[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Cardenal Herrera University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":478},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,49,77,106,135,172,198,224,259,285,315,339,360,380,403,430,457],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100642040","prospective-cohort-study-of-villarreal-cf-youth-players-100642040",false,"NCT07653633","Prospective Cohort Study of Villarreal CF Youth Players","A Single-season Prospective Observational Cohort Study of the Villarreal CF Male Youth Academy\"","VILLAREALFC","Inclusion Criteria:\n\n* Active federation license with Villarreal CF during the study period.\n* Regular participation in training sessions and official competitions.\n* Aged between 10 and 45 years (encompassing academy, youth development, and first-team categories).\n* For participants under 18 years of age: mandatory written informed consent from a parent or legal guardian.\n* For minor participants aged ≥12 years: written informed assent must be provided by the athlete in addition to parental consent.\n\nExclusion Criteria:\n\n* Previous bilateral anterior cruciate ligament (ACL) reconstruction.\n* Active severe musculoskeletal injury that prevents the execution of biomechanical or physiological testing.\n* Systemic disease or medical condition that limits sports participation or interferes with the study's biological\u002Fphysiological parameters.\n* Deregistration or transfer to another sports club during the prospective follow-up period. Refusal or inability to comply with the protocol's testing procedures or long-term follow-up requirements.","ALL","10 Years","45 Years",{"count":21,"type":22},200,"ESTIMATED","4 Years","OBSERVATIONAL","Anterior cruciate ligament (ACL) injuries represent a highly relevant issue in both grassroots and professional sports, with a particularly high incidence in young and female populations. The objective of this project is to develop and validate a multiscale predictive algorithm for ACL injury risk in athletes from Villarreal CF (aged 10-45), integrating biomechanical, physiological, genetic, and gut microbiome biomarkers.\n\nThe study, with a prospective and longitudinal design (4 years), will include a cohort of 200-250 players from the academy and first team. The following assessments will be conducted: biomechanical analysis of jumps using force platforms (instrumented LESS), physiological monitoring through resting heart rate and nocturnal heart rate variability (HRV), genotyping from saliva samples, and characterization of the gut microbiome 16 rRNA sequencing. The systematic recording of training, exposures, and injuries will follow OSTRC criteria and will be supervised by the club's medical team.\n\nThe expected outcome is a multivariate predictive model, validated in a professional sports setting, capable of identifying individual risk profiles and generating a personalized score to guide preventive interventions (exercise, strength training, nutritional or probiotic strategies). This approach aims to reduce the incidence of ACL injuries, optimize performance, and translate biomedical knowledge into clinical and sports practice.",[27,28],"Anterior Cruciate Ligament (ACL) Tear","Anterior Cruciate Ligament (ACL)",[30,31,32,33,34,35],"Anterior cruciate ligament","injuries","COL1A1","COL5A1","PIEZO1\u002F2","gut microbiome","NOT_YET_RECRUITING","2026-06-16",{"date":39,"type":40},"2026-06-17","ACTUAL",{"date":42,"type":22},"2026-07",{"date":44,"type":22},"2027-05",{"name":46,"class":47},"Cardenal Herrera University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":60,"studyType":24,"phases":4,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":48},"100643246","reference-values-for-lower-limb-dynamometry-in-patients-with-chronic-kidney-disease-rehad-ckd-100643246","NCT07642778","Reference Values for Lower-Limb Dynamometry in Patients With Chronic Kidney Disease (REHAD-CKD)","REHAD- CKD","Inclusion Criteria:\n\n* ≥1 months on HD (3 weekly sessions of 4 hours)\n\nExclusion Criteria:\n\n* Lower-limb amputation;\n* Neurological, musculoskeletal or osteoarticular disorders;\n* Severe\u002Funstable comorbidities (e.g., decompensated heart failure or diabetes, unstable angina, recent MI, uncontrolled hypertension, severe lung disease, acute infection);\n* \\\u003C1 months on HD;\n* \\\u003C2 sessions\u002Fweek,\n* Inability to understand assessments.","18 Years","85 Years",{"count":59,"type":22},50,"6 Weeks","Patients with chronic kidney disease (CKD) undergoing hemodialysis present musculoskeletal complications, such as sarcopenia, which impair their functionality and are associated with an increased risk of mortality. Functional assessment in this population is complex due to the organization of hemodialysis schedules and patients' dependence on medical transportation, which hinders evaluation outside the dialysis setting.\n\nThe assessment of lower limb strength is of great relevance, as an adequate level of muscle strength in this region is essential for performing many activities of daily living, including walking, sit-to-stand and stand-to-sit movements, as well as ascending and descending stairs. Our research group has published a study demonstrating the safety and reliability of intradialytic measurement of hip flexion and abduction strength; however, reference values for the dialysis population and for individuals with CKD in general are currently unknown.