[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Case Western Reserve University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":699},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,64,90,115,145,171,196,223,247,281,310,340,366,391,414,442,468,494,521,545,574,602,623,647,670],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":39,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":63},"100635793","supporting-just-in-time-consent-for-prenatal-screening-the-inform-study-100635793",false,"NCT07557303","Supporting Just-In-Time Consent for Prenatal Screening: The INFORM Study","Inclusion Criteria:\n\n* Currently pregnant and receiving care at a participating collaborative site - University of North Carolina, Chapel Hill; Zuckerberg Chan San Francisco General Hospital; University of Florida Health, Jacksonville.\n* 18 years of age and older\n* Able to read, speak, and understand English or Spanish\n* Has not previously been offered prenatal genetic screening for the current pregnancy\n* 24 weeks (6 months) gestational age or less\n\nExclusion Criteria:\n\n* Not pregnant, not a patient at a partner clinical site\n* Younger than 18 years of age\n* Not being able to read, speak, and understand English or Spanish\n* Has previously been offered prenatal genetic screening for the current pregnancy\n* Greater than 24 weeks gestational age (6 months)",true,"FEMALE","18 Years",{"count":20,"type":21},1400,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial is about prenatal genetic screening. It will test an intervention to help people make decisions about screening. The intervention is a short set of information cards about screening. This intervention is for pregnant participants. They will use the intervention on their mobile phone before they see their doctor.\n\nThe study has one main question:\n\n* Do participants who use the intervention feel more confident when they make a decision about screening?\n\nResearchers will compare participants who use the intervention to participants who do not. All participants will have their usual care when they visit their doctor.\n\nWhat will participants do?\n\n* Participants must be pregnant. They will sign up for the study before their first doctor's visit for their pregnancy. This is the visit where their doctor usually talks with them about screening.\n* Some participants will use the intervention before their first doctor's visit. Other participants will not use it.\n* All participants will talk with a researcher on the phone after their first doctor's visit.\n* Participants who use the intervention will answer a short survey on their phone.\n* A few participants who use the intervention will talk with a researcher a second time on the phone.",[27,28,29,30,31,32,33,34,35,36,37,38],"Delivery of Health Care","Genetic Testing","Humans","Pregnancy","Noninvasive Prenatal Testing","Informed Consent","Internet-Based Intervention","Self Efficacy","Pregnant People","Decision Making","Health Education","Patient Education as Topic\u002FMethod",[40,41,42,43,44,45,46,47,48,49,50],"Non-invasive prenatal screening (NIPS)","Non-Invasive Prenatal Testing (NIPT)","Cell-free DNA (cfDNA)","Prenatal genetic screening","Informed consent","Decision making","Surveys and Questionnaires","Informed choice","Educational intervention","Decision Regret","Decision Satisfaction","NOT_YET_RECRUITING","2026-06-30",{"date":54,"type":55},"2026-07-01","ACTUAL",{"date":57,"type":21},"2026-08-01",{"date":59,"type":21},"2028-06-30",{"name":61,"class":62},"Case Western Reserve University","OTHER",3,{"id":65,"slug":66,"hasResults":12,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":16,"sex":70,"minAge":71,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":74,"phases":4,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},"100527578","changes-in-microbial-status-from-dentate-edentulous-and-after-dental-implant-placement-100527578","NCT06149585","Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement","Inclusion Criteria:\n\n1. At least 21 years of age\n2. Diagnosis of Stage III or IV periodontitis based on full mouth probing and full mouth x-rays\n3. Planned for full mouth extraction and replacement by dental implants.\n4. Rehabilitation with Implant supported restorations either maxilla and\u002F or mandible.\n5. At least 2 implants available for examination.\n6. No bone augmentation required.\n\nExclusion Criteria:\n\n1. Conditions requiring chronic routine prophylactic use of antibiotics.\n2. Conditions requiring prolonged use of steroids.\n3. History of leukocyte dysfunction and deficiencies\n4. Bleeding disorders\n5. History of neoplastic disease requiring use of radiation or chemotherapy\n6. Metabolic bone disorders\n7. Uncontrolled endocrine disorder\n8. Use of any investigational drug or device within the 30 day period prior to implant surgery.\n\n10\\. Alcoholism or drug abuse 11. Patient infected with HIV 12. Condition or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, unreliability.\n\nLocal Exclusion Criteria\n\n1. Local inflammation\n2. Mucosal disease such as erosive lichen planus\n3. History of local irradiation therapy\n4. Osseous lesion.\n5. Active infection with suppuration or fistula track.\n6. Persistent intraoral infection different than periodontitis","ALL","21 Years",{"count":73,"type":21},12,"OBSERVATIONAL","The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material\u002Fsurface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.",[77,78,79,80],"Edentulous Mouth","Periodontal Diseases","Periodontitis, Adult","Microbial Colonization","RECRUITING","2026-06-29",{"date":54,"type":55},{"date":85,"type":55},"2023-08-16",{"date":87,"type":21},"2028-05-01",{"name":61,"class":62},1,{"id":91,"slug":92,"hasResults":12,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":12,"sex":70,"minAge":18,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":99,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":89},"100638871","reframe-an-emotion-regulation-intervention-to-improve-psychological-outcomes-in-surrogate-decision-makers-of-the-critically-ill-100638871","NCT07630844","REFRAME: an Emotion Regulation Intervention to Improve Psychological Outcomes in Surrogate Decision-Makers of the Critically Ill","A Randomized Trial of REFRAME: an Emotion Regulation Intervention to Improve Psychological Outcomes in Surrogate Decision-Makers of the Critically Ill","Patient Inclusion Criteria:\n\n* 1\\. Age ≥ 35 years\n* 2\\. Lacks decision-making capacity\n* 3\\. Not expected to be discharged from the ICU in 24 hours (including death)\n\nLegally Authorized Representative Inclusion Criteria (Primary Participant)\n\n* 1\\. Age ≥ 18 years\n* 2\\. Identified as LAR by ICU team\n* 3\\. Able to speak and understand English\n* 4\\. Able to visualize content on a tablet device\n\nPatient Exclusion Criteria:\n\n* 1\\. Age \\\u003C 35 years\n* 2\\. Possesses decision-making capacity\n* 3\\. Anticipated discharge from ICU within next 24 hours.\n\nLegally Authorized Representative Exclusion Criteria:\n\n* 1\\. Age \\\u003C 18 years\n* 2\\. Not recognized as LAR by ICU team\n* 3\\. Unable to speak and understand English\n* 4\\. Unable to visualize content on a tablet device",{"count":98,"type":21},387,[24],"Every year in the United States, millions of adults make crucial medical decisions for loved ones in the intensive care unit while facing extreme emotional stress. This project will assess REFRAME, a brief tablet-based program designed to help decision-makers manage their emotions in these situations. Results from this study may lead to the creation of a widely accessible tool that alleviates emotional suffering and enhances the quality of medical decision-making for families in crisis.",[102],"Critical Illness",[104,105,106],"Emotion Regulation","Psychological Distress","Surrogate Decision-Makers","2026-06-23",{"date":109,"type":55},"2026-06-25",{"date":111,"type":21},"2027-01-04",{"date":113,"type":21},"2031-04-04",{"name":61,"class":62},{"id":116,"slug":117,"hasResults":12,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":12,"sex":70,"minAge":4,"maxAge":18,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":125,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":144},"100627825","humidity-asthma-interventions-for-low-socioeconomic-status-children-100627825","NCT07453667","Humidity Asthma Interventions for Low Socioeconomic Status Children","Novel Strategies to Improve Housing Quality and Respiratory Health for Low Socioeconomic Status