[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Centre Hospitalier Departemental Vendee\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":330},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,38,66,93,118,139,165,187,213,242,261,282,308],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100610529","assessment-of-surgeons-mental-fatigue-based-on-operating-time-100610529",false,"NCT07228767","Assessment of Surgeons' Mental Fatigue Based on Operating Time","COGNICHIR","Inclusion Criteria:\n\n* Surgeon working in the digestive surgery department at CHD Vendée\n* Surgeon capable of understanding the protocol and willing to participate in the research\n\nExclusion Criteria:\n\n* Surgeon unable to be available for the entire duration of the research","ALL","18 Years",{"count":19,"type":20},8,"ESTIMATED","OBSERVATIONAL","In May 2023, the French National Authority for Health published a solution for patient safety regarding tunnel vision. This concept, which is uncommon in the medical field, is defined as any situation in which a professional's attention is so focused on a goal that they do not hear or see warning signs that should prompt them to change their approach or even stop before an adverse event associated with care occurs.\n\nTo better understand the causes of medical errors, the research will assess surgeons' mental fatigue and the factors associated with it. This fatigue, which occurs after or during prolonged periods of intense cognitive activity, is associated with a temporary inability to maintain optimal cognitive performance. Assessing mental fatigue is crucial in surgeons, as it can directly affect their ability to perform complex procedures and make critical decisions. The aim of this research is to examine the factors that may influence the level of mental fatigue and cognitive load in surgeons during surgical procedures.",[24],"Surgical Intervention","RECRUITING","2026-06-17",{"date":28,"type":29},"2026-06-22","ACTUAL",{"date":31,"type":29},"2025-12-05",{"date":33,"type":20},"2027-01-05",{"name":35,"class":36},"Centre Hospitalier Departemental Vendee","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":59,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100545060","phase-3-hyaluronic-acid-in-shoulder-tendinopathy-100545060","NCT06376981","Hyaluronic Acid in Shoulder Tendinopathy","Benefit of a Subacromial Injection Combining Corticosteroid and Hyaluronic Acid Versus Corticosteroid Alone in Supraspinatus Tendinopathy","ACCTE","Inclusion Criteria:\n\n* Active patient aged between 18 and 65;\n* Patient suffering from pain compatible with supraspinatus tendinopathy for at least 2 months;\n* Patient with simple tendinopathy or partial tendon rupture;\n* Patient with tendinopathy confirmed by ultrasound or MRI;\n* Patient with an active pain visual analog scale ≥ 4 for more than 6 weeks;\n* Patient with an active pain visual analog scale ≥ 4 on the day of inclusion;\n* Patient failing medical treatment (rest, analgesics, NSAIDs, physiotherapy);\n* Patient able to follow the protocol and having given oral informed consent to take part in the research;\n* Patient affiliated to the social security system or entitled person;\n\nExclusion Criteria:\n\n* Patient suffering from a transfixing tendon rupture;\n* Patients suffering from post-traumatic tendon rupture;\n* Patients suffering from calcific tendinopathy (calcification \\> 5 mm);\n* Patients with associated glenohumeral osteoarthritis;\n* Patients with associated symptomatic acromioclavicular osteoarthritis;\n* Patients with shoulder pain for reasons other than tendinopathy (capsulitis, chronic inflammatory rheumatism, fibromyalgia, amyloidosis);\n* Patients who have had a subacromial infiltration in the previous 6 months;\n* Patients with a known allergy to one of the products including their excipients (methyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl alcohol);\n* Patients with a known allergy to lidocaine;\n* Patients with a local or generalised infection, or suspected infection;\n* Patients with severe coagulation disorders or taking anticoagulants;\n* Patients with severe and\u002For uncontrolled hypertension \\> 160\u002F100 mmHg;\n* Patients with unbalanced diabetes (last HbA1c \\> 8.5%);\n* Patients with a history of addiction to psychoactive substances;\n* Patient participating in another clinical research protocol with an impact on the research objectives;\n* Patient already randomised in the study;\n* Patient who is pregnant, parturient, breastfeeding or able to procreate without effective contraception\\* in the month prior to inclusion and up to 15 days after infiltration;\n* Patients under guardianship, curators or deprived of liberty;\n* Patient under a mandate for future protection activated ;\n* Patient under family guardianship ;\n* Patient under court protection ;","65 Years",{"count":48,"type":20},132,"INTERVENTIONAL",[51],"PHASE3","Multicentric, randomised study to compare the effectiveness on activity pain at 3 months of corticosteroid injection associated with hyaluronic acid with corticosteroids injection alone in patients with tendinopathy of the supraspinatus with clinical reevaluation at one, three and six