[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Centre Hospitalier Henri Laborit\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":391},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,44,74,99,121,142,166,185,205,228,248,269,289,309,329,350,370],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100625966","tdcs-and-symptom-provocation-in-treatment-resistant-ocd-100625966",false,"NCT07429500","tDCS and Symptom Provocation in Treatment-Resistant OCD","Transcranial Direct Current Stimulation Associated With Symptom Provocation in the Management of Patients With Treatment-Resistant Obsessive-Compulsive Disorder.","PPS-TDCSTOC","Inclusion Criteria:\n\n* Diagnosis of Obsessive-Compulsive Disorder (OCD) according to DSM-5, with a duration ≥ 2 years.\n* Good insight, defined as a BABS score ≤ 18.\n* Chronic OCD, with either a Y-BOCS total score \\> 20 or a subscale score \\> 15.\n* Treatment-resistant OCD, defined as:\n\n  * failure of ≥ two adequate trials of SSRIs, or\n  * failure of one SSRI plus augmentation with an atypical antipsychotic,\n* and\u002For insufficient response after ≥ one year of cognitive-behavioural therapy.\n* Stable pharmacological treatment (fixed antidepressant dose) for at least 12 weeks prior to inclusion, with no significant improvement during this period.\n* Age 18 to 70 years.\n* Ability to provide informed written consent.\n* Affiliation with the French social security system.\n\nExclusion Criteria:\n\n* Women of childbearing potential without effective contraception, or those unwilling to maintain abstinence or contraception.\n* Pregnancy or breastfeeding.\n* Compulsory psychiatric hospitalisation.\n* Legal guardianship or curatorship.\n* Current DSM-5 Axis I disorder other than OCD (schizophrenia spectrum, bipolar disorder, substance use).\n* Current major depressive episode (MADRS \\> 21).\n* Suicide risk (MADRS item 10 \\> 3).\n* Dermatological lesions at electrode placement sites.\n* History of traumatic brain injury.\n* Presence of intracranial metal, pacemaker, or epilepsy.\n* Emergency situations or inability to provide informed consent.","ALL","18 Years","70 Years",{"count":21,"type":22},178,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if symptom provocation before transcranial Direct Current Stimulation (tDCS) in Obsessive-Compulsive Disorder (OCD) patients. The main question it aims to answer is:\n\nCan symptom-provocation before tDCS improve therapeutic response in OCD patients ?\n\nResearchers will compare the clinical outcomes of OCD patients having received, in one arm, tDCS and, in the other arm, patients having received tDCS preceded by symptom provocation to see if therapeutic response and various other clinical variables differ.",[28],"Obsessive - Compulsive Disorder",[30],"tDCS","NOT_YET_RECRUITING","2026-02-17",{"date":34,"type":35},"2026-02-24","ACTUAL",{"date":37,"type":22},"2026-04-01",{"date":39,"type":22},"2029-10-15",{"name":41,"class":42},"Centre Hospitalier Henri Laborit","OTHER",6,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},"100621790","reducing-mental-health-stigmatization-among-healthcare-workers-and-students-using-a-virtual-reality-protocol-the-virtus-protocol-100621790","NCT07375199","Reducing Mental Health Stigmatization Among Healthcare Workers and Students Using a Virtual Reality Protocol: The VIRTUS Protocol","Reducing Mental Health Stigmatization Among Healthcare Workers and Students Using a Virtual Reality Protocol: The VIRTUS Protocol, a Randomized Controlled Trial","VIRTUS","Inclusion Criteria:\n\n* aged between 18 and 65\n* currently employed as a healthcare professional or enrolled as a advanced-grade student in medicine, nursing, or psychology\n* no history of psychiatric or addictive disorders (except for tobacco dependence)\n* covered by French social security\n* able to provide informed written consent after receiving appropriate information.\n\nExclusion Criteria:\n\n* current or past psychiatric or addictive disorder (except tobacco dependence)\n* use of antipsychotic medication; first-degree family history of schizophrenia; cognitive impairment\n* susceptibility to cybersickness\n* recent (\\\u003C1 year) or acute neurological disorders\n* history of epilepsy\n* known otorhinolaryngologic conditions causing vertigo, nausea or vomiting\n* pregnancy or breastfeeding\n* legal protection measures\n* any condition, in the investigator's opinion that would prevent valid questionnaire completion.",true,"65 Years",{"count":55,"type":22},128,[25],"Schizophrenia is a chronic psychiatric disorder, frequently associated with stigma, including within healthcare settings, that significantly impairs quality of life and symptoms. Virtual Reality (VR), as an immersive tool, may allow healthy individuals to experience the first-person perspective of a patient undergoing psychotic symptoms. VR exposure may facilitate perspective-taking, fosters empathy, and studies suggest VR could be a valuable tool to reduce stigma. However, the findings remain incomplete, with considerable variation between protocols and no data on implicit stigma. This study is designed to evaluate the effectiveness of a VR protocol simulating psychotic symptoms on explicit and implicit stigma.