[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Christiana Care Health Services\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":139},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,87,114],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100644230","phase-4-cyclobenzaprine-for-postoperative-pain-in-minimally-invasive-hysterectomy-100644230",false,"NCT07664956","Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy","Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\>18yo\n* Female\n* English speaking\n* Undergoing (robotic assisted or classic) total laparoscopic hysterectomy ± unilateral or bilateral salpingectomy ± unilateral or bilateral oophorectomy\n* If other procedures such as lysis of adhesions, excision of endometriosis, or ureterolysis are indicated based on intraoperative evaluation, those patients may still be included\n* Surgery took place at ChristianaCare Hospitals\n* No allergies or contraindications to standard of care post operative pain medications (acetaminophen, NSAIDs, narcotics) or cyclobenzaprine\n\nExclusion Criteria:\n\n* Age \\\u003C18yo\n* Male\n* Pregnant, breastfeeding\n* Non-English speaking\n* Primary procedures other than laparoscopic hysterectomy\n* Laparoscopic myomectomy\n* Laparoscopic resection of endometriosis\n* Laparoscopic unilateral or bilateral salpingectomy ± unilateral or bilateral oophorectomy ± unilateral or bilateral cystectomy without hysterectomy\n* Hysteroscopic procedures\n* Bartholin gland marsupialization\n* Operations that are scheduled as or converted to the open approach\n* Procedures with planned or unplanned bladder or bowel surgery\n* Allergies or contraindications to standard post operative pain control medications (acetaminophen, NSAIDs, narcotics), such as kidney or liver damage\u002Ffailure, bariatric surgery, history of gastric ulcer, etc.\n* Chronic pain issues, whether self-diagnosed or by a physician, currently undergoing management\n* Currently undergoing medication assisted treatment for opioid use disorder\n* Currently using opioids consistently\n* Allergies or contraindications to cyclobenzaprine:\n* Absolute: use of MAO inhibitors within 14 days, recent heart attack, congestive heart failure, heart block or other conduction abnormalities, cardiac arrhythmias, hyperthyroidism, history of serotonin syndrome\n* Allergies or contraindications to inactive ingredients in Flexeril, such as lactose\n* Patient's receiving gabapentin at baseline or postoperatively, due to potential sedating effects, or other sedating drugs such as scheduled benzodiazepines and barbiturates","FEMALE","18 Years",{"count":19,"type":20},36,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Typical postoperative pain control after minimally invasive hysterectomy includes ibuprofen, acetaminophen, and a short course of narcotics. The purpose of this study is to see if adding cyclobenzaprine to this regime improves pain control and lessens narcotic use.",[26,27,28,29,30,31,32,33,34],"Minimally Invasive Surgical Procedures","Abnormal Uterine Bleeding, Unspecified","Adenomyosis of Uterus","Fibroid Uterus","Chronic Pelvic Pain","Endometriosis","Menorrhagia","Endometritis","Adnexal Diseases",[36,37,38,39,40,41],"cyclobenzaprine","flexeril","hysterectomy","minimally invasive hysterectomy","pain control","multimodal pain control","NOT_YET_RECRUITING","2026-06-18",{"date":45,"type":46},"2026-06-24","ACTUAL",{"date":48,"type":20},"2026-07-01",{"date":50,"type":20},"2026-12-01",{"name":52,"class":53},"Christiana Care Health Services","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":54},"100634639","breathing-patterns-in-infants-before-and-after-extubation-100634639","NCT07542301","Breathing Patterns in Infants Before and After Extubation","Inclusion Criteria:\n\n* premature infants (born at ≤32 weeks gestation) who are intubated.\n* medical team is evaluating the baby for extubation readiness\n\nExclusion Criteria:\n\n* Infants with skeletal, neuromuscular, or abdominal surgical disorders that affect the accuracy of RIP measurements will be excluded.",true,"ALL","0 Days","6 Months",{"count":66,"type":20},30,"OBSERVATIONAL","The primary objective of this study is to compare work of breathing indices before and after extubation in intubated premature infants admitted to the Christiana Care Neonatal Intensive Care Unit. The secondary objective is to compare the ability of work of breathing indices to predict extubation failure to routine spontaneous breathing tests (SBTs) in intubated premature infants admitted to the ChristianaCare NICU.",[70,71],"Respiratory Distress Syndrome (RDS)","PreTerm