\n\nThe primary aim of this study is to propose reference values for hip flexor and abductor muscle strength measured using a hand-held dynamometer in individuals with chronic kidney disease (CKD). Secondary objectives include assessing the association between lower limb muscle strength measured with a hand-held dynamometer and handgrip strength, physical activity level, frailty, gait speed, performance in the 10-repetition sit-to-stand-to-sit test, ultrasound assessment of the rectus femoris muscle, and health-related quality of life.",[63],"Chronic Kidney Disease on Hemodialysis",[65,66,67],"Chronic Kidney Disease","Lower limb strength","Intradialytic assessment","RECRUITING","2026-06-11",{"date":71,"type":40},"2026-06-12",{"date":73,"type":22},"2026-10",{"date":75,"type":22},"2026-12",{"name":46,"class":47},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":48},"100635790","video-based-lifestyle-counseling-in-adults-with-type-2-diabetes-100635790","NCT07557264","Video-Based Lifestyle Counseling in Adults With Type 2 Diabetes.","Effectiveness of a Video-Based Lifestyle Intervention Delivered by Patients' Own Primary Care Physicians Versus an Unfamiliar Physician in Adults With Type 2 Diabetes Mellitus","LIDM2","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Diagnosis of type 2 diabetes mellitus\n* Under medical follow-up in participating centers\n* Access to the internet and a smartphone\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Pregnancy\n* Type 1 diabetes or other specific forms of diabetes\n* Severe acute or unstable medical condition\n* Contraindication to diet or exercise\n* Severe psychiatric disorder\n* Eating disorder\n* Physical disability limiting physical activity\n* Participation in another structured weight-loss or lifestyle program\n* No medical visit in the last 2 years","65 Years",{"count":87,"type":22},156,"INTERVENTIONAL",[90],"NA","This study evaluates the effectiveness of a 3-month video-based lifestyle intervention, focused on promoting healthy lifestyle habits (healthy eating and increased physical activity), on adults with type 2 diabetes mellitus (DM2). Participants will be randomly allocated to receive the intervention either delivered by their own physician (experimental group) or by a physician unknown to them (control group). Assessment will include sociodemographic variables, glycated hemoglobin \u002F HbA1c (primary outcome), body mass index, blood pressure, glycemic and lipid metabolism variables, physical activity level, adherence to the Mediterranean diet, therapeutic alliance, and health-related quality of life. The randomization process will be stratified according to HbA1c, therapeutic alliance, age, and sex.",[93,94,95,96,97],"Diabetes Mellitus (Type 2)","Glycemic Control for Diabetes Mellitus","Physical Activity","Healthy Eating","Therapeutic Alliance","2026-04-22",{"date":100,"type":40},"2026-04-29",{"date":102,"type":22},"2026-09-01",{"date":104,"type":22},"2027-05-01",{"name":46,"class":47},{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":114,"minAge":56,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":88,"phases":118,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":48},"100629176","online-pain-neuroscience-education-for-fear-of-childbirth-100629176","NCT07471269","Online Pain Neuroscience Education For Fear Of Childbirth.","Effectiveness Of An Online Pain Neuroscience Education Intervention In Reducing Fear Of Childbirth Among Pregnant Women.","Inclusion Criteria:\n\n* Pregnant women over 18 years of age, primiparous or multiparous.\n* At the beginning of the third trimester of pregnancy\n\nExclusion Criteria:\n\n* Multiple pregnancies.\n* Previous spinal surgery.\n* Psychiatric disorders.",true,"FEMALE","50 Years",{"count":117,"type":22},400,[90],"Fear of childbirth ranges from mild worry to severe anxiety and affects women of all ages. It is often linked to perceiving childbirth as unpredictable and painful. Women cope by seeking support, practicing relaxation, or attending prenatal education, with information playing a key role in reducing anxiety and increasing confidence.\n\nPain neuroscience education has shown benefits in reducing pain, anxiety, and related fears by teaching the neurobiological mechanisms underlying pain.",[121],"Fear of Childbirth",[123,124,125,126],"fear of childbirth","pregnancy","pain neuroscience education","prenatal education","2026-04-14",{"date":129,"type":40},"2026-04-15",{"date":131,"type":40},"2026-03-26",{"date":133,"type":22},"2026-09-26",{"name":46,"class":47},{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":113,"sex":17,"minAge":143,"maxAge":19,"enrollmentInfo":144,"targetDuration":4,"studyType":88,"phases":145,"briefSummary":146,"conditions":147,"keywords":152,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":171},"100611777","effect-of-mi-paste-plus-on-streptococcus-mutans-and-white-spot-lesions-in-fixed-orthodontics-100611777","NCT07244991","Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics","Effect of MI Paste Plus™ on Streptococcus Mutans Counts and White Spot Lesions in Patients With Fixed Orthodontic Appliances: A Triple-Blind Clinical Trial","MIPASTEORTHO","Inclusion Criteria:\n\n* Age between 5 and 45 years.\n* Indication for fixed orthodontic treatment, either with fixed auxiliary appliances (including orthopedic devices) or brackets with or without auxiliary components.\n* General good health with no systemic diseases affecting oral health.\n\nExclusion Criteria:\n\n* Advanced white-spot lesions with untreated dentin involvement.\n* Presence of active untreated dental caries at baseline.\n* Antibiotic therapy within the previous two months.\n* Previous diagnosis of molar-incisor hypomineralization (MIH).\n* History of immunosuppression.\n* Iron-deficiency anemia or other clinically relevant hematological disorders.