Children With Asthma","INHALE","Inclusion Criteria:\n\n* Documented diagnosis of asthma by one child (\\\u003C 18 years of age) living within the home\n* Parent\u002Fguardian able to complete informed consent\n* Residence within the City of Cleveland or immediate suburbs (e.g., East Cleveland, Garfield Heights, Warrensville Heights, Parma, Brook Park, Brooklyn\u002FOld Brooklyn)\n\nExclusion Criteria:\n\n* \\> 18 years of age\n* Rental property with landlord unwilling or unable to give consent for remediation",{"count":124,"type":21},80,[24],"The goal of this intervention study is to assess the effectiveness of low-cost humidity and mold reduction interventions in the home for reducing pediatric asthma. The study will have two groups, a treatment group that receives the healthy home interventions during the study and a second control group that will receive these after the study. We will compare pediatric asthma before and three months after the healthy home interventions are performed.",[128],"Pediatric Asthma",[130,131,132,133,134,135],"asthma","environmental health","indoor air quality","endotoxin","mold","humidity","2026-06-02",{"date":138,"type":55},"2026-06-03",{"date":140,"type":55},"2026-05-02",{"date":142,"type":21},"2027-05",{"name":61,"class":62},2,{"id":146,"slug":147,"hasResults":12,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":16,"sex":70,"minAge":18,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":155,"briefSummary":156,"conditions":157,"keywords":4,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":89},"100609620","knowledge-and-interpersonal-skills-to-develop-enhanced-relationships-kinder-100609620","NCT07216950","Knowledge and Interpersonal Skills to Develop Enhanced Relationships (KINDER)","Knowledge and Interpersonal Skills to Develop Enhanced Relationships (KINDER): Testing the Efficacy of an Intervention to Prevent Psychological Elder Abuse in Family Caregiving","KINDER","Inclusion Criteria:\n\n* Family member, including family of choice, to an individual living with AD\u002FADRD\n* Is aged 18 years or older;\n* Provides assistance with at least two instrumental activities of daily living or one activity of daily living;\n* Provides at least 4 hours of caregiving per day\n* The care recipient is at least age 65 or older\n* The care recipient has an AD8 score of 2 or higher per caregiver\n\nExclusion Criteria:\n\n* Sees the care recipient in-person less than 2 times per week\n* Has plans to place the care recipient in a skilled nursing facility within the next 8 months\n* Previously participated in the Learning Skills Together clinical trial (NCT05846984)\n* Does not have reliable access to internet, email, and a computer, smartphone, or tablet to complete study activities",{"count":154,"type":21},260,[24],"The Knowledge and Interpersonal Skills to Develop Enhanced Relationships (KINDER) intervention was developed to prevent psychological elder abuse (EA) and promote high-quality caregiving by lowering relationship strain and developing CG resourcefulness. The goal of this two-arm, randomized control trial is to determine the efficacy of KINDER at mitigating psychological EA by family caregivers to persons living with dementia and to describe how the intervention may work to reduce psychological EA.",[158,159,160,161,162],"Elder Mistreatment","Elder Abuse","Quality of Care","Dementia","Caregiving","2026-05-19",{"date":165,"type":55},"2026-05-20",{"date":167,"type":21},"2026-07-31",{"date":169,"type":21},"2029-05-11",{"name":61,"class":62},{"id":172,"slug":173,"hasResults":12,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":16,"sex":70,"minAge":18,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":184,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":190,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":89},"100518947","comparison-of-two-methods-of-covering-a-single-lower-front-tooth-with-receded-gums-100518947","NCT06037161","Comparison of Two Methods of Covering a Single Lower Front Tooth With Receded Gums","Comparison of Surgical Techniques to Treat Isolated Gingival Recession in Mandibular Incisors: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Males and females of \\> 18 years of age\n* Single Cairo's RT1 (Recession Type 1) and RT2 ( Recession Type 2) recession defects (≥3 mm in depth) in mandibular anterior teeth (Incisors).\n* Presence of identifiable cemento-enamel junction (CEJ)\n* Presence of a step ≤1 mm at the CEJ level and\u002For the presence of a root abrasion, but with an identifiable CEJ, will be accepted\n* Periodontally and systemically healthy patients\n* No contraindications for periodontal surgery and not taking medications known to interfere with periodontal tissue health or healing; and no prior periodontal surgery on the involved sites\n\nExclusion Criteria:\n\n* Vaping, chewing tobacco or smoking \\> 10 cigarettes per day\n* Uncontrolled Diabetes Mellitus (HbA1c \\> 7)\n* Pregnancy and Lactation\n* Diseases affecting connective tissue metabolism\n* Long-term steroid use\n* Recession defects associated with caries\n* Teeth associated with pulpal pathology",{"count":179,"type":21},36,[24],"The primary objective of this randomized clinical trial is to compare the mean root coverage achieved with Coronally Advanced Flap (CAF) + Connective Tissue Graft (CTG) (control) to Gingival Pedicle Split Thickness flap (GPST) + CTG (test) for the treatment of isolated gingival recession defects in mandibular incisors. The secondary objectives are to compare the percentage of complete root coverage and keratinized tissue gain between the two techniques.",[183],"Recession, Gingival",[185,186,187,188,189],"Connective tissue graft(s)","cosmetic periodontal plastic surgery","gingival recession","mucogingival surgery","treatment planning",{"date":165,"type":55},{"date":192,"type":55},"2023-05-19",{"date":194,"type":21},"2027-07-30",{"name":61,"class":62},{"id":197,"slug":198,"hasResults":12,"nctId":199,"briefTitle":200,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":16,"sex":70,"minAge":71,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":204,"briefSummary":205,"conditions":206,"keywords":208,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":217,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":89},"100519049","immediate-versus-delayed-loading-of-maxillary-overdenture-implants-100519049","NCT06038487","Immediate Versus Delayed Loading of Maxillary Overdenture Implants","Inclusion Criteria:\n\n1. Males and females must be at least ≥ 21 years of age\n2. Fully edentulous maxilla\n3. The implant site has to be healed for at least 4 months after extraction\n4. Wearing complete dentures deemed adequate\n5. Orthopantomogram available (OPT)\n6. Adequate amount of bone at least at the 2nd premolar position to house at minimum a 3.5 x 10 mm BLX-Roxolid implant\n7. No bone grafting required\n8. Implant IT ≥ 20 N\u002Fcm\n\nExclusion Criteria:\n\n1. Conditions requiring chronic routine prophylactic use of antibiotics\n2. Conditions requiring prolonged use of steroids\n3. History of leukocyte dysfunction and deficiencies\n4. Bleeding disorders\n5. History of neoplastic disease requiring use of radiation or chemotherapy\n6. Metabolic bone disorders\n7. Uncontrolled endocrine disorder\n8. Use of any investigational drug or device within the 30-day period prior to implant surgery\n9. Vaping, Tobacco Chewing or Smoking more than 10 cigarettes a day\n10. Alcoholism or drug abuse\n11. Patient infected with HIV\n12. Condition or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as as history of non-compliance, unreliability.\n13. Local inflammation including untreated periodontitis\n14. Mucosal disease such as erosive lichen planus\n15. History of local irradiation therapy\n16. Osseous lesion\n17. Severe bruxism and clenching habits\n18. Active infection with suppuration or fistula track\n19. Persistent intraoral infection\n20. Lack of primary stability \\\u003C20Ncm. In this instance, the patient must be withdrawn and treated according to the standard protocol.\n21. Inadequate oral hygiene or unmotivated home care.