[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Carle Foundation Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":105},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100639975","optimal-targeted-high-definition-transcranial-direct-current-stimulation-for-reducing-post-stroke-upper-limb-motor-impairments-100639975",false,"NCT07599774","Optimal Targeted High-definition Transcranial Direct Current Stimulation for Reducing Post-stroke Upper Limb Motor Impairments","Optimal Targeted High-definition tDCS for Reducing Post-stroke Upper Limb Motor Impairments","Inclusion Criteria:\n\n* Must be 18 years or older\n* Must have had a stroke that resulted in paresis confined to one side. The use of a wheelchair or other assisting devices are not exclusionary.\n* Must have substantial motor impairment of the paretic upper limb\n* Absence of severe wasting or contracture or significant sensory deficits in the paretic upper limb\n* Absence of severe concurrent medical problems (e.g. cardiorespiratory impairment)\n* Fugl-Meyer Upper Extremity Score of 8-50 based on assessment performed during the baseline visit.\n* Must have had either MRI or CT of the brain performed at Carle as part of their stroke care. Imaging may have been performed either during the diagnostic work-up for stroke or as follow-up after diagnosis. The most recent images from either MRI or CT will be collected for this study.\n* Capacity to provide informed consent and participate in English (Since this study is a clinical trial and the team is yet to provide the translation service at this stage, the study is restricted to those who can consent and participate in English only).\n* Must be willing and able to perform study procedures\n\nExclusion Criteria:\n\n* Self-reported sensitive skin or adhesive allergy as assessed by the tDCS Safety Screening Questionnaire\n* Has a cardiac pacemaker, defibrillator or an implantable cardiac resynchronization therapy device\n* Has metal implants in the head and\u002For brain\n* Presence of muscle tone abnormalities and motor or sensory impairment in the non-paretic limb\n* Presence of severe muscle wasting or contracture or significant sensory deficits in the paretic upper limb\n* Currently pregnant or planning to become pregnant during the study period\n* History of epilepsy, febrile convulsion, recurrent fainting spells or unexplained recurring headaches\n* Current use of illicit\u002Frecreational drugs\n* Currently undergoing anti-malarial treatment. (Note: participants can be considered for study participation after ant-malarial treatment has been discontinued)\n* Has known adverse reaction to TMS or tDCS","ALL","18 Years",{"count":19,"type":20},16,"ESTIMATED","INTERVENTIONAL",[23],"NA","Non-invasive, non-pharmaceutical technologies that augment routine clinical practice for brain diseases and manage chronic symptoms have advanced rapidly over the past two decades. Among these, non-invasive brain stimulation such as transcranial direct current stimulation (tDCS) promotes neuroplasticity in injured brains, with fewer side effects and risks than invasive, implanted approaches such as deep-brain stimulation. Stimulating the brain can improve its function and help with recovery after a stroke. It has been a challenge to do this non-invasively. This is because the brain is reshaped after a stroke, and thus, it is difficult to find the right places to stimulate from the outside. In previous research, investigators found that optimal type and target of tDCS varied among subjects. The goal of this pilot trial is to test the feasibility of combining individually optimized, targeted high-definition tDCS (THD-tDCS) with rehabilitation therapy. Investigators will include 16 chronic stroke subjects with their optimal stimulation setup, obtained from their previous research. The participants will be computer-randomized into two equal-sized groups to receive either optimal THD-tDCS or sham stimulation, together with rehabilitation therapy (modified constraint-induced movement therapy, mCIMT) for five sessions over two weeks. Outcome measures will be collected at the baseline and right after the final intervention session. The primary outcome measure will be the change in the FM-UE score from baseline to immediately post the final intervention to assess the immediate effect of the intervention on upper extremity motor impairment. The secondary outcome measure will be the Wolf Motor Function Test time score to evaluate the immediate effect on functional motor performance.",[26],"Hemiparetic Stroke",[28,29,30,31],"Upper limb","Stroke rehabilitation","Individualized intervention","High-definition transcranial direct current stimulation","NOT_YET_RECRUITING","2026-05-26",{"date":35,"type":36},"2026-05-28","ACTUAL",{"date":38,"type":20},"2026-07-01",{"date":40,"type":20},"2027-06-30",{"name":42,"class":43},"Carle Foundation Hospital","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100616915","pain-management-for-in-office-gynecologic-procedures-using-a-risk-stratification-pain-calculator-100616915","NCT07311824","Pain Management for In-Office Gynecologic Procedures Using a Risk-Stratification Pain Calculator","Pain Management Optimization for In-Office Gynecologic Procedures: The Development and Evaluation of a Risk-Stratification Pain Calculator","Inclusion Criteria:\n\n* At least 18 years of age\n* Proficient in English\n* Access to personal smart devices (smartphone, tablet, laptop, etc.)