[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Cardiff and Vale University Health Board\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":142},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,38,61,92,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100601410","using-semg-of-the-diaphragm-to-assess-readiness-for-extubation-100601410",false,"NCT07110129","Using sEMG of the Diaphragm to Assess Readiness for Extubation","Using sEMG of the Diaphragm to Assess Readiness for Extubation - Feasibility Study to Design a Pragmatic Multi-site Trial Protocol","Inclusion Criteria:\n\n* Patients requiring mechanical ventilation for \\>72 hours\n* Patients who an attempt at extubation is planned\n* Patients who are willing or able to give informed consent (Where consultee advice is sought, informed consent from the participant will be completed as soon as possible).\n\nExclusion Criteria:\n\n* Aged under 18 years\n* Patients admitted with traumatic or spontaneous brain injury\n* Patients for who extubation is planned as a palliative process\n* Contra-indication to using sEMG e.g., permanent or temporary pacemaker, internal or external cardiac defibrillator, skin lesions around site of electrode placement","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","As part of an admission to an Intensive Care Unit (ICU) many patients have breathing tube inserted into their windpipe, also referred to as intubation . This is done for a variety of reasons which can include the need for invasive breathing support and to place the patient into a medically induced coma to allow their body to rest and be treated for the underlying cause of their deterioration.\n\nOne the patient has started to recover from their illness, the process of removing the breathing tube (extubation) and stopping the breathing machine begins. Optimising this process and ensuring successful removal of the breathing tube is extremely important to optimise outcomes. Therefore, identifying new methods to determine the likelihood for successful extubation is of clinical significance.\n\nThere are several markers of extubation readiness that clinicians can use to support their decision making discussed in the literature. A novel method is the use of respiratory muscle activity monitoring via sensory electromyogram (sEMG). sEMG has previously been shown to be useful to measure the strength and activity of muscles. However, until recently measuring diaphragm activity has been a challenge due to noise from the chest movements, cardiac artefacts. Recent advancements in signal processing and growing interest in better diagnostic methods has led to an improvement in metrics. Using wavelet transforms and machine learning, new techniques have been developed to measure diaphragm muscle activity using sEMG. sEMG has been shown to be effective in detecting patient-ventilator asynchrony as well as respiratory strength in those not requiring mechanical ventilation. However, its use in assessing patients nearing readiness for extubation has not been explored.\n\nTherefore, the purpose of this feasibility trial is to explore the use of sEMG in patients undergoing trials of extubation. The results of this study will be used to design a multi-site trial.",[24],"Critical Illness","RECRUITING","2025-08-20",{"date":28,"type":29},"2025-08-21","ACTUAL",{"date":31,"type":20},"2025-08-31",{"date":33,"type":20},"2026-07-31",{"name":35,"class":36},"Cardiff and Vale University Health Board","OTHER_GOV",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":45,"targetDuration":4,"studyType":46,"phases":47,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":37},"100534848","high-flow-oxygen-therapy-after-spinal-cord-injury-100534848","NCT06244160","High Flow Oxygen Therapy After Spinal Cord Injury","High Flow Oxygen Therapy After Spinal Cord Injury - Feasibility Study to Design a Pragmatic Randomised Controlled Trial Protocol","Inclusion Criteria:\n\n1. Spinal cord injury between C4 and T4 (Include ASIA A-D)\n2. Admitted to spinal injury ward within 24-48hours of injury\n\nExclusion Criteria:\n\n1. Aged under 18 years\n2. 3 or more rib fractures or flail\n3. Sternal fracture\n4. Concomitant lung injury\n5. Unable to gain informed consent from participant\n6. Contra-indication to using high flow therapy e.g., undrained pneumothorax, facial fractures, nasal obstruction, CSF leak, suspected or confirmed base of skull fracture, active epistaxis or recent functional endoscopic sinus surgery.",{"count":19,"type":20},"INTERVENTIONAL",[48],"NA","The goal of this feasibility study is to learn about the ability to use a different form of oxygen therapy (known as high flow oxygen therapy) in patients who have a spinal cord injury in the upper back or neck.\n\nThe main questions it aims to answer are:\n\n1. Is it possible to recruit patients to the study\n2. It is possible to follow the protocol in its current format\n3. What is the impact on those receiving the intervention.\n\nParticipants will be randomised to receive either standard care or high flow oxygen therapy for 10 days following inclusion.",[51,52],"Spinal Cord Injuries","Respiratory Failure","2025-07-31",{"date":55,"type":29},"2025-08-05",{"date":57,"type":29},"2024-04-01",{"date":59,"type":20},"2026-08",{"name":35,"class":36},{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":46,"phases":71,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":37},"100590419","heel-pain-pathways-feasibility-study-100590419","NCT06967168","HeEL Pain Pathways Feasibility Study","Feasibility of Developing Personalised Treatment Pathways for Relief of Plantar Heel Pain Using a Sequential Multiple Assignment Randomised Trial (SMART) Study Design","HELPP","Inclusion Criteria:\n\n* Adults aged 18 years or over\n* Have symptomatic heel pain (in one or both feet)\n* Able to speak, read and understand written and spoken English or Welsh\n* Able to provide remote informed consent\n* Access to internet and email, or DVD player, with technical support from family, friends or carers if necessary.