[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Centre Hospitalier Régional Metz-Thionville\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":439},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,53,76,97,121,147,173,199,220,245,269,289,315,337,360,384,413],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":39,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":49,"locationsCount":52},"100642312","risk-factors-of-atrial-fibrillation-after-cardiac-surgery-100642312",false,"NCT07625033","Risk Factors of Atrial Fibrillation After Cardiac Surgery","PFAS","Inclusion Criteria:\n\n* age \\>18\n* having undergone a scheduled cardiac surgery in the study center\n* having agreed to the reuse of their hospital care data\n\nExclusion Criteria:\n\n* Atrial fibrillation at the admission in hospital.","ALL","18 Years",{"count":19,"type":20},918,"ESTIMATED","OBSERVATIONAL","Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death. Preventing the occurrence of these arrhythmias is a major challenge. This study aims to investigate risk factors and protective factors regarding atrial fibrillation and other iatrogenic cardiac arrhythmias after cardiac surgery, particularly innovative anesthetic strategies such as stellar ganglion blockade which have been recently implemented in our center.",[24,25,26,27,28,29,30,31,32,33,34,35,36,37,38],"Cardiac Surgery","Peri Operative Medicine","Thoracic Surgery","Cardiopulmonary Bypass","Coronary Artery Bypass","Heart Valve Prosthesis Implantation","Aortic Valve Replacement","Perioperative Medicine","Preoperative Care","Intraoperative Care","Postoperative Care","Enhanced Recovery After Surgery","Anesthesia","Cardiac Anesthesia","Intensive Care Unit",[40],"Stellar Ganglion Blockade, SGB, cardiac surgery","NOT_YET_RECRUITING","2026-06-23",{"date":44,"type":45},"2026-06-25","ACTUAL",{"date":47,"type":20},"2026-07-01",{"date":47,"type":20},{"name":50,"class":51},"Centre Hospitalier Régional Metz-Thionville","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":16,"minAge":17,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":52},"100626419","ventilation-during-spaceflight-phase-2-100626419","NCT07435389","VENTILATION DURING SPACEFLIGHT (PHASE 2)","VESPA-2","Inclusion Criteria:\n\n* Healthy volunteers (male or female)\n* Aged 18 to 65\n* Affiliated with a Social Security scheme and, for non-French residents, holders of a European Health Insurance Card (EHIC) or a Global Health Insurance Card (GHIC)\n* Agreeing to participate in the study\n* Agreeing to participate in the study\n* Having given their informed consent in writing\n* Who have undergone a medical examination similar to a standard aeronautical medical examination for private pilot fitness\n\nExclusion Criteria:\n\n* Individuals who have participated in a previous biomedical research protocol\n* whose exclusion period has not ended.\n* Individuals in a subordinate relationship with the principal investigator or scientific director.\n* Pregnant or breastfeeding women (urine pregnancy test for women of childbearing age).\n* Protected adults (under guardianship, curatorship, or judicial protection)\n* Flu-like symptoms, digestive symptoms (nausea, vomiting), fever.\n* Altered mental state (flight-related anxiety, phobic state).\n* Failure to attend the Novespace safety briefing.",true,"65 Years",{"count":63,"type":20},12,"INTERVENTIONAL",[66],"NA","Space flights expose astronauts to medical risks, particularly respiratory risks, which are exacerbated in microgravity. Devices such as standard oxygen therapy and non-invasive ventilation (NIV) are used, but their performance in microgravity remains poorly studied. Parabolic flights allow these technologies to be evaluated in conditions similar to those encountered during space missions. In an initial study conducted in microgravity during a parabolic flight campaign, the T1 ventilator proved superior to the other devices tested on the test bench. However, its performance in healthy volunteers has not yet been evaluated. The central hypothesis of this exploratory study on healthy volunteers is that non-invasive ventilation, particularly with the CaStar UP helmet (Intersurgical), could offer superior performance to the standard oxygen mask in microgravity, thanks to better leak reduction (data from preclinical work on a test bench).",[69],"Non-invasive Ventilation",{"date":44,"type":45},{"date":72,"type":20},"2026-09-16",{"date":74,"type":20},"2026-09-20",{"name":50,"class":51},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":52},"100624160","optical-characterization-and-multi-modality-multi-scale-modeling-of-human-skin-applied-to-cancer-diagnosis-100624160","NCT07406022","Optical Characterization and Multi-modality, Multi-scale Modeling of Human Skin Applied to Cancer Diagnosis.","OpticSkin","Inclusion Criteria:\n\n* patients with skin carcinomas and actinic keratoses\n\nExclusion Criteria:\n\n* minor patient",{"count":84,"type":20},140,"Skin carcinomas are the most commonly diagnosed cancers in fair-skinned populations, for example in France, Western