[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Chen Li\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":132},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,73,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100623734","differences-in-n-cad-concentration-and-brain-function-between-children-with-asd-and-td-100623734",false,"NCT07400484","Differences in N-CAD Concentration and Brain Function Between Children With ASD and TD","A Study on the Differences in N-CAD Concentration and Brain Function Between Children With Autism Spectrum Disorder and Typically Developing Children","Inclusion Criteria:\n\n1. Age at enrollment ≥ 3 years and \\\u003C5 years;\n2. The diagnosis was made by 2 developmental behavioral pediatricians or child psychiatrists with vice senior titles or above, and the history and clinical manifestations were in line with ASD and ICD-11 diagnostic criteria for ASD; .\n\nExclusion Criteria:\n\n1. Diagnosis or manifestation of genetic diseases or syndromes related to ASD (such as Rett syndrome);\n2. Medical or nervous system diseases affecting growth, development or cognition (such as central nervous system infection, epilepsy, congenital heart disease, etc.);\n3. Sensory impairment such as vision or hearing loss;\n4. Low birth weight (birth weight \\\u003C2000 g) or preterm birth (gestational age \\\u003C37 weeks);\n5. Adopted children;\n6. Parents refused to sign the informed consent form;\n7. Other researchers consider it inappropriate to participate in the study.",true,"ALL","3 Years","5 Years",{"count":21,"type":22},98,"ESTIMATED","1 Day","OBSERVATIONAL","The incidence of autism spectrum disorders is increasing, about 1 \u002F 36. Neural cadherin (NCAD) is closely related to synaptic structure and function. The cdh2 gene encoding NCAD has been shown to be associated with a variety of neurodevelopmental diseases and is one of the six risk genes for ASD. Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technology that uses the principle of near-infrared spectroscopy to detect the functional activation of human cortex. The application of fNIRS to explore the neural mechanism of children with ASD has developed rapidly. It has the advantages of non-invasive, portable, relatively low cost and unlimited physical activity. And for ASD children, their command compliance and self-control are relatively low, so fNIRS is more widely used in ASD children. According to dsm-5 standard, we recruited ASD children and TD children, collected their peripheral blood, and detected the plasma n-cad concentration. At the same time, the resting state of fNIRS of the two groups of children was collected, and the ultra scan monitoring was carried out simultaneously during Gesell assessment. The purpose of this study was to explore the difference of peripheral blood NCAD concentration between preschool ASD children and TD children and the difference of brain function in resting state and social interaction state. And the relationship between the characteristics of brain function and the level of cognitive development in children with ASD.",[27],"ASD",[27,29,30],"Neural cadherin","Functional Near-infrared Spectroscopy","RECRUITING","2026-02-02",{"date":34,"type":35},"2026-02-10","ACTUAL",{"date":37,"type":35},"2025-12-18",{"date":39,"type":22},"2026-03-31",{"name":41,"class":42},"Chen Li","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":43},"100600993","effects-of-systematic-exercise-training-on-core-symptoms-executive-function-and-brain-function-in-children-with-asd-100600993","NCT07104708","Effects of Systematic Exercise Training on Core Symptoms, Executive Function and Brain Function in Children With ASD","Inclusion Criteria:\n\n* Age: 3-9 years old.\n* Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria for ASD, And hold a certificate of ASD diagnosis issued by a Tertiary A hospital.\n* Borderline\u002Fnormal intelligence or mild intellectual disability.\n* No serious behavior or emotional problems.\n* Able to simply ask and answer questions.\n* Be able to proactively express the need to use the toilet.\n* There are no physical impairments that affected participation in physical activities, and participants are able to cooperate to complete the intervention.\n* Informed parental consent.\n\nExclusion Criteria:\n\n* Vision\u002F hearing disorders, schizophrenia, emotional disorders, mental retardation, Rett syndrome and other developmental disorders.\n* Medical conditions that limit the ability to be physically active, such as asthma, epilepsy, heart disease, and the acute phase after a fracture.\n* History of head trauma, physical disability, major organ disease, or severe musculoskeletal injury in the past two years.