\n* Parafunctional habits such as lip sucking or finger sucking.\n* Use of any type of dental prosthesis.\n* Smoking or tobacco use.\n* Documented allergy to nickel.\n* Requirement for orthodontic treatment using removable appliances or clear aligners.","5 Years",{"count":21,"type":22},[90],"Background This study is part of a doctoral research project at Universidad Cardenal Herrera CEU (Spain), directed by Prof. Santiago Arias de Luxán and conducted by doctoral candidate Shirli Kelmendi within the PhD program in Translational Medicine.\n\nFixed orthodontic appliances complicate oral hygiene by creating retention areas that favor bacterial colonization and alter microbial balance. These conditions increase plaque accumulation and Streptococcus mutans (S. mutans) proliferation in saliva and plaque. The frequent low-pH environment favors aciduric bacteria such as S. mutans and lactobacilli, promoting enamel demineralization and formation of white spot lesions (WSLs) or cavitations. WSLs appear as opaque white areas due to subsurface mineral loss, mainly in the gingival third of the crown. They may develop as early as one month after bracket placement, while in patients without appliances, progression occurs after at least six months. Increased S. mutans levels have been reported as early as six weeks after treatment start. Risk factors include poor brushing, lack of floss or rinse use, time since last cleaning, and presence of caries or lesions.\n\nIntervention MI Paste Plus (GC, Japan) is a remineralizing cream with 0.20% sodium fluoride (900 ppm) and 10% CPP-ACP (RECALDENT™), providing calcium and phosphate stabilized by casein phosphopeptides. It has antibacterial and remineralizing effects, suitable during or after orthodontic treatment to prevent or reduce WSLs.\n\nObjective To evaluate whether MI Paste Plus during fixed orthodontic treatment reduces S. mutans counts in saliva and\u002For WSL incidence.\n\nStudy Design A prospective, triple-blind, randomized clinical trial, approved by the Ethics Committee of the Ministry of Health of Albania and the Ethics Committee for Human Research of Universidad Cardenal Herrera CEU, Spain.\n\nThe study will include 200 patients (100 per group) from two orthodontic clinics in Tirana, Albania. Participants will be stratified by age, risk level, and appliance type, then randomized by third parties.\n\nOutcome Measures Primary variables: S. mutans counts in saliva and number of WSLs after 3 months.\n\nStandardized saliva collection, culturing, and bacterial quantification ensure consistency. Clinical assessments will be performed at 1 and 3 months using QRay Cam Pro (Inspektor Systems, Netherlands) for quantitative fluorescence and ICDAS for visual inspection.\n\nData will be analyzed using SPSS\u002FR Commander software.",[148,149,150,151],"Dental Caries","Streptococcus Mutans","Tooth Demineralization","Orthodontic Appliances, Fixed",[153,154,155,156,157,158,159,160,161,162],"MI Paste Plus","Remineralization","Streptococcus mutans","White Spot Lesions","Fixed Orthodontic Appliances","Quantitative Light-Induced Fluorescence","Randomized Controlled Trial","Triple-Blind Study","Albania","CEU Cardenal Herrera University","2026-03-24",{"date":165,"type":40},"2026-03-27",{"date":167,"type":40},"2026-01-04",{"date":169,"type":22},"2027-11",{"name":46,"class":47},2,{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":113,"sex":17,"minAge":179,"maxAge":180,"enrollmentInfo":181,"targetDuration":183,"studyType":24,"phases":4,"briefSummary":184,"conditions":185,"keywords":187,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":48},"100621693","carotid-wall-texture-as-a-cardiovascular-risk-biomarker-in-type-2-diabetes-mellitus-100621693","NCT07373938","Carotid Wall Texture as a Cardiovascular Risk Biomarker in Type 2 Diabetes Mellitus","Carotid Wall Layer Texture as a Potential Biomarker for Cardiovascular Risk Assessment in Preventive Nursing: a Study in Type 2 Diabetes Mellitus","Inclusion Criteria\n\n* European adults.\n* Age between 40 and 69 years.\n* Confirmed diagnosis of type 2 diabetes mellitus.\n* No established cardiovascular disease.\n* Availability of the required clinical and metabolic variables: Age; Sex; Systolic blood pressure; Non-high-density lipoprotein (non-HDL) cholesterol; Smoking status; Duration of diabetes; Glycated hemoglobin (HbA1c); Presence or absence of diabetes-related target organ damage (e.g., albuminuria, retinopathy)\n\nExclusion Criteria\n\n* History of clinical cardiovascular disease (secondary prevention).\n* Type 1 diabetes mellitus.\n* Patients with established severe target organ damage or conditions that automatically classify them as very high cardiovascular risk according to ESC guidelines.\n* Advanced chronic kidney disease (estimated glomerular filtration rate \\\u003C30 mL\u002Fmin\u002F1.73 m²).","40 Years","69 Years",{"count":182,"type":22},80,"1 Day","This study aims to compare carotid intima-media thickness (CIMT) and layer-specific texture characteristics of the carotid wall between individuals with Type 2 diabetes mellitus (T2DM) and normoglycemic controls, to assess the impact of T2DM on these ultrasound variables and evaluate their ability to discriminate between low and high cardiovascular risk at 10 years.",[186],"Type 2 Diabetes Mellitus",[188,189,186],"ultrasound","textural analysis","2026-01-28",{"date":192,"type":40},"2026-01-29",{"date":194,"type":40},"2026-01-25",{"date":196,"type":22},"2026-08-02",{"name":46,"class":47},{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":113,"sex":17,"minAge":56,"maxAge":85,"enrollmentInfo":205,"targetDuration":4,"studyType":88,"phases":207,"briefSummary":208,"conditions":209,"keywords":211,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":48},"100527275","intramuscular-temperature-on-the-echo-textural-characteristics-100527275","NCT06145646","Intramuscular Temperature on the Echo-textural Characteristics","Influence of Intramuscular Temperature on the Textural Characteristics of the B-mode Ultrasound Image.","Inclusion Criteria:\n\n* Acceptance of participation in the study.