[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Centre Hospitalier Emile Roux\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":315},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,41,75,100,127,149,172,194,217,244,272,293],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100618675","effects-of-implementing-a-program-to-develop-emotional-skills-and-post-traumatic-growth-in-adolescents-and-young-adults-receiving-child-welfare-services-a-pilot-study-in-the-haute-loire-department-100618675",false,"NCT07334704","Effects of Implementing a Program to Develop Emotional Skills and Post-traumatic Growth in Adolescents and Young Adults Receiving Child Welfare Services-a Pilot Study in the Haute-Loire Department","JEMotion43","Inclusion Criteria:\n\n* Minors: \\> 15 to \\\u003C 18 years old:\n\n  1. Be taken in or accompanied by a child protection service.\n  2. Have given informed consent to participate in the study.\n  3. Have obtained authorization from those with parental authority.\n\nYoung adults aged ≥ 18 to 21:\n\n1. Have signed a young adult contract (CJM) with the Child Welfare Service (ASE).\n2. Have given their informed consent to participate in the study.","ALL","15 Years","21 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"NA","Adolescents and young adults receiving child welfare services constitute a vulnerable population, with an overrepresentation of mental health issues and past trauma, often exacerbated by a difficult transition to independence. Current support focuses mainly on material needs, lacking specific interventions targeting psychological resilience. This study draws on literature demonstrating that the development of emotional skills and post-traumatic growth are major protective factors promoting psychosocial adaptation and mental health.",[27,28],"Child Protection Service","Child Welfare","NOT_YET_RECRUITING","2026-02-09",{"date":32,"type":33},"2026-02-11","ACTUAL",{"date":35,"type":21},"2026-02-01",{"date":37,"type":21},"2027-09-01",{"name":39,"class":40},"Centre Hospitalier Emile Roux","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100614501","evolution-of-insomnia-during-the-first-year-in-patients-newly-diagnosed-with-cancer-100614501","NCT07280416","Evolution of Insomnia During the First Year in Patients Newly Diagnosed With Cancer","Evolution of Insomnia During the First Year in Patients Newly Diagnosed With Cancer: a Longitudinal Study and Analysis of Associated Factors.","INDICA","Inclusion Criteria:\n\n* Confirmed diagnosis of metastatic or non-metastatic cancer,\n* Cancer treated with intravenous chemotherapy and\u002For immunotherapy administered intravenously or subcutaneously,\n* Age ≥ 18 years,\n* Ability to read and understand French,\n* Patient covered by a social security system,\n* Signed informed consent.\n\nExclusion Criteria:\n\n* SCI questionnaire score \\\u003C16\n* Diagnosed or controlled sleep disorders\n* Presence of severe cognitive disorders (e.g., Alzheimer's disease) or major psychiatric disorders (e.g., psychosis), as noted in the medical record, observed at recruitment, or reported by the patient\n* Patient in an emergency situation, or subject to a legal protection measure (guardianship, curatorship, or judicial protection) and unable to provide consent","18 Years","80 Years",{"count":52,"type":21},260,"OBSERVATIONAL","The diagnosis of cancer can be a major trigger for new sleep problems, especially insomnia, in people who did not have sleep issues before. Insomnia may appear early in the care pathway and can continue over time, often interacting with other physical or emotional symptoms.\n\nThe main goal of this preliminary study is to describe how insomnia develops during the first months after a cancer diagnosis in patients who had no sleep problems at the time of diagnosis. This will be done through regular follow-up over time.\n\nA secondary aim is to identify the factors that may contribute to the onset or persistence of insomnia, such as the cancer treatments patients receive, as well as any medical or non-medical therapies used to manage sleep difficulties.\n\nThe study will also look at whether patients who develop sleep problems are referred to psychologists trained in specific therapies for insomnia, and how well they follow and adhere to these treatments.",[56,57,58,59,60],"Cancer","Insomnia","Pain","Depression Anxiety Disorder","Quality of Life",[62,63,64,65,66],"cancer","insomnia","pain","Depresion Anxiety disorder","longitudinal","RECRUITING",{"date":32,"type":33},{"date":70,"type":33},"2025-12-16",{"date":72,"type":21},"2028-11-01",{"name":39,"class":40},1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":74},"100623709","postprandial-thermogenesis-in-obese-adolescents-effect-of-weight-loss-100623709","NCT07400159","Postprandial Thermogenesis in Obese Adolescents: Effect of Weight Loss","TEFAL","Inclusion Criteria: • Adolescents aged 11 to 17 (inclusive), at Tanner stage 3-5 of sexual maturation,\n\n* With obesity defined by a Quételet index above the 97th percentile according to national curves for adolescents with obesity and a Quételet index classifying them as normal weight adolescents for the control group,\n* Adolescents affiliated with the social security system or equivalent,\n* Adolescent who has been informed and has given written consent to participate in the study.