[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":204},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,48,79,102,123,151,178],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100631563","evacuation-time-and-tourniquet-use-as-risk-factors-for-ptsd-in-combat-related-amputation-100631563",false,"NCT07502313","Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation","Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation: A Prospective Cohort Study","EVAC-PTSD Stud","Inclusion Criteria:\n\n* Ukrainian veterans with combat-related injury (post-February 2022)\n* Single limb amputation\n* Admission to rehabilitation within 2-4 months post-injury\n* Age ≥18 years\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Prior PTSD diagnosis before current injury\n* Multiple amputations\n* Rehabilitation duration \\>3 months\n* Return to active military duty before follow-up completion","ALL","18 Years","60 Years",{"count":21,"type":22},300,"ESTIMATED","6 Months","OBSERVATIONAL","This study aims to evaluate the relationship between evacuation time, tourniquet use, and the development of post-traumatic stress disorder (PTSD) in patients with combat-related amputations. In the context of modern warfare, prolonged evacuation times and extended tourniquet application may contribute not only to physical injury but also to psychological trauma. The study will prospectively follow patients over 18 months to identify key predictors of PTSD and to assess their interaction.",[27,28,29,30],"Amputation","PTSD","Combat Posttraumatic Stess Disorder","Combat Trauma",[32,30,27,33,34],"Post-Traumatic Stress Disorder","Tourniquet Use","Evacuation Time","NOT_YET_RECRUITING","2026-03-30",{"date":38,"type":39},"2026-04-03","ACTUAL",{"date":41,"type":22},"2026-03-15",{"date":43,"type":22},"2026-11-15",{"name":45,"class":46},"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":58,"conditions":59,"keywords":66,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":78,"locationsCount":47},"100629532","negative-pressure-wound-therapy-as-a-predictor-of-persistent-pain-after-war-related-trauma-100629532","NCT07475897","Negative Pressure Wound Therapy as a Predictor of Persistent Pain After War-Related Trauma","Negative Pressure Wound Therapy as a Predictor of Persistent Pain After War-Related Trauma: A Prospective Cohort Study","NPWT-Pain Stud","Inclusion Criteria:\n\n* age ≥18 years\n* war-related trauma (blast injury, fragmentation injury, gunshot wound, burn injury, or crush injury)\n* traumatic soft tissue injury requiring surgical management\n* ability to provide informed consent\n* availability for follow-up assessments\n\nExclusion Criteria:\n\n* chronic pain in the same anatomical region prior to injury\n* severe cognitive impairment preventing pain assessment\n* inability to communicate or complete questionnaires\n* refusal to participate\n* incomplete baseline data or loss to follow-up",{"count":57,"type":22},150,"War-related trauma frequently causes complex soft tissue injuries that require repeated surgical treatment and advanced wound management techniques such as Negative Pressure Wound Therapy (NPWT). Although NPWT is widely used to promote wound healing and prepare wounds for reconstruction, its relationship with long-term pain outcomes remains unclear.\n\nThis prospective cohort study aims to investigate whether the use of NPWT after war-related trauma is associated with an increased risk of persistent post-traumatic pain six months after injury. Adult patients with traumatic soft tissue injuries requiring surgical management will be enrolled and followed for six months.\n\nIn addition to NPWT exposure, the study will evaluate several early clinical predictors of chronic pain, including acute pain intensity, number of surgical debridements, suspected nerve injury, and mechanism of trauma. Understanding these predictors may help clinicians identify high-risk patients early and develop targeted strategies for pain prevention and rehabilitation after severe trauma.",[60,61,62,63,64,65],"Phantom Limb Pain After Amputation","Chronic Pain Due to Injury","Postoperative Pain","Trauma (Including Fractures)","Amputation Stump","Amputation Stump; Infection",[67,68,69,70,71,72],"Negative Pressure Wound Therapy","War-related trauma","Post-traumatic pain","Neuropathic pain","Chronic pain after trauma","Soft tissue injury","2026-03-16",{"date":75,"type":39},"2026-03-18",{"date":41,"type":22},{"date":41,"type":22},{"name":45,"class":46},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":87,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":98,"startDateStruct":99,"completionDateStruct":100,"leadSponsor":101,"locationsCount":47},"100629530","tourniquet-exposure-and-risk-of-chronic-pain-after-severe-limb-trauma-100629530","NCT07475871","Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma","Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma: A Prospective Cohort Study","TOURNI-PAIN","Inclusion Criteria:\n\n* Age ≥18 years\n* Severe upper or lower limb trauma\n* Documented tourniquet use (prehospital or in-hospital)\n* Available documentation of tourniquet duration\n* Informed consent\n\nExclusion Criteria:\n\n* Pre-existing chronic limb pain\n* Known severe peripheral neuropathy\n* Cognitive inability to complete follow-up\n* Expected survival \\\u003C48 hours",{"count":57,"type":22},"Severe limb trauma often requires the use of a tourniquet to stop life-threatening bleeding. While tourniquets are essential for saving lives, prolonged interruption of blood flow may lead to tissue ischemia, nerve injury, and inflammatory responses that could contribute to the development of chronic pain.