[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Claude Bernard University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":99},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100504717","toothbrushes-in-daily-practice-in-patients-with-fixed-orthodontic-appliances-100504717",false,"NCT05851963","Toothbrushes in Daily Practice in Patients With Fixed Orthodontic Appliances","Comparison of the Effectiveness of Manual and Electric Toothbrushes in Daily Practice in Patients With Fixed Orthodontic Appliances","ORTHO-IOP","Inclusion Criteria:\n\n* Children to be treated with fixed upper and lower braces\n* 11 to 15 years of age at the start of treatment\n* One parent\u002Flegal guardian agrees to the terms and conditions of the study and signs the informed consent form\n* The adolescent agrees to the terms and conditions of the study and signs the informed consent form\n\nExclusion Criteria:\n\n* Less than 20 permanent teeth with braces or brackets\n* Presence of untreated cavities\n* Bleeding greater than 10% on probing\n* Presence of a gingival pocket larger than 5 mm\n* Presence of fixed prosthetic restorations\n* Presence of any enamel development defect\n* Presence of dental anomalies or direct\u002Findirect labial restorations on teeth\n* Patients requiring orthognathic surgeries\n* Presence of systemic diseases (diabetes, hepatic, renal, hematologic, cardiovascular)\n* Use of medications that may affect gingival health (such as calcium channel blockers, ciclosporin and anticoagulants)\n* Use of antibiotics and anti-inflammatory drugs for any purpose over a long period of time.\n* Having a smoking habit\n* Having a physical or mental problem that affects manual dexterity\n* Being unable to answer questions or being uncooperative",true,"ALL","11 Years","15 Years",{"count":22,"type":23},120,"ESTIMATED","INTERVENTIONAL",[26],"NA","Because of the difficulties of disorganizing the dental biofilm in these adolescents with fixed orthodontic treatment, electric toothbrushes have been proposed as an alternative to manual toothbrushes. Electric toothbrushes, available in a wide range of price points, have been developed with the goal of replicating the complex motions required by the manual toothbrush and making plaque removal more efficient. However, the overall effect size is limited, and the clinical relevance is not yet clear. Applied to orthodontics, specialized manual toothbrushes have also recently been developed. Few recent clinical trials have been conducted in patients with orthodontic appliances.\n\nThus, the question of whether and which type of manual or electric toothbrushes may be beneficial for patients with orthodontic appliances is still unresolved. Given the variety of toothbrushes available on the market, there is a need for sound clinical research to evaluate their effectiveness to guide professional recommendations. This work will provide a significant advance in the knowledge of the potential of the latest generation of electric toothbrushes on gingival inflammation, potentially reducing the risk of caries and gingival lesions.",[29],"Dental Malposition",[31,32,33,34],"toothbrush","oral prophylaxis","adolescents","orthodontic appliances","RECRUITING","2026-03-16",{"date":38,"type":39},"2026-03-18","ACTUAL",{"date":41,"type":39},"2025-04-01",{"date":43,"type":23},"2027-12-20",{"name":45,"class":46},"Claude Bernard University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100551740","complications-in-pediatric-mechanical-circulatory-assistance-evaluation-of-infection-management-100551740","NCT06464016","Complications in Pediatric Mechanical Circulatory Assistance: Evaluation of Infection Management.","Relapse of VAD Infections After Discontinuation of Anti-infective Therapies in Children.","VADINFECT","Inclusion Criteria:\n\n* patients under 18yo of age with Berlin Heart assisting device in Hospices Civils de Lyon, in France.\n\nExclusion Criteria:\n\n* patients over 18 yo at the time of BH assistance\n* unavailable documentation","1 Day","18 Years",{"count":59,"type":23},47,"OBSERVATIONAL","Heart failure is a major cause of mortality and morbidity in children. Heart transplantation can significantly improve the prognosis of patients with severe heart failure, but access is limited by a shortage of transplants.\n\nLong-term mechanical circulatory support is a major advance in the management of heart failure and can provide haemodynamic support while awaiting myocardial recovery or heart transplantation. The Berlin Heart (BH) EXCOR is the only long-term support system available for children.\n\nDespite technical and medical advances in circulatory support, infection is a common complication and a major cause of morbidity and mortality in patients on BH.\n\nThere are few studies on the management of infection with mechanical support. Current ISHLT (International Society for Heart and Lung Transplantation) recommendations are based on expert opinion and observational studies. Some experts recommend anti-infective therapy until transplantation for specific support infections or for support-associated infections with persistent bacteraemia.",[63,64,65],"Heart-Assist Devices","Infections","Heart Transplant Infection","2025-01-27",{"date":68,"type":39},"2025-01-28",{"date":70,"type":39},"2023-07-04",{"date":72,"type":23},"2025-11-01",{"name":45,"class":46},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":24,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100551969","influence-of-relaxing-breathing-before-each-station-of-an-objective-structured-clinical-examination-100551969","NCT06466993","Influence of Relaxing Breathing Before Each Station of an Objective Structured Clinical Examination","Influence on Performance of Relaxing Breathing During Rotation Pause Before Each Station of an Objective Structured Clinical Examination for Fifth Year Medical Students","ZENECOS","Inclusion Criteria:\n\n* all volontary medical students of the second cycle that came for their exam during the sessions of June 2024 from the University of Lyon (Medecine ESt)\n\nExclusion Criteria:\n\n* no exclusion criteria",{"count":83,"type":23},400,[26],"SObjective and Structured Clinical Examinations (OSCEs) has been incorporated recently in the certification process as a final national undergraduate ranking examination. This exam is an additional major stressor for medical students.\n\nThe aim of this study was to compare the efficiency on stress reduction of a standardized relaxing breathing occuring during rotation of the OSCE stations just before the start of the next upcoming OSCE station, in medical student, during the OSCE.",[87,88,89],"Performance Anxiety","Stress","Coping Skills","NOT_YET_RECRUITING","2024-08-10",{"date":93,"type":39},"2024-08-14",{"date":95,"type":23},"2024-09-05",{"date":97,"type":23},"2024-12-17",{"name":45,"class":46},""]