[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":209},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,61,97,127,160,186],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":60},"100621832","spinal-stimulation-with-gait-training-to-improve-lower-limbs-motor-recovery-in-spinal-cord-injury-100621832",false,"NCT07375745","Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury","Combined Gait Training and Transcutaneous Spinal Cord Stimulation to Enhance Lower Limbs Motor Recovery After Subacute SCI","CIMELocomotion","Inclusion Criteria:\n\n* paraplegic or quadriplegic participants with a subacute spinal cord injury (sSCI), defined as the stage of spinal cord damage occuring between 1 week and 6 months post-injury\n* above 16 years old\n* have a lesion between C1 - L2\n* be considered as AIS A to D\n* be able to stay at least 10 minutes standing with or without assistance\n* can provide informed consent (no cognitive deficits by MoCA)\n* be able to follow instructions in French or English\n\nExclusion Criteria:\n\n* pacemaker\n* active cancer on stimulation site or metastatic cancer\n* unhealed wound, scar or pain which makes positioning of the electrodes impossible\n* participants with specific contraindications to TMS (epilepsy, non-union cranial fracture and increased intracranial pressure) will be able to participate in the study, but will not receive TMS\n* chronic and severe neuropathic pain\n* pharmacology or implants that may impede with rehabilitation or spinal stimulation\n* pregnancy","ALL","16 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (\\\u003C 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to rehabilitation and external stimulation. Standard care in rehabilitation centers relies on activity-based therapy (ABT), which uses intensive, task-specific training to promote recovery. Although ABT can improve mobility, its effects are often limited due to the nature of SCI and the indirect activation of neural circuits.\n\nRecent findings suggest that adding transcutaneous spinal cord stimulation (tSCS) to ABT in chronic SCI (\\> 12 months) can enhance lower-limb motor recovery. This study will evaluate whether combining tSCS with gait training is safe and feasible in individuals with subacute SCI and whether it improves lower-limb motor outcomes compared with gait training alone.\n\nThe investigators hypothesize that pairing gait training with tSCS early after injury will be safe and feasible and that tSCS delivered during gait training will augment leg muscle activation and lead to greater functional improvements. The study will also assess the feasibility, safety and tolerability of implementing this combined intervention in a intensive functional rehabilitation setting.",[27,28,29,30,31],"Spinal Cord Injury","Spinal Cord Injury Subacute","Locomotion","Gait Disorder, Sensorimotor","Gait Disorders",[27,33,29,34,35,36,37,38,39,40,41,42,43,44,45,46,47],"Neuromodulation","tSCS","Non-invasive","Transcutaneous","Gait","Transcranial Magnetic Stimulation","Subacute","Artificial Intelligence","AI","Lower Limb","Gait training","Walking","Transcutaneous spinal stimulation","Tonic stimulation","Combined gait training and neuromodulation","NOT_YET_RECRUITING","2026-03-04",{"date":51,"type":52},"2026-03-06","ACTUAL",{"date":54,"type":21},"2026-07-01",{"date":56,"type":21},"2029-07",{"name":58,"class":59},"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal","OTHER",1,{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":22,"phases":70,"briefSummary":71,"conditions":72,"keywords":76,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":60},"100620746","upper-limb-rehabilitation-using-non-invasive-spinal-cord-stimulation-100620746","NCT07361627","Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation","Improving Upper Limb Motor Control With Spinal Stimulation","CIME_upperlimb","Inclusion Criteria:\n\n* quadraplegic participants with a subacute spinal cord injury (sSCI), defined as the stage of spinal cord damage occurring between 1 week and 6 months post-injury, that fall within the period of at least one year post-injury\n* 16 years old or above\n* have a lesion between above T2\n* residual upper limb movement\n* have injury level according to ASIA A to D\n* hospitalized in the hospital linked with the research center at Gingras Lindsay Rehabilitation Institute of Montreal, 6300 Darlington, Montreal\n* can provide informed consent (no severe cognitive deficits by MoCA)\n* be able to follow instructions in French or English\n\nExclusion Criteria:\n\n* have a pacemaker\n* have active cancer on stimulation site or metastatic cancer\n* have unstable health conditions\n* have unhealed wound, scar or pain which makes positioning of the electrodes impossible\n* participants with specific contraindications to TMS (epilepsy, non-union cranial fracture and increased intracranial pressure) will be able to participate in the study, but will not receive TMS",{"count":20,"type":21},[24],"The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury (SCI). As secondary aims, the study will also investigate at how this combination approach affects the cortical changes in the somatosensory and motor areas of the brain, as well as in the spinal cord and whether it helps participants use their arms more in daily life.\n\nThe main questions relevant to this study are:\n\n1. Can the combination of ABT + tSCS improve motor and sensory functions of the arms and hands more than ABT alone during the sub-acute stage after SCI?\n2. Does ABT + tSCS induce neuroplasticity, that is, changes in the brain and spinal cord activity linked to motor and sensory functions?