\n\nExclusion Criteria: • Refusal to participate in the study,\n\n* Refusal of consent by legal guardians,\n* Regular consumption of tobacco or alcohol,\n* Special diet,\n* Participation in regular and intense physical and sporting activities,\n* Medical or surgical history deemed by the investigator to be incompatible with the study,\n* Presence of diabetes, and any other condition limiting the application of either strategy being tested,\n* Adolescents undergoing energy restriction or a weight loss program through physical activity at the time of inclusion or during the last 6 months,\n* Taking medication that may interfere with the study results.\n* Adolescents with cardiovascular problems, i.e., subjects with a history of cardiovascular and\u002For neurovascular disease, as well as subjects with cardiovascular and\u002For neurovascular risk factors (excluding obesity\u002Foverweight).\n* Surgery in the previous 3 months,\n* Adolescents who are currently excluded from another study,\n* Pregnant or breastfeeding adolescents,\n* Adolescents under guardianship\u002Fcuratorship or legal protection,\n* Parents under guardianship\u002Fcuratorship or legal protection.","11 Years","17 Years",{"count":85,"type":21},30,[24],"The prevention and management of pediatric obesity require a thorough understanding and consideration of the various components of energy balance (i.e., intake and expenditure) and their interactions. Total energy expenditure (TEE) consists of resting metabolism (RM), energy expenditure induced by physical activity (EEPA), and dietary thermogenesis (DTE). While RM and EEPA are the two main contributors to TEE, DTE is often overlooked, even though it can account for around 10% of our daily energy expenditure. In fact, few studies have prioritized the evaluation of the thermic effect of food (TEF), defined as the increase in energy expenditure above the basal metabolic rate when fasting, despite the fact that it accounts for about 10% of total daily energy expenditure. It has been suggested that TEF may play a role in the development or maintenance of obesity.\n\nSome studies indicate a reduction in TEF in individuals living with obesity, possibly due to lower postprandial activation of the sympathetic nervous system, thereby limiting the thermogenic response after meals. Conversely, several studies have reported no decrease in TEF in individuals living with obesity. Due to these conflicting results, no consensus has been reached on the response of TEF in individuals with obesity compared to those of normal weight.\n\nWhile our team recently conducted a systematic review of the literature in this area, identifying a glaring lack of evidence, the few results available suggest a potential reduction in TEF in children and adolescents with obesity, contributing to minimizing the optimization of their daily energy balance. In their study, Maffeis and colleagues show, for example, a significantly reduced TEF in adolescents with obesity compared to their normal-weight counterparts, despite a higher-calorie test meal adapted to their energy needs.\n\nThese results are consistent with those proposed by Salas-Salvado the following year, which suggest a reduced TEF in obese adolescents, associated with their percentage of body fat.This research suggests the need to consider the effects of weight status, body composition, and the caloric composition of a meal in order to better understand TEF in this population. Furthermore, while our team has repeatedly highlighted adaptations in resting metabolism and exercise metabolism in response to weight loss in obese adolescents, the TEF responses to these interventions have also been little studied in adolescents. To our knowledge, there is only one study that has qualitatively assessed this adaptation of TEF to weight loss in this population. According to the authors, while DHEA was reduced at baseline in obese adolescents compared to their normal-weight counterparts, weight loss appeared to increase DHEA levels, but this remains to be confirmed. In this context, the objective of this study is to evaluate the effects of weight loss on dietary thermogenesis in obese adolescents. It will also compare the thermogenesis of these adolescents before weight loss with that of adolescents of normal weight.",[89],"Obesity & Overweight",[91],"dietary thermogenesis in obese adolescents","2026-02-03",{"date":94,"type":33},"2026-02-10",{"date":96,"type":21},"2026-02-28",{"date":98,"type":21},"2029-06",{"name":39,"class":40},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":108,"minAge":49,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},"100603246","educational-program-for-the-multidisciplinary-support-of-patients-with-endometriosis-100603246","NCT07134023","Educational Program for the Multidisciplinary Support of Patients With Endometriosis","Programme EducaTif d'Accompagnement pLuridisciplinaire Des Patientes Atteintes d'Endométriose","PETALE","Inclusion Criteria:\n\n* Signed informed consent,\n* Age ≥ 18 years,\n* Patient diagnosed with endometriosis confirmed by pelvic ultrasound and\u002For MRI,\n* Patient experiencing chronic pelvic-perineal pain (± dysmenorrhea, dyspareunia, etc.) for at least 3 months,\n* Ability to read and understand French,\n* Affiliation with a social security system or equivalent.