\n22. Bone grafting needed\n23. Inadequate bone volume for implants insertion as measured on the pre-treatment cone beam computed tomography (CBCT).",{"count":203,"type":21},18,[24],"The purpose of the study is to evaluate the radiographic, clinical and patient-centered outcomes of implant-retained immediately-loaded maxillary complete dentures in comparison to delayed loading approach by primarily evaluating radiographic bone loss of dental implants placed in the maxilla over 36 months",[207],"Implant Complication",[209,210,211,212,213,214,215,216],"Implant Overdenture","Immediate loading","Delayed loading","Maxillary Overdenture","Novaloc Retention System","Guided Implants","Immediate vs Delayed loading","Implant-supported overdenture",{"date":165,"type":55},{"date":219,"type":55},"2023-02-01",{"date":221,"type":21},"2028-02-01",{"name":61,"class":62},{"id":224,"slug":225,"hasResults":12,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":16,"sex":70,"minAge":18,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":233,"conditions":234,"keywords":236,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":244,"leadSponsor":246,"locationsCount":89},"100641176","self-monitoring-oct-100641176","NCT07584798","Self-Monitoring OCT","Self-Monitoring Optical Coherence Tomography Device for Retinal Telehealth","Inclusion Criteria:\n\n* 1\\. Provision of signed and dated informed consent.\n* 2\\. Age ≥ 18 years.\n* 3\\. Presenting for care at a University Hospitals Eye Institute clinic\n* 4\\. Willing to complete study questionnaires.\n* 5\\. Scheduled to undergo standard technician-acquired OCT\n\nExclusion Criteria:\n\n* 1\\. Unable to provide informed consent or, in the judgment of study staff, unable to understand study procedures.\n* 2\\. Unable to cooperate with imaging or maintain stable positioning such that an evaluable OCT scan cannot be obtained (e.g., severe tremor or inability to maintain head position).\n* 3\\. Facial skin condition or open wound at the points of device contact that would make use of the headrest unsafe.\n* 4\\. Acute medical or ocular condition requiring immediate evaluation that, in the PI's judgment, precludes participation at that time.\n* 5\\. Any other condition that, in the opinion of the PI\u002Fdesignee, would place the participant at undue risk or compromise data quality (documented).\n* 6\\. Patients with visual acuity \\\u003C20\u002F200.\n* 7\\. Patients with significant media opacities precluding an OCT scan (posterior subcapsular cataract, vitreous hemorrhage, etc), or severe ptosis.",{"count":231,"type":21},100,[24],"The purpose of this research study is to test participants ability to obtain OCT images of the eyes using an OCT device that is comparable to FDA-approved OCT devices on the market, without the help of an eye technician. Patients with ocular diseases often need to come to frequent appointments with an eye care provider for close monitoring and evaluation. Transportation difficulties, other medical problems, and limited appointments slots can make regular follow-up challenging. In addition, the anxiety of permanent vision loss and subjective nature of monitoring symptoms highlight the need for an alternative solution in which patients can self-generate OCT images of the eye for the eye care provider to review.",[235],"Obtaining OCT (Optical Coherence Tomography) Images",[237,238,239],"Ocular diseases","Eye care provider","Self monitoring","2026-05-07",{"date":242,"type":55},"2026-05-13",{"date":54,"type":21},{"date":245,"type":21},"2027-12-15",{"name":61,"class":62},{"id":248,"slug":249,"hasResults":12,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":253,"eligibilityCriteria":254,"healthyVolunteers":12,"sex":70,"minAge":255,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":22,"phases":259,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":89},"100609411","youth-empowerment-and-safety-intervention-100609411","NCT07214233","Youth Empowerment and Safety Intervention","Youth Empowerment and Safety Intervention for Systems-involved Sexual and Gender Minority Youth at Risk of Suicide","YES","Child Inclusion Criteria:\n\n* 12-17 years of age\n* Self-identify as a sexual or gender minority (SGM)\n* Involved in one or more system: juvenile justice, child welfare, and\u002For community-based mental health\n* Personal experience with self-injurious thoughts and behaviors (SITB)\n* English speaking\n* Willing and able to provide informed assent\n\nChild Exclusion Criteria:\n\n* Less than 12 or greater than 17 years of age (0-11 or 18 and over)\n* Do not self-identify as a sexual or gender minority (SGM)\n* Not involved in the juvenile justice, child welfare, and\u002For community-based mental health systems\n* No personal experience with self-injurious thoughts and behaviors (SITB)\n* Not English speaking\n* Unwilling and\u002For unable to provide informed assent\n\nCaregiver Inclusion Criteria:\n\n* 18-80 years of age\n* Primary Caregiver of youth who meet child inclusion criteria listed above\n* English speaking\n* Willing and able to provide informed consent\n\nCaregiver Exclusion Criteria:\n\n* Less than 18 or greater than 80 years of age (0-17 or 81 and over)\n* Not the Primary Caregiver of youth who meet child inclusion criteria listed above\n* Not English speaking\n* Unwilling and\u002For unable to provide informed consent","12 Years","17 Years",{"count":258,"type":21},60,[24],"This clinical trial will implement and evaluate the feasibility, acceptability, and initial impact of Peer Support Specialist (PSS) services for public system-involved sexual and gender minority (lesbian, gay, bisexual, queer and\u002For transgender) youth (SGMY) at risk of suicide.",[262,263],"Suicide","Self-Injurious Behavior",[265,266,267,268,269,270,271,272],"Self-injurious thoughts and behaviors (SITB)","Peer Support Specialist (PSS)","Behavioral health","adolescent","LGBTQ","Juvenile Justice","Foster Care","Crisis Response","2026-05-06",{"date":275,"type":55},"2026-05-08",{"date":277,"type":55},"2026-02-23",{"date":279,"type":21},"2027-11-30",{"name":61,"class":62},{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":12,"sex":70,"minAge":18,"maxAge":288,"enrollmentInfo":289,"targetDuration":4,"studyType":22,"phases":291,"briefSummary":292,"conditions":293,"keywords":297,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":89},"100593476","reach-study-recovery-environments-assessing-cognitive--brain-health-in-community-mental-health-100593476","NCT07006935","REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)","Pilot Study of the Cognitive and Neurobiological Effects of the Clubhouse Model of Psychosocial Rehabilitation for Schizophrenia and Related Conditions","Inclusion Criteria:\n\n* (1) have a DSM-V diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform confirmed by diagnostic assessment and medical record review\n* (2) between the ages of 18-50\n* (3) stabilized on psychotropic medication as indicated by no changes to the primary psychiatric medication in the last month\n* (4) able to read and speak fluent English at a sixth grade level or higher for purposes of informed consent and cognitive testing\n* For Clubhouse members, they must be a first-time, newly enrolled member\n\nExclusion Criteria:\n\n* (1) had previous membership at a Clubhouse (Magnolia or elsewhere)\n* (2) have a current severe substance use disorder\n* (3) have persistent suicidal or homicidal behavior\n* (4) a co-occurring diagnosis of an intellectual or learning disability or neurodevelopment condition (e.g., Autism; based on chart review)\n* (5) had recent psychiatric instability requiring hospitalization in the past month;\n* (6) history of a traumatic brain injury (TBI; based on record review)\n* (7) contraindicators for MRI (e.g., pacemaker, claustrophobia)\n* Participants in the usual care will be excluded if they are a current Clubhouse member or join a Clubhouse during participation in this research","50 Years",{"count":290,"type":21},30,[24],"The purpose of this study is to understand how different types of community-based mental health care affect thinking abilities, daily functioning, and brain activity in adults with schizophrenia and related conditions. The investigators are especially interested in learning whether the Clubhouse Model-a structured, supportive community for individuals with mental illness-has unique benefits compared to standard outpatient mental health services. If participants decide to join, they will be asked to complete a total of six study visits with the research team over the course of your participation. Three of these study visits are at the beginning (baseline) and the remaining three are six months later. Two of the three visits will includes interviews, questionnaires, and thinking and memory tasks (cognitive testing) and one session will be an MRI brain scan, which is a safe and non-invasive imaging procedure. The total time required for each visit will be approximately 90 minutes to two hours. Participants may take breaks as needed.",[294,295,296],"Schizophrenia","Schizo Affective Disorder","Schizophreniform Disorders",[298,299,300,301],"Clubhouse Model of Psychosocial Rehabilitation","Community mental health interventions","Cognition","Brain functioning","2026-04-24",{"date":304,"type":55},"2026-04-27",{"date":306,"type":21},"2026-06-01",{"date":308,"type":21},"2028-01-30",{"name":61,"class":62},{"id":311,"slug":312,"hasResults":12,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":316,"eligibilityCriteria":317,"healthyVolunteers":12,"sex":70,"minAge":18,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":22,"phases":321,"briefSummary":322,"conditions":323,"keywords":326,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":89},"100585311","positive-processes-and-transition-to-health---single-session-path-ss-100585311","NCT06900712","Positive Processes and Transition to Health - Single-Session (PATH-SS)","A Novel, Single-Session Intervention for Sexual Assault-Related Psychopathology","PATH-SS","Inclusion Criteria:\n\n1. Age range: from 18 to 65.