months.",[54],"Shoulder Tendinitis",[56,57,58],"Shoulder tendinitis","Hyaluronic acid","Corticosteroid injection",{"date":28,"type":29},{"date":61,"type":29},"2024-09-19",{"date":63,"type":20},"2027-03-19",{"name":35,"class":36},2,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":49,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":37},"100640162","estimation-of-the-prevalence-of-microcirculatory-dysfunction-in-uremic-cardiopathy-among-dialysis-patients-100640162","NCT07608679","Estimation of the Prevalence of Microcirculatory Dysfunction in Uremic Cardiopathy Among Dialysis Patients","PRE-COCO","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients who have been on haemodialysis for at least 6 months\n* Elevated troponin levels \\> 40 ng\u002FL in a sample taken whilst the patient was in a stable condition, dated within the last 3 months\n* Patients capable of understanding the protocol and who have given their written informed consent to participate in the research\n* Patients registered with the National Health Service or eligible for it\n\nExclusion Criteria:\n\n* Age \\> 90 years\n* Patient undergoing daily home haemodialysis\n* Symptomatic stage 3 or 4 peripheral arterial disease\n* Severe hypertrophic cardiomyopathy (genetic or amyloid)\n* Severe valvular heart disease leading to left ventricular remodelling (surgically contraindicated severe aortic stenosis, severe mitral regurgitation, severe aortic regurgitation)\n* Hospitalisation for decompensation\u002Facute heart failure within the last month\n* Acute coronary syndrome and any coronary artery disease requiring angioplasty and\u002For stent implantation within the last 3 months\n* Contraindication to METHERGIN and DOBUTAMINE\n* Patients participating in another clinical research protocol that may affect the research objectives\n* Patients already included in the study\n* Patients under guardianship, curatorship or deprived of their liberty\n* Patients under an activated future protection order\n* Patients under family authorisation\n* Patient under judicial protection\n* Pregnant patient","90 Years",{"count":75,"type":20},30,[77],"NA","Patients with end-stage renal disease have a high burden of cardiovascular mortality, yet ischemic heart disease is often asymptomatic and difficult to diagnose in this population. Recent data suggest that microvascular coronary dysfunction may contribute significantly to myocardial ischemia in dialysis patients, but its true prevalence remains unknown. This study aims to evaluate microcirculatory coronary impairment in hemodialysis patients using invasive coronary angiography with measurement of coronary flow reserve (CFR), index of microcirculatory resistance (IMR). The study will also describe the clinical and biological characteristics associated with microvascular dysfunction in this population, in order to better understand the mechanisms of uremic cardiomyopathy and improve cardiovascular risk stratification.",[80],"Hemodyalysis",[82,83],"microcirculatory disorders","hemodyalysis","NOT_YET_RECRUITING","2026-05-20",{"date":87,"type":29},"2026-05-27",{"date":89,"type":20},"2027-09",{"date":91,"type":20},"2028-09",{"name":35,"class":36},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":49,"phases":102,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},"100630603","evaluation-of-the-efficacy-of-negative-pressure-wound-therapy-on-perineal-healing-following-abdominoperineal-amputation-100630603","NCT07489820","Evaluation of the Efficacy of Negative Pressure Wound Therapy on Perineal Healing Following Abdominoperineal Amputation","AAPICO","Inclusion Criteria:\n\n* Adult patient;\n* Patient scheduled to undergo abdominoperineal resection for adenocarcinoma of the lower and very lower rectum following chemoradiotherapy (50 Gy over 5 weeks);\n* Patients capable of following the clinical trial protocol and who have provided written informed consent to participate in the clinical trial;\n* Patients enrolled in the social security system or eligible for coverage;\n\nExclusion Criteria:\n\n* Patients scheduled to undergo a salvage abdominoperineal resection for squamous cell carcinoma following chemoradiotherapy;\n* Patients scheduled to undergo an abdominoperineal resection for adenocarcinoma of the very low rectum without neoadjuvant therapy;\n* Patients with a known allergy to the dressing;\n* Patients with a contraindication to the use of the PICO 7® dressing:\n\n  * Malignancy within the wound bed or at the wound margins;\n  * Previously confirmed, untreated osteomyelitis;\n  * Non-enteric, unexplored fistulas;\n  * Necrotic tissue with pressure ulcers;\n  * Exposed arteries, veins, nerves, or organs;\n  * Exposed anastomotic sites;\n* Patients participating in another clinical research protocol that could affect the objectives of this clinical trial;\n* Patients already randomized in this clinical trial;\n* Pregnant patients, women in labor, breastfeeding women, or women of childbearing age not using effective contraception\\*;\n* Patients under guardianship, conservatorship, or deprived of their liberty;\n* Patients under an activated future protection order;\n* Patients under family authorization;\n* Patients under judicial protection.",{"count":101,"type":20},100,[77],"Abdomino-perineal resection is a surgical procedure involving the removal of the rectum and anus via abdominal and perineal approaches. During this procedure, a terminal colostomy is created and the perineum is closed. This procedure is indicated for patients with non-metastatic adenocarcinoma of the lower and very lower rectum (where preservation of the sphincter apparatus is not possible) or squamous cell carcinoma of the anal canal that does not respond to chemoradiotherapy.