[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Carnegie Mellon University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":159},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,53,81,102,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100643362","assessing-the-effects-of-hormones-on-noninvasive-transcranial-stimulation-100643362",false,"NCT07635017","Assessing the Effects of Hormones on Noninvasive Transcranial Stimulation","Inclusion Criteria:\n\n* Age between 18 and 40 years old\n* Female subjects must have regular menstrual cycles (defined as a cycle that occurs at predictable intervals, typically between 24 and 38-days length) via self-report\n\nExclusion Criteria:\n\n* Allergies to henna\n* Allergies to gel used for electrodes\n* History of seizures or epilepsy\n* Subjects must not have any serious disease, disorder, infection, or cognitive impairments that could affect their ability to participate in this study.\n* Female subjects of child-bearing potential must not be pregnant\n* Subjects must not have any implanted stimulators or pulse generators\n* Subjects must not have heart disease, including known arrhythmia\n* Subjects must not have any metal implants in their head",true,"ALL","18 Years","40 Years",{"count":20,"type":21},25,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is investigating how two types of non-invasive brain stimulation, transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS), affect brain activity, and whether combining them produces stronger or more consistent effects than either one used alone. The motivation for this comes from the observation that TMS, which is FDA-approved for treating depression, tends to work less well in postmenopausal women because lower estrogen levels reduce the brain's ability to respond to stimulation. The research team believes that pairing TMS with TES, which targets a different set of brain cells, may be able to overcome this hormonal barrier and make stimulation more effective. Participants will come into the lab for up to 24 visits over 8 months, beginning with an initial visit to establish the right stimulation settings, followed by a series of stimulation sessions in which brain activity is measured before and after receiving either TES, TMS, or both together. For female participants, sessions will be scheduled at specific points in the menstrual cycle to capture the natural monthly rise and fall of estrogen, while male participants will be scheduled on a comparable fixed interval as a comparison group. The insights gained from this study could directly inform the development of better, more reliable brain stimulation treatments for women with depression.",[27,28,29,30,31],"Cortical Excitability","Healthy","TMS","Menstrual Cycle","Menopause",[33,34,35,36,37,38,27,39],"Transcranial Magnetic Stimulation","Transcranial Electrical Stimulation","Noninvasive Neuromodulation","Perimenopause","Electromyography","Hormones","Synaptic Plasticity","NOT_YET_RECRUITING","2026-06-04",{"date":43,"type":44},"2026-06-09","ACTUAL",{"date":46,"type":21},"2026-07-01",{"date":48,"type":21},"2028-07-01",{"name":50,"class":51},"Carnegie Mellon University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":59,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100621831","transcranial-electrical-stimulation-for-noninvasive-study-of-menopausalperimenopausal-symptoms-100621831","NCT07375732","Transcranial Electrical Stimulation for Noninvasive Study of Menopausal\u002FPerimenopausal Symptoms","Inclusion Criteria:\n\n* Age between 40 and 60 years\n* Participants falling under stages -2 to +2 in the Stages of Reproductive Aging Workshop (STRAW +10) as defined below:\n* Early menopause transition (Stage -2): Increased variability in menstrual cycle defined as persistent difference of 7 days or more in the length of consecutive cycles. Persistence is defined as recurrence within 10 cycles of the first variable cycle.\n* Late menopause transition (Stage -1): Occurrence of amenorrhea of 60 days or longer.\n* Final Menstrual Period (Stage 0): Have undergone 12 consecutive months without a menstrual period, not due to other medical causes.\n* Early Postmenopause (Stage +1): 5-8 years after final menstrual period.\n* Late Postmenopause (Stage +2): \\>8 years after final menstrual period.\n* Participants having frequent hot flashes (at least once a day).