\n\nMethods and Analysis A randomized controlled trial involving 128 participants will be conducted. Participants will include healthcare workers and students (medicine, nursing, or psychology) recruited from CH Henri Laborit in Poitiers (France), Poitiers University Hospital, CH Nord-Deux-Sèvres in Thouars (France), and the University of Poitiers. Recruitment will take place over a two-year period. Participants will be randomly assigned to either the intervention group or the control group.\n\nThe protocol involves two short VR scenarios. In the intervention condition only, both scenarios will simulate auditory and visual hallucinations and persecutory delusions, to immerse participants in the experience of someone living with schizophrenia. Stigma will be assessed before the VR intervention, immediately afterward, and at one-month follow-up. Assessment will be conducted using self-report scales (Attribution Questionnaire-27 items by Corrigan et al., 2003 (AQ-27), Community Attitudes toward the Mentally Ill, Taylor \\& Dear 1981 (CAMI) and Reported and Intended Behavior Scale by Evans-Lacko et al., 2011 (RIBS) for explicit stigma, and a behavioural test (Implicit Association Task, Greenwald, McGhee et Schwartz en 1998 (IAT)) for the implicit stigma.\n\nThe primary outcome is the reduction in stigma toward individuals with schizophrenia, assessed with the AQ-27 scale, from baseline to the one-month follow-up, comparing the intervention and control groups. The expected result is a greater reduction in stigma in the intervention group compared to the control group. Secondary outcomes include a one-month reduction in implicit associations, immediate post-intervention effects on stigma, changes in self-reported prejudice and discrimination over time.\n\nEthics and Dissemination All participants receive both oral and written information and provided signed informed consent. The study is under review from the French Research Ethics Committee (reference number: 2025-A01472-47). Results will be disseminated through presentations, conferences, and publications in peer-reviewed scientific journals.",[59],"Schizophrenia Disorder",[61,62,63,64],"stigma","virtual reality","empathy","implicit associations","2026-01-21",{"date":67,"type":35},"2026-01-29",{"date":69,"type":22},"2026-03-01",{"date":71,"type":22},"2028-03",{"name":41,"class":42},1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":52,"sex":17,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":73},"100505766","evaluation-of-membrane-phospholipid-and-energy-metabolism-in-subjects-at-high-risk-of-psychotic-transition-100505766","NCT05865652","Evaluation of Membrane Phospholipid and Energy Metabolism in Subjects at High Risk of Psychotic Transition","Evaluation of Membrane Phospholipid Metabolism and Cellular Energy Metabolism in Subjects at High Risk of Psychotic Transition","MR7T-UHR","Inclusion Criteria for the UHR group:\n\n* Patient between 15 and 25 years old\n* Patient fulfilling the UHR criteria objectified by the Comprehensive Assessment of At Risk Mental State scale (CAARMS) and by the social and professional functioning assessment scale (SOFAS) (the \"Vulnerability\" group is also taken into account, combining first-degree history and functional impact.)\n* Patient with no contraindication to performing a 7T MRI examination\n* Affiliated patient or beneficiary of a social security scheme.\n* Free, informed consent, written and signed by the participant, the investigator and the legal representative if applicable (at the latest on the day of inclusion and before any examination required by the research).\n\nInclusion Criteria for the Control group:\n\n* Subjects aged 15 to 25 years old,\n* healthy volunteer subject or subject to benefit from an imaging examination, not presenting the criteria of a mental health disorder objectified by a medical interview\n* Subject with no contraindication to performing a 7T MRI examination\n* Affiliated subject or beneficiary of a social security scheme.\n* Free, informed and written consent signed by the participant, the investigator and the legal representative if applicable (at the latest on the day of inclusion and before any examination required by the research).\n\nExclusion Criteria for the UHR group:\n\n* Patient not at risk or already in a psychotic pathological process according to DSM-5 criteria.\n* Patient already receiving antipsychotic treatment or whose background treatment was changed less than a month ago.\n* Patient presenting an absolute contraindication to 7T MRI such as: foreign bodies (intracranial clips, vascular magnetic clips, cardiac or neural pacemakers, stents, coils, implantable chamber, intracorporeal metallic splinters, cochlear implants, intracorporeal metallic foreign bodies, mechanical heart valve, implanted injection pump, non-removable piercings), pregnant woman, allergy to contrast products, moderate to severe renal insufficiency, breastfeeding, implanted contraception, tinnitus, claustrophobia and braces.\n\nThe relative contraindications are to be considered, namely: previous surgical interventions, medically implanted device, tattoo or permanent make-up.\n\nExclusion criteria for the control group:\n\n\\- Subject presenting an absolute contraindication to 7T MRI such as: foreign bodies (intracranial clips, vascular magnetic clips, cardiac or neural pacemakers, stents, coils, implantable chamber, intracorporeal metallic fragments, cochlear implants, intracorporeal metallic foreign bodies, valve mechanical heart, implanted injection pump, non-removable piercings), pregnant woman, allergy to contrast products, moderate to severe renal insufficiency, breast-feeding, implanted contraception, tinnitus, claustrophobia and braces.