\n* Will be undergoing the following in-office gynecologic procedures: IUD insertion, endometrial biopsy, colposcopy with cervical biopsy, or hysteroscopy\n\nExclusion Criteria:\n\n* Under the age of 18\n* Non-English-Speaking\n* Have contraindications to taking NSAIDs, acetaminophen, lidocaine or its derivatives, or opioids\n* Patients who are taking methadone, Suboxone, and\u002For naltrexone","FEMALE",{"count":54,"type":20},200,[23],"The goal of this clinical trial is to learn how using a risk-stratification calculator to determine the risk of a patient experiencing severe pain during an in-office gynecologic procedure and subsequently assigning pain medications to be used for the procedure based on risk, will affect patients' pain during these procedures. The main questions it aims to answer are:\n\n* Does using pain medications determined by a risk-stratification calculator improve patients' pain scores during if-office gynecologic procedures?\n* Does using pain medications determined by a risk-stratification calculator improve patient satisfaction?\n\nResearchers will compare using the risk-stratification calculator to decide on pain medications to a provider using their best judgement to decide on pain medications. This will help determine if patients have improved pain scores and satisfaction if they have their pain medications assigned using the risk-stratification calculator.\n\nParticipants who are undergoing a relevant in-office gynecologic procedure will:\n\n* Receive pain medications for their procedure either based on their answers to questions for the risk-stratification calculator or based on their provider's best judgement.\n* Answer an online survey about their experience with the procedure and related pain management.",[58,59,60],"Pain Management","Patient Satisfaction","Gynecologic Procedures",[62,63,64,65,66,67,68,69],"pain management","patient satisfaction","gynecologic procedures","IUD insertion","hysteroscopy","endometrial biopsy","colposcopy","ambulatory gynecologic procedures","2025-12-16",{"date":72,"type":36},"2025-12-31",{"date":74,"type":20},"2025-12-29",{"date":76,"type":20},"2027-04-30",{"name":42,"class":43},2,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":21,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":44},"100476059","determine-the-effect-of-targeted-high-definition-transcranial-direct-current-stimulation-tdcs-on-reducing-post-stroke-upper-limb-motor-impairments-100476059","NCT05479006","Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments","Determine the Effect of Targeted High-definition tDCS on Reducing Post-stroke Upper Limb Motor Impairments","Inclusion Criteria:\n\n* Paresis confined to one side, with substantial motor impairment of the paretic upper limb\n* Capacity to provide informed consent\n\nExclusion Criteria:\n\n* Muscle tone abnormalities and motor or sensory impairment in the non-paretic limb\n* Severe wasting or contracture or significant sensory deficits in the paretic upper limb\n* Severe cognitive or affective dysfunction that prevents normal communication and understanding of consent or instruction\n* Severe concurrent medical problems (e.g. cardiorespiratory impairment)\n* Using a pacemaker\n* Metal implants in the head\n* Known adverse reactions to TMS and tDCS\n* Pregnant","90 Years",{"count":88,"type":20},30,[23],"Significant motor impairments occur in 80% of individuals after moderate to severe stroke and impact the body side to the lesioned hemisphere. Typical motor impairments involve loss of dexterity with highly prevalent upper limb flexion synergy. Advances in treating flexion synergy impairments have been hampered by a lack of precision rehabilitation. Previous studies suggest and support the role of cortico-reticulospinal tract (CRST) hyperexcitability in post-stroke flexion synergy. CRST hyperexcitability is often caused by damage to the corticospinal tract (CST). We hypothesize that: 1) inhibiting the contralesional dorsal premotor cortex (cPMd) will directly reduce the CRST hyperexcitability and thus, reduce the expression of the flexion synergy; 2) facilitating the ipsilesional primary motor cortex (iM1) will improve the excitability of the damaged CST, therefore reducing the CRST hyperexcitability and the flexion synergy. we propose to use a novel targeted high-definition tDCS (THD-tDCS) to specifically modulate the targeted cortical regions for testing his hypothesis, via the following aims: Aim 1. Evaluate the effect of cathodal THD-tDCS over the cPMd on reducing the CRST hyperexcitability and the expression of flexion synergy. Aim 2. Evaluate the effect of anodal THD-tDCS over the iM1 on improving the excitability of the CST, and determine whether this, thus, also reduces the CRST hyperexcitability and the flexion synergy. Aim 3. Evaluate the confluence effect of bilateral THD-tDCS, i.e., simultaneous cathodal stimulation over the cPMd and anodal over the iM1.",[92],"Stroke",[92,94,95],"Non-invasive Brain Stimulation","Movement Impairment","RECRUITING","2025-12-15",{"date":99,"type":36},"2025-12-19",{"date":101,"type":36},"2022-09-30",{"date":103,"type":20},"2026-06-30",{"name":42,"class":43},""]