[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Clarkson University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":77},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100642514","presentation-of-young-adults-with-and-without-joint-hypermobility-100642514",false,"NCT07657507","Presentation of Young Adults With and Without Joint Hypermobility","Prospective Study of Symptoms in People With and Without Joint Hypermobility","Inclusion Criteria: Clarkson University Health Sciences students. -\n\nExclusion Criteria: Other physical conditions that preclude collecting \\>25% of physical measurements at initial data collection.\n\n\\-",true,"ALL","18 Years","60 Years",{"count":21,"type":22},100,"ESTIMATED","5 Years","OBSERVATIONAL","People with multiple hypermobile joints are diagnosed with Generalized Joint Hypermobility (GJH) when asymptomatic, or Hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD) when symptomatic (hEDS\u002FHSD, or 'HSD' here). GJH likely affects about 20% of the U.S. population, while HSD affects 0.5-3% of the US population. Although joint hypermobility is the most visible presentation of HSD, it is a systemic connective tissue disorder affecting multiple body systems. Due to frequent health concerns, HSD may contribute to more than 30% of patients in chronic pain, rheumatology, orthopedic and physical therapy clinics. It is still unclear why some people have asymptomatic hypermobility and others develop complex chronic health issues. However, recent research suggests that the transition might be triggered by severe physiological stress, such as viral infection.\n\nHSD is commonly associated with Postural Orthostatic Tachycardia Syndrome (POTS) and Mast Cell Activation Syndrome (MCAS), as well as gastrointestinal (GI) problems. Recent research suggests that persistent inflammation due to MCAS or COVID may trigger HSD symptoms. The correlation between POTS and HSD may be due to effects of HSD on the autonomic nervous system or to inflammation triggering both conditions. It is also unclear whether body awareness and coordination deficits seen in symptomatic HSD are due to the fundamental connective tissue disorder or due to pain and injuries in HSD. This study seeks to determine whether asymptomatic hypermobile individuals (GJH) also have balance and coordination deficits. The current study hopes to identify factors that correlate with a transition from asymptomatic GJH to symptomatic HSD by following a group of Health Science students forward in time. The study will collect baseline health information including relevant diagnoses, symptoms and function. Physical measurements will include standard clinical tests performed by physical therapists: joint hypermobility and instability, standing balance, neck movement control, and heart rate in response to standing from lying down. The study is likely to last for at least 10 years to follow participants over time.",[27,28],"Hypermobile Ehlers-Danlos Syndrome","Postural Orthostatic Tachycardia Syndrome (POTS)",[30,31,32],"hypermobile Ehlers-Danlos Syndrome","Hypermobility Spectrum Disorders","Risk factors","NOT_YET_RECRUITING","2026-06-17",{"date":36,"type":37},"2026-06-22","ACTUAL",{"date":39,"type":22},"2026-06-20",{"date":41,"type":22},"2036-06-20",{"name":43,"class":44},"Clarkson University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":45},"100511561","effects-of-vestibular-training-on-postural-control-of-healthy-adults-using-virtual-reality-100511561","NCT05941039","Effects of Vestibular Training on Postural Control of Healthy Adults Using Virtual Reality","Inclusion Criteria:\n\n* Able to stand independently (without an assistive device)\n* This study requires participants to perform postural assessments including reactive balance following mechanical perturbations.\n* Participants will also perform headshake activities and weight shift training in standing for 20 mins will mini breaks.\n* Participants must be within the age of 18-35.\n* A power analysis revealed that a sample of 24 participants will required for a two-group comparison to detect a significant difference at alpha=0.05 and 0.30 effect size at beta=0.8 (G\\*Power, Version 3.0.10)(Faul et al, 2007).\n\nExclusion Criteria:\n\n* Participants with an evidence of:\n* Concussion, vestibular, balance or oculomotor issues for the prior 6 months.\n* Neuropathic conditions, particularly affecting the lower extremities. Participants with this issue will have sensory impairments which can affect their sensory assessment.\n* Current musculoskeletal deficits including significant postural abnormalities (signs of spinal, pelvic and leg length discrepancies).\n* Pain or limitations in neck range of motion.\n* Recent (within 6 months) orthopedic surgery that impacts postural training.\n* Visual Impairment\n* Participants must be able to see and follow targets on the computer monitor. Therefore, subjects must have 20\u002F50 (corrected) vision. Subjects who are blind cannot participate.","35 Years",{"count":54,"type":22},30,"INTERVENTIONAL",[57],"NA","Postural instability is a common symptom of vestibular dysfunction that impacts a person's day-to-day activities. Vestibular rehabilitation is effective in decreasing dizziness, visual symptoms and improving postural control through several mechanisms including sensory reweighting. As part of the sensory reweighting mechanisms, vestibular activation training with headshake activities influence vestibular reflexes. However, combining challenging vestibular and postural tasks to facilitate more effective rehabilitation outcomes is under-utilized. The novel concurrent headshake and weight shift training (Concurrent HS-WST) is purported to train the vestibular system to directly impact the postural control system simultaneously and engage sensory reweighting to improve balance. Young healthy participants will perform the training by donning a virtual reality headset with an overhead harness on and a spotter present to prevent any falls. The investigators propose that this training strategy would show improved outcomes over traditional training methods by improving vestibular-ocular reflex (VOR) gains, eye movement variability, sensory reweighting and promoting postural balance. The findings of this study may guide clinicians to develop rehabilitation methods for vestibular postural control in neurological populations with vestibular and\u002For sensorimotor control impairment.",[60,61,62],"Virtual Reality","Vestibular Training","Balance Assessment",[64,65,61,66,67],"VR","Balance","EMG","EOG","RECRUITING","2025-06-15",{"date":71,"type":37},"2025-06-17",{"date":73,"type":37},"2022-10-03",{"date":75,"type":22},"2025-08-30",{"name":43,"class":44},""]