Europe, and North America in particular. The OpticSkin project will build and make available to the general public and the scientific and medical community a histological and optical spectroscopic database of healthy, precancerous, and cancerous human skin in terms of absorption, elastic and inelastic scattering (Raman), steady-state and time-resolved autofluorescence, and polarization. The aim is to identify spectroscopic signatures that will be useful for diagnosis.",[87,88],"Skin Cancer","Diagnostic","RECRUITING",{"date":91,"type":45},"2026-06-24",{"date":93,"type":45},"2025-12-01",{"date":95,"type":20},"2029-12-31",{"name":50,"class":51},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":105,"maxAge":17,"enrollmentInfo":106,"targetDuration":4,"studyType":64,"phases":108,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":115,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":52},"100549405","pilot-study-on-the-acceptability-of-auricular-vagus-nerve-neurostimulation-in-adolescents-100549405","NCT06433583","Pilot Study on the Acceptability of Auricular Vagus Nerve Neurostimulation in Adolescents","Pilot Study on the Acceptability of Auricular Vagus Nerve Neurostimulation for the Prevention of Non-suicidal Self-injury Recurrence in Adolescents","NEUROMUTE","Inclusion Criteria:\n\n* Adolescents aged between 13 and 17 years old\n* Patients with NSSI disorder as defined by DSM-5\n* Patient affiliated to a social security scheme\n* Patient who parents or guardians have signed a free and informed consent form\n* Patient able to understand neurostimulation instructions\n\nExclusion Criteria:\n\n* Contraindication to taVNS:\n* Malformation, skin pathology of the external ear. (piercings in the area concerned must be removed during the neurostimulation session).\n* Children with sleep apnea syndrome treated with NIV (non-invasive ventilation)\n* Presence of epileptic seizures\n* Proven cardiac pathology on the advice of the attending cardiologist\n* History of venous or arterial thrombosis\n* Adolescent with pacemaker or defibrillator\n* Adolescent with an active implantable device\n* Pregnancy (based on anamnestic criteria, checked by blood test if necessary)\n* Patients with psychotic episodes, confusional states or severe neurodevelopmental disorders\n* Patients with an allergic skin reaction to silicone (component of the ear electrode)\n* Patients with a cochlear implant on the stimulation side\n* Pregnant or breast-feeding women\n* Minor under guardianship\n* Minor under judicial measure or sanction","13 Years",{"count":107,"type":20},22,[66],"Non-suicidal self-injury (NSSI) are acts defined by the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders 5) as intentional and deliberate, occurring outside a psychotic state and directly causing moderate injury.\n\nTheir international prevalence is between 13 and 17% in adolescents and young adults, and has recently increased with the COVID-19 health crisis, with the prevalence of NSSI rising to 40% in adolescents. Access to psychiatrists is declining. Drug solutions, meanwhile, lack scientific proof in this indication.\n\nThe autonomic nervous system and the hypothalamo-hypophyseal axis are involved in the human response to experimentally-induced pain, as well as in stress regulation, notably via control of cortisol secretion.\n\nAbnormally low levels of the latter hormone have been detected in persons with NSSI disorder.\n\nTranscutaneous neurostimulation of the atrial vagus nerve (taVNS) has been studied for some ten years. The afferent branches of the vagus nerve stimulate the hypothalamic-pituitary axis, leading to the production of cortisol by the adrenals.\n\nThe hypothesis of this research is that stimulation of the vagus nerve by taVNS would improve the functioning of the hypothalamic-pituitary axis in patients with NSSI, and thus reduce the frequency of acting out.\n\nAlthough taVNS is an easy-to-access technique that patients can implement at home, the question of adherence to this treatment in adolescents has not yet been evaluated. The aim of this pilot study is to assess whether adolescents with NSSI will adhere to taVNS treatment.",[111],"Psychiatric Disorder",[113,114],"non-suicidal self-injury","transcutaneous auricular vagal nerve stimulation",{"date":44,"type":45},{"date":117,"type":45},"2024-11-28",{"date":119,"type":20},"2027-05-28",{"name":50,"class":51},{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":52},"100582138","prognosis-of-posterior-lamellar-keratoplasty-100582138","NCT06859411","Prognosis of Posterior Lamellar Keratoplasty","Prognosis of Posterior Lamellar Keratoplasty: an Observational Cohort Study","CORNEACOHORT","Inclusion Criteria:\n\n* patients who received a posterior lamellar keratoplasty in Metz-Thionville Regional Hospital between 2012 and 2030\n\nExclusion Criteria:\n\n* patients refusing to take part in the study",{"count":130,"type":20},1000,"Over the past decade, the management of Fuchs' endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK) has been revolutionized by the development of posterior lamellar keratoplasty techniques: DSAEK and DMEK.