[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":152},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,87,117],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100623422","effectiveness-and-implementation-of-a-national-guideline-for-acute-respiratory-tract-infections-to-reduce-antibiotic-prescribing-in-swiss-primary-care-100623422",false,"NCT07396428","Effectiveness and Implementation of a National Guideline for Acute Respiratory Tract Infections to Reduce Antibiotic Prescribing in Swiss Primary Care","Effectiveness and Implementation of a National Guideline for Acute Respiratory Tract Infections to Reduce Antibiotic Prescribing in Swiss Primary Care: the ImpProGUIDE Hybrid Type II Effectiveness-implementation Trial","ImpProGUIDE","Inclusion criteria for quality circles (QCs)\n\n* Willing to participate in a study mainly conducted in French\n* Agreeing to participate in evaluation surveys\n\nExclusion criteria for QCs\\*\n\n\\- Not having any physician included in the study\n\nInclusion criteria for walk-in clinics\n\n* The clinic offers general practice\u002Fprimary care medicine consultations, including emergencies\n* The clinic includes at least five physicians\n* The clinic has an \"Admission to practice charged to Swiss compulsory health insurance\"\n* The clinic plans to still be active in April 2026\n* Located in one of the following cantons: Vaud, Geneva, Valais, Fribourg, Jura, Neuchatel, Bern, Ticino.\n* Serving mainly adult patients\n* Willing to participate in the study\n\nPhysicians in QCs fulfilling all of the following inclusion criteria are eligible for the study:\n\n* Registered primary care physicians\n* Specialist title in general internal medicine or practicing physician.\n* Practicing in one of the following cantons: Vaud, Geneva, Valais, Fribourg, Jura, Neuchatel, Bern, Ticino.\n* Participating in a QC or working in an outpatient clinic participating in the study\\*.\n* Willing to participate in a study mainly conducted in French.\n* Agreeing to participate in evaluation surveys and agreeing to be invited to interviews\n\nEligibility criteria for physicians in clinics :\n\n\\- Having a clinical activity as primary care physician or supervising clinical activity of physicians in post-graduate training within a clinic included in the study\n\nThe only exclusion criterion for physicians is planning to retire before April 2026.\n\n\\*Note: not all physicians from a QC or a clinic are expected or required to participate individually in the study, but at least one should participate.","ALL",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"NA","The ImpProGUIDE study aims to find out whether implementing new Swiss national guidelines for acute respiratory infections (ARI) can help to reduce antibiotic prescribing in primary care. In Switzerland, most antibiotics are prescribed in outpatient care, and many of these prescriptions may not be needed - especially when infections are caused by viruses, which antibiotics do not treat. Reducing overuse of antibiotics is important to slow the spread of antibiotic resistance.\n\nThe new guidelines were developed by the Swiss Society for Infectious Diseases (SSI) to support family doctors in managing ARIs, based on a syndromic approach. They recommend the targeted use of point-of-care C-reactive protein (CRP) testing when bacterial infection is suspected, as well as shared decision-making with patients.\n\nThis study will be carried out in quality circles (QCs) - small groups of family doctors who meet regularly to discuss and improve clinical practice - and in walk-in clinics in French- and Italian-speaking regions of Switzerland. Each will be randomly assigned to either an \"intervention\" group or a \"control\" group.\n\nIn the intervention group, QC moderators and medical center directors will receive implementation resources to lead a session and distribute materials to their group in autumn 2025 on the new guidelines. Doctors can then decide whether or not to use the recommendations in their consultations.\n\nIn the control group, QCs and centers will continue their regular activities. They will receive access to the same educational materials later, in summer 2026.\n\nThroughout the study, the researchers will collect de-identified data from health insurance billing records to track antibiotic prescribing and the use of diagnostic tests. Doctors and QC moderators will also be invited to complete short online surveys twice a year (10-15 minutes) and may be asked to join optional interviews or group discussions after the winter season.\n\nThe study will also explore the effectiveness of the implementation strategies on the adoption of the SSI guidelines, as well as the barriers and facilitators to adoption. This study type is known as a hybrid effectiveness implementation study, simultaneously evaluating an intervention's impact on antibiotic prescribing and the strategies used to implement the new national guidelines in a real-world setting.\n\nParticipation in the study is voluntary. Doctors can withdraw at any time. All data will be handled confidentially and in line with Swiss data protection laws.