[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Chaudhry Pervaiz Elahi Institute of Cardiology\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100612290","comparison-of-early-postoperative-outcomes-between-minimally-invasive-valve-surgery-via-right-thoracotomy-and-conventional-valve-surgery-via-sternotomy-100612290",false,"NCT07251660","Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and Conventional Valve Surgery Via Sternotomy.","Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and Conventional Valve Surgery Via Sternotomy","Inclusion Criteria:\n\n* Patients of any age and gender.\n* Undergoing elective, isolated mitral or aortic valve surgery.\n* Considered suitable for either:\n\n  * MIVS via right thoracotomy, or\n  * Conventional valve surgery , as decided by the operating surgical team.\n* Patients giving written informed consent.\n\nExclusion Criteria:\n\n* Emergency or redo cardiac surgeries\n* Concomitant cardiac procedures (e.g., CABG, multiple valve replacements)\n* Ejection Fraction \\\u003C30%\n* Severe pulmonary hypertension (identified as the mean pulmonary artery pressure (mPAP) exceeding 45 mmHg on echocardiography, as outlined by the AHA guidelines(10).\n* Active systemic infections or sepsis at the time of surgery\n* Refusal to participate in the study","ALL",{"count":18,"type":19},32,"ESTIMATED","INTERVENTIONAL",[22],"NA","This randomized controlled trial aims to compare early postoperative outcomes between Minimally Invasive Valve Surgery (MIVS) via right thoracotomy and Conventional Valve Surgery via median sternotomy in patients undergoing elective, isolated mitral or aortic valve surgery. Minimally invasive techniques are believed to reduce postoperative pain, ventilation time, chest drain output, and wound complications, but evidence from Pakistan is limited.\n\nThe study will enroll patients of all ages and genders who are scheduled for isolated valvular procedures at Chaudhary Pervaiz Elahi Institute of Cardiology (CPEIC), Multan. Participants will be randomly assigned to undergo either minimally invasive thoracotomy or conventional sternotomy.\n\nPrimary outcomes include ventilation time, CPB duration, cross-clamp time, pain scores, and chest drain output. Secondary outcomes include wound healing (Day 7 and 30 days), return to routine activity, echocardiographic evaluation, transfusion requirements, and 30-day mortality. Findings from this study may provide evidence to guide the adoption of minimally invasive valvular surgery techniques in low-resource and developing settings.",[25,26,27,28],"Heart Valve Diseases or Prosthesis","Aortic Valve Stenosis","Aortic Valve Insufficiency","Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)",[30,31,32,33,34],"Heart valve disease","Mitral valve surgery Aortic valve surgery Minimally invasive cardiac surgery","Conventional open-heart surgery","Aortic cross-clamping","Early postoperative outcomes","NOT_YET_RECRUITING","2025-11-19",{"date":38,"type":39},"2025-11-26","ACTUAL",{"date":41,"type":19},"2025-12-15",{"date":43,"type":19},"2026-08-15",{"name":45,"class":46},"Chaudhry Pervaiz Elahi Institute of Cardiology","OTHER_GOV",""]