\n* Healthy subjects.\n* Subjects between the ages of 18 and 65.\n\nExclusion Criteria:\n\n* Have known neurological, cardiovascular, metabolic or orthopedic conditions that prevent them from participating in the study.\n* Present metal implants in the heating area.\n* Wear a pacemaker.\n* Perform physical activity during the 48 hours prior to data collection.\n* Contraindications of dry needling such as: Belonephobia, history of abnormal reaction to the puncture or injection, anticoagulant treatment or thrombocytopenia, lymphedema over the area of intervention, severely compromised immune system, vascular diseases, diabetes mellitus, pregnancy, epilepsy, allergy to metals or that the intervention area has wounds, scars, tattoos, or stains.",{"count":206,"type":22},30,[90],"Echointensity and echotexture have been used as a physiological marker for changes in skeletal muscle quality and structure caused by physical training, low activity, ageing and some neuromuscular disorders. However, there are some influencing factors on muscle echo-intensity and echotexture, such as temperature, which may not be taken into account when performing an ultrasound assessment and may alter the results.\n\nThis study aims to investigate the effects of muscle temperature on echointensity and other 2nd order echotextures variables such as homogeneity, contrast, correlation and entropy of muscle tissue, in order to gain a better understanding of this correlation and minimise its influence, which would allow greater precision in the use of muscle ultrasound as a diagnostic tool.\n\nThe methodology of this study includes firstly the acquisition of ultrasound images of the vastus lateralis muscle. This acquisition will be performed during the continuous recording of muscle temperature, carried out during a passive cooling process after 20 min of heating using microwave equipment. In addition, to standardise the results, a correction factor will be calculated to compensate for the influence of subcutaneous adipose tissue thickness on echogenicity and echotexture.",[210],"Healthy Subjects",[212,213,214,188,215],"muscle","temperature","texture","echo intensity","2026-01-20",{"date":218,"type":40},"2026-01-22",{"date":220,"type":40},"2023-11-30",{"date":222,"type":22},"2026-04-20",{"name":46,"class":47},{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":232,"enrollmentInfo":233,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":235,"conditions":236,"keywords":243,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":48},"100616706","clinical-morphometric-and-biochemical-effects-on-adiposopathy-associated-with-the-use-of-glp-1ra-in-ckd-100616706","NCT07309094","Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD","Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1 Receptor Agonists in Chronic Kidney Disease","ADIPO-CKD","Inclusion Criteria:\n\n* \\> or = 18 years of age\n* diagnosed with CKD in stages G1, G2, G3a, G3b, and G4, not candidate for dialysis\n* had uncontrolled T2DM, CVDs and\u002For obesity\n* willing to participate in the study and sign informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* pregnancy\n* CKD in stage G5 or G4 candidate for dialysis\n* neuropsychiatric diseases preventing the patient from understanding the benefits\u002Frisks associated with the project\n* refusal to participate and\u002For consent revocation were considered as exclusion criteria","90 Years",{"count":234,"type":22},250,"Chronic kidney disease (CKD) is the progressive damage to kidney function, associated with an increased risk of cardiovascular diseases, such as stroke or myocardial infarct, particularly in the most severe stages of CKD, in which the patient requires dialysis. Several risk factors are reported for CKD, such as diabetes mellitus, obesity and hypertension. One of the most increasingly recognized risk factors is the fat tissue malfunction, known as adiposopathy. The accumulation of fat tissue around the organs in conditions of obesity or diabetes accelerates the production of pro-inflammatory factors that may worsen the kidney and heart damage. New antidiabetic medications, such as glucagon-like peptide-1 receptor agonists (GLP-1RA), have proven beneficial effects on the kidney and heart due to several mechanisms, including anti-inflammatory actions and a potential action on the fat tissue.