[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Centro Universitário Augusto Motta\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":191},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,47,80,107,135,163],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100642339","neuroscience-education-and-spinal-manipulation-on-health-locus-of-control-in-low-back-pain-100642339",false,"NCT07639216","Neuroscience Education and Spinal Manipulation on Health Locus of Control in Low Back Pain","Pain Neuroscience Education Associated With Spinal Manipulation on Shifting Health Locus of Control in Patients With Low Back Pain: A Randomized Controlled Trial","LHC-LBP","Inclusion Criteria:\n\n* Both sexes.\n* Aged between 18 and 60 years.\n* Diagnosed with non-specific chronic low back pain (lasting 3 months or longer).\n* Functional disability score of 4 points or higher on the Roland-Morris Disability Questionnaire.\n* Has not received manual therapy for their condition within the previous 3 months.\n* Able to understand Portuguese well enough to complete the study questionnaires.\n\nExclusion Criteria:\n\n* Pregnant women.\n* Main area of pain is not located in the lumbar spine.\n* Main pain is located in the leg.\n* Less than 6 months post-surgery in the lumbar spine, lower limbs, or abdominal region.\n* Has undergone any invasive procedure for pain relief within the last 3 months.\n* Scoliosis.\n* Rheumatological diseases.\n* Progressive neurological disease.\n* Disorders related to red flags, such as malignancy\u002Fcancer, acute trauma (e.g., car or motorcycle accidents), fractures, infection, or spinal cord\u002Fcauda equina compression.\n* Chronic low back pain persisting after previous spinal surgery.","ALL","18 Years","60 Years",{"count":21,"type":22},74,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to evaluate the effects of combining Pain Neuroscience Education (PNE) with spinal manipulation for individuals suffering from chronic low back pain. Participants will be randomly assigned to one of two groups: one group will receive the combined intervention (neuroscience education plus spinal manipulation), while the control group will receive spinal manipulation alone.\n\nThe primary goal of the researchers is to investigate whether this combined approach can help patients change their health locus of control-shifting from an external belief (that their health depends on external factors or clinicians) to an internal belief (that they have control over their own recovery and pain management). The total study period will last 3 months, consisting of 4 weeks of intervention followed by an 8-week follow-up period to assess long-term changes in pain intensity, disability, and health beliefs.",[28],"Low Back Pain",[30,31,32,33],"internal-external control","low back pain","spinal manipulation","pain education","NOT_YET_RECRUITING","2026-06-05",{"date":37,"type":38},"2026-06-10","ACTUAL",{"date":40,"type":22},"2026-07",{"date":42,"type":22},"2027-07",{"name":44,"class":45},"Centro Universitário Augusto Motta","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100639545","efficacy-of-cognitive-functional-therapy-in-individuals-with-chronic-low-back-pain-after-spinal-surgery-100639545","NCT07576062","Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal Surgery","Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal Surgery: A Randomized, Sham-Controlled Trial","Inclusion Criteria:\n\n* Age 18-75 years\n* Chronic low back pain ≥12 weeks\n* History of lumbar surgery ≥3 months\n* Pain intensity ≥3 (NPRS)\n* ODI ≥14%\n\nExclusion Criteria:\n\n* Serious spinal pathology\n* Neurological disorders\n* Radiculopathy\n* Pregnancy\n* Unstable cardiac conditions","75 Years",{"count":56,"type":22},90,[25],"Chronic low back pain after spinal surgery is a complex and disabling condition influenced by biopsychosocial factors. Cognitive Functional Therapy (CFT) is a promising intervention targeting these multidimensional aspects. This randomized, sham-controlled trial aims to compare the efficacy of CFT versus a sham intervention (detuned photobiomodulation) in participants with chronic low back pain after spinal surgery.",[60,61,62],"Chronic Low Back Pain","After Lumbar Spine Surgery","Failed Back Surgery Syndrome (FBSS)",[64,65,66,67,68,69,70,31,71],"Cognitive Functional Therapy","Spinal Surgery","Low-intensity light therapy","Placebo","Pain management","back pain","chronic pain","Sham","2026-05-03",{"date":74,"type":38},"2026-05-08",{"date":76,"type":22},"2026-05",{"date":78,"type":22},"2027-11",{"name":44,"class":45},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":46},"100476211","cognitive-functional-therapy-compared-with-pilates-in-elderly-patients-with-chronic-low-back-pain-100476211","NCT05480982","Cognitive Functional Therapy Compared With Pilates in Elderly Patients With Chronic Low Back Pain","Cognitive Functional Therapy Compared With Pilates in Elderly Patients With Chronic Low Back Pain Treated Via Telerehabilitation: A Randomized Controlled Trial","Inclusion Criteria:\n\n* A main complaint of pain in the area between the 12th rib and buttock crease with or without accompanying non-radicular leg pain;\n* Episode of ongoing low back pain for at least 12 weeks' duration;\n* Presenting to a primary care clinician at least 6 weeks ago for this episode of LBP;\n* Being able to walk independently (with or without aids);\n* Ability to understand Portuguese well enough to be able to fill in the questionnaires.