[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"City University of New York\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":81},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100645258","phase-4-nutrition-intervention-combined-with-resmetirom-for-mash-100645258",false,"NCT07680478","Nutrition Intervention Combined With Resmetirom for MASH","Assessing Nutrition-aligned Resmetirom Roll-out","NOURISH-MASH","Inclusion Criteria:\n\n* Provide informed consent\n* Be 18-75 years old\n* Have non-cirrhotic MASH with fibrosis stage F2-F3 (VCTE 8-20 kPa and CAP =280 dB\u002Fm)\n* Be initiating resmetirom per standard of care\n* Be able to comply with study procedures, including fasting visits\n* Reside in one of the five New York City boroughs\n\nExclusion Criteria:\n\n* Have cirrhosis or decompensated liver disease\n* Have other chronic liver diseases\n* Are pregnant or breastfeeding\n* Consume alcohol above defined thresholds or have PEth =20 ng\u002FmL\n* Have recent major surgery or hospitalization\n* Are on glucagon-like peptide-1 agonist therapy (e.g., exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, semaglutide and albiglutide), unless the dose is stable for 12 weeks prior to the baseline evaluation and they have not experienced a \\>5% weight loss in the 6 months preceding resmetirom initiation.\n* Are undergoing bariatric surgery\n* Are living with any other end-stage organ disease (e.g., heart, lung or kidney failure requiring dialysis) or have any active malignancy in the last 5 years.\n* Have conditions preventing consumption of provided meals","ALL","18 Years","75 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This randomized control trial aims to evaluate the effectiveness of combining resmetirom therapy (first approved pharmacological therapy for treating metabolic dysfunction-associated steatohepatitis (MASH)) with a nutritional intervention compared to resmetirom therapy alone over one year in improving liver health among 120 patients living with non-cirrhotic MASH. We hypothesize that patients receiving resmetirom and nutritional intervention will experience more significant improvements in liver function than those receiving only resmetirom therapy.",[28],"Metabolic Dysfunction-Associated Steatohepatitis (MASH)",[30,31,32,33],"MASLD\u002FMASH","Resmetirom therapy","Medically tailored meal (MTM)","Nutrition-based intervention","NOT_YET_RECRUITING","2026-06-25",{"date":37,"type":38},"2026-07-02","ACTUAL",{"date":40,"type":22},"2026-10-01",{"date":42,"type":22},"2028-06-30",{"name":44,"class":45},"City University of New York","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":46},"100373472","transcranial-direct-current-stimulation-tdcs-with-verb-network-strengthening-treatment-vnest-in-chronic-aphasia-100373472","NCT04142866","Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia","This study recruits individuals with post-stroke aphasia as well as a group of healthy volunteers matched for age, sex, and education.\n\nINCLUSION Criteria:\n\n* Right handed (pre-stroke for participants with aphasia)\n* High school education or equivalent\n* Native English fluency without early 2nd language exposure (before age 10)\n* Ability to perform the required discourse and MRI tasks (determined via in-person screening)\n\nAdditional INCLUSION Criteria for participants with APHASIA:\n\n* Single-event left hemisphere stroke \\> 6 months prior to enrollment\n* Aphasia diagnosis per Western Aphasia Battery-Revised\n* Not receiving any other speech therapy for the entire study period (20 weeks)\n* Ability to perform the required therapy tasks (determined via in-person screening)\n\nEXCLUSION Criteria:\n\n* Failed vision or hearing screening\n* MRI contraindications (including pacemaker)\n* Pregnancy\n* History of seizure or change in seizure medication in past 12 months\n* History of speech\u002Flanguage, psychiatric, or neurological disorder, or current serious medical condition (except chronic stroke comorbidities for participants with aphasia)\n\nAdditional EXCLUSION criteria for participants with APHASIA are:\n\n* Unmodifiable hair style precluding scalp contact by electrodes\n* Sensitive scalp by self-report",true,"21 Years","80 Years",{"count":57,"type":22},30,[59],"NA","The purpose of this study is to assess changes in language abilities of participants with chronic, post-stroke aphasia following an 8-week therapy period combined with brain stimulation. The investigators use a stimulation method called transcranial direct current stimulation (tDCS). The investigators cover two electrodes in damp sponges, place them on the scalp, and pass a weak electrical current between them. Some of this current passes through the brain and can change brain activity. One electrode is placed over language areas a bit above and in front of the left ear. The other is placed on the forehead above the right eye. Stimulation is provided twice a week for 8 weeks during aphasia therapy. The investigators believe that this stimulation may increase the effectiveness of therapy.",[62,63],"Aphasia","Stroke",[65,66,67,68,69,70,71],"aphasia","stroke","tDCS","language","stimulation","brain","speech therapy","RECRUITING","2025-01-06",{"date":75,"type":38},"2025-01-07",{"date":77,"type":38},"2025-01-03",{"date":79,"type":22},"2026-12-31",{"name":44,"class":45},""]