\n\nMost often, treatment for non-metastatic adenocarcinoma of the lower and very lower rectum is part of a therapeutic sequence that includes neoadjuvant chemoradiotherapy followed by surgery 7 to 12 weeks later. Recently, the GRECCAR group (Rectal Surgery Research Group) published the results of the Prodigy 23 study demonstrating the benefit of intensification chemotherapy prior to neoadjuvant chemoradiotherapy.\n\nThis neoadjuvant regimen, and in particular chemoradiotherapy, can lead to impaired postoperative wound healing due to radiation-damaged tissue.\n\nThe incidence of impaired wound healing following chemoradiotherapy varies in the literature, with rates ranging from 30% to 70%. These wound complications can lead to local skin infections that may progress to pelvic sepsis, resulting in septic shock.\n\nThe perineum can be closed directly with a skin suture, but perineal reconstructions using a musculocutaneous flap have also been described. These reconstruction techniques require more extensive operating room coordination due to the need for a plastic and reconstructive surgery team. For this reason, the use of musculocutaneous flaps is not routine.\n\nIn recent years, pharmaceutical companies have developed a negative-pressure wound therapy system that allows for the absorption of infectious material and exudate through the wound. This system is intended to reduce surgical site infections. Results in the literature are inconsistent, with varying indications.\n\nRather et al. report a nearly 40% improvement in wound healing using a negative pressure therapy system on a closed perineal wound. In the literature review published by Meyer et al. in 2021, positive results of this technique are reported, with a 25% to 30% improvement in wound healing.\n\nThese results are encouraging, but currently there are no studies with a high level of evidence analyzing this practice.\n\nFor this reason, it is necessary to evaluate negative pressure therapy on perineal scars following chemoradiotherapy and abdominoperineal resection.",[105],"Adenocarcinoma (NOS)",[107,108,109],"adenocarcinoma","abdominal-perineal resection","negative pressure wound therapy",{"date":111,"type":29},"2026-05-22",{"date":113,"type":20},"2026-05-01",{"date":115,"type":20},"2029-06-15",{"name":35,"class":36},5,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":49,"phases":127,"briefSummary":128,"conditions":129,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":37},"100420141","early-evaluation-of-the-introduction-of-pre--and-post-operative-psychological-and-physiotherapeutic-follow-up-in-vascular-surgery-in-amputee-patients-100420141","NCT04750876","Early Evaluation of the Introduction of Pre- and Post-operative Psychological and Physiotherapeutic Follow-up in Vascular Surgery in Amputee Patients","EPKIVA","Inclusion Criteria:\n\n* Patient over the age of majority, no age limit\n* Amputation related to obliterative arteriopathy of the lower limbs\n* Trans-tibial or trans-femoral amputation\n* Patient with an indication of discharge to a rehabilitation and re-education service\n* Patient with the ability to understand the protocol\n* Patient who has agreed to participate in the study and has given express oral consent\n* Patient receiving social security cover or entitled to it\n\nExclusion Criteria:\n\n* Trauma related amputation\n* Amputation of upper limb, trans-metatarsal or one or more toes\n* Amputation of comfort in a palliative care setting\n* Patient leaving home after surgery\n* Patient undergoing psychological or psychiatric treatment\n* Pregnant or breastfeeding woman, or a woman who is able to procreate without effective contraception\n* Patient unable to follow the protocol as judged by the investigator\n* Patient participating in another interventional research protocol involving a drug or medical device\n* Patient under guardianship, curators or legal protection measure",{"count":126,"type":20},40,[77],"An amputation represents a real ordeal for the person who will have to overcome the loss of a limb and face long months of rehabilitation. It is most often carried out following arterial insufficiency.\n\nAs paramedical professionals, we see in our daily practice a physical and psychological suffering for amputee patients. In spite of our skills acquired through training and professional experience, we are unable to offer comprehensive care for these patients and therefore feel that we are offering incomplete care. A multidisciplinary care, including a medical and paramedical team, would seem to us to be more appropriate for patients with lower limb amputations.