\n\nExclusion Criteria:\n\n* Patient having already participated in an educational program or received multidisciplinary follow-up (involving at least 3 different healthcare professionals simultaneously within the same facility) in the past 12 months,\n* Patient in an emergency situation, or under legal protection measures (guardianship, curatorship, or judicial protection) and unable to give consent,\n* For patients at the experimental center only: inability to comply with study follow-up due to geographical, social, or psychological reasons.","FEMALE",{"count":52,"type":21},[24],"Background:\n\nEndometriosis is a chronic gynecological condition characterized by the ectopic presence of endometrial tissue outside the uterine cavity. It affects approximately 2 to 10% of women of reproductive age and up to 50% of women with chronic pelvic pain. In France, between 1.5 and 2.5 million women are estimated to be affected. Endometriosis significantly impairs quality of life, with consequences on cognitive, behavioral, sexual, and emotional well-being, and has substantial socio-economic impact.\n\nRationale:\n\nCurrent medical and surgical treatments primarily aim to reduce pain and preserve fertility but show limited effectiveness and are often discontinued due to adverse effects. Many women resort to self-management strategies, which may pose risks if not properly supervised. A multidisciplinary and integrative approach is essential to address the complex and multifactorial symptoms of endometriosis. Therapeutic patient education (TPE) is a recommended strategy that can empower patients in the management of chronic conditions, yet remains underdeveloped in endometriosis care pathways.\n\nObjective:\n\nThis study aims to evaluate the effectiveness of a multidisciplinary educational program combined with nurse-led telephone follow-up on the quality of life of patients with endometriosis.\n\nMethods:\n\nThe intervention will consist of a series of workshops led by various healthcare professionals (medical and paramedical), alongside regular nurse-led telephone follow-up. This approach intends to provide continuous support, assess patients' evolving needs, and facilitate access to supportive care services, particularly within regional endometriosis networks (ENDAURA and ENDOSUD).\n\nExpected Outcomes:\n\nThe study will assess whether this intervention improves quality of life among women with endometriosis. It also aims to provide evidence for the scalability and transferability of such a program at a national level, in alignment with current public health priorities.",[113],"Endometriosis",[113,115,116,117],"Quality of life","Multidisciplinary","Nurse follow-up","2025-12-19",{"date":120,"type":33},"2025-12-22",{"date":122,"type":33},"2025-12-17",{"date":124,"type":21},"2029-01-01",{"name":39,"class":40},2,{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":108,"minAge":49,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":74},"100610863","energy-expenditure-and-neuromuscular-function-in-young-adult-women-with-a-naturally-thin-build-leanergy-100610863","NCT07233109","Energy Expenditure and Neuromuscular Function in Young Adult Women With a Naturally Thin Build (LeanErgy)","LeanErgy","Inclusion Criteria:\n\n* BMI ≤ 17.5 kg\u002Fm2\n* 20 kg\u002Fm2 ≤ BMI ≤ 25 kg\u002Fm2\n\nExclusion Criteria:\n\n* For women with Constitutional thinness :\n\n  * Women under guardianship or deprived of their liberty by judicial or administrative decision\n  * Women who are pregnant, breastfeeding, or likely to become pregnant\n  * Women who engage in intense physical activity (more than 3 sessions of physical activity per week)\n  * Abnormal levels of IGF-1, estradiol, free T3, cortisol, and leptin\n  * For the MC group specifically: cases of thinness due to a suspected organic cause. This includes Marfan syndrome, identifiable by: personal or family history of degenerative aortic disease (aneurysm, dissection), ligamentous hyperlaxity, arachnodactyly\n  * History or presence of a systemic condition likely to interfere with the physiological and metabolic parameters measured (e.g., diabetes, endocrine or metabolic disease)\n  * Any acute or chronic disease that may influence the results (e.g., infections, tumors, inflammatory diseases)\n  * Medical or surgical history deemed by the investigator to be incompatible with this study (e.g., muscular, neurological, or joint disorders, or contraindications to the application of a magnetic field, etc.) Presence of diabetes, and any other condition limiting the application of either strategy under trial\n  * Use of medications that may interfere with the study results\n  * Cardiovascular conditions (history of cardiovascular and\u002For neurovascular disease, as well as the presence of cardiovascular and\u002For neurovascular risk factors other than obesity\u002Foverweight, such as: high blood pressure, high cholesterol, diabetes, heart rhythm disorder, known carotid atherosclerosis, thrombophilia)\n  * Surgery within the previous 3 months\n  * Women excluded from another study\n  * Regular tobacco or alcohol consumption\n  * Specific diets likely to impact metabolism, influence biological parameters (FT3, cortisol in particular) or skew results (deficiencies, low calorie intake). This includes vegan, mono, ketogenic, and low-calorie diets, intermittent fasting, or diets requiring specific supplementation that may interfere with the endocrine system.\n\nFor women Normal-Weighted Women\n\n* Women under guardianship or deprived of their liberty by judicial or administrative decision\n* Women who are pregnant, breastfeeding, or likely to become pregnant.\n* Women who engage in intense physical activity (more than 3 sessions of physical activity per week)\n* History or presence of a systemic condition likely to interfere with the physiological and metabolic parameters measured (e.g., diabetes, endocrine or metabolic disorders)\n* Any acute or chronic disease that may influence the results (e.g., infections, tumors, inflammatory diseases)\n* Medical or surgical history deemed by the investigator to be incompatible with this study (e.g., muscular, neurological, or joint disorders, or contraindications to the application of a magnetic field, etc.)