\n* Those who have participated in physical exercise regularly within the last 6 months.\n* Participants who changed treatment intervention midway after inclusion.\n* Unable to cooperate with persistent completion of intervention.","9 Years",{"count":52,"type":22},70,"INTERVENTIONAL",[55],"NA","Studies have shown that children with ASD simultaneously have deficits in overall executive function and impairments in basic motor skills, which have a negative impact on cognitive and social all-round development. In recent years, intervention measures for the motor skills of children with ASD have gradually developed. However, based on the existing literature, there is still a lack of recommendations for sports training at present. The sustained effect of exercise intervention training on the core symptoms of ASD remains unclear. In terms of executive function, there are relatively few studies on the executive function of preschool children. The impact of motor training on working memory in school-aged children is still inconsistent. Furthermore, the connection characteristics of different brain regions in children with ASD after physical training remain unclear. This study will include 70 children with ASD aged 3 to 9 years for a multicenter randomized controlled trial (RCT). These children will be randomly assigned to the intervention group (Child-Parent-Trainer program) and the control group (regular physical education program) for 12 weeks, 5 days\u002Fweek, 60 minutes\u002Fday training. Children's core symptoms, executive function, child\u002Ffamily quality of life, and functional near-infrared spectroscopy (fNIRS) were assessed at baseline (training weeks 0) and endpoints (training weeks 13 and 17), respectively. To verify the improvement effect of this exercise program on the autism severity, core symptoms and executive functions of children with ASD, as well as its impact on family quality of life. Furthermore, through fNIRS for monitoring changes in brain function, the potential neural physiological mechanisms will be explored.",[58],"Autism Spectrum Disorder",[60,61,62,63],"executive function","brain function","exercise training","Autism spectrum disorder","NOT_YET_RECRUITING","2025-08-09",{"date":67,"type":35},"2025-08-14",{"date":69,"type":22},"2025-08",{"date":71,"type":22},"2028-06",{"name":41,"class":42},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":53,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},"100559310","prevention-and-intervention-of-overweight-and-obesity-in-preschool-children-100559310","NCT06562465","Prevention and Intervention of Overweight and Obesity in Preschool Children","Research on Prevention and Intervention of Overweight and Obesity in Preschool Children","Inclusion Criteria:\n\noverweight or obese Children Currently, there are no projects related to overweight and obesity management (such as weight loss management, etc.) Parents and children are willing to accept dietary and exercise management for a period of 4 months Willing to measure height, weight, BMI, blood pressure, body composition, questionnaire survey (exercise, diet, etc.) and other items before intervention and 1 month, 2 months, 3 months, and 4 months after intervention (a total of 5 times) Willing to undergo blood tests before and 4 months after intervention (2 times in total); The questionnaire information is filled in accurately and meets the questionnaire quality control standards\n\nExclusion Criteria:\n\nRecruiter exclusion criteria:\n\nPreschool children with underlying diseases (such as congenital heart disease, liver and kidney disease, thyroid disease, malignant tumors, etc.) or uncontrolled underlying diseases\n\nQuestionnaire exclusion criteria:\n\nIncorrect information filling in the questionnaire, which does not meet the questionnaire quality control standards","6 Years",{"count":82,"type":22},174,[55],"Obesity is an important public health problem, which is directly related to the risk of childhood complications and the increase of incidence rate and mortality of adult complications. The consequences are more serious than malnutrition such as low weight. Since the 1980s, the obesity rate among children in China has gradually increased. Currently, overweight and obesity are important health issues for children in rural and urban areas of China, with obesity rates in many large cities approaching or exceeding those in developed countries. The Report on Nutrition and Chronic Disease Status of Chinese Residents (2020) shows that the overweight and obesity rate among children aged 6-17 in China has approached 20%, with 10% of children