[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Chang Gung University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":221},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,48,77,103,131,156,177,202],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100535149","effectiveness-of-online-program-and-task-related-training-for-parkinsons-disease-100535149",false,"NCT06248073","Effectiveness of Online Program and Task-related Training for Parkinson's Disease","Comparing the Effectiveness of Online Self-management Program and On-site Task-related Training for People With Early Stage Parkinson's Disease on Activity Participation and Quality of Life","Inclusion criteria:\n\n1. Willingness to sign the informed consent form.\n2. Age between 45 and 70 years, with mild idiopathic Parkinson's disease and Hoehn and Yahr stage 1-2.\n3. No cognitive impairment.\n4. No severe depression that could affect the motivation to participate in the study.\n5. No history of shoulder dislocation or fracture that could affect body proprioception.\n6. No diseases that could affect the ability to reach for objects, such as stroke.\n7. No diseases that could affect peripheral sensation, such as diabetes.\n8. No severe tremors; patients whose hands, when relaxed and placed on the apparatus, still exhibit significant tremor interfering with the experiment will not be included.\n9. Able to follow instructions and complete the assessment process.\n10. Have not received physical or occupational therapy in the past year.\n\nExclusion criteria:\n\n1. Other central nervous system diseases, such as stroke.\n2. Have major surgery on the head or upper limbs.\n3. Inability to perform the reaching task while sitting.","ALL","45 Years","70 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare the effectiveness of online self-management program and on-site task-related training for people with early stage Parkinson's disease.\n\npeople with early stage of Parkinson's disease (age range: 45-70 years) will be randomly assigned into the following three groups: control group, online self-management program group and on-site task-related training group.The control group will receive no treatment during the experimental period. For the other two groups, participants will receive the intervention twice a week, one hour per session and 12 sessions in total.\n\nThe main questions it aims to answer are:\n\n1. the potential impact of motor and non-motor symptoms on activity participation and quality of life for people with early stage of Parkinson's disease (PD).\n2. compare and examine the the effectiveness of online self-management program and on-site task-related training for people with early stage Parkinson's disease on activity participation and quality of life.",[27,28,29,30],"Parkinson Disease","Occupational Therapy","Telerehabilitation","Activities of Daily Living",[29,32,33,34],"early intervention","patient-reported outcome assessment","self-perception","RECRUITING","2026-03-18",{"date":38,"type":39},"2026-03-20","ACTUAL",{"date":41,"type":39},"2024-03-01",{"date":43,"type":21},"2027-12-31",{"name":45,"class":46},"Chang Gung University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100546285","effects-of-rhythmic-auditory-cueing-augments-cognitive-treadmill-walking-training-in-individuals-with-chronic-stroke-100546285","NCT06392945","Effects of Rhythmic Auditory Cueing Augments Cognitive Treadmill Walking Training in Individuals With Chronic Stroke","Effects of Rhythmic Auditory Cueing Augments Cognitive Treadmill Walking Training on Community Walking Capacity, Walking Automaticity, and Social Participation in Individuals With Chronic Stroke: a Randomized Controlled Trial","Inclusion Criteria:\n\n* diagnosed with first-time stroke;\n* more than 6 months after stroke onset;\n* able to walk 10 meters;\n* no severe vision, hearing, or speech impairments;\n* understand and follow the instructions and sign the Informed Consent Form;\n* older than 20 years old.