\n* Medium or high risk score on STartback screening tool.\n\nExclusion Criteria:\n\n* Known or suspected red flag disorders like fracture, malignancy\u002Fcancer, cauda equina syndrome or progressive neurological disorder, inflammatory or infective diseases of the spine;\n* Suspected radicular pain (dominant leg pain, positive neural tissue provocation tests and\u002For any two of altered strength, reflexes or sensation for the same nerve root, assessed clinically);\n* Spinal surgery \\\u003C 6 months previously;\n* Invasive procedures for pain relief (ex: epidural injection, rhizotomy) in the last three months;\n* Scoliosis (if considered the primary cause of pain);\n* Unstable heart conditions;\n* Chikungunya or Dengue virus disease transmitted by mosquitoes;\n* Relevant cognition deficit measured by 10 point cognitive screener, with a cut-off point of less than 8 points, 18 for participants with elementary education, and 26 for participants with secondary and\u002For higher education;\n* Post Covid-19 sequelae of pain.","65 Years",{"count":89,"type":22},200,[25],"There is evidence of three randomized controlled trials that face-to-face CFT reduces disability compared with active interventions for adults with chronic low back pain. The pandemic enabled the popularization of tele rehabilitation around the globe, but there are still no clinical trial testing the effectiveness of Cognitive Functional Therapy (CFT) via tele rehabilitation for elderly people with chronic low back pain. The aim of this study is to investigate the effectiveness of CFT compared with Pilates, both via tele rehabilitation in elderly patients with chronic low back pain.",[28],[31,94,95,96,97,98],"cognitive functional therapy","telehealth","Pilates","behavioral therapy","exercise therapy","RECRUITING",{"date":101,"type":38},"2026-05-07",{"date":103,"type":38},"2022-09-02",{"date":105,"type":22},"2028-12",{"name":44,"class":45},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":134},"100606999","prevalence-of-pain-in-mechanically-ventilated-patients-in-intensive-care-units-100606999","NCT07182851","Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units","PainICU","Inclusion Criteria\n\nParticipants of both sexes, aged 18 or over;\n\nParticipants who are using invasive mechanical ventilation,\n\nExclusion Criteria:\n\nParticipants undergoing treatment with neuromuscular blockers,;\n\nParticipants with any condition associated with altered pain perception (e.g., Guillain-Barré Syndrome, SCI, etc.);\n\nParticipants with any condition that would likely interfere with behavioral assessments of pain (e.g., decortication or decerebration posture)\n\nAs the assessments will be carried out before and after the tracheal aspiration procedure, if the patient does not have objective criteria for tracheal aspiration, he\u002Fshe will be excluded from the study, irrefutably preventing the procedure from being carried out without express need.",{"count":115,"type":22},370,"OBSERVATIONAL","Introduction: Pain is a subjective symptom, a physiological response that is difficult to assess, which affects the body physically and\u002For emotionally. It is a common phenomenon among clinical and surgical patients in Intensive Care Units (ICU). And its effects are the combined results of physiological and behavioral aggressions caused by clinical conditions, immobility and the execution of common procedures in ICU's. The presence of pain appears to be independently associated with worse clinical outcomes, including higher infection rates, patient-ventilator asynchronies, delirium, prolonged mechanical ventilation (MV), length of hospital stay and higher healthcare costs. Objectives: To evaluate the prevalence of pain and its associated factors in mechanically ventilated surgical patients in ICU's. Methods: This is a cohort, prospective, multicenter study designed to estimate the prevalence of pain, its intensity, its associated factors, correlating them to outcomes such as patient-ventilator asynchrony rate, time to weaning, and 28-day mortality in mechanically ventilated patients. All research participants who meet the inclusion criteria and who are not using neuromuscular blockers, or have any other condition associated with altered pain perception, will be evaluated using the Behavioral Pain Scale (BPS) and the Critical Care Pain Observation Tool (CPOT) on the 2nd day of mechanical ventilation and on the first day of awakening, when the RASS scale is between 4 and -2. At the same time, data will be collected on the ongoing sedoanalegesia strategy, and the asynchrony index will be calculated \\[(Nº of asynchronous ventilatory cycles\u002FNº of ventilatory cycles studied) \\*100\\]. The end point of the research will be 28 days, where the time until weaning, time until discharge or death will be established using the Kaplan-Meier estimators. Expected results: The prevalence of pain and its intensity is associated with the presence of patient-ventilator asynchronies and thus with harsh outcomes related to the length of stay in the ICU, time until weaning and thirty-day mortality in the ICU. It is estimated that there is agreement between the BPS and CPOT scales in mechanically ventilated patients.",[119,120,121],"Sedation and Analgesia","Pain Intensity Assessment","Mechanical Ventilation Complication",[123,124,125],"mechanical ventilation","intensive care unit","Pain