\n\nDSAEK (Descemet Stripping Automated Endothelial Keratoplasty) involves replacing the patient's endothelium and pathological descemetum with a descemetic endothelial graft combined with a thin stromal lamella. The endothelial density of the grafts is generally greater than 2,400 cells\u002Fmm². Depending on the grafting center and tissue bank, grafts may be either pre-cut in the tissue bank or cut on the operating table by the surgeon himself.\n\nThe donor graft is placed on an artificial anterior chamber, and automated microkeratome cutting produces grafts with an average thickness of 100 to 200µm, sometimes less than 100um (known as UT-DSAEK or ultra-thin DSAEK).\n\nDMEK (Descemet Membrane Endothelial Keratoplasty) is a strictly endothelium and Descemet's membrane graft, as close as possible to the original anatomy of the cornea. The graft is dissected manually either in a tissue bank (pre-cut grafts) or on the operating table by the surgeon. The thickness of the graft is between 15 and 18 microns.\n\nThe primary objective of this observational cohort is to compare the evolution of visual acuity after DMEK, DSAEK or UT-DSAEK transplantation.\n\nSecondary objectives are to compare the evolution of endothelial cell density, corneal thickness and early and late post-operative complications, and to identify factors predictive of these different endpoints.",[133,134],"Fuchs' Endothelial Corneal Dystrophy","Pseudophakic Bullous Keratopathy",[136,137,138,139],"posterior lamellar keratoplasty","cornea","DMEK","DSAEK","2026-06-20",{"date":91,"type":45},{"date":143,"type":45},"2024-06-01",{"date":145,"type":20},"2040-01-01",{"name":50,"class":51},{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":16,"minAge":155,"maxAge":4,"enrollmentInfo":156,"targetDuration":4,"studyType":64,"phases":158,"briefSummary":159,"conditions":160,"keywords":163,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":166,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":172},"100579011","effectiveness-of-pkp-vs-dsaek-in-terms-of-2-year-postoperative-visual-acuity-in-advanced-bpk-100579011","NCT06818747","Effectiveness of PKP vs DSAEK in Terms of 2-year Postoperative Visual Acuity in Advanced BPK","Comparative Effectiveness of PKP and DSAEK in Terms of 2-year Postoperative Visual Acuity in Advanced Bullous Pseudophakic Keratopathy: a Randomised Clinical Trial","DESPEK","Inclusion Criteria:\n\n* The patient:\n\n  1. Is ≥ 50 years old.\n  2. Has advanced PBK, with a best corrected visual acuity that lies between being able to see a hand move (i.e. 2 logMAR, included) and 2\u002F10 excluded (i.e. 0.7 logMAR, excluded) and a central corneal thickness that exceeds 600 μm.\n  3. Is indicated for a corneal transplant.\n  4. Is pseudophakic.\n  5. Has provided free and informed written consent.\n  6. Is affiliated to a social security scheme.\n  7. Can be followed-up by the same investigating team during the study period.\n\nExclusion Criteria:\n\n* The patient:\n\n  1. Has a history of corneal transplant on either eye (i.e. the study surgery will be the first corneal transplant for the patient).\n  2. Has an anterior chamber lens implant or is aphakic.\n  3. Has an ocular comorbidity that will impact visual acuity recovery: exudative or advanced atrophic AMD, advanced diabetic retinopathy (macular edema), advanced glaucoma (damage to the central visual field), important sequelae of central venous thrombosis of the retina or retinal detachment, previous amblyopia.\n  4. Has a contraindication to general anesthesia.\n  5. Is deprived of freedom, or under a legal protective measure.\n  6. Is included in another clinical study.\n  7. Has a severe general condition that might lead to premature discontinuation of the trial before the end of treatment period.","50 Years",{"count":157,"type":20},334,[66],"This is an open-label multicenter randomised controlled clinical trial with 2 parallel arms with a 1:1 ratio. Patients meeting the eligibility criteria will be offered to participate in the study during an ophthalmology consultation. If they agree, they are randomised into one of the 2 arms, surgery is scheduled, and baseline visual acuity, quality of life, patient satisfaction, pain level, and central corneal thickness are recorded (inclusion visit). The following visits involve: the corneal transplant procedure (DSAEK or PKP depending on the randomisation) and follow-up visits at 1, 6, 12, and 24 months. At each visit, visual acuity, patient satisfaction, pain level and complications will be determined. At 6, 12, and 24 months, endothelial cell density, central corneal thickness and required optical correction will be measured. At 12 and 24 months, quality of life, will also be determined.",[161,162],"Bullous Pseudophakic Keratopathy","Penetrating Keratoplasty",[164,165],"Best corrected monocular visual acuity","Quality of