\n\nExclusion Criteria:\n\n* Disorders that may mask or coincide with menopause and peri-menopause, such as: Primary Ovarian Insufficiency, Thyroid disease (Hyper\u002Fhypothyroidism), Hyperprolactinemia, Cushing's syndrome, Endometrial\u002FOvarian Cancer, Polycystic Ovary Syndrome (PCOS), Functional hypothalamic amenorrhea\n* Concurrent drugs:\n* GnRH agonist\u002Fantagonist\n* Tamoxifen\u002Faromatase inhibitors\n* Other conditions: Recent hematoma (\\\u003C48 hours), History of hemorrhagic disorders (any platelet disorder (ITP, TTP, HUS, Glanzmann thrombasthenia), Hemophilia A\u002FB, history of arterial insufficiency, any prior history of malignancy, current pregnancy, a lifetime history of severe, uncontrolled mood disorders (anxiety, depression, bipolar), psychotic disorders, other neural disorders, or heart disease, any condition that makes them unable to perform tasks outlined in experiment, tattoos on sensory testing sites.","FEMALE","60 Years",{"count":62,"type":21},50,[24],"Participants are being invited to a research study. This research aims to assess the tolerability of transcranial electrical stimulation of the brain, and explore the response of TES on menopausal\u002Fperimenopausal symptoms including hot flashes effects, depression\u002Fanxiety, memory-problems, and muscular problems. This study will assess what types of electrical brain stimulation affect different menopausal related symptoms. This study will help guide the development of electrical stimulation to be used for improving women's health during menopause transition.",[66,67,31,68],"Menopausal Depression","Menopause Hot Flashes","Menopause Related Conditions",[35,34,70,71,72],"Depression","Vasomotor Symptoms","Hot Flashes","2026-01-26",{"date":75,"type":44},"2026-01-29",{"date":77,"type":21},"2026-02",{"date":79,"type":21},"2027-04",{"name":50,"class":51},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":52},"100300543","electrophysiological-source-imaging-guided-transcranial-focused-ultrasound-100300543","NCT03192436","Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound","Inclusion Criteria:\n\n* Apparently healthy volunteers.\n* Age 18-64.\n* Willing and able to provide written consent.\n* Able to communicate in the English language.\n\nExclusion Criteria:\n\nSubjects having any of the following conditions will be excluded from this study:\n\n* Evidence of a current significant medical illness or psychiatric or central or peripheral neurologic disorder\n* History of loss of consciousness of more than ten minutes in the past year or loss of consciousness in a lifetime that required rehabilitation services\n* Personal or family history of seizure\n* Any history of stroke\u002Ftransient ischemic attack (TIA)\n* Taking any medications that are known to decrease the threshold for seizure\n* Pregnancy\n* Affirmative answers to one or more questions of the provided attached safety questionnaires. These are not absolute contraindications to this study but the risk\u002Fbenefit ratio will be carefully considered by the PI\n* Failure to follow laboratory or study procedures","64 Years",{"count":89,"type":21},80,[24],"Neuromodulation is a fast growing field that offers a wide range of applications for both understanding and treating the brain. Future research for non-invasive neuromodulation will need to elucidate the optimal frequency, duration, and intensity of stimulation for a variety of technologies and diseases. Closed loop stimulation is thus a promising research area that allows for responsive stimulation and real time symptom management. Our project is proposed to develop and test a novel noninvasive neuromodulation integrating transcranial focused ultrasound stimulation (tFUS) with electrophysiological source imaging (ESI-tFUS) to allow evidence-based neuromodulation for brain research and the management of brain conditions. Despite the recent developments and attention surrounding tFUS, relatively little is known about the mechanisms and optimal parameters of this stimulation technology. The addition of ESI neuroimaging, aimed at providing biomarkers to assess the effects of tFUS neuromodulation, could provide crucial necessary information regarding the neural response to the applied stimulation in real-time. In order for tFUS to be further developed and transformed into a robust neuromodulation technology, an integrated electrophysiological source-imaging-guided tFUS system to allow for individualized and responsive stimulation is needed.