\n\nFollowing this observation, we would like to highlight the interest for the patient and the care team to include a psychologist and a physiotherapist in the care offer to evaluate the improvement of the physical and emotional state of the amputee patient.",[130],"Amputation","2026-05-12",{"date":133,"type":29},"2026-05-15",{"date":135,"type":29},"2021-04-08",{"date":137,"type":20},"2027-10-18",{"name":35,"class":36},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":49,"phases":149,"briefSummary":150,"conditions":151,"keywords":154,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":19},"100512416","evaluation-of-the-impact-of-tractions-vs-placebo-tractions-in-patients-with-cervical-radiculopathy-100512416","NCT05952167","Evaluation of the Impact of Tractions vs. Placebo Tractions in Patients With Cervical Radiculopathy","Evaluation of the Impact of Tractions vs. Placebo Tractions in Patients With Cervical Radiculopathy, Randomised Controlled Trial in a Single-blind Study","TracCerv2","Inclusion Criteria:\n\n* Patient over 18\n* Neck Disability Index ≥ 15\u002F50\n* Presence of at least three of the four signs clinically validating the presence of cervical radiculopathy (Wainner et al. 2003)\n\n  * a) upper limb nerve tension test A (ULNT1a): positive,\n  * b) amplitude of cervical rotation on the side concerned: \\\u003C 60°,\n  * c) positive cervical distraction test: relief\n  * d) positive Spurling test: reproduction of symptoms.\n* Cervical radiculopathy diagnosed 3 to 24 months previously\n* Absence of cervical traction in the 5 years prior to inclusion\n* MRI or CT scan performed prior to hospitalisation in relation to current pathology\n* Patient able to understand the protocol and having given oral informed consent to take part in the research.\n* Patient affiliated to the social security system or entitled beneficiary.\n\nExclusion Criteria:\n\n* Patients with vertebral artery pathology at the time of inclusion\n* Patients with myelopathy, cervical cancer, cervical fracture, cervical dislocation, cervical spondylolisthesis, spinal infection, symptomatic cervical pain without radiculopathy and\u002For cervical surgery in the 2 years prior to inclusion.\n* Patient participating in another clinical research protocol with an impact on the objectives of the research.\n* Patient who is pregnant, breastfeeding or able to procreate without effective contraception\\*.\n* Patient under guardianship, curatorship or deprived of liberty\n* Patient under activated future protection mandate\n* Patient under family habilitation\n* Patient under court protection.",{"count":148,"type":20},206,[77],"Cervical radiculopathy is a common disease related to compression of the nerve roots of the spine (prevalence: 3.5\u002F1000). Dysfunction and pain are the main repercussions and can lead to time off work and high costs in terms of treatment.\n\nSecond-line surgical treatments appear to be less effective and present risks of side effects. In the first instance, treatments are conservative and include medication but above all physiotherapy with manual therapy, muscle exercises and cervical traction. These cervical tractions performed by a physiotherapist require little equipment and are inexpensive compared with the surgical alternative. They involve stretching the cervical spine and soft tissues to open the intervertebral foramen and mobilise the facet joints.\n\nSeveral authors have written summaries of their interest. Thoomes reports two studies and describes an absence of effect. In a meta-analysis, Romeo et al. added three more recent studies to the previous review and concluded that traction is effective, highlighting an \"effect-dose\" relationship. These recent results therefore seem to reverse the recommendations made barely two years later. Nevertheless, almost all the studies compared \"manual therapy + exercises\" with \"manual therapy + exercises + cervical traction\". Only Young et al. tested \"manual therapy + exercises + cervical traction at an effective weight\" compared to \"manual therapy + exercises + cervical traction placebo at an ineffective weight\". The study did not reveal any difference between the groups. However, several limitations appear in this study when comparing the protocol to studies that have shown efficacy. The main limitation is the low intensity (i.e. protocol with fewer sessions and longer duration). These clinical limitations may explain the lack of evidence of a positive outcome. Following on from a preliminary study evaluating an intensive cervical traction protocol over five days, and in order to discern the effect specific to the treatment (specific effect) and the effect independent of the nature of the treatment (contextual effect), the investigators wish to evaluate the impact of this intensive protocol by comparing it with placebo traction.