\n\nThe relative contraindications are to be considered, namely: previous surgical interventions, medically implanted device, tattoo or permanent make-up.","15 Years","25 Years",{"count":85,"type":22},22,[25],"The management of schizophrenia is a major public health issue, due to its particularly disabling psychotic symptoms and their onset at an early age, typically in adolescents or young adults.\n\nThe physiopathological hypothesis of an anomaly relating to the renewal of cell membranes and energy metabolism in schizophrenia was proposed as early as the 1930s. This is based on anomalies at certain times in the development of the balance between phosphomonesters, precursors of membrane phospholipids, and phosphodiesters, catabolites of membrane phospholipids. Alterations of these different balances sign neurodevelopmental disorders, and can be objectified by specific techniques such as phosphorus-31 magnetic resonance spectroscopy (SMR-31P). This is used in particular to characterize the energy metabolism of the brain and allows in vivo quantification of phosphorus metabolites.\n\nThe application of SMR-31P techniques to assess the metabolism of membrane phospholipids and cellular energy metabolism in subjects at high risk of psychotic transition could make it possible to objectify a difference between subjects subsequently suffering from a psychotic transition compared to those who do not suffer from it. Alterations in the metabolism of membrane phospholipids could thus represent a biomarker of psychotic transition. Secondarily, this approach would make it possible to provide elements as to the validity as a diagnosis of this category, which is very heterogeneous in its future.\n\nAmong the Ultra High Risk (UHR) group, subjects with a psychotic transition (UHR-T) are compared to subjects without this transition (UHR-NT) during the two years of follow-up.\n\nThe UHR group is compared to the control group.\n\nAt T0, UHR patients and healthy volunteers will perform brain MRI with Phosphorus 31 magnetic resonance spectroscopy.\n\nUHR patients will then be reviewed:\n\n* at T+1 year for a clinical assessment medical interview to assess the patient's functioning and the appearance of symptoms;\n* at T+2 years for the realization of a follow-up interview with passing of the scales CAARMS (Comprehensive Assessment of At Risk Mental State) and SOFAS (scale of evaluation of the social and professional functioning) in order to determine if the subject belongs to the UHR-T or UHR-NT group.",[89],"Patients With Ultra High Risk of Psychotic Transition","RECRUITING","2026-01-12",{"date":93,"type":35},"2026-01-13",{"date":95,"type":35},"2023-05-02",{"date":97,"type":22},"2026-05",{"name":41,"class":42},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":107,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":110,"conditions":111,"keywords":113,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":115,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":73},"100504078","cerebral-and-cognitive-markers-of-treatment-resistance-in-obsessive-compulsive-disorder-100504078","NCT05843604","Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder","Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care","3TOC","Inclusion Criteria:\n\n* Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)\n* Understand and accept the constraints of the study\n* Be a beneficiary or affiliated to a Health Insurance scheme\n\nExclusion Criteria:\n\n* Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)\n* Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)\n* Have a serious intercurrent pathology\n* Being a pregnant woman\n* Being a woman of childbearing age without effective contraception.\n* Being hospitalized under duress or on an outpatient basis in a care program\n* Being under judicial protection (reinforced curatorship, guardianship)",{"count":108,"type":22},100,"OBSERVATIONAL","This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.",[112],"OCD",[114],"functional MRI",{"date":93,"type":35},{"date":117,"type":35},"2023-07-03",{"date":119,"type":22},"2027-09",{"name":41,"class":42},{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":52,"sex":128,"minAge":18,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":23,"phases":131,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":136,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":73},"100507329","detection-of-eating-disorders-in-pregnant-women-100507329","NCT05885971","Detection of Eating Disorders in Pregnant Women","PREGN'ED","Inclusion Criteria:\n\n* Adult pregnant woman\n* Woman with current diagnosed Eating Disorders or without Eating Disorders\n* Having a good command of the French language\n* Having given their consent for their participation in the research\n\nExclusion Criteria:\n\n* Underage pregnant woman\n* Woman who does not have a good command of the French language.\n* Woman with past Eating Disorders","FEMALE",{"count":130,"type":22},50,[25],"Eating disorders (ED) are insufficiently detected and belatedly or not treated during pregnancy.\n\nThere are many screening questionnaires for eating disorders in the literature, but we note the absence of a specific and validated tool for their screening during pregnancy, which would make it possible to differentiate maternal dietary concerns related to pregnancy from symptoms linked to a proven eating disorder.