\n\nExclusion Criteria:\n\n* orthopedic problems affecting walking or other diseases that may interfere with study participation;\n* a score of less than 24 on the mini-mental state examination (MMSE);\n* severe balance disorder with a total score of less than 45 points Berg Balance Scale.","20 Years","85 Years",{"count":58,"type":21},90,[24],"The first objective of this study is to examine the superiority of the combined rhythmic auditory cueing with cognitive treadmill training (combined group) in people with stroke as compared with the cognitive treadmill walking training (cognitive group) or treadmill walking training alone (treadmill group) (Aim 1). The study's second aim is to investigate the factors affecting the improvement in community walking capacity after interventions and to explore whether changes in community walking capacity are associated with changes in participation after interventions (Aim 2).",[62],"Stroke",[64,65,66,67,68],"stroke","gait rehabilitation","rhythmic auditory cueing","cognitive training","treadmill","2026-03-17",{"date":71,"type":39},"2026-03-19",{"date":73,"type":39},"2024-05-24",{"date":75,"type":21},"2027-07-31",{"name":45,"class":46},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":47},"100561900","effect-of-tscs-on-ankle-movement-training-in-individuals-with-sci-100561900","NCT06596174","Effect of tSCS on Ankle Movement Training in Individuals With SCI","Effect of tSCS on Ankle Movement Training - Evidence From Spinal Circuitry Adaptation in Individuals With SCI","Health subjects:\n\nExclusion Criteria:\n\n1. Musculoskeletal injuries on legs.\n2. Osteoporosis.\n\nSCI subjects:\n\nInclusion Criteria\n\n1\\. Participants with chronic spinal cord injury, with injury duration greater than one year.\n\nExclusion Criteria\n\n1. Current musculoskeletal or joint injuries in the lower limbs.\n2. History of central or peripheral neuromuscular diseases.\n3. Presence of a pacemaker.\n4. Current use of antispastic or antidepressant medications.\n5. Current venous thromboembolism or osteoporosis.\n6. Impairment of the soleus H-reflex arc.",true,{"count":86,"type":21},80,[24],"This clinical trial explores the effectiveness of transcutaneous spinal cord stimulation (tSCS), a non-invasive technique, in facilitating spinal circuitry adaptation in individuals with spinal cord injury (SCI). While epidural spinal cord stimulation (eSCS) has shown functional benefits, its application is limited by the side effects associated with implanted electrodes. tSCS, which shares a similar mechanism but does not require surgery, has yet to be extensively studied in large human trials.\n\nThe study aims to:\n\nDetermine optimal tSCS parameters for non-invasive spinal stimulation. Investigate the priming effect of tSCS on spinal circuitry during machine-assisted ankle movement training.\n\nExamine the long-term clinical outcomes of combining tSCS with ankle movement training in individuals with incomplete SCI.\n\nThe trial will include both healthy participants and individuals with complete and incomplete SCI, using the soleus post-activation depression (PAD) model to evaluate spinal circuitry adaptation. The results will provide insights into spinal re-adaptation and potentially introduce a novel, non-invasive approach for SCI rehabilitation.",[90],"SCI - Spinal Cord Injury",[92,93,94],"post activation depression","transcutaneous spinal cord electrical stimulation (tSCS)","machine-assist therapy","2024-11-24",{"date":97,"type":39},"2024-11-26",{"date":99,"type":39},"2024-11-25",{"date":101,"type":21},"2026-08",{"name":45,"class":46},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":130,"locationsCount":47},"100551788","efficacy-of-the-living-with-type-1-diabetes-to-grown-up-interactive-podcast-program-100551788","NCT06464640","Efficacy of the \"Living With Type 1 Diabetes to Grown-Up\" Interactive Podcast Program","Efficacy of the Interactive Podcast Program \"Living With Type 1 Diabetes to Grown-Up\": A Two-arm Randomized Controlled Trial","Inclusion Criteria:\n\n* a confirmed diagnosis of T1D by an endocrinologist before the age of 16 and a disease duration of \\>6months\n* patients aged 16-25 years\n* mean HbA1C level ≥7.5% one year before inclusion\n* ability to communicate in Chinese or Mandarin\n* patients who own smartphones with internet access\n* patients who agreed to voice recording during a session explaining the treatment process\n* patients who signed the informed consent form prior to participation; for minors, a legal representative must provide consent and sign the informed consent form.