\n\nThe aim of this study is to assess the link between adiposopathy and CKD, by investigating the changes in adiposopathy measures throughout treatment with GLP-1RA to a sample of patients with CKD.",[237,238,239,240,241,242],"Chronic Kidney Disease stage3","Chronic Kidney Disease stage4","Chronic Kidney Disease Stage 1","Chronic Kidney Disease Stage 2","Obesity","Diabetes Mellitus, Type 2",[244,245,246,247,248,249,250],"chronic kidney disease","type 2 diabetes mellitus","GLP-1RA","adiposopathy","perivisceral adipose tissue","perirenal adipose tissue","inflammation","2025-12-15",{"date":253,"type":40},"2025-12-30",{"date":255,"type":40},"2023-09-15",{"date":257,"type":22},"2028-12-31",{"name":46,"class":47},{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":267,"enrollmentInfo":268,"targetDuration":4,"studyType":88,"phases":269,"briefSummary":270,"conditions":271,"keywords":273,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":48},"100588983","effectiveness-of-an-ivr-based-therapeutic-exercise-program-with-altered-visual-feedback-in-fibromyalgia-patients-100588983","NCT06948500","Effectiveness of an IVR-based Therapeutic Exercise Program With Altered Visual Feedback in Fibromyalgia Patients","Effectiveness of an Immersive Virtual Reality-based Therapeutic Exercise Program With Altered Visual Feedback in Patients With Fibromyalgia: A Randomized Controlled Trial","IVR-F","Inclusion Criteria:\n\n* Adults diagnosed with fibromyalgia according to any of the classification criteria established by the American College of Rheumatology (ACR), including those from 1990, 2010, 2011, or 2016;\n* Ability to communicate effectively with the research staff;\n* A self-reported pain intensity score of ≥3 on a 11-point Numerical Pain Rating Scale (NRS-11).\n\nExclusion Criteria:\n\n* Presence of comorbidities and\u002For symptoms that constitute a contraindication for immersive virtual reality or exercise-based interventions;\n* Presence of medical conditions that may interfere with study outcomes, such as visual, auditory, perceptual, or sensory disorders;\n* Use of medications that could potentially affect study results;\n* Engagement in another therapeutic physical activity program during the intervention period, or any modifications to existing therapies (including medication or physical therapy) throughout the study.","80 Years",{"count":182,"type":22},[90],"The primary aim of this randomized controlled trial is to determine the efficacy of a 6-week immersive virtual reality (IVR)-based therapeutic exercise intervention, which manipulates visual proprioceptive input during exercise, for patients diagnosed with fibromyalgia (FM). Participants will be randomly allocated into two groups: an experimental group performing therapeutic exercises integrated with IVR featuring modified visual feedback, and a control group executing identical exercises without IVR integration. The primary outcome will assess the impact of fibromyalgia on daily activities, while secondary outcomes will comprehensively evaluate fatigue, sleep quality, severity of fibromyalgia symptoms, health-related quality of life, anxiety and depressive symptoms, fear-avoidance beliefs, pain catastrophizing, kinesiophobia, indicators of central sensitization, lumbar spine flexion and extension range of motion, somatosensory function, body perception distortion, muscle strength of the handgrip and quadriceps, functional mobility, lower limb strength, behavioral regulation concerning exercise adherence, and patient-reported experiences regarding IVR use. This trial seeks to elucidate whether incorporating IVR into therapeutic exercise protocols reduces the impact of fibromyalgia on patients' daily lives and improves physiological, psychological, and physical outcomes compared to traditional exercise approaches without IVR.",[272],"Fibromyalgia",[272,274,275,276],"Immersive Virtual reality","Exercise","Pain","2025-11-16",{"date":279,"type":40},"2025-11-18",{"date":281,"type":40},"2025-05-05",{"date":283,"type":22},"2027-02-10",{"name":46,"class":47},{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":4,"enrollmentInfo":293,"targetDuration":4,"studyType":88,"phases":295,"briefSummary":296,"conditions":297,"keywords":300,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":48},"100608488","effectiveness-of-the-delirium-zero-protocol-to-prevent-the-onset-of-delirium-in-patients-undergoing-hip-fracture-surgery-100608488","NCT07202208","Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery","Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery: Randomized Clinical Trial","DZ","Inclusion Criteria:\n\n* The participants will be patients over 65 years old\n* Admitted to the orthopedic hospitalization units of the La Fe University and Polytechnic Hospital (La Fe health department, Valencia, Spain).\n* Who are undergoing surgery for hip fracture\n* Accompanied by a family member\u002Fcaregiver who understands Spanish and knows how to read and write it.\n\nExclusion Criteria:\n\n* Have previously been diagnosed with severe cognitive impairment according to the Pfeiffer scale, which corresponds to a score of 8-10 points.\n* Have previously been diagnosed with any serious mental disorder (schizophrenic disorders, schizotypal disorders, persistent delusional disorders, substance-induced delusional disorders, schizoaffective disorders, other non-organic psychotic disorders, bipolar disorder, serious depressive episode with psychotic symptoms, and severe recurrent depressive disorders). - that they have delirium at the time of admission to the trauma room.\n* That they have a language barrier, deep aphasia, coma, or terminal illness.\n* That they have been previously enrolled in this study.\n* That before the surgery they were admitted to a different hospital unit than those participating in the study, although they may then be transferred to one of these trauma units.\n* That before entering the trauma hospitalization unit, they have been in the emergency room for more than 36 hours.\n* That they present brain alterations (tumors, occupying lesions).",{"count":294,"type":22},140,[90],"The main objective of this research will be to investigate whether the control of care provided by the family\u002Fcaregiver can prevent the onset of delirium in individuals undergoing surgical intervention for hip fracture.