\n\nThe main objective of the study is to evaluate which items of the Sick Control One stone Fat Food (SCOFF-F) and Eating disorders examination questionnaire (EDE-Q) questionnaires could be specific to an ED during pregnancy and not related to the simple state of pregnancy, by comparing the answers of pregnant women, for whom the diagnosis of ED has been made, to those of pregnant women without an ED.",[134,135],"Eating Disorders","Pregnancy Related",{"date":93,"type":35},{"date":138,"type":35},"2023-06-30",{"date":140,"type":22},"2026-06",{"name":41,"class":42},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":159,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":165},"100498153","effects-of-mindfulness-meditation-in-virtual-reality-on-craving-and-smoking-cessation-100498153","NCT05766553","Effects of Mindfulness Meditation in Virtual Reality on Craving and Smoking Cessation","VIREAMIND","Inclusion Criteria:\n\n* Any patient consuming 10 to 40 cigarettes per day\n* Woman or man aged 18 to 75 inclusive\n* Substance use disorder according to the DSM5 classification\n* Benefit from social security or benefit from it through a third party in accordance with French law on research involving the human person\n* Having signed the informed consent form after having received written information.\n\nExclusion Criteria:\n\n* Disabling cognitive disorders\n* Patient under 18 or over 75 years old.\n* Patient with a psychological disorder or a psychiatric pathology requiring specialized follow-up\n* Patient with addiction to another product.\n* Cardiological pathologies that could compromise the participation of patients, detected by an ECG (only for patients who will be randomized in the experimental group).\n* Advanced pulmonary, renal, and hepatic diseases, or any unstable and serious medical conditions that could compromise the patient's participation in the study, subject to the judgment of the doctor\n* Pregnant or breastfeeding woman\n* Simultaneous participation in another trial\n* Employee of the investigator or of the clinical trial site\n* Patients protected by law\n* Patients who do not speak the French language\n* People not covered by state health insurance\n* Patients who in the opinion of the investigator are unable to complete the questionnaires\n* Patient claustrophobic or anxious about using the cabin\n* Patient allergic to a molecule present in nicotine substitutes","75 Years",{"count":151,"type":22},200,[25],"Investigators seek to propose a non-drug therapeutic alternative, namely a mindfulness meditation protocol based on virtual reality training in order to induce progressive modifications of various indicators of craving.\n\nThe study hypothesis is that the practice of mindfulness meditation in a virtual reality environment reduces the craving induced by cues and stress and therefore ultimately smoking relapse.\n\nThe main objective of the protocol will be to demonstrate that mindfulness meditation can reduce long-term relapse (continuous cessation (\\> 30 days) of smoking cessation).\n\nThe participants will be randomized into two groups: the experimental group will perform six virtual reality sessions in a multisensory cabin at the rate of one session per week; the control group will be prescribed the gold standard treatment (nicotine patches and chewing gum).\n\nParticipants will be seen again at three and six months to assess whether or not there has been a smoking relapse.",[155],"Tobacco Use Disorder",[157,158],"relapse","craving",{"date":93,"type":35},{"date":161,"type":35},"2023-06-15",{"date":163,"type":22},"2026-12-15",{"name":41,"class":42},3,{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":179,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":73},"100466114","interest-of-the-tool-evaluation-of-specific-care-in-an-ecological-environment-for-patients-suffering-from-schizophrenia-like-disorders-100466114","NCT05349513","Interest of the Tool: Evaluation of Specific Care in an Ecological Environment for Patients Suffering From Schizophrenia-like Disorders","IEvaEcoSchi","Inclusion Criteria:\n\n* man or woman aged 18 to 65 inclusive;\n* diagnosis of schizophrenia or schizoaffective disorder according to the Diagnostic and Statistical Manual of Mental Disorders version number 5 (DSM-V) criteria;\n* patient receiving care in a Center for Rehabilitation and Intersectoral Therapeutic Activities (CREATIV);\n* person who consented to the study;\n* affiliate or beneficiary of a social security scheme.\n\nExclusion Criteria:\n\n* patient aged under 18 or over 65;\n* pregnant or breastfeeding women;\n* person unable or unwilling to receive a home visit;\n* person not consenting to the study;\n* presence of a diagnosis of an associated neurodevelopmental disorder;\n* presence of a diagnosis of dementia or associated neurodegenerative process;\n* person with a level of French language insufficient to understand the items.",{"count":174,"type":22},56,[25],"The study use a new ecological questionnaire called ESSME developed by a care team in order to evaluate ecological environment of patients with schizophrenia-like disorders.