuscular control program, produces significant effects in individuals aged 18-50 with patellofemoral pain syndrome (PFPS).\n\nThe main question it aims to answer is: Does Kinesio Taping compared with McConnell Taping when both combined with a standardized hip-knee exercise program, produce different effects on quadriceps neuromuscular activation (VMO-VL sEMG), pain, functional knee pain, and dynamic knee valgus over a 6 week period intervention?\n\nParticipants will be divided into three groups for comparison: the control group will receive a structured hip-knee physical therapy exercise program without any taping intervention, Kinesio Taping group with a standardized exercise program, and a McConnell Taping group with a standardized exercise program.",[511,512,73,81,513,514,515],"Patello Femoral Pain Syndrome","Anterior Knee Pain Syndrome","Patellofemoral Disorder","Patellofemoral Pain, PFP","Patellofemoral Pain (PFPS)",[517,518,519,520,521,81,522],"Electromyography","EMG","Kinesio Taping","McConnell Taping","Exercise Therapy","Single-Leg Squat",{"date":374,"type":33},{"date":525,"type":22},"2026-06",{"date":527,"type":22},"2026-10",{"name":39,"class":40},{"id":530,"slug":531,"hasResults":12,"nctId":532,"briefTitle":533,"officialTitle":533,"acronym":4,"eligibilityCriteria":534,"healthyVolunteers":12,"sex":50,"minAge":52,"maxAge":117,"enrollmentInfo":535,"targetDuration":4,"studyType":23,"phases":536,"briefSummary":537,"conditions":538,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":464,"lastUpdatePostDateStruct":540,"startDateStruct":541,"completionDateStruct":542,"leadSponsor":544,"locationsCount":41},"100645212","effect-of-pneumatic-compression-on-diaphragmatic-excursion-in-hemodialysis-patients-with-low-back-dysfunction-100645212","NCT07679425","Effect of Pneumatic Compression on Diaphragmatic Excursion in Hemodialysis Patients With Low Back Dysfunction","Inclusion Criteria:\n\n* Patients have been on regular hemodialysis (three sessions a week) at least 6 months before the start of the study\n* Patients 'Age between 40 and 60 years old\n* Patients have not participated in any physical activity program at least 6 months before the start of the study\n* Patients have chronic back pain \\> 3months\n* Patients has non specific low back pain\n* Body mass index (BMI) from 25 to 34.9 kg\u002Fm2.\n* Patients are clinically and medically stable\n\nExclusion Criteria:\n\n* Instability of patient's medical condition\n* Patients with chest infection\n* Inability to comprehend and follow instructions as in dementia or speech problems such as dysphasia,\n* uncontrolled diabetes mellitus,\n* Persistent systolic Blood Pressure (BP) greater than 200 mmHg, persistent diastolic BP greater than 120 mmHg\n* Chronic lung disease which result in significant oxygen desaturation on exercise or pulmonary congestion\n* Patients with lupus nephritis.\n* Patients with Spondylodiscitis , Compression fracture, Spinal stenosis",{"count":389,"type":22},[25],"This study will be conducted to investigate any significant effect of pneumatic compression on diaphragmatic excursion in patients with low back dysfunction .",[539],"Low Back Disorder",{"date":156,"type":33},{"date":156,"type":22},{"date":543,"type":22},"2026-11-30",{"name":39,"class":40},{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":551,"eligibilityCriteria":552,"healthyVolunteers":12,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":553,"targetDuration":4,"studyType":23,"phases":554,"briefSummary":555,"conditions":556,"keywords":558,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":561,"lastUpdatePostDateStruct":562,"startDateStruct":563,"completionDateStruct":564,"leadSponsor":566,"locationsCount":4},"100644873","effect-of-two-different-cryotherapy-irrigation-protocols-on-postoperative-endodontic-pain-100644873","NCT07676409","Effect of Two Different Cryotherapy Irrigation Protocols on Postoperative Endodontic Pain","Effect of Two Intracanal Cryotherapy Irrigation Protocols on Postoperative Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis in Mandibular Molars: A Randomized Clinical Trial.","NAOCL\u002FEDTA","Inclusion Criteria:\n\n1. Age between 20-40 years old.\n2. Systemically healthy patients (ASA I or II).