life",{"date":91,"type":45},{"date":168,"type":45},"2025-05-21",{"date":170,"type":20},"2029-08-21",{"name":50,"class":51},11,{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":180,"minAge":17,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":183,"conditions":184,"keywords":187,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":192,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":198},"100558396","evaluation-of-the-impact-of-ambulatory-epidural-on-maternal-satisfaction-during-delivery-and-postpartum-100558396","NCT06550570","Evaluation of the Impact of Ambulatory Epidural on Maternal Satisfaction During Delivery and Postpartum","PERIDEAMBU","Inclusion Criteria:\n\n* Women older than 18 years old\n* with Physiological pregnancy (fetus cephalic position, normal fetal heart rate, spontaneous work between 37 and 41 SA)\n* Having benefited from epidural, usual or ambulatory depending on the study period\n* who speeks and understand French\n* who signed a free and informed consent form\n\nExclusion Criteria:\n\n* Hearing or comprehension impairment\n* Twin pregnancies\n* Scarred uterus\n* Fetus in non cephalic position\n* Imminent delivery\n* Women under protective supervision (guardianship, curatorship)\n* Women bereaved of a spouse or child during pregnancy\n* Hospitalization of child in neonatology after delivery\n* Women hospitalized in critical care units after childbirth","FEMALE",{"count":182,"type":20},126,"Childbirth is a special event for women. Maternal satisfaction regarding childbirth is quite important, that is why this factor has to be taken into account. A bad experience related to childbirth could lead to serious psychological and organic consequences such as postpartum depression, mother-baby bond deterioration and chronic pelvic pain. Childbirth image changed over the years to the extent that an increasingly physiological process keeping analgesia and safety is more and more desired. In this perspective, this study aims to investigate an approach so-called ambulatory epidural. Indeed, only a few studies have been conducted and the ones published in 1990s did not involve the current recommended pharmacological protocols.",[185,186],"Childbirth","Epidural; Anesthesia",[188,189,190,191],"Maternal satisfaction","ambulatory epidural","physiology","analgesia",{"date":91,"type":45},{"date":194,"type":45},"2024-07-23",{"date":196,"type":20},"2026-08-23",{"name":50,"class":51},2,{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":64,"phases":209,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":214,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":52},"100553578","differential-pressure-distribution-orthosis-by-3d-printing-process-in-the-treatment-of-post-burn-hypertrophic-scarring-100553578","NCT06487910","Differential Pressure Distribution Orthosis by 3D Printing Process in the Treatment of Post-burn Hypertrophic Scarring","Pilot Study on the Design of a 3D-printed Differential Pressure Distribution Orthosis for the Treatment of Post-burn Hypertrophic Scarring","EPIDERM","Inclusion Criteria:\n\n* Adult Patients aged \\> 18 years old\n* Patient with at least one hypertrophic burn scar in the process of healing localized on a skin area that can benefit from a compression garment and requiring the use of an ORDP\n* Patient able to give informed consent\n* Patient affiliated to a social security scheme\n\nExclusion Criteria:\n\n* Patients under guardianship, curatorship or safeguard of justice\n* Pregnant or breast-feeding women",{"count":208,"type":20},25,[66],"This is a pilot, single-center, feasibility study to evaluate a new 3D printing method for ORDP design.\n\nTo our knowledge, there is no technical or clinical evaluation of ORDPs, particularly in the treatment of hypertrophic scars. The aim of our study is therefore to assess the feasibility of an innovative method of designing ORDPs for the curative treatment of post-burn hypertrophic scars, using a 3D printing process, and to describe the procedures (production time and cost).",[212,213],"Burns","Hypertrophic Scar",{"date":91,"type":45},{"date":216,"type":45},"2025-01-10",{"date":218,"type":20},"2027-01-10",{"name":50,"class":51},{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":64,"phases":229,"briefSummary":230,"conditions":231,"keywords":233,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":239,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":198},"100530818","kinetics-of-urinary-excretion-of-gadolinium-contrast-agents-used-in-mri-examinations-100530818","NCT06191731","Kinetics of Urinary Excretion of Gadolinium Contrast Agents Used in MRI Examinations","GADODURABLE","Inclusion Criteria:\n\nPatients:\n\n* over 18 years of age\n* with a prescription for MRI with gadolinium-based contrast agents (Gd-CAs) injection validated by a radiologist\n* affiliated with a health insurance plan\n* have signed an informed consent form\n\nExclusion Criteria:\n\n* Patients:\n* with known allergy to gadolinium-based contrast agents (Gd-CAs)\n* with known severe renal impairment (GFR \\\u003C 30 mL\u002Fmin)\n* on dialysis\n* with urinary incontinence\n* with an ongoing urinary tract infection\n* under hydric or hydrosodic restriction\n* unable to