\n3. Do participants who receive ABT + tSCS report greater use of their arms in daily activities compared to those who receive ABT only?\n\nIn this study, participants will:\n\n* Receive either ABT + tSCS or ABT + sham stimulation (a low-intensity current that does not facilitate the movements)\n* Take part in 20 training sessions over 6-8 weeks (3 times per week, 45 min of active training each). During this, they will perform strengthening, task-based training, and mental imagery exercises with a therapist.\n* Complete clinical tests and neurophysiological assessments (transspinal electrical stimulation, electroencephalography and transcranial magnetic stimulation) at three time points-- at the start, after training, and one month later to measure recovery and brain activity changes.\n\nResearchers will compare the assessment outcomes across the three time points.",[73,74,75],"Spinal Cord Injury Cervical","Spinal Cord Injury, Acute","Spinal Cord Injury (Quadraplegia)",[77,78,33,79,80,81,82,83,84,85,38,86,87,88],"Spinal cord injury","Sub-acute","transcutaneous Spinal Cord Stimulation","Activity-based therapy","Upper extremity motor score","Rehabilitation","Electroencephalography","EEG","Somatosensory evoked potential","Motor evoked potential","Clinical assessment","Neuroplasticity","2026-02-27",{"date":91,"type":52},"2026-03-02",{"date":93,"type":21},"2026-04-01",{"date":95,"type":21},"2028-08-09",{"name":58,"class":59},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":104,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100612529","virtual-walking-and-neuromulation-to-reduce-neuropathic-pain-after-a-spinal-cord-injury-100612529","NCT07254767","Virtual Walking and Neuromulation to Reduce Neuropathic Pain After a Spinal Cord Injury","Combination of Visuo-proprioceptive Virtual Walking and Neuromodulation to Reduce Neuropathic Pain in Individuals With Spinal Cord Injury","Inclusion Criteria:\n\n* over 18 years old\n* a score of ≥ 4\u002F10 on the Douleur Neuropathique en 4 Questions (DN4)\n* classified AIS A to D\n* neuropathic pain with an intensity of ≥ 4\u002F10 on the simple numerical rating scale (This threshold is often chosen to better observe a potential analgesic effect)\n\nExclusion Criteria: The main exclusion criteria are contraindications to tDCS and virtual reality\n\n* pregnancy,\n* epilepsy,\n* cancer,\n* pacemaker,\n* metallic implants in the brain or eyes,\n* uncontrolled severe headaches,\n* uncontrolled psychotic disorders,\n* open scalp wounds,\n* severe visual impairments. If participants have suffered a major traumatic brain injury with significant cognitive impairments, inclusion in the study will depend on the medical team's judgment. Finally, participants with allodynia in the areas where vibrators will be placed will not be included in the protocol","18 Years",{"count":106,"type":21},10,[24],"The goal of this single-subject design is to evaluate an intervention combining neuromodulation, virtual reality, and muscle vibration to reduce neuropathic pain in individuals following a spinal cord injury.\n\nThe investigators aim to quantify the effects of the intervention on the intensity and characteristics of neuropathic pain, as well as its impact on daily functioning in individuals undergoing SCI rehabilitation. Additionally, the investigators seek to gain a better understanding of participants' experiences with the intervention by exploring effects not captured by standardized questionnaires, and by examining the role and meaning of the intervention in their management and experience of pain.\n\nFinally, the investigators aim to assess the feasibility and clinical relevance of implementing this intervention in a rehabilitation setting.\n\nAll participants living with neuropathic pain following a spinal cord injury will take part in ten intervention sessions. They will also be invited to complete standardized questionnaires and participate in a semi-structured interview. In addition, their clinicians will be invited to participate in a focus group.",[110],"Neuropathic Pain",[112,113,114,115,116,117,118],"neuropathic pain","spinal cord injury","mixed methods","single subject design","tDCS","virtual reality","muscle vibration","2025-11-20",{"date":121,"type":52},"2025-11-28",{"date":123,"type":21},"2025-12-01",{"date":125,"type":21},"2027-09",{"name":58,"class":59},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":134,"sex":17,"minAge":104,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":144,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":159},"100582728","effectiveness-of-a-customized-digital-platform-to-increase-coordination-of-care-and-uptake-of-evidence-based-practices-100582728","NCT06867081","Effectiveness of a Customized Digital Platform to Increase Coordination of Care and Uptake of Evidence-based Practices","Effectiveness of a Customized Digital Platform to Increase Coordination of Care and Uptake of Evidence-based Practices: a Protocol for a Stepped-wedge Cluster Randomized Trial in Quebec","Inclusion Criteria:\n\nClinicians, coordinators, managers, working in the 8 participating programs.\n\nPatients and caregivers must be able to:\n\n* Provide informed consent to collect secondary outcomes (not needed for primary outcome, as identified administrative data will be provided by health regions)\n* Speak and read English or French.