[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Chalmers University of Technology\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":112},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,58,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":36,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100590898","the-switch-dietary-and-behavioural-intervention-study-100590898",false,"NCT06973408","The SWITCH Dietary and Behavioural Intervention Study","Switching to a Healthy and Sustainable Diet for Planetary and Human Health","SWITCH","Inclusion Criteria:\n\n* Age 18-70 years\n* Body mass index 25-35 kg\u002Fm2\n* Stable dietary patterns at the entry to the study (no specific dieting the last 4 weeks).\n* Willingness to adhere to advised diet pattern and to consume provided key foods.\n* Medications stable for the previous 14 days of relevant medicines\n* Access to a -18⁰ C freezer to store key foods at home.\n* Signed informed consent\n\nExclusion Criteria:\n\n* Currently having an infection or other relevant illness.\n* Cardiovascular events (myocardial infarction or stroke) during the previous 6 months. To be included, the disease needs to be stable.\n* Diagnosis of diabetes (any type).\n* Blood Pressure (BP): ≥185\u002F105 mmHg.\n* Serum Cholesterol (S-Chol): ≥8 mmol\u002FL.\n* Blood Glucose (B-Glucose): fasting value \\>7 mmol\u002FL.\n* Currently on GLP-1 receptor agonists.\n* History of stomach or gastrointestinal diagnoses (inflammatory bowel disease, Crohn's disease, hepatitis, malabsorption, celiac disease etc.).\n* IBS- if severe and recent (\\\u003C0.5year)?\n* Previous colostomy, bowel resection, bariatric surgery or other major gastrointestinal surgery.\n* Renal or liver failure (creatinine \\\u003C1.7 mg\u002Fdl and alanine aminotransferase\u002F aspartate aminotransferase \\> 2 times than normal values (ASAT, ALAT), respectively).\n* Anemia or Hemoglobin (Hb): \\\u003C100 g\u002FL\n* Blood donation (or participation in a clinical study with blood sampling) within 30 days prior to inclusion\n* Currently on a specific diet.\n* A diet incompatible with protocol diets such as strict vegan\u002Fvegetarian.\n* Food allergies or intolerances to food items included in the intervention.\n* High level of regular physical activity at baseline - scale 4 on SG-PALS.\n* History of drug or alcohol abuse.\n* Not able to understand written or spoken Swedish.\n* Any other reason for lack of suitability for participation in the trial, as judged by the principal investor and\u002F or the clinical investigator.\n* Pregnant or lactating or planning to become pregnant during the study period.\n* Involved in another potentially interfering research study.",true,"ALL","18 Years","70 Years",{"count":22,"type":23},300,"ESTIMATED","INTERVENTIONAL",[26],"NA","The overall objective of this study is to evaluate the effectiveness of an optimized lifestyle intervention based on dietary advice, behavioral support, and provision of key foods compared to dietary advice with behavioral support or dietary advice alone. The intervention aims to improve nutritional status, metabolic risk factors, and planetary sustainability.\n\nA total of 300 participants (150 men and 150 women) who meet all inclusion criteria and none of the exclusion criteria will be recruited. The study will be conducted at the Centre for Lifestyle Intervention at Östra Hospital in Gothenburg, led by researchers from Chalmers University of Technology, University of Gothenburg, and Sahlgrenska University Hospital. Participants will be recruited from two different socioeconomic areas in Gothenburg to examine how dietary interventions function in diverse population groups.\n\nThe study follows a twelve-week randomized, controlled, parallel intervention design. Participants will be randomized into three groups, each with 100 individuals:\n\nOptimized lifestyle intervention group - receiving dietary advice, behavioral support, and provision of key foods.\n\nBehavioral support intervention group - receiving dietary advice and behavioral support.\n\nControl group - receiving dietary advice according to the SWITCH diet. The SWITCH diet, developed within the EU project SWITCH, is designed to align with European dietary guidelines and promote sustainable and healthy eating habits. It emphasizes whole grains, vegetables, fruits, legumes, and sustainable seafood while limiting processed foods, added sugars, and salt.\n\nThroughout the study, participants will undergo clinical assessments at baseline, midpoint (week 7), and endpoint (week 13). Key measurements include anthropometric data, blood pressure, blood glucose, blood lipids, and inflammatory markers. Dietary intake and sustainability aspects of food consumption will also be evaluated. Participants in the intervention groups will receive personalized coaching and access to practical resources, such as meal plans, recipes, and visual educational materials.