\n\nThe research will be a randomized, single-blind, parallel, two-arm clinical trial that compares two conditions: intervention group, hereafter IG (Delirium Zero protocol based on a space-temporal orientation poster for the patient, a clock hung on the wall next to the orientation poster, and a checklist for the preventive measures taken by the caregiver\u002Ffamily), and control group, hereafter CG (standard of care).\n\nThe participants will be patients over 65 years old, admitted to the trauma hospitalization units of the La Fe University and Polytechnic Hospital (La Fe Health Department, Valencia, Spain), operated on for hip fracture and accompanied by a relative\u002Fcaregiver.\n\nThe research will be carried out at the La Fe University and Polytechnic Hospital (La Fe Health Department, Valencia, Spain) because it is the reference hospital for the Valencian Community, and because the rooms in this center are private, which allows for no interference between the intervention under study (in GI) or the standard care (GC).",[298,299],"Hip Fracture","Delirium - Postoperative",[301,302,303,304,305,306],"hip fracture","Family","Care","Care Protocol","Delirium","Caregiver","2025-09-23",{"date":309,"type":40},"2025-10-01",{"date":311,"type":40},"2025-01-15",{"date":313,"type":22},"2028-07-31",{"name":46,"class":47},{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":88,"phases":323,"briefSummary":324,"conditions":325,"keywords":328,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":338,"locationsCount":48},"100571431","air-polishers-with-erythritol-in-the-treatment-of-dental-black-stain-of-bacterial-origin-100571431","NCT06720168","Air Polishers With Erythritol in the Treatment of Dental Black Stain of Bacterial Origin","Inclusion Criteria:\n\n* Patients with 2 or more teeth with black stain\n\nExclusion Criteria:\n\n* Sistemic diseases\n* Patients with physical and\u002For cognitive impairment which prevents participation in a dental prophylaxis.\n* Use of oral antibiotics fifteen days before the intervention\n* Allergy to erythritol",{"count":322,"type":22},40,[90],"Black stains on the teeth, caused by the accumulation of chromogenic microorganisms that produce iron compounds, are more common in the pediatric population and have a negative impact on dental aesthetics and patients' self-esteem. The etiology of these stains remains unclear and is not related to oral hygiene. Currently, there is no definitive treatment that prevents the reappearance of these stains, and they can only be removed by mechanical removal, which can cause injuries to the tooth structure. This study aims to evaluate the effectiveness of erythritol powder air polishers, which have antimicrobial properties, compared to conventional prophylaxis in preventing the recurrence of stains.\n\nA randomized clinical trial will be carried out with a follow-up of 12 months, during which patient satisfaction and duration of treatment will be assessed. The results of this study could provide valuable information to improve treatment and management strategies for dental stains in the affected population, thus contributing to the emotional well-being of patients and reducing damage to their tooth enamel.",[326,327],"Black Stain","Black Plaque",[329,330,331],"dental black stain","dental prophylaxis","erythritol air polisher","2025-02-18",{"date":334,"type":40},"2025-02-19",{"date":336,"type":40},"2024-12-05",{"date":42,"type":22},{"name":46,"class":47},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":267,"enrollmentInfo":346,"targetDuration":4,"studyType":88,"phases":348,"briefSummary":349,"conditions":350,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":48},"100527273","effects-of-a-prehabilitation-program-in-patients-undergoing-lumbar-radiculopathy-surgery-100527273","NCT06145620","Effects of a Prehabilitation Program in Patients Undergoing Lumbar Radiculopathy Surgery","Effects of a Prehabilitation Program Based on Therapeutic Exercise, Back Care Education and Neuroscience Pain Education in Patients Undergoing Lumbar Radiculopathy Surgery","Inclusion Criteria:\n\n* Adults aged 18 years or older, diagnosed with lumbar radiculopathy, and scheduled for surgery. The symptoms will be predominantly leg pain with or without neurological deficit, with surgical decompression justified.\n\nExclusion Criteria:\n\n* Patients currently receiving any other non-pharmacological treatment or physical therapy for the management of lumbar radiculopathy.\n* Proposed for surgery with instrumentation (e.g., spinal fusion, arthrodesis).\n* Suffering from a chronic pain-related condition (e.g., fibromyalgia, chronic fatigue syndrome).\n* Symptoms of spinal cord compression.\n* Diagnosed with a malignant tumor.\n* Mental illness.\n* Previously undergone spinal surgery.\n* No access to any internet-enabled device.",{"count":347,"type":22},100,[90],"The purpose of the following study is to analyze the effects of a prehabilitation program based on therapeutic exercise, back care education and pain neuroscience education through the visualization of videos, compared to standardized written therapeutic exercise in patients undergoing lumbar radiculopathy surgery.",[351],"Lumbar Radiculopathy","2025-02-10",{"date":354,"type":40},"2025-02-12",{"date":356,"type":22},"2025-04",{"date":358,"type":22},"2027-04",{"name":46,"class":47},{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":88,"phases":370,"briefSummary":371,"conditions":372,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":374,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":4},"100382485","myofascial-release-in-patients-with-chronic-obstructive-pulmonary-disease-100382485","NCT04260243","Myofascial Release in Patients with Chronic Obstructive Pulmonary Disease","Effects of Myofascial Release in Patients with Chronic Obstructive Pulmonary Disease: a Randomized Clinical Trial","MFR-COPD","Inclusion Criteria:\n\n* COPD;\n* Forced expiratory volume in the first second (FEV1) \\\u003C 80%;\n* FEV1\u002FForced vital capacity (FVC) \\\u003C 70%;\n* Maximal inspiratory pressure (MIP) \\\u003C 70%.