\n3. Mature Mandibular molar teeth with :\n\n   * Preoperative sharp pain and symptomatic apical periodontitis marked on NRS scale by reading not less than 6.\n   * Absence or slight widening in the periodontal ligament (PDL).\n   * Vital response of pulp tissue to cold pulp tester and (ethyl chloride spray).\n   * Positive response to percussion test.\n4. Restorable teeth.\n5. Ability to complete the endodontic treatment in a single visit.\n6. Positive patient acceptance for participation in the trial. -----------------------------------------------------------------\n\nExclusion Criteria:\n\n1. Medically compromised patients (ASA III or IV)\n2. Patients who used NSAIDs in the 24 hours before treatment.\n3. Patients with two or more adjacent teeth requiring endodontic treatment.\n4. Pregnant women.\n5. Patients reporting bruxism or clenching.\n6. Teeth associated with :\n\n   * Acute periapical abscess and\u002For swelling.\n   * Greater than grade I mobility or pocket depth greater than 5mm.\n   * Non-restorable teeth.\n   * Immature Apex.\n7. Radiographic evidence of external or internal root resorption, vertical root fracture, perforation, calcification.",{"count":54,"type":22},[25],"The aim of this study is to evaluate the effect of intracanal cryotreated (2-3°C) 2.5% sodium hypochlorite and Saline used throughout the procedure, compared with a room-temperature irrigation protocol with a final cryotreated saline flush or an entirely room temperature irrigation protocol, on postoperative pain in patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis in mandibular molars.",[557],"Cryotherapy",[557,559,560],"Postoperative endodontic pain","irrigation","2026-06-24",{"date":240,"type":33},{"date":442,"type":22},{"date":565,"type":22},"2027-07-15",{"name":39,"class":40},{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":50,"minAge":574,"maxAge":4,"enrollmentInfo":575,"targetDuration":4,"studyType":23,"phases":576,"briefSummary":577,"conditions":578,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":561,"lastUpdatePostDateStruct":580,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":585,"locationsCount":4},"100638038","tertiary-alveolar-cleft-reconstruction-using-double-mandibular-cortical-bone-blocks-technique-versus-double-iliac-corticocancellous-bone-blocks-technique-100638038","NCT07612423","Tertiary Alveolar Cleft Reconstruction Using Double Mandibular Cortical Bone Blocks Technique Versus Double Iliac Corticocancellous Bone Blocks Technique","Tertiary Alveolar Cleft Reconstruction Using Double Mandibular Cortical Bone Blocks Technique Versus Double Iliac Corticocancellous Bone Blocks Technique A Randomized Clinical Trial","Inclusion Criteria:\n\n* patients with unilateral alveolar cleft who missed the mixed dentition phase window.\n* patients with previously repaired cleft lip and palate.\n* patients with proper oral hygiene.\n\nExclusion Criteria:\n\n* Immunocompromised patients.\n* patients with active periodontitis.\n* patients with inadequate oral hygiene.","12 Years",{"count":478,"type":22},[25],"The current study aims to compare the double mandibular corticocancellous bone blocks technique with mandibular cancellous bone particles in between versus the double iliac corticocancellous bone blocks technique with iliac cancellous bone particles in between in the tertiary cleft grafting to find out which technique maintained better graft width, height, and volume with the least adverse effects after the healing period and hence would allow for restoration of the targeted function and esthetics and improve the cleft patients psychologically and hence improve their quality of life.",[579],"Alveolar Cleft Grafting",{"date":374,"type":33},{"date":582,"type":22},"2026-06-01",{"date":584,"type":22},"2028-01",{"name":39,"class":40},{"id":587,"slug":588,"hasResults":12,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":4,"eligibilityCriteria":592,"healthyVolunteers":12,"sex":50,"minAge":362,"maxAge":593,"enrollmentInfo":594,"targetDuration":4,"studyType":193,"phases":4,"briefSummary":596,"conditions":597,"keywords":599,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":603,"lastUpdatePostDateStruct":604,"startDateStruct":605,"completionDateStruct":606,"leadSponsor":608,"locationsCount":4},"100644298","assessment-of-caries-impacts-and-experiences-in-a-visually-impaired-versus-sighted-children-using-caries-qca-100644298","NCT07665047","Assessment of Caries Impacts and Experiences in a Visually Impaired Versus Sighted Children Using CARIES-QC\u002FA","Assessment of Caries Impacts and Experiences in a Visually Impaired Versus Sighted Pediatric Population Using a Caries-Specific Quality-of-Life Questionnaire: A Comparative Cross-sectional Study","Inclusion Criteria:\n\n* Children's age ranges from 6 to 14 years.