\n\nIndeed, evaluation in an ecological environment would make it possible to be as close as possible to the concerns of theses patients, which could improve the care of this population, by making it possible to set with the patient objectives anchored in their daily life.",[178],"Patients With Schizophrenia-like Disorders",{"date":93,"type":35},{"date":181,"type":35},"2022-02-23",{"date":183,"type":22},"2026-02",{"name":41,"class":42},{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":199,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":73},"100432923","nursing-care-of-bipolar-patients-with-sleeping-disorders-using-luminotherapy-and-or-psychoeducation-program-biplumino-100432923","NCT04917419","Nursing Care of Bipolar Patients With Sleeping Disorders Using Luminotherapy and \u002For Psychoeducation Program (BIPLUMINO)","Prise en Charge infirmière Des Anomalies du Sommeil et du Rythme Circadien Par luminothérapie et\u002Fou un Programme Court de psychoéducation Chez Des Patients Souffrant de Troubles Bipolaires","BIPLUMINO","Main inclusion Criteria:\n\n* Bipolar disorder (type 1 and 2 according to DSM V)\n* Mood Disorder Questionnaire MDQ ˂ 7\n* Sleeping and Circadian Rhythms Disorders\n* Under treatment\n\nMain exclusion Criteria:\n\n* No addiction except for tobacco\n* Narcolepsy\n* Sleep Apnea\n* Psychiatric comorbidities\n* Suicidal ideation",{"count":194,"type":22},170,[25],"Bipolar disorder affects more than 1% of the population. This pathology is considered as one of the most serious psychiatric disorder because of it is high suicide rates. It impacts patients life quality on many aspects, and specially their sleeping and circadian Rhythms. This can lead to more severe symptoms up to for thymic relapses. It was shown that Luminotherapy and Psychoeducation Program have a positive impact on these type of symptoms.",[198],"Bipolar Disorder",{"date":93,"type":35},{"date":201,"type":35},"2022-12-05",{"date":203,"type":22},"2026-12",{"name":41,"class":42},{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":213,"targetDuration":4,"studyType":23,"phases":215,"briefSummary":216,"conditions":217,"keywords":219,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":222,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":226,"locationsCount":227},"100434198","bilateral-lateral-ofc-rtms-in-obsessive-compulsive-disorder-100434198","NCT04934007","Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder","A Randomized Control Trial of Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder","ORBITOC3","Inclusion Criteria:\n\n* Age: Participants will be both males and females, 18-65 years of age included.\n* diagnosis of OCD\n* all the patients must have failed to respond to at least two different pharmacological treatment used for at least 6 weeks\n* Affiliation to a social security system (recipient or assignee),\n* Signed written inform consent form\n\nExclusion Criteria:\n\n* The exclusion criteria are a diagnosis of another psychiatric disorder (except for anxious disorders), a diagnosis of a significant active medical illness, pregnancy or other neurological illness\n* In accordance with the safety criteria for rTMS, patients with a history of seizure or bearing pacemakers, mobile metal implants, implanted medical pumps, or metal clips placed inside the skull will also be excluded\n* The patients won't be allowed to change their medication during the trial. The treatment must be stable at least 3 week before day 0.\n* Female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing,\n* Patient under curators\n* Patient hospitalized under duress\n* Patient unable to give his or hers informed consent",{"count":214,"type":22},136,[25],"According to the literature the lateral part of the Orbito Frontal Cortex (lOFC) is a relevant bilateral target for repetitive Trans-cranial Magnetic Stimulation (rTMS) in Obsessive Compulsive Disorder (OCD). Both hemispheres are concerned in terms of target.",[218],"Obsessive-Compulsive Disorder",[220,221],"rTMS","D-B80 A\u002FP",{"date":93,"type":35},{"date":224,"type":35},"2021-09-06",{"date":119,"type":22},{"name":41,"class":42},2,{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":23,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":242,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":73},"100435883","effects-of-a-classic-high-frequency-rtms-treatment-versus-a-deep-rtms-treatment-100435883","NCT04956016","Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment","Open-label Randomized Comparative Study of the Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment in the Management of Resistant Depression","HAUVERDEEP","Inclusion Criteria:\n\n* Volunteer subjects over 18 years old\n* Having signed a free and informed consent\n* Having a diagnostic of caracterised depressive episod recurrent or isolated according to DSM IV criteria (A.P.A 1994).\n* Having an antidepressant treatment not modified since 3 weeks\n* Score to MADRS scale ≥ 21\n* Subject affiliated to a social security regimen\n\nExclusion Criteria:\n\n* Depression with psychotic caracteristics\n* Co-morbid diagnosis according to axis I (DSM IV) of schizophrenia, dependence (or abuse) on alcohol and \u002F or another substance (lifetime)\n* Patient who has already undergone seismotherapy for current episode and non-responder to this treatment\n* Patient hospitalized under duress or under legal protection (guardianship, curatorship)\n* Patient with a high risk of suicide (item 10 of MADRS \\> 4) in the absence of hospitalization.