\n* Presence of diabetes or any other condition limiting the application of either strategy under investigation\n* Taking medications that may interfere with the study results\n* Cardiovascular conditions (history of cardiovascular and\u002For neurovascular disease, as well as the presence of cardiovascular and\u002For neurovascular risk factors other than obesity\u002Foverweight, such as: high blood pressure, high cholesterol, diabetes, heart rhythm disorder, known carotid atherosclerosis, thrombophilia)\n* Surgery within the previous 3 months\n* Women excluded from another study\n* Regular tobacco or alcohol consumption\n* Specific diets likely to impact metabolism, influence biological parameters, or skew results (deficiencies, low calorie intake). This includes vegan, mono, ketogenic, and low-calorie diets, intermittent fasting, or diets requiring specific supplementation that may interfere with the endocrine system.","35 Years",{"count":136,"type":21},36,[24],"People with a low BMI (\\\u003C17.5) are most often considered to have anorexia nervosa (AN). However, recent literature suggests that there is a category of individuals with the same low BMI who do not meet the diagnostic criteria for anorexia nervosa but who have specific differences that make them a separate entity: constitutional thinness (CM). Constitutional thinness differs from anorexia nervosa in several ways. First, unlike AN, CM individuals do not have eating disorders and express a strong desire to gain weight. Another difference concerns the menstrual cycle: without oral contraception, AN individuals experience amenorrhea, while CM individuals have regular menstrual cycles. Biological signs of malnutrition are also present in anorexia nervosa, whereas this is not the case in constitutional thinness. Indeed, concentrations of IGF1, free T3, and leptin are significantly reduced in AN compared to healthy subjects, whereas there is no significant difference between healthy subjects and CT. Finally, in terms of body composition, there is a significant difference in particular in the percentage of fat mass between MC and AM subjects, with the MC group having a significantly lower percentage of fat mass than the control subjects but significantly higher than the AM subjects. The clinical management of MC patients could involve nutritional management of patients but also management in the form of an Adapted Physical Activity intervention program. However, this type of program using physical activity and a nutritional approach must be based on a characterization of the energy profile and physical abilities of MC patients, which remains to be studied. Germain et al. proposed measuring the physical activity level of MC patients using Actiheart (a combination of heart rate and accelerometer) and compared it with that of normal-weight (NW) individuals, finding no difference between the groups. However, this analysis remains a secondary analysis of their study, as the statistical power and choice of tool are certainly not appropriate for this question. Our team recently conducted the Nutrilean project, which for the first time questioned the aerobic and muscular capacities of women with CM compared to their NP counterparts. While our results show lower force production capacity in CM patients, suggesting neuromuscular adaptations to the chronic mechanical unloading caused by CM rather than an impairment of contractile abilities themselves, this remains to be explored more specifically. Indeed, these differences disappeared after normalization to body weight or muscle mass, suggesting a reduced gross force production capacity, but probably reflecting a normal physiological adaptation to low body and muscle mass. It now appears necessary to carry out more specific neuromuscular analyses in order to better understand the mechanisms, adaptations, and\u002For potential neuromuscular dysfunctions in this population. Similarly, while the results do not appear to show any impairment in the aerobic capacity of CM, they do highlight a potential impairment in their energy efficiency during locomotion, which may also reflect an adaptation to chronic exposure to lower mechanical loads.\n\nIn this context and following on from the work carried out to date by our team, the main objective of this study is i) to compare the lipid oxidation capacity and energy cost of walking between MC and NP participants; ii) to explore the adaptations of this energy cost in MC women in response to mechanical overload.",[140],"Constitutional Thinness","2025-11-14",{"date":143,"type":33},"2025-11-18",{"date":145,"type":21},"2025-12-15",{"date":147,"type":21},"2028-02-15",{"name":39,"class":40},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":16,"minAge":156,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":4},"100604917","effect-of-simulated-weight-loss-on-the-energy-cost-of-locomotion-in-overweight-or-obese-adolescents-100604917","NCT07155746","Effect of Simulated Weight Loss on the Energy Cost of Locomotion in Overweight or Obese Adolescents","DELOAD","Inclusion Criteria:\n\n* Adolescents aged 12 to 16 (inclusive), at Tanner stage 3-5, with obesity defined as a body mass index (BMI) above the 97th percentile according to national growth charts.