\n* Apparently healthy children\n* Parents' acceptance of their children's participation in the study.\n\nExclusion Criteria:\n\n* Children on long-term medication.\n* Parents who refuse to participate in the study","14 Years",{"count":595,"type":22},140,"The goal of this observational study is to to compare dental caries impacts and experience among visually impaired and sighted children. The main question it aims to answer is:\n\nAmong schoolchildren aged 6-14 years, does visual impairment compared to normal sight lead to poorer caries experiences and lower caries-related quality of life?",[598],"Visual Impairment",[600,601,602],"visually impaired","caries","quality of life","2026-06-23",{"date":561,"type":33},{"date":413,"type":22},{"date":607,"type":22},"2027-08",{"name":39,"class":40},{"id":610,"slug":611,"hasResults":12,"nctId":612,"briefTitle":613,"officialTitle":613,"acronym":614,"eligibilityCriteria":615,"healthyVolunteers":12,"sex":50,"minAge":362,"maxAge":363,"enrollmentInfo":616,"targetDuration":4,"studyType":23,"phases":618,"briefSummary":619,"conditions":620,"keywords":622,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":628,"completionDateStruct":629,"leadSponsor":631,"locationsCount":632},"100643867","effect-of-plyometric-training-cross-education-on-strength-selective-motor-control-and-balance-in-children-with-hemiplegic-cerebral-palsy-100643867","NCT07669857","Effect of Plyometric Training Cross Education on Strength, Selective Motor Control and Balance in Children With Hemiplegic Cerebral Palsy","PLYO-HCP","Inclusion Criteria:Children eligible for participation in this study must meet all the following criteria:\n\n1. Diagnosed with HCP by a pediatric neurologist.\n2. Age range 6 and 10 years old.\n3. Their grade of spasticity level 1 or 1+ according to MAS.\n4. Their gross motor function level is I, II on GMFCS.\n5. Able to follow verbal instructions and cooperate during assessment and training.\n\nExclusion Criteria:Children will be excluded from this study if they have any of the following:\n\n1. Presence of corrective neurological\u002Fmusculoskeletal surgery of the lower limb in the previous year or botulinum toxin injections of the lower limb within the previous 6 months.\n2. Presence of visual or auditory impairments that would affect balance performance.\n3. Uncontrolled epileptic seizures or recent medication changes",{"count":617,"type":22},40,[25],"The goal of this clinical trial is to evaluate the effect of plyometric training with cross-education on lower limb muscle strength, selective motor control, and balance in children with hemiplegic cerebral palsy (HCP). It will also assess the safety and feasibility of applying this training program in pediatric rehabilitation.\n\nThe main questions it aims to answer are:\n\nDoes plyometric training with cross-education improve lower limb muscle strength in children with HCP? Does it improve selective motor control in the affected lower limb? Does it improve balance in children with HCP? Researchers will compare a study group receiving conventional physiotherapy plus plyometric training applied to the less affected limb to a control group receiving conventional physiotherapy only.\n\nParticipants will:\n\nReceive treatment for 12 weeks (2 sessions per week) Attend regular physiotherapy sessions including stretching, strengthening, balance, and gait training Participate in plyometric exercises (study group only) Be assessed before and after the intervention using standardized tests for muscle strength, selective motor control, and balance",[621],"Hemiplegic Cerebral Palsy",[623,624,625],"Cross-education effect","Hemiplegic cerebral palsy","Plyometric training","2026-06-21",{"date":464,"type":33},{"date":464,"type":22},{"date":630,"type":22},"2026-09-30",{"name":39,"class":40},3,""]