\n\nIn current practice, treatment varies between establishments. The paucity of studies on cervical traction in radiculopathy has resulted in routine use being guided by habit rather than evidence. It remains a clinical question which raises a major issue requiring a robust experimental design. Ultimately, this study follows on from a preliminary study and is part of a comprehensive research project aimed at proposing new recommendations for the use of traction in patients suffering from cervical radiculopathy. The investigators are investigating the impact of an intensive traction vs. placebo traction protocol in patients with cervical radiculopathy.",[152,153],"Radiculopathy","Cervical",[155,156],"Cervical traction","Cervical radiculopathy","2026-04-10",{"date":159,"type":29},"2026-04-15",{"date":161,"type":29},"2024-03-25",{"date":163,"type":20},"2031-09-25",{"name":35,"class":36},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":49,"phases":174,"briefSummary":175,"conditions":176,"keywords":178,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":184,"leadSponsor":186,"locationsCount":37},"100617028","impact-of-foot-reflexology-on-nausea-after-obesity-surgery-100617028","NCT07313293","Impact of Foot Reflexology on Nausea After Obesity Surgery","IRANNO","Inclusion Criteria:\n\n* Adult patient\n* Patient scheduled to undergo sleeve gastrectomy\n* Patient capable of understanding the protocol and having given their informed verbal consent to participate in the study\n* Patient affiliated with the social security system or entitled to benefits\n\nExclusion Criteria:\n\n* Patients receiving long-term morphine and opioid treatment\n* Patients with phlebitis, a wound under the foot, or recent foot trauma (cast immobilisation, splint, etc.)\n* Patients under guardianship, curatorship, or deprived of their liberty\n* Patients who are pregnant, breastfeeding, or refusing contraception\n* Patients participating in another clinical research protocol that has an impact on the objective of the study\n* Patients under an activated future protection mandate\n* Patients under family authorisation\n* Patients under judicial protection",{"count":173,"type":20},60,[77],"Obesity is a major public health issue. The Obépi epidemiological survey, the results of which were published in 2020, shows a steady increase in obesity among the French population.\n\nCurrently, more than 23 million French people are overweight or obese, and more than 8 million French people are obese. The most effective treatment currently available is surgery. These procedures are governed by specific recommendations. Between 50,000 and 60,000 procedures are performed in France each year. Three procedures are authorised: gastric banding, sleeve gastrectomy and gastric bypass.\n\nHallyday \\& al report 65% of patients experiencing nausea\u002Fvomiting after bariatric surgery. In 2019, Suh \\& al showed that nausea and vomiting were more common after sleeve gastrectomy and that they were responsible for an increase in the length of hospitalisation. These episodes of nausea and vomiting occur within 48 hours after sleeve gastrectomy and can cause difficulties in resuming eating. One of the factors contributing to the occurrence of nausea and vomiting was the use of opioids.\n\nThe benefits of foot reflexology were reported in 2023 by Dr Carrazé in rectal surgery. His doctoral thesis in medicine showed that foot reflexology sessions on days 1, 2 and 3 following rectal surgery reduced post-operative ileus and post-operative pain. The reduction in post-operative ileus led to a decrease in episodes of nausea and vomiting.\n\nIn 2021, Murat-Ringot \\& al demonstrated the beneficial effect of foot reflexology on nausea and vomiting during chemotherapy sessions, in addition to the anti-emetic treatments used for prevention. Anderson \\& al. in 2021 also demonstrated a beneficial effect on pain in cancer patients, with no effect on nausea.\n\nThe principle of foot reflexology is based on the fact that each organ, gland or part of the body corresponds to a reflex zone on the foot, hand, ears or face. Stimulation of the reflex zones is thought to activate the autonomic nervous system. Currently, there is very little scientific evidence on how this practice works and what its effects are. Despite various scientific publications on the results of foot reflexology, scientific evidence of its effectiveness remains weak. Only one prospective randomised trial has been found in the literature (Dalal \\& al.) on the quality of life of patients with epilepsy.\n\nDespite the lack of high-quality studies, it appears that foot reflexology could benefit patients by reducing nausea and vomiting. To date, no studies have evaluated its effectiveness in the post-operative period, particularly after bariatric surgery.\n\nThe aim of our randomised trial is to evaluate the impact of foot reflexology on nausea and vomiting after sleeve gastrectomy.",[177],"Sleeve Gastrectomy",[179],"foot reflexology","2026-04-01",{"date":182,"type":29},"2026-04-02",{"date":180,"type":29},{"date":185,"type":20},"2028-07-03",{"name":35,"class":36},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":197,"conditions":198,"keywords":200,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":65},"100617131","prospective-study-in-laser-treatment-of-pilonidal-cysts-100617131","NCT07314632","Prospective Study in Laser Treatment of Pilonidal Cysts","Prospective Study on the Incidence of Recurrence in Laser Treatment of Pilonidal Cysts","LASPRO","Inclusion Criteria:\n\n* Patients requiring laser surgery for pilonidal sinus, of any type (including recurrence after radical cure or laser treatment)\n* Patient able to understand the protocol and having given written informed consent to participate in the study,\n* Patient affiliated to the social security system or entitled to it.