\n* No regular consumption of tobacco or alcohol,\n* No diet (no calorie restriction, no specific diet such as a normal-calorie diet enriched with protein, vegetarian, or other),\n* Adolescents affiliated with the social security system or equivalent,\n* Adolescent who has been informed and has given written consent to participate in the study,\n* Signed consent of both holders of parental authority (or one in the event of death, major incapacity, or withdrawal of parental authority).\n\nExclusion Criteria:\n\n* Refusal to participate in the study,\n* Refusal of consent by parents or guardians,\n* Participation in regular and intense physical and sporting activities (no more than 150 minutes of moderate structured activity per week (according to WHO recommendations),\n* Medical or surgical history deemed by the investigator to be incompatible with the study,\n* Presence of diabetes or any other condition limiting the application of either strategy being tested,\n* Adolescents undergoing energy restriction or a weight loss program through physical activity at the time of inclusion or during the previous 6 months,\n* Taking medications that may interfere with the study results.\n* Adolescents with cardiovascular problems, i.e., subjects with a history of cardiovascular and\u002For neurovascular disease, as well as subjects with cardiovascular and\u002For neurovascular risk factors (excluding obesity\u002Foverweight).\n* Surgery in the previous 3 months,\n* Adolescents who are currently excluded from another study,\n* Pregnant or breastfeeding adolescents,\n* Adolescents under guardianship\u002Fcuratorship or legal protection,\n* Parents under guardianship\u002Fcuratorship or legal protection.","12 Years","16 Years",{"count":159,"type":21},20,[24],"Current literature suggests that part of the energy response to weight loss is not due to changes in fat mass and lean mass, but rather to a homeostatic adaptation aimed at limiting or even preventing weight loss and preserving individuals' energy reserves, an adaptation known as \"adaptive thermogenesis\". This phenomenon calls for a closer look at the respective contributions of metabolic and mechanical changes induced by weight variations, with greater consideration given to the recently proposed hypothesis of dual regulation of homeostatic energy balance involving both leptin-dependent and \"gravitostatic\" pathways . While leptin-dependent regulation of body weight has been described and reinforced several times since the 1950s, the gravitostatic conception of this regulation is more recent and hypothesizes that terrestrial animals use gravity to regulate their body weight through receptors and pathways that have not yet been identified. This regulation would involve adaptations in energy consumption based on body weight when working against gravity, involving weight detection by osteocytes in weight-bearing bones, and leading to feedback regulation of energy metabolism and body weight . Preclinical and clinical studies conducted on rodents and human participants have shown a reduction in body weight after several weeks of mechanical overload (simulating weight gain), explained by adaptations in their food intake and energy metabolism , adaptations suggested to be particularly due to the regulation of muscle mass. Interestingly, preliminary results from this group highlight specific post-weight loss energy adaptations to such simulated weight regain in adolescents with obesity, suggesting the establishment of specific mechanisms promoting weight regain. Indeed, after weight loss, energy metabolism during locomotion was explored with and without simulated weight regain, and interestingly, energy expenditure did not return to pre-weight loss values, as a potential means of preserving weight regain. More recently, the investigators team has been able to show that such mechanical simulation of weight gain in adolescents with obesity but stable weight does not lead to an increase in their energy expenditure during locomotion, further reinforcing a susceptibility to not activating energy defense mechanisms against this weight gain.Overall, these results suggest the presence of mechanisms for preserving body mass by conserving energy stores as a compensatory defense system against weight loss, while highlighting the absence of activation of these mechanisms in the context of simulated weight gain. Indeed, while the compensatory mechanisms implicated in response to weight fluctuations have thus far been nutritional in nature, these energy adaptations, if confirmed, would suggest an upstream activation mechanism, particularly as a tonic signal for homeostatic control.\n\nIt seems necessary to study in greater depth the energy adaptations to weight variations in young people with obesity, both metabolic and mechanical, in order to better understand the control of their energy balance and the mechanisms involved, which corresponds to the objectives of this project.