under 6 years old. The imbalance between energy intake and expenditure is the direct cause of individual overweight and obesity. The 2021 \"Healthy Children Action Plan (2021-2025)\" explicitly requires the implementation of early screening, early diagnosis, and early treatment prevention and control strategies for risk factors such as obesity that seriously endanger children's health, reducing disease burden, promoting children's health, emphasizing the principle of prevention first and combining prevention and treatment. Given the current status of children's nutrition and health in China, it is an urgent need to establish a standardized and regulated monitoring and management system for obesity and overweight in preschool children, as well as service standards, for the development of children's health. This project aims to establish a complete prevention, improvement, and intervention promotion plan for obesity and overweight in preschool children, as well as a comprehensive monitoring and management system that combines medicine, education, home, and community. It will strengthen children's nutrition feeding and exercise guidance, reduce sedentary time, promote food and movement balance, and prevent and reduce childhood overweight and obesity. Provide children with comprehensive, full process, and warm children's healthcare clothing, and provide small-scale policy research references for the implementation of support systems for children's nutrition improvement projects.",[86],"Overweight and Obesity",[88,89,90,91,92],"Diet management","sports management","overweight","obesity","preschool children","2024-08-16",{"date":95,"type":35},"2024-08-20",{"date":97,"type":35},"2024-03-01",{"date":99,"type":22},"2025-09-30",{"name":41,"class":42},2,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":80,"studyType":24,"phases":4,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},"100363828","relationship-about-pregnancy-health-and-offspring-developmental-behavioral-outcomes-100363828","NCT04017286","Relationship About Pregnancy Health and Offspring Developmental &Behavioral Outcomes","A Prospective Cohort Study of the Association Between Pregnancy Health and Offspring Developmental & Behavioral Outcomes(Multi-Centered)","APCSAHAODBO","Inclusion Criteria:\n\n1. Inclusion criteria for pregnant women: Aged 20\\~49;\n2. no cognitive impairment, able to complete the scale test;\n3. Hamilton Depression Scale (HAMD questionnaire) is normal (HAMD score \\\u003C8 points) or mild to moderate positive (HAMD questionnaire score: 8\\~35 points);\n4. Participants are asked for their own written informed content for the study;\n\nExclusion Criteria:\n\n1. Patients receiving anti-depression therapy during the first 6 months of gestation or during pregnancy;\n2. Patients with severe depression with scores of no less than 35 points in the HAMD questionnaire;\n3. Patients with other mental disorders;\n4. Patients with neurological diseases;\n5. Patients with cognitive dysfunction.","3 Months","72 Months",{"count":113,"type":22},3000,"This topic puts forward a hypothesis: genetic and environmental factors such as major depressive disorder during pregnancy, nutritional status of vitamin A, D, E, and folic acid, intestinal microecology, and bisphenol A exposure, may affect the cognitive development level of the offspring through the genetic correlation with attention deficit hyperactivity disorder, developmental delay\u002Fintellectual disability, and major depressive disorder, allelic heterogeneity and pleiotropy of ITIH3 mediated by SNP and CACNB2, neurotransmitters like dopamine, and metabolic pathways, thereby increasing the risk of attention deficit hyperactivity disorder and developmental delay\u002Fintellectual disability prevalence on offspring.\n\nThis topic planning from allelic heterogeneity and pleiotropy of attention deficit hyperactivity disorder and major depressive disorder mediated by SNP, neurotransmitters like dopamine, and metabolic pathways, explores deeply the influences on children's development level and the risk of common neurological disorder caused by genetic and environmental factors during pregnancy, looking for reasonable prevention, early diagnosis of biomarkers and therapeutic targets, in order to provide data support for further improvement and revision of national mother and infant healthcare policy .",[116,117],"Children Behavior Problem","Pregnancy",[119,120,121,122],"Developmental assessment","Homocysteine","physique growth","nutrients","2021-01-29",{"date":125,"type":35},"2021-02-01",{"date":127,"type":35},"2019-07-01",{"date":129,"type":22},"2028-12-31",{"name":41,"class":42},5,""]