urinate independently\n* Protected persons (under guardianship, curatorship or safeguard of justice)\n* Pregnant or breast-feeding women",{"count":228,"type":20},60,[66],"This is a single-center cohort study aimed to describe the urinary excretion kinetics of gadolinium contrast agents (Gd-CAs). Patients with a prescription for injected MRI are invited to participate in the study. If they agree, blood and urine samples are collected before Gd-CAs injection, and urine samples are collected between 0- and two-and-a-half-hours post-injection of Gd-CAs.",[232],"Magnetic Resonance Imaging",[234,235,236,237,238],"Contrast agents","Gadolinium","Recycling","MRI","Gadoteric acid",{"date":91,"type":45},{"date":241,"type":45},"2024-04-12",{"date":243,"type":20},"2028-04-12",{"name":50,"class":51},{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":251,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":255,"conditions":256,"keywords":258,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":263,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":52},"100507557","detection-of-periapical-lesions-on-dental-panoramic-radiographs-based-on-artificial-intelligence-100507557","NCT05888935","Detection of Periapical Lesions on Dental Panoramic Radiographs Based on Artificial Intelligence","Detection of Periapical Lesions on Dental Panoramic Images Based on Artificial Intelligence Using Cone Beam Computed Tomography","OPTITOMO","Inclusion Criteria:\n\n* Patients who have had CBCT and panoramic dental imaging with less than 3 months between the two examinations\n\nExclusion Criteria:\n\n* Patients who refused to participe in the study.",{"count":254,"type":20},2000,"Dental periapical damages can have various reasons and is reflected by a radiolucent lesion on complementary imaging: angulated retro-alveolar (RA) radiographs, dental panoramic radiographs, and three-dimensional imaging such as computed tomography (CT) or cone-beam computed tomography (CBCT).\n\nFor the radiographic detection of these deep periodontal lesions, the dental panoramic represents a first approach commonly performed with relatively low radiation. The investigation can be followed by retroalveolar radiology imaging that are more localized and more precise. However, using these techniques, the detection rates of these lesions are low (20% and 36% respectively), it is necessary to use three-dimensional tomographic investigation to be more discriminating (69%). The gold standard imaging for detection of these lesions is CBCT followed by retroalveolar radiography (\\~2x less sensitive than CBCT) and panoramic radiography (\\~2x less sensitive than RA). Although not a full-thickness radiograph, the dental panoramic has the advantage of being more commonly performed while being less radiating than CBCT and giving a global view of the dental arches on a single image.\n\nThe detection of periapical lesions is done after a clinical assessment and a visual appreciation of the complementary examinations.\n\nThe aim of this project is to improve the detection of periapical lesions, by developing an algorithm able to identify them on a panoramic dental radiograph. This algorithm is based on a deep learning system trained with reference data including panoramic dental imaging and CBCT with an acquisition interval of less than 3 months. The model is based on a previous work, will improve the quality of the initial data (using CBCT), using innovative artificial intelligence algorithms (transfer learning).",[257],"Periapical Diseases",[259,260,261,262],"tomography","dental injury","artificial intelligence","periapical lesions",{"date":91,"type":45},{"date":265,"type":45},"2022-10-01",{"date":267,"type":20},"2027-12-01",{"name":50,"class":51},{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":275,"eligibilityCriteria":276,"healthyVolunteers":11,"sex":16,"minAge":61,"maxAge":4,"enrollmentInfo":277,"targetDuration":4,"studyType":64,"phases":279,"briefSummary":280,"conditions":281,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":283,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":52},"100475795","impact-of-discontinuing-contact-precautions-for-extended-spectrum--lactamase-enterobacteriaceae-in-a-geriatric-unit-100475795","NCT05475574","Impact of Discontinuing Contact Precautions for Extended-spectrum β-lactamase Enterobacteriaceae in a Geriatric Unit","Impact of Discontinuing Contact Precautions for Extended-spectrum β-lactamase Enterobacteriaceae (ESBLE) in a Geriatric Unit: an Interventional Prospective Noninferiority Non-randomized Double-blind Controlled Before and After Study","Ger-SP","Inclusion Criteria:\n\n* Adult patient (\\> 65 years old)\n* Patient hospitalized in geriatrics during the study period\n* Free and informed consent obtained from the patient (or his trusted person or legal representative) within 48 hours of its admission at the geriatric unit\n* Patient affiliated to a social security scheme\n\nNon Inclusion Criteria:\n\n* Patient requiring contact precaution for an indication other than ESBLE (COVID-19, classical PCC excluding EBLSE, Clostridium difficile PCC, scabies PCC and BHRe PCC) on admission\n* Patient under legal protection\n* Person deprived of liberty\n\nExclusion criteria:\n\n* Patient requiring contact precaution for an indication other than ESBL during the patient stay (COVID-19, classical PCC excluding EBLSE, Clostridium difficile PCC, scabies PCC and BHRe PCC)\n* Patient's stay period less than 4 days",{"count":278,"type":20},954,[66],"This is an interventional multicenter prospective noninferiority non-randomized double-blind controlled before and after study.