\n\nExclusion Criteria:\n\n\\# T1D patients with other concomitant metabolic diseases, chromosomal aberrations, major illnesses, and cognitive impairment will be excluded from this study.","16 Years","25 Years",{"count":113,"type":21},88,[24],"The present study aims to evaluate the intervention effectiveness of the Online Interactive Podcast Program\"Living with Type 1 Diabetes to Grown-Up\"in patients with type 1 diabetes transitioning from adolescence to early adulthood.",[117],"Type 1 Diabetes Mellitus",[119,120,121,122],"type 1 diabetes","transition","podcast","self-regulation","NOT_YET_RECRUITING","2024-10-10",{"date":126,"type":39},"2024-10-15",{"date":128,"type":21},"2024-11-01",{"date":43,"type":21},{"name":45,"class":46},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":152,"completionDateStruct":153,"leadSponsor":155,"locationsCount":47},"100562109","pas-balance-training-for-parkinson-disease-pd-100562109","NCT06598891","PAS Balance Training for Parkinson Disease (PD)","Effect of Combined PAS Balance Training on Individuals With PD","Inclusion Criteria:\n\n\\- Clinical diagnosis of Parkinson disease.\n\nExclusion Criteria:\n\n* Musculoskeletal injuries on legs\n* Osteoporosis.\n* Any peripheral or central nervous system injury or disease patients.",{"count":139,"type":21},60,[24],"Gait initiation (GI) difficulty is a common problem in individuals with Parkinson's disease (PD), often linked to impaired anticipatory postural adjustments (APA). Currently, there are no targeted rehabilitation programs designed specifically for GI-related APA in PD patients. Research has shown that while motor learning deficits are common in PD, explicit learning is better preserved than implicit learning. Therefore, a GI-related APA training system using an explicit learning model could be particularly effective for this population.\n\nDuring motor learning, long-term potentiation (LTP) increases the excitability of the primary motor cortex. Paired associative stimulation (PAS) has been demonstrated to induce LTP-like changes in the motor cortex, making it a potential priming method to enhance motor learning. However, the priming effect of PAS targeted at leg muscles and the motor cortex on motor learning related to GI-APA has not been previously studied.\n\nThe objectives of this study are:\n\n1. To investigate the effects of explicit and implicit training on GI-related APA.\n2. To evaluate the priming effect of PAS on GI-related APA training and the associated plasticity changes in the motor cortex.",[143],"PD - Parkinson's Disease",[145,146,147,148,149],"Gait Initiation","Paired associative stimulation (PAS)","Balance training","Motor learning","Anticipatory postural adjustment (APA)","2024-10-09",{"date":124,"type":39},{"date":150,"type":39},{"date":154,"type":21},"2026-05",{"name":45,"class":46},{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":84,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":165,"briefSummary":166,"conditions":167,"keywords":168,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":173,"startDateStruct":174,"completionDateStruct":175,"leadSponsor":176,"locationsCount":47},"100561901","differential-assessment-of-hypertonia-100561901","NCT06596187","Differential Assessment of Hypertonia","Differential Assessment of Hypertonia Related to CNS Impairment","Health subjects:\n\nExclusion Criteria:\n\n1. Musculoskeletal injuries on legs.\n2. Osteoporosis.\n\nSCI subjects:\n\nInclusion Criteria 1. Participants with chronic spinal cord injury, with injury duration greater than one year.\n\nExclusion Criteria\n\n1. Current musculoskeletal or joint injuries in the lower limbs.\n2. History of central or peripheral neuromuscular diseases.\n3. Presence of a pacemaker.\n4. Current use of antispastic or antidepressant medications.\n5. Current venous thromboembolism or osteoporosis.\n6. Impairment of the soleus H-reflex arc.\n\nPD subjects:\n\nInclusion Criteria:\n\n\\- Clinical diagnosis of Parkinson disease.\n\nExclusion Criteria:\n\n1. Musculoskeletal injuries on legs\n2. Osteoporosis.\n3. Any peripheral or central nervous system injury or disease patients.",{"count":164,"type":21},45,[24],"Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements. Spasticity is characterized by a velocity-dependent increase in stretch reflexes, accompanied by exaggerated tendon responses, while rigidity is marked by consistent resistance throughout the range of motion, traditionally considered independent of stretch velocity. However, recent studies suggest that rigidity may also be influenced by stretch velocity. This study aims to investigate muscle tone by examining spasticity, rigidity, and normal muscle function through neural and biomechanical changes. Standard clinical tools, such as the Modified Ashworth Scale and Unified Parkinson's Disease Rating Scale, along with additional assessments like the Myoton and Post-Activation Depression (PAD), will be employed.",[90,143],[169,170,171,172],"Spasticity","Post activation depression","Passive motion device (CPM)","Rigidity",{"date":126,"type":39},{"date":150,"type":39},{"date":101,"type":21},{"name":45,"class":46},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":16,"minAge":184,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":187,"briefSummary":188,"conditions":189,"keywords":191,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":200,"leadSponsor":201,"locationsCount":47},"100562215","cycling-based-priming-coordination-training-for-enhancing-ataxia-recovery-and-brain-plasticity-100562215","NCT06600269","Cycling-Based Priming Coordination Training for Enhancing Ataxia Recovery and Brain Plasticity","The Effect of Cycling Priming Coordination Training on Ataxia and Brain Plasticity","Inclusion Criteria:\n\n\\- Clinical diagnosis of SCA.\n\nExclusion Criteria:\n\n* Musculoskeletal injuries on legs\n* Osteoporosis.\n* Any peripheral or central nervous system injury or disease patients.","18 Years",{"count":186,"type":21},40,[24],"Effective walking and balance require not only lower limb muscle strength but also coordinated movement. For individuals with Spinocerebellar Ataxia (SCA), rehabilitation strategies targeting coordination are essential to improving mobility and reducing the burden on caregivers. However, evidence-based rehabilitation approaches for ataxia remain limited.\n\nRecent studies suggest that improvements in motor learning are often accompanied by changes in cortical excitability. Abnormal cortical excitability in SCA patients may hinder rehabilitation efforts, yet priming strategies-such as exercise or specific stimuli-have been shown to enhance motor learning by modulating cortical excitability. Cycling exercise, in particular, has demonstrated the potential to improve coordination and influence cortical plasticity in individuals with SCA, making it a promising priming strategy for coordination training.\n\nThis clinical trial aims to:\n\n1. Investigate the priming effect and neural mechanisms of acute cycling exercise on coordination training in patients with SCA.\n2. Explore the long-term impact of priming cycling training on cortical plasticity and functional mobility in individuals with SCA.\n\nThis study seeks to provide insights into optimized rehabilitation interventions that could enhance the quality of life and independence for people with SCA.",[190],"Spinocerebellar Ataxias",[192,193,194,195],"Transcranial Magnetic Stimulation (TMS)","Gait","Motor Control","Motor Learning","2024-10-04",{"date":198,"type":39},"2024-10-08",{"date":196,"type":39},{"date":101,"type":21},{"name":45,"class":46},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":208,"targetDuration":4,"studyType":22,"phases":209,"briefSummary":210,"conditions":211,"keywords":212,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":218,"leadSponsor":220,"locationsCount":47},"100562108","ar-gait-training-for-parkinsons-disease-100562108","NCT06598878","AR Gait Training for Parkinson's Disease","Effect of AR Environment Stimulation on Proactive and Reactive Modulation of Gait in Individuals With Parkinson Disease",{"count":139,"type":21},[24],"Gait disorders in Parkinson's disease (PD), particularly in complex environments or under stress, present challenges for accurate evaluation and classification, such as in cases of freezing of gait. Traditional clinical and laboratory settings often fail to replicate the complexity needed for precise classification, making effective rehabilitation difficult. This study aims to address these challenges by developing an augmented reality (AR)-based environment that mimics real-world stressors and dynamically adapts to the patient's condition. The AR system is designed to facilitate individualized gait training and rehabilitation by modifying environmental difficulty based on real-time feedback from gait performance and stress levels.\n\nBuilding on Gentile's taxonomy of tasks, the investigators have incorporated PD-specific factors, such as cognitive dual tasks, into our environment classification system. Preliminary results suggest that this system effectively elicits varying gait and heart rate variability (HRV) responses, indicating different stress levels.\n\nThis trial will further test the AR environment's ability to classify patients based on their responses to complex, interactive environments, while also investigating the effects of adaptive AR-based gait training on both gait and stress management in individuals with PD.",[143],[213,214,215],"Augmented Reality","Gait Taining","Heart Rate Variability (HRV)",{"date":198,"type":39},{"date":196,"type":39},{"date":219,"type":21},"2026-07",{"name":45,"class":46},""]