\n\nExclusion Criteria:\n\n* N\u002FA",true,{"count":136,"type":21},962,[24],"Background: Cardiovascular and neurological conditions are major causes of disability worldwide. Early, intensive rehabilitation is essential but often challenging to access in current healthcare systems. In Canada, the direct and indirect costs of acquired brain injury (ABI) are substantial, emphasizing the need for improved rehabilitation services. In collaboration with four health regions and the Canadian Foundation of Innovation (CFI) funded BRILLIANT research group, investigators are implementing a digital health platform (the BRILLIANT platform), which includes five modules to address current gaps and support a person-centered integrated care continuum for cardiovascular and neurological conditions. In this stepped wedge randomized trial, investigators plan to implement and evaluate the use of the BRILLIANT Platform for improving transitions of care in the rehabilitation of ABI individuals in Quebec.\n\nMethods: A stepped wedge cluster randomized trial will be conducted across four healthcare regions with eight programs. Eligible participants included new cardiovascular and neurological patients, caregivers, clinicians, coordinators, and managers. The BRILLIANT platform intervention, implemented in 2 phases, will provide standardized assessments, communication tools, shared intervention plans, self-management support, and quality improvement dashboards. Outcomes will include rehabilitation intensity measured in minutes, time from admission to rehabilitation, health-related quality of life, care experience, and costs. Data analysis will use mixed-effects models for quantitative data and content analysis for qualitative data.\n\nDiscussion: This study will provide valuable evidence on the effectiveness and feasibility of the BRILLIANT platform in improving rehabilitation care for patients with cardiovascular and neurological conditions in Quebec. Investigators anticipate that by addressing the challenges and pursuing future directions, the implementation of this digital platform can contribute to improving patient outcomes and healthcare delivery.",[140,141,142,143],"Aquired Brain Injury","Traumatic Brain Injuries","Stroke","Cardiovascular Diseases",[145,146,82,147,148,149,150],"Acquired brain injury","Digital health platform","Transition of care","Person-centered care","Implementation science","stepped wedge trial","2025-08-22",{"date":153,"type":52},"2025-08-28",{"date":155,"type":21},"2025-09-30",{"date":157,"type":21},"2029-12",{"name":58,"class":59},2,{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":17,"minAge":167,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":177,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":60},"100441024","functional-evolution-of-traumatic-brain-injured-adults-during-rehabilitation-and-social-participation-100441024","NCT05022940","Functional Evolution of Traumatic Brain Injured Adults During Rehabilitation and Social Participation","Functional Evolution of Traumatic Brain Injured Adults During Rehabilitation and Social Participation: a Continuum of Care to Community Study","Inclusion Criteria:\n\n* All adult TBI patients receiving post-acute rehabilitation services.\n\nExclusion Criteria:\n\n* TBI patients that do not complete at least one month of rehabilitation.","17 Years",{"count":169,"type":21},1500,"OBSERVATIONAL","The research project aims to better understand the multiple factors related to the clinical evolution and the social participation of traumatic brain injured (TBI). The project will provide better understanding of the patients' evolution during rehabilitation after TBI in terms of adaptation and social participation, assess the effect of rehabilitation and study social participation outcomes and quality of life of TBI patients one-year post-rehabilitation. Project benefits include improvement of clinical practices and support in decision-making.\n\nThe objectives of this research project are:\n\nPart 1: To provide a picture of the evolution, in terms of social adaptation and participation of patients during rehabilitation after a TBI.\n\nPart 2: To study social participation outcomes and quality of life of TBI individuals one year after the end of their rehabilitation.",[173],"Traumatic Brain Injury",[175,176],"Social participation","Quality of life","RECRUITING","2024-08-27",{"date":180,"type":52},"2024-08-28",{"date":182,"type":52},"2017-06-01",{"date":184,"type":21},"2026-06-01",{"name":58,"class":59},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":104,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":22,"phases":195,"briefSummary":196,"conditions":197,"keywords":198,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":208,"locationsCount":60},"100546353","early-mobilization-in-cardiovascular-units-100546353","NCT06393829","Early Mobilization in Cardiovascular Units","Implementation of an Early Mobilization Program in Cardiovascular Units","Inclusion Criteria:\n\n* All healthcare professionals working in the cardiovascular unit at the Jewish General Hospital.\n* All patients admitted to the cardiovascular unit at the Jewish General Hospital.\n\nExclusion Criteria:\n\n* Patients who don't speak English or French.",{"count":194,"type":21},350,[24],"Insufficient mobility contributes to functional decline in hospitalized cardiac patients. Early mobilization programs were shown to improve functional status, increase the likelihood of home discharges, and reduce the length of stay \\[1\\]. Therefore, there is a need to adapt and implement early mobilization programs in Quebec hospitals. The overall goal of this study is to adapt and implement an early mobilization program in the Cardiovascular units of the Jewish General Hospital (JGH).",[143],[199,200,201],"Early mobilization program","cardiovascular","Level of mobility","2024-04-26",{"date":204,"type":52},"2024-05-01",{"date":206,"type":21},"2024-06-01",{"date":54,"type":21},{"name":58,"class":59},""]