[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"China International Neuroscience Institution\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":91},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100588813","phase-4-assessing-the-time-course-of-dexmedetomidine-induced-analgesia-via-eeg-100588813",false,"NCT06946277","Assessing the Time-Course of Dexmedetomidine-Induced Analgesia Via EEG","Mapping the Temporal Profile of Dexmedetomidine-Induced Analgesia Via EEG Signatures in Brain","Inclusion Criteria:\n\nPatients with hip osteoarthritis scheduled for total hip arthroplasty under intrathecal anesthesia; Age 18-70 years; American Society of Anesthesiologists (ASA) physical status classification I-III; Body mass index (BMI) 22-30 kg\u002Fm².\n\nExclusion Criteria:\n\nPre-existing peripheral or central nervous system disorders; Mental disorders; Cognitive impairment; Emergency surgery; or Hearing impairment.","ALL","18 Years","70 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Objective: To investigate the temporal dynamics of dexmedetomidine's analgesic effects in the brain using EEG.\n\nMethods: Eligible patients scheduled for total hip arthroplasty under intrathecal anesthesia received a continuous infusion of DEX at 1.5 μg\u002F(kg·h) for 15 minutes before neuraxial puncture, followed by an additional 15-minute infusion. The study was divided into three phases:\n\nPhase 1: Non-dosing phase (Baseline). Phase 2: DEX preemptive analgesia phase (DEX infusion). Phase 3: DEX cessation phase (Post-infusion).\n\nOutcomes:\n\nPrimary safety outcome: EEG spectral analysis at different phases. Secondary outcomes: NRS scores, postoperative nausea and vomiting (PONV), dizziness, agitation, and time to intestinal exhaust within 48 hours. Intraoperative hemodynamics were also monitored.",[27,28,29],"Total Hip Arthroplasty (THA)","Intrathecal Anesthesia","Hip Osteoarthritis","NOT_YET_RECRUITING","2025-04-23",{"date":33,"type":34},"2025-04-27","ACTUAL",{"date":36,"type":21},"2025-04-25",{"date":38,"type":21},"2025-05-26",{"name":40,"class":41},"China International Neuroscience Institution","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":42},"100567679","phase-4-preemptive-analgesia-of-dexmedetomidine-reduces-per-operation-pain-100567679","NCT06671327","Preemptive Analgesia Of Dexmedetomidine Reduces Per-operation Pain","Preemptive Analgesia Of Dexmedetomidine Reduces Per-operation Pain After Noncardiac Surgery","Inclusion Criteria:\n\n* 18 years to 85 years old,\n* body mass index (BMI,calculated as weight in kilograms divided by height in meters squared): 18.5\\~35.\n* ASA (American Society of Anesthesiologists) Grade I- III;\n* Scheduled for non-cardiac surgery undergoing general anesthesia\n* expected duration of operation 0.5\\~3 h.\n\nExclusion Criteria:\n\n* disagreed to participate;\n* body mass index (BMI) of greater 35\n* American Society of Anesthesiologists (ASA) classification 4 or above;\n* previous severe central nervous systemheart, liver, kidney or and lung dysfunction ;\n* diagnosed neuropsychological disorders, that is, schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis，Alzheimer's disease and other autonomic disorders of patients affecting EEG outcomes;\n* comatose, dementia, or language barrier which impeded communication and assessment;\n* history of neurosurgical procedures;\n* Systolic blood pressure continuously lower than 85mmHg or higher than 180mmHg; heart rate continuously lower than 45 times \u002F min; sever arrhythmia need intervation and implantable pacemaker.","85 Years",{"count":52,"type":21},208,[24],"Background:Preemptive analgesia is the initiation of analgesic regimen before the onset of nociceptive stimulation, preventing the amplification of pain due to peripheral and central sensitization and thereby reducing subsequent pain. Preemptive analgesia of dexmedetomidine (DEX) in the epidural and subarachnoid space can effectively prevent the central sensitization, and significantly reduce the phantom limb pain, residual pain after one year of lower limb amputation.\n\nObjective: To investigate the per-operative effects of DEX preemptive analgesia.\n\nMethod:The patients scheduled noncardiac surgery undergoing general anesthesia were selected and divided into DEX group and Placebo group randmized. The DEX group was continuously pumped at 1.5 μg \u002F(kg·h) for 15 minutes before induction, and 15min after induction. The Placebo group was infused with equal amounts of normal saline.The Coprimary efficacy outcome was a composite of analgesia effect, one is the Compliance Rate of IOC2 target in intra-operation, another is the the rate of none-to-slight post-operative pain assessed with the p-NRS≦3 at 12 hours after surgery \\[Pain numeric rating scale was assessed with the (Numeric Rating Scale, p-NRS)\\].",[56,57],"Pain Management","Noncardiac Surgery","2025-04-07",{"date":60,"type":34},"2025-04-09",{"date":62,"type":21},"2025-04-03",{"date":64,"type":21},"2025-06-30",{"name":40,"class":41},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":74,"enrollmentInfo":75,"targetDuration":77,"studyType":78,"phases":4,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":42},"100567013","ed50-of-sufentanil-for-intraoperative-analgesia-100567013","NCT06662656","ED50 of Sufentanil for Intraoperative Analgesia","ED50 of Sufentanil with Dexmedetomidine Analgesia During Laparoscopic Cholecystectomy","ED50","Inclusion Criteria:\n\n1. ASA I \\~ II level;\n2. BMI22-30kg\u002Fm2;\n3. Those who intend to undergo laparoscopic cholecystectomy;\n4. Age 18\\~65 years.\n\nExclusion Criteria:\n\n1. Has been allergic to the drugs used in this study;\n2. Patients with a history of chronic use of alcohol, smoke or other sedative drugs;\n3. Patients took opioids and other analgesics before surgery;\n4. Emergency operation;\n5. Stress, anxiety resulting in secretion of catecholamine;\n6. Patients with neuropsychiatric disorders, coma, depression, cognitive impairment and Alzheimer's disease;\n7. Patients with epilepsy, autonomic nervous dysfunction and other diseases with abnormal EEG results;\n8. SBP\\\u003C 85 mmHg or HR\\\u003C 45次\u002Fmin;\n9. Has implanted pacemaker;\n10. Patients were unwilling or disable to finish whole study;\n11. Patients with acute upper respiratory infections, liver or kidney failure and severe cardiopulmonary dysfunction.","65 Years",{"count":76,"type":21},26,"1 Day","OBSERVATIONAL","1. Sufentanil as an strong analgesic is used widespreadly during laparoscopic cholecystectomy.\n2. Lower dosages of sufentanil facilitated with dexmedetomidine can offer enough analgesia effect.\n3. The investigator are planning use the most classical method for determining the ED50 or half effective concentration of sufentanil facilitated with dexmedetomidine using sequential method, which is also called\" up and down method\" and\" ladder method\".",[81,82],"Laparoscopic Cholecystectomy","Analgesics，Opioid","2024-10-27",{"date":85,"type":34},"2024-10-29",{"date":87,"type":21},"2024-11-01",{"date":89,"type":21},"2025-01-30",{"name":40,"class":41},""]