\n\nExclusion Criteria:\n\n* Patient participating in another interventional clinical research protocol involving a drug or clinical investigation of a medical device\n* Patient already included in a research study\n* Patient under guardianship, conservatorship, or deprived of liberty\n* Patient under an activated future protection mandate\n* Patient under family authorization\n* Patient under judicial protection.",{"count":196,"type":20},240,"The goal of this observational study is to evaluate the recurrence rate after laser treatment of pilonidal sinus within two years of the procedure in adult patients who require this procedure to treat their pilonidal sinus.\n\nThe main question it aims to answer is:\n\n• Is there a clinical recurrence (presence of a fistula in the intergluteal cleft) 2 years after laser treatment of pilonidal sinus? Participants who undergo surgery as part of their regular medical care will answer survey questions about recurrence at 1 and 2 years.",[199],"Pilonidal Sinus",[201,202,203,204],"Pilonidal sinus","laser","risk factors","Recurrence rates","2026-03-20",{"date":207,"type":29},"2026-03-23",{"date":209,"type":29},"2026-03-19",{"date":211,"type":20},"2030-06-12",{"name":35,"class":36},{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":221,"enrollmentInfo":222,"targetDuration":4,"studyType":49,"phases":224,"briefSummary":225,"conditions":226,"keywords":230,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":241},"100529204","radiofrequency-ablation-vs-doppler-guided-haemorrhoidal-artery-ligation-in-the-treatment-of-haemorrhoidal-disease-100529204","NCT06170736","Radiofrequency Ablation vs Doppler-guided Haemorrhoidal Artery Ligation in the Treatment of Haemorrhoidal Disease","Radiofrequency Haemorrhoidal Thermoablation Versus Doppler-guided Haemorrhoidal Artery Ligation With Mucopexy in the Treatment of Haemorrhoidal Disease: a Multicenter Randomized Non-inferiority Trial","RADIOLIGA","Inclusion Criteria:\n\n* Major patient,\n* With symptomatic Grade II or III haemorrhoidal disease,\n* Requiring surgical management,\n* Patient able to understand the protocol and having given written informed consent to participate in the study,\n* Patient affiliated to the social security system or entitled to it.\n\nExclusion Criteria:\n\n* Hemostasis disorders\n* Active external haemorrhoidal disease (thrombosis)\n* History of surgical procedure for treatment of haemorrhoids (instrumental treatment is not a contra-indication)\n* Associated proctological pathology (anal fissure, chronic suppuration, external rectal prolapse)\n* History of colorectal cancer\n* History of inflammatory bowel disease\n* History of rectal resection\n* Patient participating in another interventional clinical research protocol involving a drug or clinical investigation of a medical device\n* Patient who is pregnant, breastfeeding or able to procreate without effective contraception\\* at the time of inclusion\n* Patient under guardianship, curators or deprived of liberty.\n* Patient under court protection.\n\n  * oral contraceptive (pill), monthly vaginal ring, weekly transdermal patch, subcutaneous implant, intrauterine devices (IUD), or sterilisation.","80 Years",{"count":223,"type":20},168,[77],"Surgical treatment of grade II\u002FIII internal haemorrhoidal disease is indicated in the case of medical and\u002For instrumental treatment failure. Minimal invasive alternatives to haemorrhoidectomy have been introduced in the last decades to treat grade II\u002FIII haemorrhoids. Doppler-Guided haemorrhoidal artery ligation (DGHAL) represents a good therapeutic option in this condition with good short and mid-term outcomes but postoperative recurrence rates up to 35% at 5 years.\n\nRecently, a technique of radiofrequency ablation (RFA) has been introduced with promising outcomes. A recent systematic review reported a significant improvement of preoperative symptoms and a recurrence rate \\\u003C 5%.\n\nTo date, there is no study comparing DGHAL to RFA in the treatment of grade II\u002FIII haemorrhoids.\n\nThe aim of this study is to demonstrate the non-inferiority in terms of failure rate of haemorrhoidal radiofrequency ablation compared to Doppler-guided haemorrhoidal artery ligation, associated with mucopexy, in the treatment of grade II and III haemorrhoidal disease",[227,228,229],"Haemorrhoids","Internal Haemorrhoids","Grade II\u002FIII Haemorrhoids",[227,231,232],"Radiofrequency","Doppler-guided haemorrhoidal artery ligation","2026-03-12",{"date":235,"type":29},"2026-03-13",{"date":237,"type":29},"2024-02-21",{"date":239,"type":20},"2030-09-15",{"name":35,"class":36},18,{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":246,"conditions":251,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":37},"100619087","statistical-association-between-bicarbonate-levels-and-death-or-admission-to-intensive-care-within-48-hours-in-patients-presenting-to-the-emergency-department-100619087","NCT07340060","Statistical