[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"CentraCare\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":71},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100546832","ventilatory-parameters-in-predicting-outcomes-in-ards-patients-100546832",false,"NCT06400095","Ventilatory Parameters in Predicting Outcomes in ARDS Patients","Occlusion Pressure at 100 Msec, TCe ( Expiratory Time Constant ), Stress Energy Density, Mechanical Power, Ventilatory Ratio and C20\u002FCdyn in Predicting Outcomes in Patients With Moderately Severe ARDS, Who Are on Mechanical Ventilation","OCTANE","Inclusion Criteria:\n\n* Patients with Acute respiratory failure needing mechanical ventilation\n* Diagnosis of Severe ARDS with severity: PF ratio \\\u003C 150, with PEEP\u002FCPAP \\> 5\n\nExclusion Criteria:\n\n* r2 \\\u003C 0.95, monitored on the ventilator\n* Expiratory flow that is not first-order or non-exponential decay\n* Patients with Nor-epinephrine requirements \\> 0.1 mcg\u002Fkg\u002Fmin within 2 hours of intubation\n* Patients requiring ECMO ( Extracorporeal membrane oxygenation)\n* Patients with COPD or pulmonary fibrosis with a premorbid FEV1 \\\u003C 1.5 L\n* Severe atherosclerotic vascular disease\n* Patients with a chest tube, intra-abdominal hypertension or with its risk factors\n* Patients with structural heart disease including pulmonary hypertension (RVSP \\> 45) and heart failure\n* All comfort care orders in the ICU\n* Patients who underwent tracheostomy","ALL","19 Years","80 Years",{"count":21,"type":22},50,"ESTIMATED","OBSERVATIONAL","This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20\u002FCdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation",[26,27],"ARDS","Mechanical Power",[29,30,31,32],"Expiratory time constant","Ventilator ratio","Cdyn\u002FC20","Occlusion pressure at 100 msec","RECRUITING","2024-08-20",{"date":36,"type":37},"2024-08-22","ACTUAL",{"date":39,"type":37},"2023-06-01",{"date":41,"type":22},"2025-07",{"name":43,"class":44},"CentraCare","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100546091","passive-leg-raise-and-mini-fluid-challenge-effect-on-various-cardiac-output-surrogates-for-fluid-responsiveness-100546091","NCT06390423","Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness","Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates Such as Pulse Pressure Variation (PPV), End-tidal CO2 (Carbon Dioxide), Bioreactance (Stroke Volume Index -SVI) and Velocity Time Integral on Echocardiographic Exam for Fluid Responsiveness in Patients With Moderately Severe ARDS (Acute Respiratory Distress Syndrome)","PHOENIX","Inclusion Criteria:\n\n* Age between 30 - 90 years\n* Diagnosis of Vasodilatory Shock with no other obvious cause of hypotension\n* Diagnosis of ARDS with PF ratio \\\u003C 150 , PEEP \\> 8\n* Patients who are under paralysis or deeply sedated, on a mechanical ventilator\n\nExclusion Criteria:\n\n* Patients with arrhythmias including atrial fibrillation\n* Patients with chest tube, intra-abdominal hypertension or with its risk factors\n* Patients with structural heart disease including pulmonary hypertension (RVSP \\> 45) and heart failure\n* Patients on extracorporeal support such as ECMO, CRRT or MCS.\n* Patients with COPD with a premorbid FEV1 \\\u003C 1.5 L\n* Severe atherosclerotic vascular disease","30 Years","90 Years",{"count":57,"type":22},64,"In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed. Uncorrected hypovolemia with inappropriate vasopressors lead to organ hypoperfusion where as overzealous fluid administration especially in ARDS (Adult respiratory distress syndrome) can increase mortality. It has been estimated that only 50% of hemodynamically unstable critically ill patients are volume responsive, hence dynamic assessment of preload responsiveness has been proposed to better identify those individuals who would benefit from fluid bolus.",[60],"Fluid Responsiveness",[62,63,64],"Pre-load responsiveness","Passive leg raise","Mini-fluid challenge",{"date":36,"type":37},{"date":67,"type":37},"2023-07-01",{"date":69,"type":22},"2025-06",{"name":43,"class":44},""]