\n\nExclusion Criteria:\n\n* Taken part in a prescribed exercise intervention or used prescribed insoles (past 3 months)\n* History of major trauma or fracture of the lower leg or below ankle surgery\n* Heel pain secondary to a systemic condition\u002Fsyndrome\u002Fmalignancy\n* Requires ankle-foot orthoses or lower limb device (splint)\n* Diabetes or peripheral neuropathy\n* History of inflammatory joint disease or autoimmune condition\n* Chronic pain syndrome\n* Pregnancy\n* Pacemaker or other electrical implant\n* Blood clotting disorder (haemophilia), blood clot (thrombosis), or current use of anticoagulant medication\n* Cortisone injection therapy within the last two weeks\n* Unable to complete exercises in self-help resources.",{"count":70,"type":20},50,[48],"At the moment, no-one is sure what the best way to treat heel pain is. The purpose of this research is to try out some study methods to prepare for a future clinical trial, that will assess how helpful combining different treatments are for people with heel pain (plantar fasciitis). At this stage, the aim is only to test the study processes and ask for feedback - that is why this is called a feasibility study. No experimental techniques or devices will be tested. All of the treatments in the study are routinely carried out in NHS clinics, but participants will be allocated to different combinations of treatments.\n\nEach participant will be asked to complete questionnaires and a diary for around six months in total. Some people will also be invited to take part in an interview or focus group discussion.",[74],"Plantar Fasciitis",[76,77,78,79,80,81,82,83],"pain management","podiatry","musculoskeletal diseases","foot diseases","foot orthoses","extracorporeal shockwave therapy","conservative treatment","self care","2025-05-08",{"date":86,"type":29},"2025-05-13",{"date":88,"type":29},"2024-09-02",{"date":90,"type":20},"2025-11-28",{"name":35,"class":36},{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":37},"100579867","are-we-providing-timely-access-to-musculoskeletal-outpatient-therapy-services-an-exploratory-study-100579867","NCT06829875","Are We Providing Timely Access to Musculoskeletal Outpatient Therapy Services? an Exploratory Study","MSk EATS","Inclusion Criteria:\n\n* aged 18 years or over\n* have entered a waiting list for outpatient podiatry, occupational therapy or physiotherapy with a musculoskeletal complaint\n* able to provide informed consent\n* be able to read and write english\n\nExclusion Criteria:\n\n* are considered a vulnerable adult\n* exhibit additional communication needs, to include but not limited to, language barrier",{"count":100,"type":20},135,"Waiting times for NHS services are of growing public interest. This is because accessing some services is getting more difficult, and we know that longer waits can result in negative impacts for those waiting.\n\nPeople in Wales waiting for care for their musculoskeletal problems are deemed to be cared for in good time if they get an appointment in less than 14 weeks. This target has been set by Welsh Government, for everyone who waits, no matter what condition they are waiting with and how that condition is affecting them.\n\nWe know that impact of wait for people with MSK problems can vary, from complete recovery, to worsening of their pain and function. The impact experienced seems to be influenced by factors such as their age and their mental health statusz\\\\. This suggests that setting one target for all may not be the right thing to do. However, we don't yet know whether waiting over 14 weeks has a big effect on impact. We also don't know about the lived experience of those waiting, while they wait, despite knowing that learning this is vital to informing change.\n\nWe plan to study the impact of waiting for these services by asking those waiting to complete a survey that measures the impact of their msk problem, at the start and end of their wait, and then understanding how the scores correlate with length of time waited. We will also ask some of these people to document their experience as they wait. We hope that this will provide an understanding of how effective the current target is at measuring access to these services, and whether we need to think differently. People will be able to complete this work in their own home.",[103],"Musculoskeletal",[105,106,107,108,109,110,111,112,113,114],"access","waiting times","impact of wait","musculoskeletal pain","msk pain","musculoskeletal conditions","physiotherapy outpatients","podiatry outpatients","occupational therapy outpatients","musculoskeletal therapy services","2025-02-11",{"date":117,"type":29},"2025-02-17",{"date":119,"type":29},"2025-02-04",{"date":121,"type":20},"2025-09",{"name":35,"class":36},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":129,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":37},"100487890","an-observational-study-of-epilepsy-biology-and-outcomes-using-real-world-data-100487890","NCT05632978","An Observational Study of Epilepsy: Biology and Outcomes Using Real-world Data","Inclusion Criteria:\n\n* Individual is being investigated for epilepsy and under the clinical care of the epilepsy unit at Cardiff \\& Vale University Health Board or regional clinics in Cwm Taf.\n* Individual is at least 16 years old.\n* Informed consent sought and given by individual.\n\nExclusion Criteria:\n\n* None","16 Years",{"count":131,"type":20},2000,"The goal of this observational study is to learn more about phenotypic, genetic, biochemical, neurophysiological and radiological patterns in epilepsy.\n\nParticipants will be asked to consent to use of clinical and paraclinical data (obtained during standard care) for research, and will be asked to donate blood samples at their routine clinic visits.",[134],"Epilepsy",{"date":136,"type":29},"2025-02-13",{"date":138,"type":29},"2023-04-24",{"date":140,"type":20},"2032-12",{"name":35,"class":36},""]