Association Between Bicarbonate Levels and Death or Admission to Intensive Care Within 48 Hours in Patients Presenting to the Emergency Department","BRAVOinED","Inclusion Criteria:\n\n* Adult patient\n* Patient with blood ionogram performed upon admission to the emergency department\n* Patient capable of understanding the protocol and not opposed to participating in the research\n\nExclusion Criteria:\n\n* NA",{"count":250,"type":20},6500,[252],"Urgency","2026-03-03",{"date":255,"type":29},"2026-03-04",{"date":257,"type":29},"2026-02-10",{"date":259,"type":20},"2026-08-10",{"name":35,"class":36},{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":49,"phases":270,"briefSummary":271,"conditions":272,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":37},"100591546","physical-activity-for-haemodialysis-patients-evaluation-of-personalised-support-by-an-adapted-physical-activity-teacher-and-an-advanced-practice-nurse-100591546","NCT06981832","Physical Activity for Haemodialysis Patients: Evaluation of Personalised Support by an Adapted Physical Activity Teacher and an Advanced Practice Nurse","HE-MOVE","Pre-Inclusion Criteria:\n\n* Patient over 18 years of age\n* Patient who has been receiving haemodialysis for less than a year\n* Patient with medical prescription for physical activity\n* Patient able to understand the protocol and having given consent to participate in the research,\n* Patient affiliated to the social security system or entitled beneficiary\n\nInclusion Criteria:\n\n* Patient with physical activity considered low or moderate according to the IPAQ questionnaire\n\nExclusion Criteria:\n\n* Patients with medical contraindications to adapted physical activity\n* Patients with a lower limb amputation\n* Patients undergoing peritoneal dialysis\n* Patient with a peritoneal dialysis project\n* Patient participating in another clinical research protocol with an impact on the research objectives\n* Patient already randomised in the study\n* Patient who is pregnant, parturient, breastfeeding or able to procreate without effective contraception at the time of inclusion\\*.\n* Patients under guardianship, curatorship or deprived of liberty\n* Patient under activated future protection mandate\n* Patient under family habilitation\n* Patient under court protection",{"count":269,"type":20},70,[77],"Physical activity is defined as 'any bodily movement produced by skeletal muscles that results in an energy expenditure greater than that of the resting metabolism'. Physical activity includes 'activities of daily living, physical exercise and sporting activities'.\n\nThe scientific community is agreed in recognising the benefits of physical activity, both in healthy individuals and in those suffering from chronic diseases.\n\nWith this in mind, the law of 2 March 2022 allows doctors to prescribe Adapted Physical Activity.\n\nIn the case of chronic renal failure, there are a number of factors that can limit physical activity in haemodialysis patients, such as anaemia, nutritional status and post-dialysis fatigue.\n\nHowever, the risks associated with a sedentary lifestyle play a role in the development of chronic disease, in particular hypertension and diabetes. The benefits of physical activity have been widely identified in chronic renal failure, particularly in terms of cardiovascular and muscular function.\n\nMore generally, physical activity has a positive impact on physical, psychological and social quality of life (increase in overall quality of life score, improved sleep, reduced pain, etc.).\n\nPhysical activity should therefore be encouraged in patients with chronic renal failure, whether on dialysis or not, whatever their age.\n\nThe aim of this study is to assess whether individualised support (from an advanced practice nurse and an adapted physical activity teacher) improves the practice of physical activity at home in patients who have been on haemodialysis for less than a year, and whether this improvement is sustainable over time.",[273],"Hemodialysis","2025-12-17",{"date":276,"type":29},"2025-12-23",{"date":278,"type":29},"2025-10-28",{"date":280,"type":20},"2028-04",{"name":35,"class":36},{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":289,"targetDuration":4,"studyType":49,"phases":291,"briefSummary":292,"conditions":293,"keywords":295,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":307},"100438851","evaluation-of-omentopexy-on-gastro-oesophageal-reflux-following-sleeve-gastrectomy-100438851","NCT04994665","Evaluation of Omentopexy on Gastro-oesophageal Reflux Following Sleeve Gastrectomy","Sleevepexie","Inclusion Criteria:\n\n* Patient ≥ 18 years old,\n* Patient to be operated in first intention of a sleeve gastrectomy\n* Initial BMI between 35Kg\u002Fm² and 40 Kg\u002Fm² associated with at least one severe comorbidity likely to be improved after surgery according to HAS recommendations.\n\nOR initial BMI ≥ 40 Kg\u002Fm².\n\n* Multidisciplinary follow-up of at least 6 months before surgery\n* Validation of the surgical intervention in a multidisciplinary consultation meeting\n* Certificate of no contraindication by a psychiatrist\n* Patient who has the capacity to understand the protocol and has given consent to participate in the research,\n* Patient with social security coverage.