[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Canterbury Christ Church University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":136},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,70,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100640041","evaluating-a-workbook-to-promote-autistic-wellbeing-100640041",false,"NCT07630376","Evaluating a Workbook to Promote Autistic Wellbeing","Evaluating the Use of a Guided Self-help Workbook to Promote Wellbeing for Autistic Adults: A Mixed-methods Multiple Single-case Study","Inclusion Criteria:\n\n* A pre-existing diagnosis of autism OR on a waiting list for autism assessment OR self-identified as autistic and scoring above cut-off on the autism quotient (AQ-50) screening questionnaire.\n* Aged 18 years or over and able to give informed consent to participate.\n* Under the care of a community-based mental health team in Kent and Medway Mental Health NHS Trust and not due for discharge during the study period.\n* Have already completed assessment processes (including risk assessment) during intake by the clinical team and a management plan is in place.\n* The named clinician assesses that the individual is in sufficiently stable condition to participate in the study, and is likely to remain engaged in the intervention.\n* Proficiency in reading and writing English.\n* If on medication for mental health, the dose is stable (minimum of 3 months) with no planned changes during the study.\n\nExclusion Criteria:\n\n* Presence of a moderate to severe learning disability that would limit independent engagement with self-help materials.\n* Engaged in another psychological therapy or psychologically-informed intervention, or due to begin another during the study.\n* Current acute mental health crisis or elevated risk to self\u002Fothers requiring intensive intervention (assessed via clinical team judgement).\n* Insufficient capacity to engage with the study protocol or complete measures (as determined by the care team).","ALL","18 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to examine the feasibility and acceptability of a brief guided self-help wellbeing intervention for autistic adults accessing UK secondary mental health services. The study also aims to begin to evaluate whether use of the workbook is associated with any changes in wellbeing. The main questions it aims to answer are:\n\n1. Is it feasible to recruit and retain autistic adults to participate in the study?\n2. Do participants find the workbook acceptable and relevant?\n3. Are there measurable improvements in wellbeing following workbook use?\n4. What changes, if any, do participants recommend for future versions of the intervention?\n\nParticipants will:\n\n* Take part in 4-6 sessions of 30-60 minutes using the guided self-help workbook with the support of a trained National Health Service support worker, assistant psychologist, or mental health professional\n* Complete wellbeing questionnaires before, during, and after using the workbook\n* Complete brief daily wellbeing ratings throughout the study\n* Take part in a 1:1 semi-structured interview of up to an hour to discuss their experience of the workbook",[26,27],"Autism","Wellbeing","NOT_YET_RECRUITING","2026-06-01",{"date":31,"type":32},"2026-06-05","ACTUAL",{"date":34,"type":20},"2026-06",{"date":36,"type":20},"2027-04",{"name":38,"class":39},"Canterbury Christ Church University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":68,"locationsCount":69},"100596863","feasibility-of-a-tailored-online-self-compassion-intervention-100596863","NCT07051005","Feasibility of a Tailored Online Self-compassion Intervention","A Feasibility Randomised Controlled Trial of Online Self-compassion Training Tailored for Adults Living With Type 1 and Type 2 Diabetes Mellitus","Inclusion Criteria:\n\n* 18 years old or older.\n* Diagnosed with Type 1 or Type 2 diabetes by a clinician in the NHS more than one year ago.\n* Self-managing theircondition.\n* Identified by their NHS team as needing support with their mental health due to diabetes-related distress.\n\nExclusion Criteria:\n\n* \\\u003C18\n* Individuals experiencing a current mental health crisis, including severe depression, active suicidal thoughts, or acute psychosis\n* Unable to read\u002Fspeak English\n* Gestational diabetes, Wolfram, and other rarer conditions\n* Individuals currently experiencing severe substance abuse issues that could interfere with participation in the programme\n* Individuals without reliable access to the internet and a compatible device (computer or smartphone).","99 Years",{"count":50,"type":20},50,[23],"The goal of this clinical trial is to examine the feasibility and acceptability of an online programme that is based on Compassionate Mind Training (CMT) over four-weeks. The programme intends to share information and strategies to reduce diabetes distress, self-criticism, and shame, and improve physical health in people who have Type 1 and Type 2 Diabetes Mellitus.",[54,55],"Type 1 Diabetes Mellitus","Type 2 Diabetes Mellitus (T2DM)",[57,58,59,60],"Diabetes","Online intervention","Compassion","Feasibility RCT","RECRUITING","2026-03-19",{"date":64,"type":32},"2026-03-20",{"date":66,"type":32},"2025-06-18",{"date":29,"type":20},{"name":38,"class":39},2,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":40},"100588113","blood-pressure-following-isometric-exercise-in-inactive-adults-100588113","NCT06937164","Blood Pressure Following Isometric Exercise in Inactive Adults","Beliefs and Expectation Effects on Blood Pressure Following Isometric Exercise in