\n\nThe objective of this project is therefore to study energy adaptations (energy cost and use of energy substrates) to simulated weight loss during incremental walking exercise. Adolescents with obesity will perform a walking exercise on an AlterG (anti-gravity) treadmill, first without and then with a simulated weight loss that places them in the overweight or normal weight category.",[163],"Obesity and Overweight","2025-09-15",{"date":166,"type":33},"2025-09-19",{"date":168,"type":21},"2025-09-12",{"date":170,"type":21},"2027-05-31",{"name":39,"class":40},{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":16,"minAge":179,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":22,"phases":182,"briefSummary":183,"conditions":184,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":126},"100500649","dance-workshop-for-institutionalized-seniors-with-behavioral-and-psychological-symptoms-of-dementia-100500649","NCT05799001","Dance Workshop for Institutionalized Seniors With Behavioral and Psychological Symptoms of Dementia","APAISE","Inclusion Criteria:\n\n1. Institutionalized patient (male or female) over 65 years of age ;\n2. Patient with behavioral problems, as measured by an NPI-ES ≥ 4 on any item and an NPI-ES impact scale ≥ 3 ;\n3. Patient able to mobilize the upper body at a minimum (arms, trunk, head);\n4. Medication (antipsychotics, antidepressants, anxiolytics and related hypnotics) without major modification for at least 30 days prior to inclusion after medical advice;\n5. Possibility of including patients under guardianship or curatorship;\n6. Patient affiliated to a social security plan;\n7. Obtaining consent from the patient or legal representative.\n\n   Exclusion Criteria:\n8. Inability of the patient to follow the sessions (e.g., major visual\u002Fauditory disabilities), difficult follow-up, or any other reason at the discretion of the investigator;\n9. Inability of the health care team to complete the NPI-ES questionnaire for the patient;\n10. Patient has a concurrent psychiatric disorder (e.g., bipolar disorder, schizophrenia, or other).","65 Years",{"count":181,"type":21},180,[24],"It is estimated that the prevalence of dementia in France is 5% for people over 65 years of age and that this increases to 18% for people over 75 years of age. Behavioral disorders are frequent in patients with dementia and are the main cause of institutionalization, representing up to 50% of cases. Dementia syndromes can be translated into behavioral and psychological symptoms of dementia (BPSD), which are defined as perceptual, mood or behavioral disorders. To date, there is no cure for dementia, but certain measures can be taken to reduce symptoms. The HAS suggests that physical exercise would reduce BPSD and could improve the ability to perform activities of daily living or slow down the cognitive decline of this type of patient. Indeed, several articles have highlighted the benefits of physical activity in demented patients. A meta-analysis has shown a significant decrease in BPSD via the Neuropsychiatric Inventory (NPI) score. Nevertheless, it is often observed that there is a difficulty in adhering to the program in very elderly population groups. Dance is a complete physical activity that integrates physical, cognitive and social elements. A meta-analysis has shown that dance has a significant effect on global cognition but also on neuroplasticity and physical functioning in patients with mental disorders. The music component of dance also has an effect on the behavioral problems of demented patients, stimulating language ability and social and emotional function.\n\nHowever, at present, no study of good methodological quality has been able to demonstrate the effectiveness of dance-based physical activity for the treatment of dementia symptoms. As a result of these findings, the APAISE project was developed and should help slow the onset of BPSD in patients with dementia.",[185],"Dementia","2025-08-06",{"date":188,"type":33},"2025-08-07",{"date":190,"type":33},"2023-03-08",{"date":192,"type":21},"2026-07-31",{"name":39,"class":40},{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":179,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":204,"briefSummary":205,"conditions":206,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":216},"100592670","evaluation-of-a-foot-health-program-incorporating-minimalist-footwear-on-fall-risk-factors-in-older-people-living-in-senior-nursing-homes-a-pilot-study-100592670","NCT06996444","Evaluation of a Foot Health Program Incorporating Minimalist Footwear on Fall Risk Factors in Older People Living in Senior Nursing Homes: a Pilot Study.","Évaluation d'un Programme de santé du Pied Incorporant Des Chaussures Minimalistes Sur Les Facteurs de Risque de Chute Chez Des Personnes âgées Vivant en EHPAD : Une étude Pilote","GRAND'PAS","Inclusion Criteria:\n\n* People over 65 years of age\n* Able to walk independently with or without a walking aid (cane, walker, etc.)\n* Persons affiliated with a social security system or assimilated\n* Persons (participants, guardians, or curators where applicable) who have been informed and have given their written consent to participate in the study.\n\nExclusion Criteria:\n\n* People who already wear minimalist shoes.\n* People with a contraindication to wearing minimalist shoes\n* People wearing orthopedic shoes prescribed by a health professional.\n* People taking part in a falls prevention program.\n* Persons unable to walk\n* Persons with any other contraindication at the investigator's discretion",{"count":203,"type":21},50,[24],"Every year in France, 2 million falls by people over 65 are responsible for 10,000 deaths, the leading cause of accidental death, and more than 130,000 hospitalizations.