\n\nThe aim of this study is to demonstrate that standard precautions alone are not inferior to contact precautions by comparing the incidence density of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae acquired in geriatric units before and after discontinuing contact precautions.",[282],"Infection, Hospital",{"date":91,"type":45},{"date":285,"type":45},"2023-03-07",{"date":287,"type":20},"2029-09-21",{"name":50,"class":51},{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":16,"minAge":296,"maxAge":17,"enrollmentInfo":297,"targetDuration":4,"studyType":64,"phases":299,"briefSummary":300,"conditions":301,"keywords":304,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":52},"100582744","study-of-the-efficacy-of-moderate-sedation-with-intra-nasal-dexmedetomidine-monitored-by-eeg-monitoring-100582744","NCT06867289","Study of the Efficacy of Moderate Sedation With Intra-NAsal Dexmedetomidine Monitored by EEG MOnitoring","DINAMO","Inclusion Criteria:\n\n* Indication of DEX sedation for brain NMRI at the CHR de Metz-Thionville\n\n  * in a patient aged between 12 months and 5 years or\n  * for a patient aged between 5 and 18 whose cooperation during the examination appears compromised (previous failure, autism spectrum disorders, etc.).\n* Membership of a social security scheme\n* Free and informed consent obtained from the patient's legal guardian(s).\n\nExclusion Criteria:\n\n* Weight \\\u003C 10 kg\n* Patients with contraindications to the use of DEX\n\n  * Hypersensitivity to the active ingredient or to any of the excipients listed in the section on \"Hypersensitivity\".\n  * Advanced heart block (level 2 or 3), unless pacemaker implanted\n  * Uncontrolled hypotension\n  * Acute cerebrovascular pathologies\n* Patients with nasal obstruction\n* Parental refusal of DEX administration\n* Minors under guardianship\n* Minors under judicial sanction","1 Year",{"count":298,"type":20},50,[66],"This is a prospective, monocentric diagnostic study aiming to evaluate whether a sedation score obtained by a per-procedural electroencephalogram (EEG), the PSI score, could identify patients for whom a 2 μg\u002Fkg dose of DEX would not be sufficient for the successful performance of cerebral NMRI, and who could therefore benefit from a higher dosage of DEX (4 μg\u002Fkg).",[302,303],"Procedural Sedation and Analgesia","Pediatric ALL",[237,305,306],"dexmedetomidine","EEG","2026-03-11",{"date":309,"type":45},"2026-03-12",{"date":311,"type":45},"2025-04-08",{"date":313,"type":20},"2027-04-08",{"name":50,"class":51},{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":321,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":64,"phases":325,"briefSummary":327,"conditions":328,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":333,"completionDateStruct":334,"leadSponsor":336,"locationsCount":52},"100552198","phase-2-evolution-of-the-initial-distribution-volume-of-glucose-in-the-severe-burned-adults-100552198","NCT06469970","Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults","INDICIA: Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults","INDICIA","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patients hospitalized with burns of at least 30% of body surface area\n\n  * By a thermal mechanism\n  * At the CHR Metz-Thionville burn center\n  * managed within the 8 hours post-burn\n* Patient affiliated to a social security scheme\n* Written consent obtained from the patient (or from the trusted person, family or relatives if the patient is unable to sign\u002Fexpress consent) or emergency inclusion if the patient is unable to express consent and neither the trusted support person nor any member of the family or relatives is present at the time of inclusion.\n\nExclusion Criteria:\n\n* Diabetic patients on insulin\n* Patient with a CONTRAINDICATION to GLUCOSE 30% PROAMP, solution for injection\n* Patients with pre-hospital cardiac arrest\n* extra corporeal circulation patient: Extra Corporeal Membranous Oxygenation (ECMO) or Extra Corporeal Life Support (ECLS) or CRRT (Continuous Renal Replacement Therapy)\n* patient without a central venous line or arterial catheter\n* Patient moribund or immediately subject to therapeutic limitation\n* Impossibility of trans-pulmonary thermodilution monitoring (vascular access difficulties)\n* Pregnant, parturient or breast-feeding women\n* Patient under guardianship, curatorship or safeguard of justice\n* Cognitive impairment or language barrier",{"count":324,"type":20},15,[326],"PHASE2","This is