\n2. Has experienced unwanted sexual contact or sexual assault with a minimum of 12 weeks since the event and a maximum of 5 years since the event.\n3. Residence in the state of Ohio.\n4. Elevated symptoms on either the Posttraumatic Diagnostic Scale (PDS-5) or the Quick Inventory of Depressive Symptomatology (QIDS-SR), at least moderate: 18 on PDS-5 (Foa et al., 2016) and\u002For 11 on QIDS (moderate depression severity; Rush et al., 2003), with symptoms persisting for 1 month or longer.\n\nExclusion Criteria:\n\n1. Current diagnosis of schizophrenia, delusional disorder, or organic mental disorder as defined by DSM-5.\n2. Current diagnosis of bipolar disorder, depression with psychotic features, or depression severe enough to require immediate psychiatric treatment (i.e., serious suicide risk with intent and plan).\n3. Severe self-injurious behavior or suicide attempt within the previous three months.\n4. Currently engaged in cognitive behavioral psychotherapy.\n5. No clear memory of the event.\n6. Unstable dose of psychotropic medications in prior 3 months.\n7. Ongoing intimate relationship with the perpetrator.\n8. Current diagnosis of a substance use disorder (DSM-5).\n9. Residence outside the state of Ohio.","65 Years",{"count":320,"type":21},45,[24],"The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a sexual assault. This research will explore whether this new psychotherapy reduces sexual assault related distress, including posttraumatic stress and depression symptoms. The main questions it aims to answer are:\n\nDoes PATH-SS leads to improvements in PTSD and depression symptoms (pre- to post- and 1-month follow-up)? Do participants perceive PATH-SS to be acceptable, helpful, and do they complete\u002Fadhere to treatment? Participants will complete a pre-treatment\u002Fbaseline assessment to confirm eligibility, and those who are eligible will receive the single-session intervention and will complete a post-treatment and a 1-month follow-up assessment of stressor-related symptoms.",[324,325],"PTSD","Depression",[327,328,329,330,331],"ptsd","trauma","depression","stressor","posttraumatic stress","2026-04-20",{"date":334,"type":55},"2026-04-22",{"date":336,"type":55},"2025-07-17",{"date":338,"type":21},"2027-05-31",{"name":61,"class":62},{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":22,"phases":350,"briefSummary":351,"conditions":352,"keywords":356,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":144},"100590293","nourishing-tomorrow-role-of-medically-tailored-groceries-in-addressing-food-insecurity-during-pregnancy-100590293","NCT06965530","Nourishing Tomorrow: Role of Medically Tailored Groceries in Addressing Food Insecurity During Pregnancy","The Role of Medically Tailored Groceries in Mitigating Food Insecurity and Improving Pregnancy Outcomes Through Clinic-Community Partnerships","Inclusion Criteria:\n\n* 18 years of age and older\n* Pregnant patients \\>10 weeks and \\\u003C22 weeks gestation at randomization (must be consented by 18 weeks)\n* Eligible for Medicaid\n* Singleton pregnancy, confirmed by ultrasound\n* An established patient of the UH or Metro pregnancy clinic\n* English speaking\n* Lives in Cuyahoga County, Ohio\n\nExclusion Criteria:\n\n* Under 18 years old","55 Years",{"count":349,"type":21},360,[24],"Medically tailored groceries (MTG), involving grocery items to be prepared at home, selected by a nutritional professional based on a treatment plan, is a growing approach adopted by healthcare systems to address food insecurity in their patient populations, a leading contribution to health disparities such as poor birth outcomes within pregnant populations. However, transportation and other social needs can often hinder patient uptake of clinic-based approaches. Findings from this study will help to better understand how home delivery of MTGs, with and without supplemental education and support to improve food literacy, behavioral and health outcomes.",[353,354,355],"Pregnancy Related","Prematurity","Birth Outcome, Adverse",[357,358],"Randomized trial","Behavioral intervention","2026-04-16",{"date":332,"type":55},{"date":362,"type":55},"2025-11-12",{"date":364,"type":21},"2029-05-31",{"name":61,"class":62},{"id":367,"slug":368,"hasResults":12,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":12,"sex":70,"minAge":288,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":22,"phases":375,"briefSummary":376,"conditions":377,"keywords":382,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":390,"locationsCount":89},"100461830","optimizing-technology-to-improve-medication-adherence-and-bp-control-optima-bp-100461830","NCT05293756","OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)","OPtimizing Technology to Improve Medication Adherence and Blood Pressure Control","Inclusion Criteria:\n\n1. Self-identify as African American\n2. 50 years of age or older\n3. Diagnosed with hypertension, with a systolic blood pressure≥ 130 mmHg but less than 170 mmHg\n4. Prescribed at least two hypertensive, one of which is a diuretic\u002Fthiazide and or calcium channel blocker antihypertensive medication\n5. Own a smartphone with a data plan, the capability to download the Medisafe app, or view videos\n6. Able to read\u002Funderstand English\n\nExclusion Criteria:\n\n1. Unable to give informed consent or judged to have impaired cognitive ability or severe memory\n2. Currently using a medication management application (app)\n3. Experienced a major CVD event or procedure (e.g., myocardial infarction, stroke, heart surgery) within the past year\n4. Patients with a diagnosis of chronic kidney disease (defined as estimated glomerular filtration rate (eGFR) \\\u003C 60 ml\u002Fmin\u002F1.73m2) and\u002For receiving dialysis.",{"count":374,"type":21},208,[24],"Hypertension (HTN) has a greater impact on African Americans (AA) than any other U.S. racial group. Uncontrolled blood pressure (BP) contributes to higher rates of disability, death, and health resource use among AA. HTN is the single most influential risk factor for cardiovascular disease (CVD), as well as a risk factor for the incidence of stroke, diabetes, chronic kidney disease, and dementia. Importantly, older adults account for 15% of the U.S. population, and two-thirds of older adults over age 60 have HTN, with higher rates observed in AA older adults. Strategies to support self-managing HTN and BP control are crucial as the older population is projected to age considerably and become more racially and ethnically diverse. Research has documented the negative effects on health and health outcomes of poorly controlled BP and is one of the most important modifiable CVD risk factors. Lower BP targets will require aggressive management and an increase in antihypertensive medications. Therefore, to achieve lower targets in this population, greater efforts, including patient-centered methods will be needed to support self-managing HTN, especially in terms of medication adherence.