\n\nThe main objective of this study is to evaluate the evolution of mobility in older people living in nursing homes, following 12 foot health workshops, carried out by a health professional, including the wearing of minimalist shoes.",[207],"Fall Prevention","2025-07-30",{"date":210,"type":33},"2025-08-03",{"date":212,"type":33},"2025-04-07",{"date":214,"type":21},"2026-07-01",{"name":39,"class":40},5,{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":225,"enrollmentInfo":226,"targetDuration":4,"studyType":22,"phases":228,"briefSummary":229,"conditions":230,"keywords":232,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":243},"100570522","impact-of-bevel-orientation-on-arteriovenous-fistula-puncture-in-hemodialysis-100570522","NCT06708338","Impact of Bevel Orientation on Arteriovenous Fistula Puncture in Hemodialysis","Impact of Bevel Orientation on Arteriovenous Fistula Puncture in Hemodialysis: A Multicenter Randomized Comparative Study","FAVORI","Inclusion Criteria:\n\n* male or female with Chronic Kidney Disease\n* patient requiring 4-hour hemodialysis sessions, 3 times per week, in a dialysis center\n* Native arteriovenous fistula (AVF) (without prosthesis), mature, with no prior puncture, located in the upper limb\n* First fistula for a hemodialysis patient\n* Expected duration of dialysis ≥ 1 year\n* Double-needle dialysis\n* Hemodialysis possible on AVF\n* Average AVF flow rate between 500 and 2,000 mL\u002Fmin\n* Affiliated with a social security scheme\n* Free and informed consent\n\nExclusion Criteria:\n\n* Auto-dialysis at home\n* Puncture using the buttonhole technique\n* Patient requiring AVF puncture with a catheter\n* Planned transplant within the next 12 months\n* Previous AVF creation, except for the fistula of interest\n* Patient with a history of cancer within the past 5 years or active cancer\n* Patient under court protection or guardianship\n* Pregnant and breast-feeding women\n* Patient with psychiatric pathologies or cognitive disorders\n* Patient follow-up difficult or impossible for geographical or other reasons, at the investigator's discretion","85 Years",{"count":227,"type":21},240,[24],"End-stage renal disease (ESRD) is a condition in which the filtration function of the kidneys has deteriorated, necessitating dialysis or transplantation. With an aging population, the number of patients undergoing dialysis for CKD is constantly increasing.\n\nThere are different types of dialysis treatment: hemodialysis and peritoneal dialysis.\n\nHemodialysis involves exchanges between blood and a dialysate (a liquid used to purify blood) via a dialyzer (artificial filter), coordinated by a generator. This method requires a vascular approach, of which there are 3 types: the arteriovenous fistula (AVF), the arteriovenous graft and the central venous catheter.\n\nThe AVF remains the vascular access of choice for hemodialysis sessions, and its preservation is an essential objective for patients with CKD.\n\nOne of the major challenges for AVFs is to achieve a successful puncture, an act performed around 310 times a year per patient, for dialysis performed three times a week with double needles. This repeated procedure can cause damage to the AVF, leading to complications such as stenosis, thrombosis, aneurysm, superficial infection, hematoma, bleeding, parietal rupture or dissection.\n\nHowever, there is no official recommendation on the most conservative puncture technique for AVF. In view of the number of patients concerned and the recurrence of puncture, it would seem essential to evaluate the impact of bevel orientation on the occurrence of complications during dialysis by means of a randomized prospective study.",[231],"End-Stage Renal Disease Requiring Haemodialysis",[233,234,235],"arteriovenous fistula","puncture technique","vascular approach",{"date":237,"type":33},"2025-07-31",{"date":239,"type":21},"2025-12-01",{"date":241,"type":21},"2029-06-30",{"name":39,"class":40},4,{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":108,"minAge":49,"maxAge":252,"enrollmentInfo":253,"targetDuration":4,"studyType":22,"phases":255,"briefSummary":256,"conditions":257,"keywords":259,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":265,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":271},"100423455","therapeutic-education-and-nursing-support-program-for-supportive-care-in-patients-treated-with-hormone-therapy-for-non-metastatic-breast-cancer-100423455","NCT04794075","Therapeutic Education and Nursing Support Program for Supportive Care, in Patients Treated With Hormone Therapy for Non-metastatic Breast Cancer","Programme d'Éducation Thérapeutique et d'Accompagnement Infirmier Vers Les Soins de Support, Chez Les Patientes Sous Hormonothérapie Pour un Cancer du Sein Non métastatique","ETAPH","Inclusion Criteria:\n\n* Female patients aged 18 to 75 years inclusive\n* Patients with non-metastatic breast cancer for whom adjuvant hormone therapy (anti-oestrogen or anti-aromatase) is indicated, depending on the decision of the multidisciplinary consultation meeting.\n* Performance status (ECOG) ≤ 2\n* Patient able to read and understand French (common use)\n* Patient with access to an internet connection (for collection of adverse events and responses to questionnaires on the electronic platform)\n* Patient who has been informed and has given written consent to participate in the study\n* Patient affiliated to the French social security system or equivalent\n\nExclusion Criteria:\n\n* Patient with metastatic cancer (stage IV)\n* Patient undergoing neoadjuvant hormone therapy\n* Patient who started hormone therapy prior to inclusion in the study\n* Patient with a history of other cancer treated by radiotherapy, chemotherapy or hormone therapy, with an end of treatment less than 2 years ago.\n* For patients in the experimental group: Inability of the patient to travel to the hospital to attend the initial assessment day and the proposed group outpatient workshops; follow-up of the program difficult for geographical, physical or other reasons (at the discretion of the investigator).\n* For patients in the control group: patients for whom telephone nursing follow-up is planned for 2 months or more or more than 4 sessions of therapeutic education.