\n\nExclusion Criteria:\n\n* Eating disorder or mental disorder\n* Misunderstanding of the protocol\n* Psychiatric contraindication\n* Initial BMI \\\u003C35Kg\u002Fm².\n* Initial BMI between 35Kg\u002Fm² and 40 Kg\u002Fm² without comorbidities.\n* Esophagitis of grade B and above on the Oeso-Gastro-Duodenal Fibroscopy\n* CARLSSON score (score ≥ 4) preoperatively\n* Presence of a Proton-Pump Inhibitors treatment\n* Patient to have a 2-stage surgery (first sleeve gastrectomy then gastric bypass or Single Anastomosis Duodeno-Ileal bypass)\n* Patient participating in another interventional clinical research protocol involving a drug or medical device\n* Patient who are pregnant, breastfeeding, or who have the potential to become pregnant without effective contraception at the time of inclusion and up to 24 months after surgery\n* Patient under guardianship, curators or legal protection,P",{"count":290,"type":20},526,[77],"The aim of the study is to assess impact of omentopexy on de novo gastro-oesophageal reflux disease (GERD) after sleeve gastrectomy.\n\nThis will be assess 2 years postoperatively. This study is a prospective, multicentric, randomized trial. Five hundred twenty six patients should be included with 263 in each arm. First arm will include patients who have a sleeve gastrectomy. The second arm will include patients who have sleeve gastrectomy with omentopexy.\n\nTwo years after surgery , it will be collected a CARLSSON score and BAROS score (quality of life).\n\nThe main objective is to show that omentopexy decreases the rate of de novo GERD after sleeve gastrectomy at 2 years postoperatively without the use of Proton-Pump Inhibitors (PPIs)",[294],"Obesity",[296,297,298],"sleeve gastrectomy","omentopexy","gastro-oesophageal disease","2025-09-18",{"date":301,"type":29},"2025-09-23",{"date":303,"type":29},"2021-12-07",{"date":305,"type":20},"2028-11-01",{"name":35,"class":36},9,{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":315,"targetDuration":4,"studyType":49,"phases":316,"briefSummary":317,"conditions":318,"keywords":320,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":65},"100564708","virtual-reality-headset-and-acceptability-of-rectosigmoidoscopy-in-ulcerative-colitis-a-randomised-controlled-trial-100564708","NCT06632691","Virtual Reality Headset and Acceptability of Rectosigmoidoscopy in Ulcerative Colitis: a Randomised Controlled Trial","VIRTU","Inclusion Criteria:\n\n* Patients aged 18 or over with UC in the active phase or in remission of their disease\n* Patient who has already undergone rectosigmoidoscopy without general anaesthetic\n* Patient requiring rectosigmoidoscopy (with colonoscope and air insufflation) as part of routine care\n* Patient able to follow the Clinical Investigation protocol and having given written informed consent to participate\n* Patient affiliated to the social security system or entitled beneficiary\n\nExclusion Criteria:\n\n* Patients with Crohn disease or indeterminate colitis\n* Patients hospitalised with severe acute colitis, as defined by the truelove criteria.\n* Patients with a stoma in place or with a history of colorectal resection.\n* Patients with a contraindication to the use of the virtual reality headset:\n\n  * Psychotic patients or patients diagnosed with psychiatric disorders\n  * Patients with uncontrolled epilepsy\n  * Patients with visual problems (lack of binocular vision, blindness) and\u002For hearing problems (deafness) that prevent them from using virtual reality.\n* Patients taking part in another clinical research protocol having an impact on the objectives of the clinical investigation\n* Patients already randomized in the clinical investigation\n* Pregnant, parturient or breast-feeding patients\n* Patients under guardianship, curatorship or deprived of their liberty\n* Patient under activated protection mandate or family habilitation\n* Patients under court protection.",{"count":101,"type":20},[77],"Haemorrhagic rectocolitis is an inflammatory bowel disease that continuously affects the rectum and colon, with lesions that extend variably from the rectum into the upstream colon. This disease requires repeated assessment of both clinical activity (transcribed by the clinical Mayo score) and endoscopic activity. ACCEPT study showed that the acceptability of rectosigmoidoscopy is low, and the main determinants of this low acceptability were pain and bloating (51%) and embarrassment during the examination (30%).\n\nVirtual reality headsets has analgesic and anxiolytic properties, thanks to specially designed virtual environments that apply different principles such as medical hypnosis, music therapy and cardiac coherence to enhance therapeutic action.\n\nThe aim of our project is to study the benefit of medical hypnosis provided by the use of a virtual reality headset in terms of tolerance of lower digestive endoscopy in patients with ulcerative colitis.",[319],"Haemorrhagic Rectocolitis",[321],"Haemorrhagic rectocolitis","2025-07-31",{"date":324,"type":29},"2025-08-01",{"date":326,"type":29},"2024-10-09",{"date":328,"type":20},"2027-04-09",{"name":35,"class":36},""]