\n\nAs we shifted into the digital age, the use of mHealth technologies (smart phones, applications, SMS or text messaging) has been a powerful approach and mechanism for the treatment and management of chronic diseases. However, behavioral interventions that incorporate technology do not reach minorities or disadvantaged AA older adults with HTN. OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP) will leverage existing knowledge of effective technology-based components for HTN self-management to support and improve BP control using unique aspects of mHealth platforms in AA older adults. Findings from this study, if confirmed, will improve BP control and support self-managing HTN, as well as has the potential to close the health disparity gap between AA and non-AA older adults with HTN.",[378,379,380,381],"Hypertension","Self-Management","Technology","Quality of Life",[378,379,383],"Home Blood Pressure Monitoring","2026-03-30",{"date":386,"type":55},"2026-04-03",{"date":388,"type":55},"2021-02-14",{"date":338,"type":21},{"name":61,"class":62},{"id":392,"slug":393,"hasResults":12,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":4,"eligibilityCriteria":397,"healthyVolunteers":12,"sex":70,"minAge":18,"maxAge":398,"enrollmentInfo":399,"targetDuration":4,"studyType":22,"phases":401,"briefSummary":402,"conditions":403,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":63},"100391602","optimization-of-nibs-for-treatment-of-addiction-100391602","NCT04379115","Optimization of NIBS for Treatment of Addiction","Optimization of Non-Invasive Brain Stimulation for Treatment of Addiction","Inclusion Criteria\n\nParticipants must meet all of the following:\n\n* Provide informed consent\n* Age 18-85 years\n* Diagnosis of opioid use disorder (DSM-5) with ongoing non-prescription opioid use confirmed by self-report and urine toxicology\n* Report current opioid craving\n* Enrolled in a certified Opioid Treatment Program and receiving methadone maintenance treatment\n* Stable methadone dose prior to enrollment\n* Reside locally with no plans to relocate during the study Exclusion Criteria\n\nParticipants will be excluded if they:\n\n* Are pregnant\n* Have frequent illicit stimulant use or acute stimulant intoxication\n* Are using substances or medications that may interfere with study assessments (e.g., stimulant medications, buprenorphine-based therapies, naltrexone)\n* Have significant neurological conditions (e.g., stroke, epilepsy, brain tumor), abnormal EEG findings, history of brain surgery, significant head injury, or unexplained syncope\n* Have contraindications to noninvasive brain stimulation (e.g., metal in the head, implanted brain devices)\n* Have moderate to severe depression or active suicidal ideation\u002Fbehavior\n* Have active malignancy\n* Consume substances that could confound opioid toxicology results (e.g., poppy-seed products)","85 Years",{"count":400,"type":21},126,[24],"The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug use and improved psychosocial assessments with active stimulation, when compared to sham stimulation.",[404,405],"Opioid-use Disorder","Chronic Pain","2026-03-03",{"date":408,"type":55},"2026-03-04",{"date":410,"type":55},"2021-04-04",{"date":412,"type":21},"2027-10-31",{"name":61,"class":62},{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":420,"eligibilityCriteria":421,"healthyVolunteers":16,"sex":70,"minAge":18,"maxAge":4,"enrollmentInfo":422,"targetDuration":4,"studyType":22,"phases":424,"briefSummary":425,"conditions":426,"keywords":430,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":89},"100603401","preventing-athlete-under-fueling-through-nutrition-100603401","NCT07136038","Preventing Athlete Under-fueling Through Nutrition.","Prevention and Education for RED-S Through Fueling Outcomes and Research in Metabolic Health","PERFORM","Inclusion Criteria:\n\n1. Age range: from 18 years of age and up\n2. Currently active and NCAA-eligible (including academic standing) member of any Case Western Reserve University (CWRU) Athletic Team\n3. Signed Informed Consent\n\nExclusion Criteria:\n\n1. Under 18 years of age\n2. Pregnant women or women who are nursing\n3. Unwilling to provide anthropometrics, questionnaires or other collection needs\n4. History of a diagnosed disordered eating",{"count":423,"type":21},300,[24],"The goal is to improve nutrition screening and support for Division III athletes.\n\nThe study will use standard, low-risk nutrition screening methods, such as measuring height, weight, grip strength, and body composition, as well as having athletes complete questionnaires. Dietitians trained in sports nutrition will provide nutrition advice based on these screenings.\n\nData will be collected at three points during the season: before the season starts, mid-season, and after the season ends. This study builds on earlier research conducted at Case Western Reserve University that showed nutrition support can improve athletes' health and performance.",[427,428,429],"Athlete","Relative Energy Deficiency in Sport","Low Energy Availability",[431,432,433,434],"collegiate","sport","lean body mass","fat mass","2026-03-02",{"date":408,"type":55},{"date":438,"type":55},"2025-08-19",{"date":440,"type":21},"2026-12-31",{"name":61,"class":62},{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":4,"eligibilityCriteria":448,"healthyVolunteers":12,"sex":70,"minAge":18,"maxAge":4,"enrollmentInfo":449,"targetDuration":4,"studyType":22,"phases":451,"briefSummary":453,"conditions":454,"keywords":456,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":89},"100615857","early-phase-1-effect-of-arestin-enhanced-srp-on-periodontal-and-glycemic-outcomes-in-diabetics-100615857","NCT07298057","Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics","Effectiveness of Scaling and Root Planing With and Without Minocycline Microspheres (Arestin) in Improving Periodontal and Glycemic Outcomes in Diabetic Patients With Periodontitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Adults (≥18 years) with type 2 diabetes mellitus (HbA1c ≥ 7.0% and ≤9.5%)\n2. Diagnosed with moderate to severe periodontitis (≥5 mm probing pocket depth in at least 6 distinct interproximal sites, on different teeth)\n3. At least 16 teeth present\n4. No periodontal treatment in the last 6 months\n\nExclusion Criteria:\n\n1. Allergy to minocycline or tetracycline\n2. Unable to receive or to tolerate local anesthesia\n3. Unable to tolerate tooth instrumentation with ultrasonic instruments.\n4. Require IV sedation to receive scaling and root planing\n5. Use of antibiotics within the past 3 months\n6. Pregnancy or breastfeeding\n7. Morbid Obesity (BMI 40+)\n8. Smokers or patients with poorly controlled systemic diseases other than diabetes",{"count":450,"type":21},42,[452],"EARLY_PHASE1","Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.",[455],"Periodontitis, Diabetes Mellitus Type 2",[457,458,459],"Scaling and Root Planing","Arestin","Diabetes Mellitus Type 2","2026-02-18",{"date":462,"type":55},"2026-02-19",{"date":464,"type":55},"2026-02-06",{"date":466,"type":21},"2028-06",{"name":61,"class":62},{"id":469,"slug":470,"hasResults":12,"nctId":471,"briefTitle":472,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":12,"sex":70,"minAge":475,"maxAge":318,"enrollmentInfo":476,"targetDuration":4,"studyType":22,"phases":477,"briefSummary":478,"conditions":479,"keywords":482,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":489,"completionDateStruct":491,"leadSponsor":493,"locationsCount":89},"100610284","development-of-optimal-sensory-feedback-strategies-to-maximize-function-after-tetraplegia-100610284","NCT07225582","Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia","Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia: A Sub-study of the Reconnecting the Hand and Arm to the Brain (ReHAB) Clinical Trial","Inclusion Criteria:\n\n1. Enrolled in the ReHAB clinical trial and received ReHAB system components via implantation surgery.\n2. Willingness and availability to follow the study protocol.\n\nExclusion Criteria:\n\n1. Lack of function or operability of all implanted ReHAB system components\n2. Severe pain or other chronic medical condition that would prevent the participant from completing study-related activities","22 Years",{"count":63,"type":21},[24],"The goal of this clinical trial is to learn more about how stimulating the nerves involved in sensation (either in the limbs or in the brain) can be used to restore sensation in participants who have a spinal cord injury. Participants in this study will have already been enrolled in the \"Reconnecting the Hand and Arm to the Brain (ReHAB)\" study, and received small electrodes in a part of the brain that is involved in sensing touch and pressure in the hand. The ReHAB study participants will also have received electrodes around the nerves in their arm. In this clinical trial, participants will receive two types of electrical stimulation:\n\n* Intracortical microstimulation (ICMS) which involves sending small electrical pulses to the part of the brain that processes sensation.