\n\nThe primary outcome of the study is the difference in cardiometabolic risk factors (e.g., blood lipids, blood pressure, glucose, insulin resistance markers) between the intervention groups. Secondary outcomes include changes in dietary intake, nutritional status markers, inflammatory markers, and sustainability measures (e.g., CO₂ emissions, land use, biodiversity impact). Additionally, exploratory analyses will investigate associations between diet, lifestyle changes, gut microbiota, and metabolic responses.\n\nThis study aims to generate valuable insights into the effectiveness of different dietary intervention strategies in real-life Nordic conditions. The results will contribute to the development of evidence-based recommendations for sustainable and health-promoting dietary patterns.",[29,30,31,32,33,34,35],"Dietary Behaviour","Dietary Intakes","Dietary Intervention","Metabolic Diseases","Blood Lipid Profiles","Blood Glucose Metabolism","Diet, Healthy",[37,38,39,40,41,42,43,44],"Cardiometabolic health","Lifestyle intervention","Dietary adherence","Sustainable diet","Nordic diet","Metabolic risk factors","Randomized controlled trial","nevironmental impact of diet","RECRUITING","2025-05-14",{"date":48,"type":49},"2025-05-15","ACTUAL",{"date":51,"type":49},"2025-03-03",{"date":53,"type":23},"2026-11-30",{"name":55,"class":56},"Chalmers University of Technology","OTHER",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":18,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":24,"phases":70,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":57},"100585044","personalized-metabolic-responses-to-rapid-slow-and-resistant-starch-100585044","NCT06897241","Personalized Metabolic Responses to Rapid, Slow and Resistant Starch","Personalized Metabolic Responses to Rapid, Slow and Resistant Starch (PerStarch)","PerStarch","Inclusion Criteria:\n\n* Men and post-menopausal women\n* Age 30-75 years\n* BMI 27-40 kg\u002Fm2\n* Waist circumference \\> 102\u002F88 cm for men\u002Fwomen\n* Weight stable during previous 3 months (± 3 kg)\n* Willingness to consume the intervention diets\n* Ability to deal with the monitoring devices\n* Medications stable for the previous 14 days\n* Signed informed consent\n\nExclusion Criteria:\n\n* Cardiovascular events (myocardial infarction or stroke) during the previous 6 months\n* Diagnosis of diabetes (any type) or use of any drug who can interfere with glucose homeostasis (i.e., metformin, incretin analogues, SGLT-2 inhibitors)\n* History of stomach or gastrointestinal conditions (inflammatory bowel disease, Crohn's disease, malabsorption, etc.)\n* Colostomy, bowel resection, bariatric surgery or other major gastrointestinal surgery\n* Renal or liver failure (creatinine \\\u003C1.7 mg\u002Fdl and alanine aminotransferase\u002Faspartate aminotransferase \\\u003C 2 times than normal values, respectively)\n* Anemia (hemoglobin below the age and sex specific normal reference ranges at screening)\n* Blood donation (or participation in a clinical study with blood sampling) within 30 days prior to inclusion\n* Having been treated with antibiotics within the past 3 months or planning to undergo treatment during the study period.\n* Habitual use of probiotic\u002Fprebiotic supplements or foods enriched in probiotics\n* Celiac disease\n* Vegan\u002Fvegetarian diet (or a diet incompatible with protocol diets)\n* Intense physical activity regimen (\\> 7 h\u002Fweek of moderate intensity or \\> 3 h\u002Fweek of high intensity)\n* History of drug or alcohol abuse\n* Not able to understand written and spoken Swedish\n* Any other reason for lack of suitability for participation in the trial, as judged by the principal investor or co-principal investigator","30 Years","75 Years",{"count":69,"type":23},96,[26],"The study aims to investigate how individuals with varying gut microbiota composition and AMY1 gene copy number respond to three different types of starch. A 12-week trial will therefore be conducted, where all participants will go through three different 17-day interventions in a randomized order. Each intervention will contain a different type of starch:\n\nA) Resistant starch B) Slow digestible starch C) Rapid digestible starch\n\nEach intervention will contain a preparation day, a meal challenge test day at clinic, a 14-day dietary intervention at home followed by a follow up visit at clinic. The interventions will be separated with a 14-day wash-out period, where participants are consuming their normal food.