\n* Contra-indication for IRM exam or rTMS : personnal history of comitial crisis, of neurological or neurochirurgical pathologies, metallic prosthetic material or foreign body (pacemaker, intraoculare ferromagnetic material, implanted cardiac defibrillator, cochlear implant, metal clip\n* Pregnancy\n* Simultaneous participation to another interventionnal study",{"count":237,"type":22},152,[25],"The main objective is to demonstrate that dTMS is more efficient than high frequency rTMS with a conventional coil.\n\nThe patient will receive treatment arm A or B :\n\nArm A : classic rTMS treatment (use of the 8-shaped coil) and standard therapy Arm B: treatment with deep rTMS (use of the H-shaped coil (helmet)) and standard therapies.\n\n20 rTMS sessions are planned (5 sessions per week) and 3 follow-up visits : at Day 30, Day 60 and Day 90.",[241],"Depressive Disorder, Treatment-Resistant",{"date":93,"type":35},{"date":244,"type":35},"2021-08-23",{"date":246,"type":22},"2028-08",{"name":41,"class":42},{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":252,"acronym":253,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":255,"targetDuration":4,"studyType":23,"phases":257,"briefSummary":258,"conditions":259,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":73},"100614063","influence-of-control-deprivation-on-the-use-of-the-analytical-cognitive-style-in-anorexic-subjects-100614063","NCT07274722","Influence of Control Deprivation on the Use of the Analytical Cognitive Style in Anorexic Subjects","PriCo-SCASA","Inclusion Criteria:\n\n* Be undergoing treatment at Centre Hospitalier Laborit (CHL) or Centre Hospitalier Universitaire (CHU) de Poitiers for an Eating Disorder (ED) of the Anorexia Nervosa type.\n* Patients must meet the diagnostic criteria for Anorexia Nervosa according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5; American Psychiatric Association, APA, 2013), or present a sub-clinical symptomatology requiring treatment:\n\n(A) Restriction of energy intake relative to requirements, leading to a significantly low body weight, taking into account age, sex, developmental stage, and physical health; (B) Intense fear of gaining weight or becoming fat, or persistent behavior that interferes with weight gain, even when at a significantly low weight; (C) Disturbance in the way body weight or shape is experienced, undue influence of body weight or shape on self-esteem, or persistent lack of recognition of the seriousness of the current low body weight.\n\nExclusion Criteria:\n\n* Objection of the referring therapist\n* Currently receiving cognitive remediation targeting mental flexibility and central coherence\n* Body Mass Index (BMI) less than 14\n* Inability to understand instructions in French\n* Visual impairment or dyslexia",{"count":256,"type":22},54,[25],"The use of an analytical cognitive style is a specific feature of anorexia nervosa and is thought to contribute to the maintenance of the disorder, in particular by encouraging fragmented body perception and a focus on certain parts of the body to the detriment of overall harmony and coherence. The need for control has also been described as an important element in the pathology. At the same time, some authors have shown that, outside of any pathology, recourse to the analytical cognitive style could respond to a need to restore control and, in turn, improve the feeling of control. However, at present, no causal relationship has been demonstrated between the feeling of loss of control and the analytical cognitive style in anorexia nervosa. However, such a relationship would enable us to gain a better understanding of the underlying mechanisms of the disorder and to better target the treatment of patients.",[260],"Anorexia Nervosa","2025-11-27",{"date":263,"type":35},"2025-12-10",{"date":265,"type":35},"2024-04-04",{"date":267,"type":22},"2026-04-03",{"name":41,"class":42},{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":128,"minAge":18,"maxAge":4,"enrollmentInfo":276,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":278,"conditions":279,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":227},"100594135","self-dehumanization-and-hesitation-to-report-domestic-violence-100594135","NCT07015502","Self-Dehumanization and Hesitation to Report Domestic Violence","DESHUMA","Inclusion Criteria:\n\n* Woman over 18\n* Victim of physical and\u002For psychological domestic violence taken into care for this reason, following an initial complaint\n* Understanding and speaking French\n* Subject affiliated to a social security scheme\n\nExclusion Criteria:\n\n* Patient under legal protection measure (guardianship or legal protection)\n* Presence of a disabling mental or cognitive disorder\n* Patient employed by the investigator",{"count":277,"type":22},84,"The patients included in the study will be adult women who are victims of domestic violence, consulting for this reason. The duration of participation of each patient will be one hour.\n\nAfter obtaining the patient's non-opposition to her participation in the study, socio-demographic and history of violence suffered will be collected during an interview with the doctor\u002Fnurse. After that, the hetero-questionnaire MADRS (Montgomery-Asberg Depression Rating Scale) will be administered to the patient. This first part will last 30 minutes.