[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Chris McIntyre\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100286122","sodium-deposition-in-soft-tissues-of-patients-with-kidney-disease-100286122",false,"NCT03004547","Sodium Deposition in Soft Tissues of Patients with Kidney Disease","Evaluation of Sodium Deposition in Soft Tissues of Patients with Kidney Disease and Its Association with Patient Symptomatology","Inclusion Criteria:\n\n* Age greater than or equal to 6 years\n* For patients on maintenance hemodialysis or peritoneal dialysis: more than 3 months duration of therapy\n* For patients with CKD stage 1-5: CKD stage 1-5 and no indications to start dialysis\n* For heart failure patients: with or without renal dysfunction\n* For healthy controls: lack of kidney disease, heart failure, liver cirrhosis, and peripheral edema\n\nFor subsequent visits (must meet 1 of the below indicators):\n\n* Change in dialysis prescription\n* Change in renal replacement therapy modality\n* Change in medication\n* Parathyroidectomy\n* Intervention added to or removed from dialysis (i.e. such as but not limited exercise, cooling, and ischemic preconditioning)\n\nExclusion Criteria:\n\n* Pregnant, breastfeeding or intending pregnancy\n* Unable to give consent or understand written information\n* Contraindication to MRI study",true,"ALL","6 Years",{"count":20,"type":21},400,"ESTIMATED","OBSERVATIONAL","Sodium (Na+) hemostasis is abnormal in CKD patients, and this element can be deposited in the skin, muscle, and skeleton - to cope with long term sodium loading. It is known that sodium stored in this non-osmotically active way, is profoundly inflammatory. Furthermore, inflammation has been associated with several uremic symptoms. The investigators will use novel Na+ MRI imaging to examine the Na+ deposition in the skin, muscle, and skeleton of five groups:1) chronic in-center hemodialysis patients, 2) chronic peritoneal dialysis patients, 3) adult and paediatric patients with CKD stage 1-5 and 4) heart failure patients with and without renal dysfunction 5) sex and age-matched healthy adult and paediatric controls. Additionally, they will investigate the association between sodium deposition in these tissues with uremic symptomatology and biochemical markers of metabolism.",[25],"Haemodialysis Complication",[27,28],"Sodium","Soft Tissues","RECRUITING","2025-02-10",{"date":32,"type":33},"2025-02-12","ACTUAL",{"date":35,"type":33},"2018-03-05",{"date":37,"type":21},"2026-02-28",{"name":39,"class":40},"Chris McIntyre","OTHER",""]