\n\nThe TOURNI-PAIN Study is a prospective observational study designed to investigate whether the duration of tourniquet use during the treatment of severe limb injuries is associated with an increased risk of persistent pain after recovery. The study will enroll adult patients with major upper or lower limb trauma who required tourniquet application in the prehospital or hospital setting.\n\nResearchers will collect information about the duration and characteristics of tourniquet use, details of the injury, surgical treatment, and recovery. Participants will be followed for up to 6 months after injury to assess pain levels, possible neuropathic pain, functional recovery, and quality of life.\n\nThe goal of this research is to better understand whether longer tourniquet exposure increases the risk of long-term pain. The findings may help improve trauma care practices by balancing the life-saving benefits of hemorrhage control with strategies that minimize long-term complications and improve recovery for patients with severe limb injuries.",[90,91,60,92],"Pain","Pain After Surgery","Military Combat Stress Reaction",[94,95,96,97],"Tourniquet","Chronic Pain","Phantom Limb Pain","Trauma Rehabilitation",{"date":75,"type":39},{"date":41,"type":22},{"date":41,"type":22},{"name":45,"class":46},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":110,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":121,"leadSponsor":122,"locationsCount":47},"100629533","venous-thromboembolism-and-chronic-pain-after-major-limb-trauma-100629533","NCT07475910","Venous Thromboembolism and Chronic Pain After Major Limb Trauma","Venous Thromboembolism and Chronic Pain After Major Limb Trauma: A Prospective Cohort Study","THROMBO-PAIN","Inclusion Criteria:\n\n* Age ≥18 years\n* Major upper or lower limb trauma\n* Surgical treatment and\u002For immobilization ≥72 hours\n* Enrollment within 72 hours of admission\n* Informed consent\n\nExclusion Criteria:\n\n* Pre-existing chronic pain unrelated to trauma (investigator judgment)\n* Therapeutic anticoagulation prior to trauma\n* Cognitive inability to complete follow-up\n* Expected survival \\\u003C48 hours",{"count":57,"type":22},"Major limb trauma is associated with a high risk of venous thromboembolism (VTE) due to systemic inflammation, endothelial injury, immobilization, and hypercoagulability. While VTE is commonly studied as a short-term complication affecting morbidity and mortality, its potential relationship with long-term pain outcomes after trauma has not been well investigated.\n\nThis prospective observational cohort study aims to evaluate whether objectively confirmed VTE is associated with an increased risk of persistent clinically significant pain after major limb trauma. Adult patients with severe upper or lower limb injuries requiring surgical treatment or prolonged immobilization will be enrolled within 72 hours of hospital admission and followed for six months.\n\nThe study will assess whether patients who develop VTE have a higher likelihood of persistent pain compared with those without VTE. In addition, the study will explore the association between baseline VTE risk (using the Trauma Embolic Scoring System, TESS), thromboprophylaxis timing, and long-term pain outcomes. Secondary analyses will evaluate neuropathic pain symptoms, pain interference with daily activities, quality of life, opioid consumption, and functional recovery.\n\nUnderstanding the relationship between thromboembolic complications and persistent pain may help improve risk stratification, optimize thromboprophylaxis strategies, and support early rehabilitation planning in patients with major limb trauma.",[113,60,95,61],"VTE (Venous Thromboembolism)",[115,116,70,117,118],"Venous thromboembolism","Post-traumatic chronic pain","Major limb trauma","Trauma Embolic Scoring System (TESS)",{"date":75,"type":39},{"date":41,"type":22},{"date":41,"type":22},{"name":45,"class":46},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":131,"enrollmentInfo":132,"targetDuration":133,"studyType":24,"phases":4,"briefSummary":134,"conditions":135,"keywords":139,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":148,"leadSponsor":150,"locationsCount":47},"100629425","from-battlefield-to-recovery-continuous-regional-anaesthesia-for-war-related-lower-limb-trauma-100629425","NCT07474506","From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma","From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma - A Multicenter Comparative Cohort Study","CRA-WAR-LIMB S","Inclusion Criteria:\n\n* age ≥18 years\n* war-related