\n\nThe second part of the study, carried out immediately after the interview, will be carried out on computer in the form of 4 self-questionnaires (Childhood Trauma Questionnaire, Deshumanization Measure within Romantic Relationships scale, self-esteem scale, violentometer) and an implicit association test (IAT). This second part will last 30 minutes.\n\nThen, the participation of the patient in the study is over.",[280],"Domestic Violence","2025-06-03",{"date":283,"type":35},"2025-06-11",{"date":285,"type":35},"2024-12-20",{"date":287,"type":22},"2025-12-19",{"name":41,"class":42},{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":297,"targetDuration":4,"studyType":23,"phases":299,"briefSummary":300,"conditions":301,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":73},"100517451","tdcs-associated-with-symptom-provocation-in-the-management-of-patients-with-resistant-obsessive-compulsive-disorder-100517451","NCT06017713","tDCS Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive Disorder","Direct Transcranial Stimulation With Direct Current Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive","PPSTDCS-TOC","Inclusion Criteria:\n\n* Patient suffering from OCD evolving for at least 2 years diagnosed according to DSM-V criteria;\n* Patient with good insight, defined by a score less than or equal to 18 at the threshold of delusions on the BABS (Brown Assessment of Beliefs Scale) insight scale;\n* Absence of a current depressive episode (MADRS score \\\u003C 21) or suicidal risk (MADRS score item 10 \\\u003C 3);\n* Absence of epileptic pathology;\n* Chronic obsessive-compulsive disorder defined by a total YBOCS score \\> 20, or a subscale score \\> 15;\n* Drug-resistant obsessive-compulsive disorder despite treatment with:\n\n  1. at least 2 antidepressants of the IRS type at an effective dose and for a sufficient duration\n  2. and\u002For Behavioral and Cognitive therapy for at least 1 year;\n* Therapeutic stability (antidepressants) for more than 12 weeks without significant improvement. This treatment, at a fixed dose, will be maintained during the study;\n* Patient aged between 18 and 70 included\n* Patient who has given his\u002Fher informed consent after having received written information on the planned procedure;\n* Patient benefiting from social security or by benefiting through a third party.\n\nExclusion Criteria:\n\n* Woman of childbearing age without effective means of contraception (hormonal\u002Fmechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)\n* Pregnant or nursing woman;\n* Patient hospitalized under duress (SPDT, SPDRE);\n* Patient under guardianship or curatorship;\n* Patient with another DSM-V Axis 1 diagnosis (Schizophrenic Disorder, Bipolar Disorder, Substance Abuse or Substance Dependence).\n\nGeneralized anxiety disorder, social phobia, nicotine addiction and history of major depressive episodes are not exclusion criteria. Axis I comorbidity will be explored using MINI 5.0.0. ;\n\n* Patient suffering from a current depressive episode;\n* Patient at risk of suicide;\n* Patient with skin lesions on the scalp;\n* History of head trauma;\n* Patient with an intracerebral metal object\n* Patient with a pacemaker;\n* Presence of epileptic pathology;\n* Patient in an emergency situation or unable to give personal consent",{"count":298,"type":22},25,[25],"This is a single-center study about patients with severe resistant OCD.\n\nMain assumption is that performing 10 tDCS sessions with the anode positioned at the level of the right orbitofrontal cortex, and the cathode at the level of the supplementary motor area, associated with the provocation of symptoms before each session is effective in the reduction in obsessive-compulsive symptoms.\n\nAfter the inclusion visit, the treatment period is provided from D1 to D12 (one session per day from Monday to Friday, for two consecutive weeks, i.e. a total of ten sessions). Each tDCS session lasts 30 minutes at an intensity of 2 mA and is preceded by symptom provocation using a standardized procedure performed by trained personnel.\n\nThe patients are then assessed on D42 and D102 (i.e. 1 month and 3 months after the end of the tDCS sessions).",[218],{"date":303,"type":35},"2025-06-05",{"date":305,"type":35},"2023-10-17",{"date":307,"type":22},"2027-07",{"name":41,"class":42},{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":317,"targetDuration":4,"studyType":23,"phases":318,"briefSummary":319,"conditions":320,"keywords":322,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":323,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":227},"100516822","effects-of-transcranial-direct-current-stimulation-tdcs-in-the-management-of-suicidal-ideation-100516822","NCT06009523","Effects of Transcranial Direct Current Stimulation (tDCS) in the Management of Suicidal Ideation","Effects of Transcranial Direct Current Stimulation (tDCS) in the Management of Suicidal Ideation in Treatment-resistant Depression : a Pilot Study","tDCS-IDSDEP","Inclusion Criteria:\n\n* Age over 18 years\n* Written informed consent\n* Diagnosis of recurrent or isolated depressive episode according to DSM IV criteria (A.P.A. 1994).\n* Stable antidepressant treatment for 3 weeks\n* MADRS score ≥ 20\n* SSI score \\> 3\n* Subject affiliated to a health insurance system\n* Woman with effective contraception and agreeing to maintain it throughout the study period.