\n\nThe purpose of this study is to develop and evaluate the proposed ESI-tFUS in human subjects using motor and somatosensory paradigms.",[28],"RECRUITING","2025-11-13",{"date":96,"type":44},"2025-11-14",{"date":98,"type":44},"2018-09-01",{"date":100,"type":21},"2030-06-30",{"name":50,"class":51},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":15,"sex":16,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":119,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":52},"100579281","drinking-in-young-adult-duos-dyad-study-100579281","NCT06822257","Drinking in Young Adult Duos (DYAD) Study","Understanding Alcohol Use in Young Adult Couples","Inclusion Criteria:\n\nBoth members of the couple must:\n\n* be between the ages of 21 and 30\n* regularly consume alcohol\n* own a smartphone\n\nExclusion Criteria:\n\nNeither member of the couple:\n\n* has a history of adverse reaction to the amount of beverage used in the study\n* has a history of major problems related to alcohol\n* is taking medications that could adversely interact with alcohol\n* is pregnant","21 Years","30 Years",{"count":112,"type":21},504,[24],"This study examines the role of alcohol use in understanding the dynamics of romantic relationships. Couples will participate in a research session where they consume either an alcoholic or non-alcoholic beverage and complete study tasks. After the session, participants will provide information about their drinking habits, alcohol- and non-alcohol-related experiences, and relationship factors through brief surveys on their smart phones and again at 6-month and 12-month follow-up sessions. The findings from this study aim to improve understanding of alcohol use in close relationships and may inform future strategies for promoting healthier relationships and behaviors.",[116,117,118],"Alcohol Consumption","Alcohol Drinking","Alcohol Intoxication",[120,121],"alcohol administration","couples","2025-05-22",{"date":124,"type":44},"2025-05-28",{"date":126,"type":44},"2025-02-01",{"date":128,"type":21},"2029-09",{"name":50,"class":51},{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":15,"sex":16,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":146,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":52},"100536394","game-based-pediatric-diabetes-education-100536394","NCT06264258","Game-based Pediatric Diabetes Education","Evaluating Game-based Pediatric Diabetes Education","DVx-T1D","For youth:\n\n* Be between the age of 6 to 12 years.\n* Have been diagnosed with type 1 diabetes for at least 1 year.\n* Be currently taking insulin through multiple daily injections or an insulin pump.\n* Check blood sugar with a meter at least 4 times per day or use a continuous glucose monitor.\n* Be willing to comply with all study visits and procedures.\n\nFor Parent:\n\n* Biological or adopted parent with custody and medical decision making of the patients\n* Living with identified patients\n* Over 18 years old\n* Resident of Allegheny County\n\nExclusion Criteria:\n\n-Children with type 2 diabetes, cystic fibrosis related diabetes, or secondary diabetes.","6 Years","12 Years",{"count":89,"type":21},[24],"The goal of this study is to evaluate the impact of a mobile app video game called Digital Vaccine for Type 1 Diabetes (DVx-T1D)™, proposed as a low-risk, non-invasive, digital therapeutic candidate for behavior change in children 6 to 12 years of age with Type 1 Diabetes (T1D).\n\nThe investigators hypothesize that adoption of DVx-T1D™ by T1D patients will positively influence healthy dietary and physical activity behaviors by providing nutrition and lifestyle education through a playful, Artificial Intelligence (AI)-based, cartoon-style medium of mobile gaming, and result in improvements in their T1D control. The investigators propose to conduct a longitudinal randomized controlled trial (RCT) over a 3-month period with a study population of 80 T1D participants (40 each in two arms of the trial) of 6-12 years old. The investigators will quantify the impact of the mobile game app plus standard care vs. standard care (with no exposure to the app) on T1D control (assessed by glycosylated hemoglobin or HbA1c measured during clinic visits and continuous glucose monitoring (CGM) parameters measured at home), physical activity levels and food choices of children (measured using food logs and surveys). Game telemetry, food logs, clinical, anthropometric, demographic, and survey data will be collected to obtain adequately powered, theory-driven evidence of the value of game-based approaches delivered via mobile apps.",[144,145],"Diabetes Mellitus, Type 1","Behavior, Health",[147,148,149,150],"app","game","children","pediatrics","2025-02-10",{"date":153,"type":44},"2025-02-12",{"date":155,"type":44},"2024-05-22",{"date":157,"type":21},"2026-06-30",{"name":50,"class":51},""]