\n\nExclusion Criteria:\n\n* Recent (6 months) spine or abdominal surgery;\n* Allergic status of any kind;\n* systemic diseases (rheumatic, infectious conditions, febrile state, vascular alterations, endocrine diseases including diabetes, metabolic, and neoplastic syndromes);\n* neuromuscular or neurological injuries;\n* previous myofascial release treatment.","75 Years",{"count":206,"type":22},[90],"The main objective of this study is to assess the effects of a myofascial release protocol in patients with chronic obstructive pulmonary disease (COPD).",[373],"Copd",{"date":354,"type":40},{"date":376,"type":22},"2026-03",{"date":378,"type":22},"2027-06",{"name":46,"class":47},{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":113,"sex":114,"minAge":56,"maxAge":4,"enrollmentInfo":387,"targetDuration":389,"studyType":24,"phases":4,"briefSummary":390,"conditions":391,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":48},"100578612","parental-stress-and-attachment-in-preterm-infants-100578612","NCT06813560","Parental Stress and Attachment in Preterm Infants","Parental Stress and Attachment in Premature Infants in Their First Months of Life in Early Months of Life in Child Development and Early Care Centres.","Inclusion Criteria:\n\n* Children born under 37 weeks of gestation,\n* Parents of legal age and who have sufficient cognitive capacity to understand the informed consent.\n\nExclusion Criteria:\n\n\\-",{"count":388,"type":22},60,"1 Year","Introduction: Advances in neonatology mean a significant reduction in mortality in premature infants as well as an increase in the risk of morbidity in the medium, short and long term. Furthermore, previous studies have linked prematurity, as an associated risk factor, with possible alterations in the bonding between the child and his or her mother in the first years of life. The possible impact that the stay in the neonatal unit may have on the mental health of the parents is noted. In fact, several studies have shown that the hospital environment of neonatal units may contribute to increased stress and anxiety in mothers. On the other hand, prematurity is one of the causes of referral to Child Development and Early Care Centres, to address their development in the first years of life, as well as for family support. One of the functions of early childhood professionals is to guarantee the development of a secure attachment between the child and his or her caregivers. Little is known about whether maternal stress levels can influence mother-child interactions and thus influence the attachment relationship in the early years of life.\n\nObjective: to analyse the association between mothers' stress level due to preterm birth and attendance at a Child Development and Early Care Centre and child development and patterns of mother-child interactions.",[392,393,394],"Premature Birth","Psychological Stress","Physiological Stress","2025-02-03",{"date":397,"type":40},"2025-02-07",{"date":399,"type":22},"2025-02-01",{"date":401,"type":22},"2025-08-01",{"name":46,"class":47},{"id":404,"slug":405,"hasResults":11,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":85,"enrollmentInfo":410,"targetDuration":4,"studyType":88,"phases":412,"briefSummary":414,"conditions":415,"keywords":418,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":422,"lastUpdatePostDateStruct":423,"startDateStruct":425,"completionDateStruct":427,"leadSponsor":429,"locationsCount":48},"100574941","phase-3-transcranial-magnetic-stimulation-in-patients-with-dual-disorders-100574941","NCT06765824","Transcranial Magnetic Stimulation in Patients with Dual Disorders","Transcranial Magnetic Stimulation in the Treatment of Dual Disorders: Study in Patients with Depression and Tobacco Addiction","Inclusion Criteria:\n\n* Patients over 18 years of age being monitored in the mental health area of the province of Castellón, with a dual disorder: major depression and substance abuse disorder\n* Patients who are refractory to two or more lines of pharmacological treatments, ensuring correct completion beforehand\n* Acceptance of informed consent\n\nExclusion Criteria:\n\n* Psychotic symptoms or catatonia\n* Other addictions, or psychiatric or personality disorders\n* Language barrier\n* Mental retardation that will interfere with the ability to understand and subsequent acceptance or rejection of informed consent\n* Patients diagnosed with epilepsy\n* Patients diagnosed with a space-occupying lesion in the brain\n* Tinnitus\n* Confirmed pregnancy; if suspected, a test will be requested\n* Metal piece in the body or implanted medical device, except for dental material",{"count":411,"type":22},36,[413],"PHASE3","According to the WHO, 280 million people are diagnosed with depression, the prevalence of which is almost twice as high in women as in men, with the incidence among young people increasing in recent years. Another public health problem in Spain is tobacco consumption, with one in four adults being tobacco users. The presence of an addiction and another mental illness in the same patient is called dual disorder, and it is very common for depression to be associated with smoking. This is due to a shared biopsychosocial vulnerability between the two disorders. Although there are currently pharmacological treatments that address both disorders, their efficacy is limited; in