Neonate",[73,74,75,76,77],"preterm infants","intubated","respiratory distress","extubation","work of breathing","RECRUITING","2026-04-14",{"date":81,"type":46},"2026-04-21",{"date":83,"type":46},"2025-04-14",{"date":85,"type":20},"2026-12",{"name":52,"class":53},{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":62,"minAge":94,"maxAge":17,"enrollmentInfo":95,"targetDuration":4,"studyType":21,"phases":97,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":54},"100578160","abnormal-connectivity-involving-the-social-reciprocity-network-in-autism-and-the-impact-of-neurostimulation-in-mitigating-the-abnormalities-100578160","NCT06807684","Abnormal Connectivity Involving the Social Reciprocity Network in Autism and the Impact of Neurostimulation in Mitigating the Abnormalities","Discerning the Abnormal Functional Connectivity Involving the Social Reciprocity Network in Autism Spectrum Disorder and the Impact of Transcranial Magnetic Stimulation in Mitigating the Abnormalities","Inclusion criteria\n\n1\\. Fulfilling the DSM-V criteria for ASD and confirmed by CARS2, HF Exclusion criteria\n\n1. Patients with ASD exhibiting significant anxiety or contact avoidance, precluding them from cooperating with the procedure\n2. Patients with a known diagnosis of seizures\n3. Presence of any metallic implants or devices in the head or neck area\n4. Pregnant women","13 Years",{"count":96,"type":20},12,[98],"NA","There is no consensus regarding the neurological substrate underpinning ASD. The investigators describe the novel concept of \"social reciprocity network\" and hypothesize that aberrant connectivity\u002Foscillatory patterns affecting this network contribute to the core deficits in ASD.\n\nThe overarching goal of this trial is to explore abnormalities involving the neuronal connectivity and oscillatory patterns within the social reciprocity network and to elucidate the role of modulating this network via rTMS in improving the above measures and social cognition in ASD. Quantitative electroencephalography (QEEG) coherence and spectral power analysis are reliable measures of neuronal connectivity and dynamics. The investigators aim to study the QEEG coherence\u002Fspectral power analysis to explore the neuronal dynamics affecting the social reciprocity network in ASD.",[101],"Autism Spectrum Disorder",[103,104,105],"Autism spectrum","transcranial magnetic stimulation","neuronal connectivity","2025-02-20",{"date":108,"type":46},"2025-02-21",{"date":110,"type":46},"2024-08-15",{"date":112,"type":20},"2025-12-31",{"name":52,"class":53},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":21,"phases":125,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":54},"100536715","oxytocin-rest-to-reduce-cesarean-delivery-100536715","NCT06268431","Oxytocin Rest to Reduce Cesarean Delivery","Oxytocin Rest to Reduce Cesarean Delivery in Prolonged Labor: An Open-Label, Randomized Controlled Trial","ORCA","Inclusion Criteria:\n\n* ≥18 years of age\n* Singleton gestation in vertex presentation\n* ≥36 weeks gestation\n* Prolonged latent labor, defined as cervical dilation \\\u003C6cm after ≥8 hours since rupture of membranes and on continuous oxytocin\n\nExclusion Criteria:\n\n* Not meeting the above criteria\n* Any contraindication to continuous oxytocin at time of randomization\n* Cesarean section anticipated by the clinical team at time of randomization (for any reason excepting labor dystocia)\n* \\>18 hours between rupture of membranes and randomization\n* Known intraamniotic infection at randomization\n* Fetal demise\n* Any contraindication to vaginal delivery\n* Maternal eclampsia","55 Years",{"count":124,"type":20},350,[98],"Prolonged labor is usually managed with continuous oxytocin infusion. \"Oxytocin rest\" has been proposed as a strategy to resolve protracted labor in patients who have received continuous oxytocin without progress. This strategy involves discontinuing oxytocin then restarting infusion after a period of time, under the theory that washout of the oxytocin receptor will strengthen uterine contractions to improve labor progress. \"Oxytocin rest\" is performed on labor and delivery units across the United States. Yet, there is no randomized or prospective data to support the practice.\n\nThe purpose of this study is to assess whether oxytocin rest of 60 minutes in patients with prolonged labor reduces risk for cesarean delivery.",[128,129,130],"Prolonged Labor","Failed Induction","Labor Dystocia","2024-10-15",{"date":133,"type":46},"2024-10-17",{"date":135,"type":46},"2024-03-19",{"date":137,"type":20},"2026-03-15",{"name":52,"class":53},""]