\n* Peripheral nerve stimulation (PNS) which involves sending small electrical pulses to the nerves in the arm that transmit sensations from the hand.\n\nResearchers will try different patterns of stimulation for both ICMS and PNS and study how the participants perceive the sensations from the different stimulation patterns. The researchers will also study how combining ICMS and PNS affects the perceived sensations.",[480,481],"Spinal Cord Injury Cervical","Spinal Cord Injuries (Complete and Incomplete)",[483,484,485,486],"spinal cord injury","tetraplegia","intracortical microstimulation","peripheral nerve stimulation","2026-02-17",{"date":462,"type":55},{"date":490,"type":55},"2026-01-13",{"date":492,"type":21},"2030-09-01",{"name":61,"class":62},{"id":495,"slug":496,"hasResults":12,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":4,"eligibilityCriteria":500,"healthyVolunteers":12,"sex":70,"minAge":501,"maxAge":502,"enrollmentInfo":503,"targetDuration":4,"studyType":22,"phases":505,"briefSummary":506,"conditions":507,"keywords":511,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":516,"completionDateStruct":518,"leadSponsor":520,"locationsCount":89},"100462214","the-effect-of-womb-recordings-on-maturation-of-respiratory-control-in-preterm-infants-100462214","NCT05298748","The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants","Womb Recordings and Respiratory Control Maturation in Neonates","Inclusion Criteria:\n\n* preterm infants 29-33 weeks gestational age at birth\n* 34 weeks corrected age\n* off respiratory support \\>1.5 lpm\n\nExclusion Criteria:\n\n* on respiratory support \\>1.5 lpm\n* congenital anomalies","1 Week","5 Weeks",{"count":504,"type":21},34,[24],"The aim of this proposal is to characterize the acute effect of early postnatal sound exposure on neuronal maturation of the respiratory control regions of the brain in preterm infants.",[508,509,510],"Apnea of Prematurity","Intermittent Hypoxemia","Bradycardia",[512],"apnea, intermittent hypoxemia, bradycardia, audio recording","2025-12-04",{"date":515,"type":55},"2025-12-05",{"date":517,"type":55},"2022-09-16",{"date":519,"type":21},"2026-11",{"name":61,"class":62},{"id":522,"slug":523,"hasResults":12,"nctId":524,"briefTitle":525,"officialTitle":526,"acronym":4,"eligibilityCriteria":527,"healthyVolunteers":16,"sex":70,"minAge":528,"maxAge":4,"enrollmentInfo":529,"targetDuration":4,"studyType":22,"phases":531,"briefSummary":532,"conditions":533,"keywords":535,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":538,"startDateStruct":540,"completionDateStruct":542,"leadSponsor":544,"locationsCount":89},"100609367","lt-comparative-effectiveness-of-2-caries-treatments-100609367","NCT07213661","LT Comparative Effectiveness of 2 Caries Treatments","Long-term Comparative Effectiveness of 2 Treatments to Arrest Dental Caries in Older Adults","Inclusion Criteria: To be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Were participants in the original study from the 33 housing sites\n* Provide signed and dated long-term follow-up informed consent form\n* Willingness to stay in the LTFU study for 1 year\n* Additionally for focus groups, completed the treatment phase of the study\n\nExclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Sensitivity to silver or other heavy-metal ions\n* Serious life-threatening medical disease\n* Additionally, any participant with the presence of gingival\u002Fperioral ulceration or stomatitis or tooth abscess in any specific tooth will be referred to a dentist but can only be enrolled after resolution","62 Years",{"count":530,"type":21},480,[24],"This study is a continuation of a cluster randomized clinical trial (cRCT) conducted in 33 publicly subsidized housing facilities\u002Fsites (HUD Section 202) and other low-income housing voucher programs in NE Ohio. The Intervention Arm (18 sites) - participants received biannual silver diamine fluoride (SDF) versus the Control Arm (15 sites) where participants received atraumatic restorative treatment (ART) with glass ionomer cement (GIC) + biannual fluoride varnish (FV) application. A total of 568 participants were recruited in the original study, and 480 participants (Intervention Arm: 287, Control Arm: 193) are expected to continue in this long-term follow-up study. Since enrollment in the original study was done over time, each participant will contribute data at 3 to 6 years (from randomization) in the LTFU depending on study entry to assess clinical equipoise of the two treatments.\n\nCommunity-dwelling older adults, regardless of medical, cognitive, or motor impairments, were considered for inclusion in the original study and were: (1) aged ≥ 62 years in the 33 housing facilities; (2) have at least one untreated active root or coronal carious lesion with ICDAS-II lesion severity code of 3 or greater ; (3) willingness to stay in the study for 1 year. Exclusion criteria: (1) sensitivity to silver or other heavy-metal ions; (2) serious life-threatening medical disease. Additionally, any participant with the presence of gingival\u002Fperioral ulceration or stomatitis or tooth abscess in any specific tooth were referred to a dentist and enrolled after resolution. The LTFU study will follow the same enrolled participants long-term. The current mean (sd) age of the 480 participants who will enter the LTFU study will be 73.73 (6.92) years.",[534],"Dental Caries",[534,536,537],"Oral Health Quality of Life","Tooth Loss",{"date":539,"type":55},"2025-11-13",{"date":541,"type":55},"2025-10-08",{"date":543,"type":21},"2030-01",{"name":61,"class":62},{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":4,"eligibilityCriteria":551,"healthyVolunteers":12,"sex":70,"minAge":552,"maxAge":553,"enrollmentInfo":554,"targetDuration":4,"studyType":22,"phases":556,"briefSummary":557,"conditions":558,"keywords":564,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":567,"startDateStruct":569,"completionDateStruct":571,"leadSponsor":573,"locationsCount":89},"100341763","restoring-flow-by-revascularization-with-submaximal-angioplasty-in-hemodynamic-intracranial-atherosclerotic-stenosis-100341763","NCT03729817","REstoring Flow by REvascularization With Submaximal Angioplasty in Hemodynamic IntraCranial Atherosclerotic Stenosis","VERiTAS-2 REFRESH ICAS (REstoring Flow by REvascularization With Submaximal Angioplasty in Hemodynamic IntraCranial Atherosclerotic Stenosis)","Inclusion:\n\n* Non-severe recent stroke (within 30 days) attributed to 70-99% stenosis of intracranial artery (internal carotid, middle cerebral, vertebral, basilar); must be confirmed by CTA (or DSA if already available) for enrollment into the trial.\n* Hemodynamic compromise based on borderzone infarct pattern\\* for the anterior circulation (internal carotid and middle cerebral artery stenosis) and by low flow state on QMRA\\*\\* for the posterior circulation (vertebral and basilar artery stenosis).\n* Target vessel with minimal nominal diameter of 2mm\n* Target length of stenosis \\\u003C18mm\n* Symptoms within 30 days of enrollment\n* Age ≥30 and ≤90 years old#\n* Able to provide informed consent\n\n  * \\*Sole or predominant borderzone infarct pattern of qualifying event, as defined by SAMMPRIS cohort analysis \\*\\*Low flow state as determined by optimized flow algorithm as defined by the VERiTAS Study\n  * #Those 30-49 years of age must also have the presence of established atherosclerotic disease in another vascular bed (coronary, extracranial carotid, peripheral) or the presence of 2 or more risk factors (hypertension, diabetes mellitus, hyperlipidemia, tobacco abuse within the last 2 years).