this sense, transcranial magnetic stimulation (TMS) offers a way to treat these dual disorders. TMS is a technique in which a magnetic field is applied to the cortex through a coil, generating an electric current that can induce changes in the different neurotransmitter systems, stimulating or inhibiting them. A randomised, double-blind, placebo-controlled clinical trial is proposed to evaluate the efficacy of TMS in the treatment of a sample of 36 patients with resistant major depression and nicotine dependence. Both depression and smoking will be assessed at baseline, at various times during treatment and at the end of the study using psychometric tests, neurophysiological and biochemical assessments. It is expected that the experimental group will show improvements in depression, nicotine dependence and certain cognitive functions. TMS treatment of dual disorders (resistant depression + smoking) could represent a health and social advance, especially for women.",[416,417],"Major Depression","Tobacco Addiction",[419,420,417,421],"Transcranial Magnetic Stimulation","Major depressive disorder","Dual disorder","2025-01-03",{"date":424,"type":40},"2025-01-09",{"date":426,"type":22},"2025-02",{"date":428,"type":22},"2026-06",{"name":46,"class":47},{"id":431,"slug":432,"hasResults":11,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":436,"eligibilityCriteria":437,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":438,"targetDuration":4,"studyType":88,"phases":439,"briefSummary":440,"conditions":441,"keywords":444,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":48},"100366036","virtual-reality-intradialysis-last-vs-first-part-of-the-session-100366036","NCT04046042","Virtual Reality Intradialysis: Last vs. First Part of the Session","Virtual Reality Exercise Intradialysis: Tolerance and Dialysis Dose Effects During the Last vs. First Part of the Hemodialysis Session","VRI","Inclusion Criteria:\n\n* At least 3 months in hemodialysis treatment\n* Clinically stable\n\nExclusion Criteria:\n\n* Recent cardiac events (less than 3 months)\n* Unable to exercise",{"count":59,"type":22},[90],"The main objective of this investigation is to assess if an intradialysis virtual reality exercise program during the last two hours of the hemodialysis session results in greater hemodynamic stability than exercise performed during the first two hours of the hemodialysis session.\n\nThe secondary aims are to assess the impact of intradialysis virtual reality exercise during the last two hours of the hemodialysis session on dialysis efficacy, postdialysis molecules rebound, adherence to exercise, functional capacity, physical activity level, health-related quality of life, cognitive function, morbidity, frailty and dependency. We will also analyze the reliability of muscle strength assessment of lower limb muscles with a handheld dynamometer during hemodialysis.",[442,443],"End Stage Renal Disease on Dialysis","Hemodialysis Complication",[275,445,446,447,448],"Virtual reality","physical function","health-related quality of life","hemodynamic instability","2024-06-13",{"date":451,"type":40},"2024-06-14",{"date":453,"type":40},"2019-09-02",{"date":455,"type":22},"2024-08-30",{"name":46,"class":47},{"id":458,"slug":459,"hasResults":11,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":463,"eligibilityCriteria":464,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":465,"targetDuration":466,"studyType":24,"phases":4,"briefSummary":467,"conditions":468,"keywords":470,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":171},"100540007","chronic-pain-in-patients-in-hemodialysis-100540007","NCT06311240","Chronic Pain in Patients in Hemodialysis","Chronic Pain in Patients With Chronic Kidney Disease in Hemodialysis","DolERC","Inclusion Criteria:\n\n* Patients with End-Stage Renal Disease (ESRD)\n* Have been on hemodialysis treatment for at least 3 months and are medically stable.\n* Able to walk a few steps, even if they require walking aids such as canes or walkers.\n\nExclusion Criteria:\n\n* Myocardial infarction in the past 6 weeks.\n* Unstable angina during exercise or at rest.\n* Amputation of lower limbs above the knee without prosthetics.\n* Cerebrovascular disease such as stroke or transient ischemic attacks in the last 6 months or with significant sequelae affecting lower limb mobility.\n* Musculoskeletal or respiratory disorders that worsen with exercise.\n* Inability to perform study tests\u002Fquestionnaires.",{"count":322,"type":22},"6 Months","Pain is one of the most common symptoms among patients with End Stage Renal Disease (ESRD), and often goes unrecognized or inadequately managed in hemodialysis patients. More than 50% of patients undergoing hemodialysis suffer from pain, with 75% of them being treated ineffectively due to healthcare professionals\\' lack of awareness of this symptom. Therefore, pain management in this population is a complex and challenging task for healthcare providers. The most prevalent pain syndromes in hemodialysis patients include musculoskeletal disorders, metabolic neuropathies, in addition to typical intradialytic pain.\n\nThe aim of this study is to assess the presence and characteristics of chronic pain in patients with ESRD undergoing hemodialysis to determine whether it is relevant to include the management of chronic pain in the holistic treatment (physical activity, nutrition, and psychological support) already being implemented in various studies for these patients.",[469,65],"Chronic Pain",[65,469],"2024-06-12",{"date":451,"type":40},{"date":474,"type":40},"2024-05-02",{"date":476,"type":22},"2024-09",{"name":46,"class":47},""]