\n* Pregnant and breastfeeding women\n* Patient with a documented history of cognitive or psychiatric disorders\n* Refusal to participate, protected adult patient, under guardianship or curatorship","75 Years",{"count":254,"type":21},300,[24],"To compare the efficacy of the addition of a therapeutic education program combined with nursing phone follow-up, compared to conventional management alone, on the management of adverse events (AEs) related to adjuvant hormone therapy during the first year of treatment in patients with non-metastatic breast cancer.",[258],"Neoplasm of Breast",[260,261,262,263,264],"Therapeutic Education","Nursing Support Program","Hormone Therapy","Non-metastatic Breast Cancer","Breast Cancer",{"date":210,"type":33},{"date":267,"type":33},"2021-08-09",{"date":269,"type":21},"2027-08",{"name":39,"class":40},9,{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":22,"phases":282,"briefSummary":283,"conditions":284,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":74},"100520116","optimization-of-the-care-pathway-for-patients-with-chronic-pain-assessing-the-value-of-integrating-sleep-specialists-100520116","NCT06052384","Optimization of the Care Pathway for Patients With Chronic Pain: Assessing the Value of Integrating Sleep Specialists","Optimisation du Parcours de Soins Des Patients Atteints de Douleurs Chroniques : étude randomisée évaluant l'intérêt de l'intégration Des spécialistes du Sommeil","DOLOREPIT","Inclusion Criteria:\n\n* First consultation at the pain management center\n* Patient with chronic pain as defined by the \"Haute Autorité de Santé\". The pain must have several of the following characteristics:\n\n  * Persistence or recurrence\n  * Duration beyond what is usual for the presumed initial cause, especially if the pain has been evolving for more than 3 months;\n  * Inadequate response to treatment;\n  * Important and progressive deterioration of the patient's functional and interpersonal abilities in activities of daily living at home, school, or work due to the pain.\n* Patients with chronic primary pain (according to the typology defined by the International Classification of Diseases-11) and classified into one of the 4 following categories:\n\n  * Chronic generalized pain\n  * Complex regional pain syndrome\n  * Chronic primary headache or orofacial pain\n  * Chronic primary musculoskeletal pain\n* Pittsburgh Sleep Quality Index (PSQI) must be completed by the patient and the score must be available (for randomization purposes)\n* Have access to an internet connection as a self-administered questionnaire is to complete online, and at least have access to the online platform for CBT treatment if insomnia is detected\n* Affiliation to a French social security system\n* Free informed consent\n\nExclusion Criteria:\n\n* Patients undergoing cancer treatment or who have completed treatment within the last 2 years\n* Patient with a chronic inflammatory disease (e.g. rheumatoid arthritis, ankylosing spondylitis, chronic inflammatory bowel disease, Horton's disease, Wegener's disease, myositis, Still's disease, lupus erythematosus, etc.)\n* Immunocompromised patient\n* Patient with severe psychiatric pathology that does not allow study follow-up (at the discretion of the investigator)\n* Patient already treated for a sleep disorder by a sleep specialist (the only prescription of hypnotics is not considered as a criterion of non-inclusion)\n* Patient follow-up difficult (for geographic motives or other reasons)\n* Patient under judicial protection of incapable adults or guardianship\n* Refusal to participate in the research",{"count":281,"type":21},664,[24],"DOLOREPIT is an interventional, RIPH 2, multicenter, randomized, controlled, open-label study comparing two care pathways for the management of patients with chronic pain.",[285],"Chronic Pain","2025-07-28",{"date":208,"type":33},{"date":289,"type":33},"2023-12-07",{"date":291,"type":21},"2027-06",{"name":39,"class":40},{"id":294,"slug":295,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":299,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":301,"conditions":302,"keywords":304,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":74},"100569347","impact-of-general-practice-follow-up-on-emergency-hospitalization-of-patients-admitted-for-chest-pain-100569347","NCT06693063","Impact of General Practice Follow-up on Emergency Hospitalization of Patients Admitted for Chest Pain","Inclusion Criteria:\n\n* Patient admitted to Emile Roux hospital emergency department with chest pain\n* Patient affiliated to the Social security system\n* Patient able to give informed non-opposition to participating in research\n\nExclusion Criteria:\n\n* Patient under guardianship, curatorship, safeguard of justice or prisoners\n* Patient with cognitive disorders\n* Pregnant or breast-feeding women\n* Refusal to participate",{"count":300,"type":21},100,"This is a prospective observational study carried out in the emergency department of Emile Roux Hospital. Its aim is to compare the medical, psychological and social characteristics of patients followed up by a general practitioner and those without regular follow-up, using an anonymous questionnaire completed by the general practitioner in the emergency department, for patients consulting for the reason \"chest pain\".",[303],"Chest Pain",[305,306],"emergency admission","general practitioner","2024-11-15",{"date":309,"type":33},"2024-11-18",{"date":311,"type":33},"2024-10-14",{"date":313,"type":21},"2025-07",{"name":39,"class":40},""]