Inactive Adults","BELIEF-BP","Inclusion Criteria:\n\n* Age 18 years or older\n* Self-reported physically inactive or insufficiently active (not meeting current physical activity guidelines)\n* Not currently engaged in structured resistance or isometric exercise training\n* Able to attend lab sessions over a 4-week period\n* Provides written informed consent\n\nExclusion Criteria:\n\n* Current diagnosis of hypertension requiring medication\n* Any known cardiovascular, neurological, or musculoskeletal condition contraindicating isometric exercise\n* Formal education or professional background in exercise science, physiology, or a related field\n* Pregnant or planning to become pregnant during the study period\n* Inability to follow verbal instructions or complete study protocols",true,"55 Years",{"count":81,"type":20},36,[23],"This study investigates how isometric exercise training (IET) affects blood pressure in physically inactive adults. Isometric exercise involves sustained muscle contractions without movement-for example, pushing against a fixed object. Previous research has shown that IET may help reduce blood pressure, but the mechanisms involved are not fully understood.\n\nThe purpose of this study is to assess both the immediate (acute) and long-term (chronic) effects of IET on cardiovascular outcomes. Participants will complete a series of lab-based exercise sessions over several weeks. In these sessions, they will perform repeated bouts of isometric leg extensions while seated on an exercise machine designed to measure muscle force.\n\nThroughout the study, researchers will monitor participants' blood pressure, heart rate, and muscle activity. Acute responses-such as post-exercise hypotension (a short-term drop in blood pressure)-will be measured immediately after exercise. Chronic changes, such as resting blood pressure improvements, will be evaluated across the training period.\n\nAdditional measurements will include heart rate variability (HRV), which gives insight into autonomic nervous system activity, and electromyography (EMG), which tracks muscle fatigue and activation patterns. These data will help explore potential mechanisms behind the cardiovascular benefits of IET.\n\nBy examining how repeated sessions of isometric exercise influence blood pressure and related physiological responses, this research may support the use of IET as a non-pharmacological strategy for managing or preventing hypertension in physically inactive individuals.",[85,86,87],"Hypertension","Elevated Blood Pressure","Sedentary Lifestlye",[89,90,91,92,93,94,95,96,97,98,99,100,76],"Isometric Exercise","Blood Pressure","Post-Exercise Hypotension","Physical Inactivity","Heart Rate Variability","Electromyography (EMG)","Muscle Fatigue","Cardiovascular Adaptation","Exercise Intervention","Non-Pharmacological Treatment","Hypertension Prevention","Autonomic Nervous System","2025-05-15",{"date":103,"type":32},"2025-05-16",{"date":105,"type":32},"2025-04-21",{"date":107,"type":20},"2025-09",{"name":38,"class":39},{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":21,"phases":118,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":40},"100580321","neurophysiological-mechanisms-of-placebo-and-nocebo-effects-in-sports---a-protocol-paper-100580321","NCT06835777","Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - a Protocol Paper","Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - Protocol Paper of a Randomised Controlled Study","Inclusion Criteria:\n\n* Healthy adult participants (18+)\n* physically active (WHO, 2020)\n* no medical history pf psychological disorders\u002Fmental health issues\n* no acute or regular medication intake\n* no severe injury to the lower limb within the last 6 months\n* proficient in english\n* normal or corrected eyesight",{"count":117,"type":20},56,[23],"This clinical trial aims to investigate the neurophysiological mechanisms of placebo and nocebo effects on sports performance, using Electroencephalography (EEG) and isometric strength testing of the lower extremities.\n\nThe primary objective of this trial is to identify temporal mechanisms and cortical regions and networks involved in generating placebo and nocebo effects before (expectation) and at onset of athletic performance (perception).\n\nThe trial will include four groups, two of them experimental, one an active control and one natural history, meaning participants in this group will receive no intervention and won't be EEG controlled. Data will be collected on two occasions with baseline data for EEG, expectations and performance as well as key participant characteristics being collected on day one. On day two, in a deceptive process, participants in the two experimental groups will take an inert substance presented as either performance enhancing or inhibiting and subsequently experience a reinforcement of beliefs via exposure to explicit adjectives. EEG data will be collected during reinforcement of beliefs. In the active control group, participants will receive no substance, but this group will follow the same procedure as the experimental groups with neutral adjectives. Participants will then perform isometric strength and fatigue resistance tests on an isometric dynamometer. EEG data as well as subjective data on expectations and rating of perceived exhaustion will be collected.",[121,122],"Placebo Effect","Nocebo Effect",[124,125,126,127],"EEG","Placebo","Nocebo","Sports Performance","2025-02-13",{"date":130,"type":32},"2025-02-19",{"date":132,"type":20},"2025-03-01",{"date":134,"type":20},"2025-12-31",{"name":38,"class":39},""]