a prospective, observational, monocentric, phase II (exploratory) cohort study aiming to describe the evolutionary profile of the initial volume of glucose distribution (IDVG) during the first four days of management of severely burned patient.",[212,329,330],"Intensive Care","Emergencies","2026-03-10",{"date":309,"type":45},{"date":117,"type":45},{"date":335,"type":20},"2027-03-28",{"name":50,"class":51},{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":345,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":347,"conditions":348,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":52},"100624158","referral-of-patients-with-biological-abnormalities-to-an-emergency-department-100624158","NCT07405996","Referral of Patients With Biological Abnormalities to an Emergency Department","Referral of Patients With Biological Abnormalities to an Emergency Department : ORA","ORA","Inclusion Criteria:\n\n* Any patient presenting at an emergency department participating in the IOA (nurse coordinating reception) system with the reason for referral \"Abnormal laboratory results.\n\nExclusion Criteria:\n\n* minor patients (\\\u003C18 years old)\n* expression of the patient's opposition to the collection of data relating to their hospital stay.",{"count":346,"type":20},5000,"Biological testing is an essential part of general medical practice and plays a role in 60% to 70% of diagnoses. 68.5% of prescriptions are written by general practitioners, and one in seven general medical consultations ends with a prescription for biological testing. The study of patient trajectories is a recent emerging topic in the literature, encompassing general concepts. The angle most often taken is medico-economic and focused on specific chronic conditions such as diabetes, cancer, or cardiovascular disease. To our knowledge, there are a number of referrals to emergency departments by general practitioners for patients with biological abnormalities. However, to our knowledge, no study to date has attempted to quantify these specific referrals.",[349,350,351],"Biological Abnormality","Emergency Department Visit","General Practitioner","2026-02-09",{"date":354,"type":45},"2026-02-12",{"date":356,"type":20},"2026-02-01",{"date":358,"type":20},"2027-02-01",{"name":50,"class":51},{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":368,"targetDuration":4,"studyType":64,"phases":370,"briefSummary":371,"conditions":372,"keywords":374,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":379,"completionDateStruct":381,"leadSponsor":383,"locationsCount":198},"100438162","influence-of-analgesic-technique-on-post-operative-rehabilitation-after-median-laparotomy-100438162","NCT04985695","Influence of Analgesic Technique on Post Operative Rehabilitation After Median Laparotomy","Influence of Analgesic Technique on Post Operative Rehabilitation After Median Laparotomy: Comparison Between Thoracic Epidural Anesthesia Versus Bilateral Rectus Sheath Block","QORRECTCATH","Inclusion Criteria:\n\n* ASA (American Society of Anesthesiologists) Class I-IV adult, with programmed midline laparotomy\n* Have given an informed written consent\n* Able to read and understand french language\n* Affiliation to a social security system\n\nExclusion Criteria:\n\n* Local anesthesic contraindication (allergy, porphyria, haemolytic anaemia, uncontrolled epilepsy, or severe cardiac conduction disorders) or TEA (coagulation disorders, progressive neurological disease, or severe spinal disorder),\n* Epidural analgesia contraindication\n* With impossibility to set up bilateral rectus sheath block\n* Participation in another clinical study\n* Pregnant women\n* Patients deprived of their liberty by a judicial or administrative decision,\n* Patients undergoing psychiatric care under articles L.3212-1 and L.3213-1 of the French Public Health Code",{"count":369,"type":20},110,[66],"Randomized controlled trial (1:1) in two parallel groups, multicentric, open-label, comparing two locoregional anesthesia (LRA) techniques as integral parts of multimodal analgesia: the control group will benefit from epidural anesthesia, while the experimental group will benefit from bilateral placement of catheters in the sheath of the rectus abdominis muscles.",[373],"Laparotomy",[375],"postoperative rehabilitation","2025-12-09",{"date":378,"type":45},"2025-12-16",{"date":380,"type":45},"2021-10-11",{"date":382,"type":20},"2029-04-10",{"name":50,"class":51},{"id":385,"slug":386,"hasResults":11,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":390,"eligibilityCriteria":391,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":392,"targetDuration":4,"studyType":64,"phases":394,"briefSummary":395,"conditions":396,"keywords":398,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":52},"100590817","efficacy-of-treadmill-walking-with-hidden-vision-for-rehabilitation-in-the-subacute-phase-of-stroke-100590817","NCT06972355","Efficacy of Treadmill Walking With Hidden Vision for Rehabilitation in the Subacute Phase of Stroke","Efficacy of Treadmill Walking With Hidden Vision for Rehabilitation in the Subacute Phase of Stroke, Randomized Controlled Trial","MAVREEC","Inclusion Criteria:\n\n1. 