Assessment","2025-09-17",{"date":128,"type":38},"2025-09-19",{"date":130,"type":38},"2025-06-01",{"date":132,"type":22},"2026-03-31",{"name":44,"class":45},4,{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":144,"conditions":145,"keywords":151,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":46},"100596453","association-between-the-sit-to-stand-test-and-the-prognosis-of-patients-with-heart-failure-100596453","NCT07045649","Association Between the Sit-To-Stand Test and the Prognosis of Patients With Heart Failure","Association Between Performance in the 1-Minute Sit-To-Stand Test and Clinical and Functional Outcomes of Patients Hospitalized for Heart Failure - Prospective Observational Study","Inclusion Criteria:\n\n* Patients diagnosed with CDI;\n* Over 18 years of age;\n* With an Intensive Care Unit Mobility Scale (IMS) \\> 4 at discharge from the ICU;\n* Able to sit and stand up from a chair without support from the upper limbs (ULs) will be included in the study.\n\nExclusion Criteria:\n\n* Patients with cognitive alterations;\n* Level of consciousness, with \\[RASS (Richmond Agitation and Sedation Scale) \\>+1 or \\\u003C-2 and Glasgow \\\u003C13 (Coma Scale)\\], neurological and orthopedic, which compromise the understanding and performance of the assessment will be excluded;\n* Patients with advanced invasive ventilatory and circulatory support or in cardiogenic shock.",{"count":143,"type":22},68,"Introduction: Heart failure (HF), among cardiovascular diseases, is the disease that has been increasing its incidence and prevalence the most in recent years in the world population, due to the aging of the population. In addition, HF is the most frequent hospital diagnosis in the elderly, and is the main cause of hospitalization, with significant expenditure in public and private health care worldwide. Some functional tests have been used to predict the prognosis in patients with HF, however, the use of the 1-minute sit-to-stand test (SST1) to predict prognosis in HF has little scientific evidence, due to the lack of studies found in the literature for this population. Thus, the present study aims to evaluate the association between SST1 at discharge from the Cardio Intensive Care Unit (ICU) and the clinical outcome after 90 days in patients hospitalized for decompensated heart failure (DHF). Methods: This is a prospective cohort study analyzing the association between performance on the TSL1 and clinical outcome in patients hospitalized for DHF from June 2025 to October 2025. Sociodemographic, family, social, and clinical data will be collected from the participants, after which the TSL1 will be performed. The outcome of death and hospital readmission within 90 days after discharge from the ICU will be identified through telephone contact, which will be carried out by the researcher. Expected results: It is expected that from the results of this study it will be possible to understand whether performance on the TSL1 predicts clinical outcome for patients hospitalized for DHF and that it will even be possible to determine a cutoff point capable of predicting the outcomes of interest.",[146,147,148,149,150],"Heart Failure","Heart Failure NYHA Class IV","Heart Failure; With Decompensation","Heart Failure NYHA Class III","Heart Failure NYHA Class II",[152,153,154],"Functional Status","Hospitalization","Prognosis","2025-07-18",{"date":157,"type":38},"2025-07-23",{"date":159,"type":38},"2025-07-16",{"date":161,"type":22},"2026-02",{"name":44,"class":45},{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":23,"phases":171,"briefSummary":172,"conditions":173,"keywords":175,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":190},"100525892","rehabilitation-of-people-with-post-tuberculosis-lung-disease-100525892","NCT06127641","Rehabilitation of People With Post-tuberculosis Lung Disease","Inclusion Criteria:\n\n* Patients with post-tuberculosis lung disease, clinically stable and able to perform \\>80% of training sessions.\n\nExclusion Criteria:\n\n* Presence of comorbidities not related to PD-PTB.\n* Patients with inability to perform TGlittre.\n* Patients who have cognitive changes that impair their inclusion in the study.\n* Treatment abandonment during the application of the PR protocol.\n* Uncontrolled hypertension or use of psychotropic medications.\n* Any significant limitations due to osteoarthropathy.\n* Having had any orthopedic surgery in the previous year.",{"count":170,"type":22},40,[25],"Tuberculosis (TB) can leave numerous sequelae, where survivors experience a transition from an acute illness to living with a multifaceted chronic illness. Post-TB lung disease (PD-PTB) encompasses lung diseases and pathologies that occur after one or more episodes of TB, which can affect the patient's lung health and cause disabling symptoms that strongly affect their long-term health. In 2020, it was estimated that there were 155 million TB survivors still alive worldwide, with a large proportion of them carrying functional sequelae with profound socioeconomic repercussions. Thus, the aim of this study is to evaluate the effect of pulmonary rehabilitation (PR) on functionality and health-related quality of life (HRQoL) of people with PD-PTB and to build a PD-PTB severity scoring system based on the data. of pre-RP individuals using artificial intelligence technique.",[174],"Pulmonary Tuberculosis",[176,177,178,179,180,181],"Pulmonary tuberculosis","Tuberculosis sequelae","Rehabilitation","ADL-Glittre test","Functionality","Quality of life","2023-11-07",{"date":184,"type":38},"2023-11-13",{"date":186,"type":38},"2023-10-28",{"date":188,"type":22},"2027-12-31",{"name":44,"class":45},2,""]