lower limb trauma\n* hospital admission requiring surgical treatment or wound management\n* documented pain assessment during hospitalization\n* availability of analgesic treatment data\n* informed consent where required\n\nExclusion Criteria:\n\n* age \\\u003C18 years\n* isolated upper limb trauma\n* missing key pain outcome data\n* contraindication to regional anaesthesia prior to treatment\n* refusal to participate (for prospective component)","50 Years",{"count":57,"type":22},"6 Weeks","To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.",[136,137,138],"Pain Management","Perioperative Analgesia","War-Related Injuries",[140,141,142,143],"acute pain","pain managment","analgesia","war related trauma","2026-03-14",{"date":146,"type":39},"2026-03-17",{"date":41,"type":22},{"date":149,"type":22},"2026-06-15",{"name":45,"class":46},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":158,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":160,"conditions":161,"keywords":162,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":47},"100625562","chronic-pain-after-combat-related-traumatic-brain-injury-ctbi-pain-study-a-prospective-cohort-study-of-pain-chronification-after-combat-related-traumatic-brain-injury-100625562","NCT07424248","Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury","TBI-Pain","Inclusion Criteria:\n\n* Age 18 to 60 years\n* Combat-related traumatic brain injury (blast, impact, or combined mechanism)\n* Mild to moderate traumatic brain injury\n* Enrollment within 14 days after injury\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Severe traumatic brain injury with prolonged impaired consciousness\n* Pre-existing severe psychiatric disorder unrelated to trauma\n* Chronic pain condition predating the traumatic brain injury\n* Inability to complete follow-up assessments\n* Severe medical condition limiting participation",{"count":159,"type":22},100,"Combat-related traumatic brain injury (cTBI), particularly blast-related injury, is frequently associated with the development of persistent and disabling chronic pain. This prospective observational cohort study aims to determine the incidence, phenotypes, and early predictors of chronic pain following mild to moderate combat-related TBI. Adults will be enrolled within 14 days of injury and followed for 6 months. The primary endpoint is clinically significant chronic pain at 3 months, defined by pain intensity and functional interference. The study will evaluate clinical, psychological, and physiological factors to develop and internally validate a prognostic model for chronic pain risk after cTBI.",[90,95,61],[163,164,165,166,70,167,168,169],"Combat-related traumatic brain injury","cTBI","Blast injury","Chronic pain","Sleep disturbance","Pain prediction","Military trauma","2026-02-22",{"date":172,"type":39},"2026-02-24",{"date":174,"type":22},"2026-02-15",{"date":176,"type":22},"2026-12-15",{"name":45,"class":46},{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":131,"enrollmentInfo":186,"targetDuration":4,"studyType":187,"phases":188,"briefSummary":190,"conditions":191,"keywords":192,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":202,"leadSponsor":203,"locationsCount":47},"100626154","silencing-neuroma-pain-botulinum-toxin-versus-local-anesthetic-injection-100626154","NCT07431944","Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection","SILENCE-NEUROMA Trial: Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection in a Randomized Controlled Trial","SILENCE-NEUROM","Inclusion Criteria:\n\n* Age ≥18 years\n* History of limb trauma and\u002For limb amputation at least 3 months prior to enrollment\n* Clinical diagnosis of neuroma-related pain with focal tenderness and positive - - Tinel sign\n* Imaging confirmation of neuroma by ultrasound or MRI\n* Average pain intensity ≥4 on a 0-10 Numerical Rating Scale (NRS) during the week prior to screening\n* Stable analgesic regimen for at least 14 days prior to enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Chronic pain condition unrelated to neuroma that predominates clinical symptoms\n* infection at or near the planned injection site\n* Known neuromuscular junction disorders (e.g., myasthenia gravis)\n* Pregnancy or breastfeeding\n* Botulinum toxin treatment within the previous 4-6 months\n* Planned surgical neuroma revision during the study period\n* allergy or hypersensitivity to botulinum toxin or local anesthetics",{"count":159,"type":22},"INTERVENTIONAL",[189],"NA","Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia. The SILENCE-NEUROMA Trial is a multicenter, randomized, double-blind, active-controlled study designed to compare the efficacy and safety of botulinum toxin type A versus local anesthetic injection for the treatment of neuroma-related pain. The primary outcome is pain reduction at 8 weeks after treatment.",[136,90,96,60],[193,194,166,195,27,196,197],"Neuroma pain","Local anesthetic","Limb trauma","Botulinum toxin","Ultrasound-guided injection","2026-02-21",{"date":200,"type":39},"2026-02-25",{"date":174,"type":22},{"date":176,"type":22},{"name":45,"class":46},""]