\n\nExclusion:\n\n* Major disabling stroke mRS \\>3; progressive or fluctuating deficit within 24 hours\n* Hemorrhagic infarction (based on CT) within 14 days of enrollment\n* Any large stroke (\\>5cm) to be at risk for hemorrhagic conversion\n* Any neurological disease which would confound follow-up assessment\n* Any co-morbid disease condition with \\\u003C12 month life expectancy\n* Known cardiac disease associated with elevated cardioembolic risk, specifically, atrial fibrillation, prosthetic valve, endocarditis, left atrial\u002Fventricular thrombus, cardiomyopathy with EF\\\u003C25%, cardiac myxoma\n* Blood dyscrasias, specifically polycythemia vera, essential thrombocytosis, sickle cell disease\n* Active bleeding diathesis, h\u002Fo major systemic hemorrhage within 30 days, active PUD, platelets\\\u003C100K (severe liver impairment (AST or ALT\\>3 x normal, cirrhosis)\n* Non-atherosclerotic stenosis including dissection, fibromuscular dysplasia, vasculitis, radiation induced vasculopathy, suspected recanalized embolus, suspected vasospastic process\n* Mori C classification of stenosis (i.e. diffuse lesion, extremely angulated \\>90⁰, excessive proximal tortuosity) Previous treatment of target lesion with stent, angioplasty or other mechanical device\n* Extracranial vertebral artery or carotid artery tortuosity, stenosis or occlusion prohibiting access to the target lesion (not exclusionary if does not prohibit access to target lesion)\n* Unable or unwilling to undergo MRI\n* Unable to undergo cerebral angiography\n* Pregnancy\n* Concurrent participation in another study which would conflict with the current study\n* Allergy or contraindication to aspirin or Plavix\n* Indication for warfarin or NOAC beyond enrollment (e.g. venous thrombo-embolism, atrial fibrillation)\n* Thrombolytic therapy within 24 hours","30 Years","90 Years",{"count":555,"type":21},159,[24],"By assessing the safety and durability of an endovascular intervention, this study will justify and inform the design of a subsequent seamless feasibility\u002Fpivotal trial aimed at the treatment of intracranial atherosclerotic stenosis (ICAS), an entity which carries a high risk of stroke despite existing medical therapies, and has no other treatment options. Given the global burden of ICAS as a leading cause of stroke, there is a high potential for public health impact not just in the U.S., but world-wide.",[559,560,561,562,563],"Intracranial Atherosclerotic Disease","Stroke","Angioplasty, Balloon","Hemodynamics","Device Safety",[565,560,561,562,563],"Intracranial atherosclerotic disease","2025-11-03",{"date":568,"type":55},"2025-11-04",{"date":570,"type":21},"2027-10",{"date":572,"type":21},"2032-10-31",{"name":61,"class":62},{"id":575,"slug":576,"hasResults":12,"nctId":577,"briefTitle":578,"officialTitle":579,"acronym":4,"eligibilityCriteria":580,"healthyVolunteers":16,"sex":70,"minAge":347,"maxAge":4,"enrollmentInfo":581,"targetDuration":4,"studyType":22,"phases":583,"briefSummary":584,"conditions":585,"keywords":588,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":594,"lastUpdatePostDateStruct":595,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":601,"locationsCount":89},"100558738","oral-health-intervention-in-adult-primary-care-100558738","NCT06555029","Oral Health Intervention in Adult Primary Care","Multi-Level Interventions to Reduce Oral Health Disparities Among Adults in Primary Care Settings","Inclusion Criteria:\n\nPractices:\n\n* Use Epic EHR\n* Have older adults covered by Medicaid\n* Located within 60 miles of the CWRU research offices\n\nProvider (medical staff or clinician):\n\nMedical staff (MA, nurse):\n\n* Do not float between practices\n* Plan not to leave practice within a year\n* Provide a signed and dated consent form\n\nClinicians (Physician, NP):\n\n* Have a minimum of 2 patient-care days per week\n* Do not float between practices\n* Plan not to leave practice within a year\n* Provide signed and dated consent form\n\nOlder Adult\u002FPatient Participant:\n\n* Enrolled in CareSource Medicaid Plan\n* Female or male aged 55 years or older\n* Attending non-urgent primary care visits (PCV) at enrolled site\n* Provide signed and dated informed consent form\n* Planning to stay in the immediate area for the next year\n* Enrolled in the Adult Wellness Registry\n\nExclusion Criteria:\n\n* The presence of any serious medical health condition (such as dementia or other cognitive disorder not allowing them to participate) where the clinician indicates they should not participate.\n* The presence of any serious mental health disorders such as schizophrenia where the clinician indicates they should not participate.",{"count":582,"type":21},929,[24],"This study is a Stage III cRCT to test the efficacy of multi-level interventions at the practice- and provider-level to address low dental utilization (attendance) among Medicaid-enrolled older adults 55 years or older attending non-urgent primary care visits (PCV) in MetroHealth practice settings. Twelve practices will be randomized into two arms: A) Intervention arm will receive the multi-level intervention that includes: 1. Practice-level: EHR changes to include: ask, advise, assess, and connect (AAAC) strategies; 2. Provider-level: Medical staff (MA, nurse): Training in the AAAC process and complete AAAC for enrolled older adults; Clinicians (physician\u002Fnurse practitioner): CSM-based education (didactic), skills training (video training with standardized patients), and view completed AAAC in EHR to deliver core oral health (OH) facts to older adults, reinforce importance of dental visits, and document in EHR that OH facts were delivered. B) Control arm will receive, at the provider-level only (clinicians), non-theory-based information about retaining a healthy mouth using the ADA Mouth Healthy Series and deliver standard OH care for patients. Older Adults will be followed at 12 months and 24 months to determine if the participant had any dental attendance.\n\nThe primary objective is to test the efficacy of the practice level EHR strategy to ask \\[OH risk assessment\\], advise \\[going to dentist\\], assess \\[willingness for referral\\], and connect \\[eReferral, resources\\] together with clinician theory-based education to communicate OH facts versus clinician alone (standard oral health care) in increasing dental attendance in primary care settings.\n\nThe secondary objectives are to assess oral hygiene behavior, Geriatric Oral Health Quality of life, biometric measures (BP, serum cholesterol, blood glucose, hbA1c) abstracted from EHR data, potential mediators and moderators to investigate pathways that affect the primary and secondary outcomes, and assess implementation strategies: adoption, reach, fidelity, and maintenance of providers and practices that affect older adult primary and secondary outcomes.\n\nThe hypothesis is that medical staff completing the AAAC strategy and clinicians with improved OH knowledge (chronicity, systemic effects) will deliver consistent oral health messaging to older adults at PCVs that will result in increased preventive and restorative dental utilization compared to those providers delivering standard care.",[534,586,78,587],"Dry Mouth","Bleeding Gum",[589,590,591,592,593],"Oral Health","Primary Care","Older Adults","Common Sense Model of Self-Regulation","EHR Modifications (Oral Health Questions and Referral)","2025-10-13",{"date":596,"type":55},"2025-10-15",{"date":598,"type":55},"2024-09-25",{"date":600,"type":21},"2028-10-30",{"name":61,"class":62},{"id":603,"slug":604,"hasResults":12,"nctId":605,"briefTitle":606,"officialTitle":607,"acronym":4,"eligibilityCriteria":608,"healthyVolunteers":12,"sex":70,"minAge":18,"maxAge":318,"enrollmentInfo":609,"targetDuration":4,"studyType":22,"phases":611,"briefSummary":612,"conditions":613,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":616,"lastUpdatePostDateStruct":617,"startDateStruct":619,"completionDateStruct":621,"leadSponsor":622,"locationsCount":63},"100523301","positive-processes-and-transition-to-health-path-100523301","NCT06093906","Positive Processes and Transition to Health (PATH)","Treatment of Stress-Related Psychopathology: Targeting Maladaptive and Adaptive Event Processing","Inclusion Criteria:\n\n* Destabilizing life event involving profound loss or threat, with a minimum duration of 12 weeks since the event, but occurred within the last 5 years.\n* Between the ages of 18 and 65.\n* Elevated target: Scores of at least moderate (1 or higher) on at least 2 of the 3 target mechanisms: re- experiencing or ruminative processing of the destabilizing event (PSS-I items: 1, 2, 3, 4 or QIDS-C item 11), avoidance (PSS-I items 6, 7, 8), or reward deficits (PSS-I items 12, 13, or QIDS-C item 13).\n\nExclusion Criteria:\n\n* Current diagnosis of schizophrenia, delusional disorder, or organic mental disorder as defined by DSM-5.\n* Current diagnosis of bipolar disorder, depression with psychotic features, or depression severe enough to require immediate psychiatric treatment (i.e., serious suicide risk with intent and plan).\n* Severe self-injurious behavior or suicide attempt within the previous three months.