\n\nExclusion Criteria:\n\n* Depression with psychotic features Axis I (DSM IV) co-morbid diagnosis of schizophrenia, alcohol and\u002For other substance dependence (or abuse) (lifetime)\n* Patient who has already undergone an electroconvulsive therapy course for the current episode and does not respond to this treatment\n* Patient deprived of liberty\n* Patient with high suicide risk (item 10 MADRS \\> 4) in the absence of hospitalization\n* Contraindication to tDCS: intracerebral metallic implant (with the exception of dental implants), cardiac pacemaker, active or non-implanted devices in the region of the head, acute eczema in the planned stimulation area\n* Pregnant, parturient or breastfeeding woman\n* Simultaneous participation in another interventional research",{"count":130,"type":22},[25],"The main objective of this study is to demonstrate that 15 transcranial direct current stimulation (tDCS) sessions of 30 minutes at 2 mA intensity are effective to reduce suicidal ideation",[321],"Depression and Suicide",[30],{"date":303,"type":35},{"date":325,"type":35},"2023-10-26",{"date":327,"type":22},"2027-12-01",{"name":41,"class":42},{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":337,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":338,"conditions":339,"keywords":341,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":344,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":4},"100435730","attachment-and-prognostic-factor-the-implicit-approach-100435730","NCT04954027","Attachment and Prognostic Factor: the Implicit Approach","Place of Attachment as a Post-weaning Prognostic Factor: Interest of the Implicit Approach","AIA","Inclusion Criteria:\n\n* Patients between 18 and 65 years old\n* Patients with a use-related disorder as defined by DSM5\n* Patients weaning for a substance, supported within the addictology sector of Henri Laborit Hospital\n* Having expressed non-opposition to participating in the study after receiving written information.\n\nExclusion Criteria:\n\n* Person who cannot read or write\n* Simultaneous participation in a therapeutic trial involving oxytocin\n* Patients protected by law\n* Patients who do not have French as their native language\n* Patients who, in the opinion of the investigator, are unable to complete the questionnaires",{"count":151,"type":22},"This is a prospective longitudinal study aimed at better understanding the determinants of the prognosis of patients with substance dependence.\n\n5 visits are planned during the study :\n\n* the inclusion visit : during this visit the patient's non-opposition is obtained and then the patient answer to self-administered questionnaires online\n* 4 telephone interviews for follow-up by investigator.",[340],"Dependence Addictive",[342,343],"implicit approach","post-weaning prognostic factor",{"date":303,"type":35},{"date":346,"type":22},"2026-09",{"date":348,"type":22},"2028-09",{"name":41,"class":42},{"id":351,"slug":352,"hasResults":11,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":356,"eligibilityCriteria":357,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":358,"enrollmentInfo":359,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":361,"conditions":362,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":364,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":73},"100434287","comparative-study-of-gender-identity-disorder-versus-control-100434287","NCT04935164","Comparative Study of Gender Identity Disorder Versus Control","Comparative Study of Gender Dysphoria Phenomenology and Neurophysiology: Clinical and Experimental Exploration of Gender Identity Disorder","TRANSIDENT","Inclusion Criteria:\n\n* Patients with gender dysphoria\n* Without psychotropic\n* Without hormono-therapy\n* Without sexual surgery assignation\n\nExclusion Criteria:\n\n* Any depression\n* Any addiction","60 Years",{"count":360,"type":22},120,"Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity.",[363],"Gender Dysphoria, Adult",{"date":303,"type":35},{"date":366,"type":35},"2021-03-26",{"date":368,"type":22},"2029-12",{"name":41,"class":42},{"id":371,"slug":372,"hasResults":11,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":377,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":379,"conditions":380,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":390},"100399150","french-observatory-of-electroconvulsive-therapy-ect-100399150","NCT04477434","French Observatory of ElectroConvulsive Therapy (ECT)","Observatoire National d'ElectroConvulsivoThérapie (ECT)","Inclusion Criteria:\n\n* Patients consecutively referred for ECT.\n\nExclusion Criteria:\n\n* Not specified",{"count":378,"type":22},2000,"Since the 30s, ECT has been a psychiatric treatment mainly used for drug-resistant depressive illnesses. Clinical studies have shown its therapeutic efficiency compared to standard treatments also in other psychiatric illnesses. Although efficient, ECTs also induce side effects. In France, there is currently no consensus on providing the suitest medical care. It is therefore important to review our nowadays health care models in order to maintain and improve the recommendations of the French National Agency for Accreditation and Evaluation in Health, the last of which date from 1997! Within this context, this project has the dual objective of (1) identifying ECT medical procedure in France and (2) developing research to evaluate and to improve the effectiveness of this treatment.",[381],"Mental Disorders","2024-08-19",{"date":384,"type":35},"2024-08-20",{"date":386,"type":35},"2018-04-24",{"date":388,"type":22},"2027-12",{"name":41,"class":42},30,""]