\n\nBlood, saliva and fecal samples will be collected during the trial, together with data from continuous glucose monitoring and body measurements. Questionnaires on dietary intake and lifestyle, food preferences, self-reported appetite, health-related quality of life, sleep quality and daytime sleepiness will also be filled out by the participants.",[73],"Adults With Overweight and Obesity",[75,76,77,78,79,80,81],"Glucose metabolism","Prevotella","AMY1 copy number","Continuous glucose monitoring","Meal tolerance test","Fecal redox potential","Home sampling",{"date":83,"type":49},"2025-05-16",{"date":85,"type":49},"2025-04-08",{"date":87,"type":23},"2026-05-01",{"name":55,"class":56},{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":17,"sex":18,"minAge":97,"maxAge":20,"enrollmentInfo":98,"targetDuration":4,"studyType":24,"phases":100,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":5},"100580832","the-nutriome-study---a-data-driven-precision-nutrition-intervention-100580832","NCT06842433","The NUTRIOME Study - a Data-driven Precision Nutrition Intervention","The NUTRIOME Meal Study - a Data-driven Precision Nutrition Intervention Study Using Meal Responses","NUTRIOME","Inclusion Criteria:\n\n* Men and women\n* Age 40 to 70 years\n* Body mass index (BMI) 27-35 kg\u002Fm2\n* Signed informed consent\n\nExclusion Criteria:\n\n* History of diagnosed cardiovascular disease (e.g. stroke, heart disease)\n* Diagnosed type 1 or type 2 diabetes\n* Finger prick glucose test at screening indicating diabetes (fasting \\>6.9 mmol\u002FL; non-fasting \\>11.0 mmol\u002FL)\n* Antibiotic use in the last 3 months\n* Taking medication that can interfere with the planned outcome measures, as judged by the study physician (e.g. peroxisome proliferator-activated receptor-α \\[PPAR-α\\] or PPAR-γ agonists \\[fibrates\\], sulfonylureas, biguanides, α-glucosidase inhibitors, thiazolidinediones, repaglinide, nateglinide and insulin, chronic use of NSAIDs). Statins and hypertension medication are allowed if the medication regimen has been stable for the last three months\n* Stomach and gastrointestinal conditions (e.g. Morbus Chron, Ulcerative colitis, irritable bowel syndrome, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.)\n* History of major gastrointestinal surgery\n* Anaemia: Hb concentrations \\\u003C 8.5 mmol\u002FL for men and \\\u003C 7.5 mmol\u002FL for women\n* Recent blood donation (within 2 months prior to the screening)\n* Recent participation in another intervention study (within 2 months prior to the screening)\n* Allergy or intolerance to medical skin adhesives\n* Chronic or acute inflammatory conditions (e.g., rheumatoid arthritis, psoriatic arthritis)\n* Autoimmune disorders\n* Thyroid disorders\n* Significant renal or liver dysfunction or chronic kidney or liver disease\n* Known food allergies\u002Fintolerances to intervention foods or food products used in the study\n* Following specific dietary regimen that could impact results or not suitable for the study design (e.g. vegetarian, vegan)\n* Habitual tobacco consumption (e.g. smoking, use of snus, vaping)\n* Alcohol intake ≥ 14 alcoholic beverages\u002Fweek for women and ≥ 21 alcoholic beverages\u002Fweek for men\n* Current or planned pregnancy or lactating\n* Other serious medical conditions that could interfere with participation or study outcomes\n* Unable to sufficiently understand written and spoken national language (where the study centre is located) to provide written consent and understand information and instructions from the study personnel.\n* Deemed unsuitable for participation in the trial, for any reason, as judged by the research physician or PI.\n* Working at the division conducting the trial at any of the three study centres.\n* Do not have a mobile phone that is suitable for the use of a research app.","40 Years",{"count":99,"type":23},120,[26],"The overall objective of this multi-center study is to use metabolic response data from different dietary challenges to develop personalized dietary advice. Effectiveness of this personalized dietary advice compared to a general healthy diet based on national dietary guidelines on markers of cardio-metabolic health will be tested.\n\nA total of 120 men and women who meet all inclusion criteria and none of the exclusion criteria will be invited to participate. The study will be conducted at three sites: Chalmers University of Technology (Sweden), University of Wageningen (Netherlands), and University of Oslo (Norway), with 40 participants per site.The study is conducted in two parts. The first part, the characterization phase, is a three-way randomized, controlled cross-over design, featuring one-day meal tests with isocaloric meals containing different carbohydrate, fat and protein quantity as well as quality. Based on the metabolic response to the meal tests a personalized diet will be constructed. In the second part, the main intervention, effectiveness of this personalized dietary advice compared to a general healthy diet will be tested in a six week parallel group intervention study.",[103],"Metabolic Control","2025-03-20",{"date":106,"type":49},"2025-03-21",{"date":108,"type":49},"2025-03-14",{"date":110,"type":23},"2026-06-30",{"name":55,"class":56},""]