\n* Unwilling or unable to discontinue current cognitive behavioral psychotherapy.\n* No clear memory of the destabilizing event or event occurred before age 3.\n* Unstable dose of psychotropic medications in prior 3 months.\n* Ongoing intimate relationship with the perpetrator (in assault related event).\n* Current diagnosis of a substance use disorder (DSM-5).",{"count":610,"type":21},135,[24],"The R33 will be a randomized controlled trial to replicate changes in the targets (unproductive processing, avoidance, reward deficits) from the R61 phase in a larger sample of 135 participants who have experienced a destabilizing life event involving profound loss or threat, report persistent stressor-related symptoms of PTSD and\u002For depression, and are elevated on symptoms related to 2 of the 3 therapeutic targets. Additionally, this study will examine Positive Processes and Transition to Health (PATH)'s impact on stressor-related psychopathology in comparison to Progressive Muscle Relaxation (PMR). In the R33 phase, the investigators will examine changes in target mechanisms predicting improvements in PTSD and depressive symptoms, as well as feasibility and acceptability. Patients will receive 6 sessions of PATH or PMR (with 2 boosters, if partial responders). Primary targets will be assessed at pre-treatment, week 3, post-treatment, and at 1- and 3-month follow-up; secondary targets at pre-treatment, weekly during treatment, post-treatment, and at 1- and 3-month follow-ups.",[614,615],"Posttraumatic Stress Disorder","Major Depressive Disorder","2025-07-29",{"date":618,"type":55},"2025-07-30",{"date":620,"type":55},"2023-09-12",{"date":52,"type":21},{"name":61,"class":62},{"id":624,"slug":625,"hasResults":12,"nctId":626,"briefTitle":627,"officialTitle":628,"acronym":629,"eligibilityCriteria":630,"healthyVolunteers":12,"sex":70,"minAge":631,"maxAge":256,"enrollmentInfo":632,"targetDuration":4,"studyType":22,"phases":634,"briefSummary":635,"conditions":636,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":639,"lastUpdatePostDateStruct":640,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":646,"locationsCount":89},"100595484","developing-resilience-and-anxiety-management-through-the-arts-100595484","NCT07033052","Developing Resilience and Anxiety Management Through the Arts","Developing Resilience and Anxiety Management Through the Arts (DRAMA) 2","DRAMA","Inclusion Criteria:\n\n* Between 8 and 17 years of age\n* Individuals must have parental\u002Fguardian consent\n* Elevated levels of anxiety or depression based on\n\n  1. Screen for Child Anxiety Related Disorders (SCARED) score of 15 or higher, or;\n  2. Revised Children's Anxiety and Depression Scale (RCADS) Depression T score of 65 or higher, or;\n  3. Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) clinician severity rating of 3 on any anxiety disorder or on a mood-related disorder\n\nExclusion Criteria:\n\n* Diagnosed with Conduct Disorder or with behavioral symptoms that would make it difficult for the child\u002Fadolescent to participate in the group or comply with directions given by the group leader (such as difficulty following instructions, difficulty staying in one's seat, defiance of adults, harming animals or people, threatening others, getting into physical fights, hyperactivity, impulsivity, difficulty waiting for one's turn, etc.)\n* Autism or developmental delays\n* Psychotic symptoms or active suicidality\n* Active Eating Disorders that raise concerns about morbidity and therefore need to be addressed in an intervention and actively monitored\n* Unsteady dosage or recently or impending changes to psychotropic medication(s)\n* Non-English-speaking individuals\n* Wards of the State","8 Years",{"count":633,"type":21},110,[24],"The Developing Resilience and Anxiety Management Through the Arts (DRAMA) Study examines the degree to which the arts can help to address stress, anxiety, and sad mood in children and adolescents. The researchers will pair theatrical improvisation exercises with cognitive-behavioral therapy (CBT) techniques versus improvisation exercises alone versus a social craft group on reducing elevated levels of anxiety and depression.",[637,325,638],"Anxiety","Mood","2025-07-16",{"date":641,"type":55},"2025-07-20",{"date":643,"type":55},"2025-04-15",{"date":645,"type":21},"2027-07-01",{"name":61,"class":62},{"id":648,"slug":649,"hasResults":12,"nctId":650,"briefTitle":651,"officialTitle":652,"acronym":653,"eligibilityCriteria":654,"healthyVolunteers":16,"sex":70,"minAge":18,"maxAge":4,"enrollmentInfo":655,"targetDuration":4,"studyType":74,"phases":4,"briefSummary":657,"conditions":658,"keywords":661,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":639,"lastUpdatePostDateStruct":662,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":668,"locationsCount":669},"100079306","genetic-determinants-of-barretts-esophagus-and-esophageal-adenocarcinoma-100079306","NCT00288119","Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma","Genetic and Environmental Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma","FBE","Eligible cases will be defined as those patients and their family members who meet the following criteria:\n\n* Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus.\n* Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent.\n* Ability to give informed consent, if patient is age 18 or older.",{"count":656,"type":21},2000,"The overall objectives of this BETRNet Research Center (RC) are:\n\n1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA)\n2. to increase the biological understanding of key observations made by our clinical researchers;\n3. to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the outcomes of EAC;\n4. to foster a transdisciplinary and translation research culture and to effectively expand and enhance scientific research focused on BE and EAC;\n5. to evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratorydiscoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.",[659,660],"Barrett's Esophagus","Esophageal Neoplasm",[659],{"date":663,"type":55},"2025-07-18",{"date":665,"type":55},"2005-10-01",{"date":667,"type":21},"2028-07-31",{"name":61,"class":62},10,{"id":671,"slug":672,"hasResults":12,"nctId":673,"briefTitle":674,"officialTitle":675,"acronym":676,"eligibilityCriteria":677,"healthyVolunteers":12,"sex":70,"minAge":71,"maxAge":678,"enrollmentInfo":679,"targetDuration":4,"studyType":22,"phases":680,"briefSummary":681,"conditions":682,"keywords":687,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":691,"lastUpdatePostDateStruct":692,"startDateStruct":694,"completionDateStruct":696,"leadSponsor":698,"locationsCount":144},"100104456","evaluation-of-an-advanced-lower-extremity-neuroprostheses-100104456","NCT00623389","Evaluation of an Advanced Lower Extremity Neuroprostheses","Evaluation of Advanced Lower Extremity Neuroprostheses","LE-IST","Phase I Inclusion Criteria\n\n1. Skeletal maturity and ability to sign informed consent (\\>18 years)\n2. Non-ventilator dependent paralysis resulting from injuries such as: mid cervical\u002Fthoracic (C4 or below) spinal cord injuries, poststroke hemiparesis, TBI, or MS, affecting the trunk and\u002For lower limbs\n3. Innervated and excitable lower extremity and trunk musculature\n4. Adequate social support and stability\n5. Willingness to comply with follow-up procedures\n\nPhase I Exclusion Criteria\n\n1. Non-English speaking\n2. Females who are pregnant\n3. Current pressure injuries that would be exacerbated by study activities\n4. Severe contractures or uncontrolled spasticity of any major joint of the upper or lower extremities that results in a fixed deformity that would interfere with study activities\n5. History of spontaneous fractures or other evidence of excessively low bone density\n6. History of vestibular dysfunction, balance problems, or spontaneous falls\n7. Acute and or\u002Funtreated orthopedic problems that would prevent a participant from weight bearing or exercising such as a dislocation or fracture.","75 Years",{"count":669,"type":21},[24],"The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and\u002For balance in people with various degrees of paralysis.",[683,560,684,685,686],"Spinal Cord Injuries","Paralysis","Tetraplegia","Paraplegia",[688,689,690,560,686,685],"Neurologic disorders","Rare disease","Spinal cord injuries","2025-06-12",{"date":693,"type":55},"2025-06-15",{"date":695,"type":55},"2018-06-01",{"date":697,"type":21},"2027-12-31",{"name":61,"class":62},""]