\n\nThe study is funded by the Swiss National Science Foundation. No support is received from pharmaceutical companies or manufacturers of diagnostic tests.",[26,27],"Acute Respiratory Infection","Influenza-like Illness",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"family medicine","primary care","implementation","hybrid design","effectiveness-implementation study","general medicine","outpatient","antibiotics","antibiotic prescribing","antimicrobial resistance","antimicrobial stewardship","guidelines","shared decision making","CRP","c-reactive protein","RECRUITING","2026-06-18",{"date":47,"type":48},"2026-06-24","ACTUAL",{"date":50,"type":48},"2025-05-19",{"date":52,"type":20},"2026-11",{"name":54,"class":55},"Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":56},"100483165","swiss-cohort-of-health-professionals-and-informal-caregivers-100483165","NCT05571488","Swiss Cohort of Health Professionals and Informal Caregivers","Swiss Cohort of Health Professionals and Informal Caregivers - SCOHPICA","SCOHPICA","Inclusion Criteria (HCPs):\n\n* Working as HCP, in any profession\n* Taking care of patients currently and actively\n* Working in any health work setting\n* Working as an independent or a salaried\n* Working in Switzerland\n\nExclusion Criteria (HCPs):\n\n* Being retired at baseline\n* Unable to read or speak in one of the national languages: German, French, Italian\n\nInclusion Criteria (ICs):\n\n* Being informal cargiver\n* Aged 18 and over (adults)\n\nExclusion Criteria (ICs):\n\n* Unable to read or speak in one of the national languages: German, French, Italian",{"count":66,"type":20},6000,"OBSERVATIONAL","The healthcare system is continuously evolving to adapt to the population's needs, both in terms of healthcare practices, and in financial and organizational aspects. The current COVID-19 pandemic has added additional pressure to the healthcare system and shown its limits in terms of preparedness. It has also shown once again that both healthcare professionals (HCPs) and informal caregivers (ICs) play a central role for the functioning of the healthcare system.\n\nAn increasing number of studies are alerting on HCPs' situation, regarding their physical and mental health (e.g. emotional exhaustion, professional well-being) on the one hand, and the functioning of the healthcare system (e.g. absenteeism, turnover, career change) on the other hand.\n\nBesides healthcare professionals, ICs, defined as \"a person in the immediate entourage of an individual whose health and\u002For autonomy is impaired and who requires assistance with certain \\[basic or instrumental\\] activities of daily living. The IC provides the person, on a non-professional and informal basis, and on a regular basis, with assistance, care or presence services of varying nature and intensity, designed to compensate for their incapacities or difficulties or to ensure their safety, identity and social ties\". Caring for others has shown to have negative impact on the ICs' life, in terms of health-related implications, psychological burden, quality of life, etc. Despite being increasingly recognized as having a key role in the provision of care, they have only been limitedly considered in studies on healthcare professionals.\n\nIn that context, the investigators develop SCOHPICA project, the Swiss cohort of healthcare professionals and informal caregivers, which is an open prospective national cohort using a concurrent embedded mixed method design. This project targets all types of HCPs and ICs, and will investigate determinants of intent to stay and well-being according to participants' trajectories.",[70,71],"Healthcare Professional","Informal Caregiver",[70,73,74,71,75,76,77,78],"Health Professional","Health Care Professional","Informal Carer","Cohort","Switzerland","Health Personnel","2025-12-31",{"date":81,"type":48},"2026-01-06",{"date":83,"type":48},"2022-10-01",{"date":85,"type":20},"2026-12-31",{"name":54,"class":55},{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":17,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":4,"studyType":21,"phases":99,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":56},"100569013","does-eco-driving-assistance-eda-have-an-impact-on-bus-drivers-health-and-well-being-100569013","NCT06688721","Does Eco-driving Assistance (EDA) Have an Impact on Bus Driver's Health and Well-being?","Does Eco-driving Assistance (EDA) Have an Impact on Bus Driver's Health and Well-being? A Pseudo-randomized Controlled Trial","Inclusion Criteria:\n\n* adult active bus driver\n* having signed the informed consent\n* having worked for at least one year as TPF bus driver\n* working at least 30 hours a week\n* no planned extended absences in the next 6 months (civil service, military service, long- term leave, retirement)\n\nExclusion Criteria:\n\n* wearing a medical active implant (pacemaker, cardiac defibrillator, neurostimulator, other electronic implant)\n* known allergy or skin sensitivity to plasters",true,"18 Years","65 Years",{"count":98,"type":20},50,[23],"The goal of this pragamatic trial is to assess the impact of eco-driving assistance (EDA) system on professional bus drivers' health and well-being.\n\nThe main questions it aims to answer are:\n\n* Does the eco-driving assistance (EDA) act as a stressor for bus drivers ?\n* Does the physiological and psychological perceived stress increase when bus drivers are driving bus equipped with eco-driving assistance (EDA) ?