18 years of age or older,\n2. With a confirmed diagnosis of ischemic or hemorrhagic stroke in sub-acute phase (stroke less than 6 months old),\n3. With NIHSS scores between 1 and 15 and MoCA scores between 18 and 30\n4. With a physiotherapy prescription for post Stroke rehabilitation\n5. Able to walk for 20 min on a treadmill with weight reduction with pauses, able to maintain bipodal balance, able to maintain bipodal balance with eyes open and closed for 30 seconds,\n6. Having expressed free, informed and written consent\n7. Affiliated with a social security scheme.\n\nExclusion Criteria:\n\n1. Patients weighing over 200 kg (maximum weight permitted for use of the Lite Gait ®),\n2. Patients with impaired vision:\n\n   1. Best corrected visual acuity below 5\u002F10 on patient examination\n   2. Homonymous lateral hemianopia, quadranopia.\n3. Inability to physically participate in intensive rehabilitation due to severe, unstabilized and comorbidities (heart, lung, kidney disease or diabetes), severe psychiatric disorders cancer active or under treatment.\n4. Patients participating in other interventional research,\n5. Pregnant or breast-feeding women,\n6. Patients under guardianship.",{"count":393,"type":20},36,[66],"Objective: The aim of this study is to compare the efficiency of vision-obscured versus vision-retained treadmill gait training in subacute post-stroke patients.\n\nMethodology: Thirty-six patients with stroke (ischemic or hemorrhagic) less than six months old will be included and randomized into two parallel groups. The experimental group will undergo treadmill gait training using an opaque mask, combined with body weight reduction (Lite Gait® harness). The control group will follow the same walking protocol, but with their eyes open. Each session will last 20 minutes, integrated into one hour of rehabilitation, at a rate of three sessions per week for six weeks. Assessment will include single- and double-task walking speed, balance parameters and proprioception.\n\nExpected results: The hypothesis is that visual deprivation will stimulate the proprioceptive and vestibular systems to a greater extent, resulting in benefits for postural balance, walking and proprioception. The main hypothesis will be the improvement in the difference between single-task and double-task walking speed. Analyses will be conducted on an intention-to-treat basis, using statistical tests adapted to the nature of the variables.\n\nConclusion: This study could highlight the value of temporary visual suppression as a therapeutic lever in stroke rehabilitation.",[397],"Subacute Stroke",[399,400,401,402,403,404],"Stroke","Gait","Treadmill","Double task","Proprioception","Postural balance","2025-09-30",{"date":407,"type":45},"2025-10-01",{"date":409,"type":45},"2025-06-04",{"date":411,"type":20},"2027-07-19",{"name":50,"class":51},{"id":414,"slug":415,"hasResults":11,"nctId":416,"briefTitle":417,"officialTitle":418,"acronym":419,"eligibilityCriteria":420,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":421,"enrollmentInfo":422,"targetDuration":4,"studyType":64,"phases":424,"briefSummary":425,"conditions":426,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":52},"100475797","apa-and-relaxation-by-biofeedback-in-patients-with-haematological-malignancy-admitted-in-icu-100475797","NCT05475600","APA and Relaxation by Biofeedback in Patients With Haematological Malignancy Admitted in ICU","Adapted Physical Activity and Relaxation by Biofeedback in Patients With Haematological Malignancy Admitted in Intensive Care unit_APAER_H Protocol","APAER_H","Inclusion Criteria:\n\n* Subjects aged between 18 and 75 years old\n* Admitted in Intensive Care Unit\n* Informed consent\n\nExclusion Criteria:\n\n* Contraindication for physical exercise\n* Inability to understand the French language (written and\u002For oral)\n* Ongoing involvement in another proprietary research protocol\n* Lack of affiliation to social security","75 Years",{"count":423,"type":20},90,[66],"Adapted Physical Activity (APA) is accepted as an effective, recommended and beneficial supportive care for the health of people with cancer during the different phases of the disease. The objective of the project is to analyse the effect of APA programs (Classic, Exergaming and Relaxation) on the state anxiety of people with severe blood diseases admitted to Intensive Care Unit (ICU). Anxiety is a major affect in this context. The interest of the practice of APA for this public is to reduce the level of state anxiety and to limit the decline of functional capacities. The main objective of this work is to identify whether specific and\u002For complementary effects result from the use of biofeedback and\u002For Exergaming.",[427,428,429,430],"Adapted Physical Activity","Hematological Malignancies","Anxiety","Relaxation","2025-03-14",{"date":433,"type":45},"2025-03-17",{"date":435,"type":45},"2022-12-02",{"date":437,"type":20},"2027-01",{"name":50,"class":51},""]