\n\nAn additional question consists in assessing the association between stress measurements and biomarkers in biological samples.\n\nResearchers will compare the heart rate variability (HRV) and perceived stress level when participant are allocated to EDA-equipped buses and non-EDA-equipped buses\n\nParticipants will:\n\n* Drive buses equipped with eco-driving assistance (EDA)\n* Drive buses without eco-driving assistance (EDA)\n* Wear a wearable electrocardiogram (ECG) device (Bittium Faros) to record the heart rate variability (HRV)\n* Answer a questionnaire at the end of each working day (end-of-service questionnaire)\n* When allocated to bus with eco-driving assistance (EDA), read the EDA-generated report and answer some related questions in the end-of-service questionnaire\n* Upon acceptance only, a collection of biological samples and physiological measurement will be performed",[102],"Healthy",[104,105,106,107,108],"Public transport","Eco-driving assistance","Occupational health","Health and well-being","Bus drivers","2025-03-10",{"date":111,"type":48},"2025-03-13",{"date":113,"type":48},"2025-02-10",{"date":115,"type":20},"2025-08",{"name":54,"class":55},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":95,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":21,"phases":127,"briefSummary":128,"conditions":129,"keywords":137,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":151},"100545076","psychiatric-consultation-liaison-intervention-in-primary-care-a-pilot-study-100545076","NCT06377189","Psychiatric Consultation-Liaison Intervention in Primary Care: A Pilot Study","A Pilot Study on the Impact of a Psychiatric Consultation-Liaison Intervention in Primary Care Medical Consultations in French Speaking Switzerland (PLIMeC-P): A Mixed Method Randomized Controlled Trial","PLIMeC-P","Inclusion Criteria:\n\n* Aged more than 18 years\n* Signed informed consent to study protocol\n* Referred by their PCP due to mental distress, psychiatric symptoms, or complexity of medical care\n* Having fluent knowledge of the local language or being accompanied by an interpreter\n\nExclusion Criteria:\n\n* Not being able to give an informed consent and follow the procedure of the study (due to dementia, restriction of intellectual capacity, acute confusional state, language problem)\n* Presenting an acute psychotic symptomatology, a hetero-aggression risk or an acute suicidality\n* Having an ongoing psychiatric follow-up",{"count":126,"type":20},30,[23],"The pilot study on the impact of a Psychiatric Consultation-Liaison Intervention in Primary Care Medical Consultations in French-speaking Switzerland (PLIMeC-P), is a mixed method randomized controlled trial. The investigated health-related intervention is a brief Consultation-Liaison (CL) psychiatry intervention in primary care.\n\nPrimary Care Physicians (PCPs) have a key role in preventing, detecting, and managing mental disorders. Therefore, the optimization of both the quality of their interventions and their cooperation with psychiatric and psychological care networks are important challenges. It is well demonstrated that multidisciplinary interventions improve the efficacy of mental health care, CL psychiatry being one such type of intervention. Therefore, community CL-psychiatry, for example in private primary care group practices, are rare. The impact of such community, primary care CL-psychiatry interventions, should be investigated.\n\nThe mixed methods randomized controlled trial PLIMeC study will examine the impact of a CL-psychiatric intervention in primary care settings, for newly reported mental illness, versus a Treatment As Usual (TAU) control arm. The intervention consists of a CL-psychiatric intervention into private medical practices, provided to patients suffering from mental health problems, a group of patients generally under-treated. The CL-psychiatrist will receive and discuss PCPs' referrals for patients with mental distress, who don't have a psychiatric follow-up. After a brief intervention (1-4 sessions), feedback conjoint (PCP-psychiatrist) session will be organized, to complete the intervention and provide proposals.\n\nThe pilot study (PLIMeC-P) will determine whether the main planned study (PLIMeC) is feasible and practicable. It will be conducted on two sites, the Neuchâtel Psychiatry Centre (CNP) and the North-west Adult Psychiatry Service (SPANO), Department of Psychiatry of CHUV, Yverdon. For the pilot study (PLIMeC-P), 15 eligible participants are expected for each group, 30 participants in total. They will be recruited in three private primary care group practices. After eligibility and randomization 15 participants will be included for the intervention arm (brief CL-psychiatric intervention) and 15 for the control arm (TAU). The expected number of participants for the main trial (PLIMeC) will be estimated through analysis of the initial results of the PLIMeC-P.",[130,131,132,133,134,135,136],"Mental Health Issue","Depression\u002FAnxiety","Quality of Life","Psychosomatic Disorders","Patients Lived Experiences","Doctor-Patient Relation","Collaboration",[138,139,140,141,142],"Consultation-Liaison psychiatry","Mental health","Mixed method","Primary Care","Healthcare Complexity","2025-02-11",{"date":145,"type":48},"2025-02-13",{"date":147,"type":48},"2024-05-01",{"date":149,"type":20},"2025-12-01",{"name":54,"class":55},3,""]