[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Claudia Schuurhuizen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100640978","higher-radiation-dose-to-the-tumor-may-help-avoid-surgery-in-rectal-cancer-patients-100640978",false,"NCT07616297","Higher Radiation Dose to the Tumor May Help Avoid Surgery in Rectal Cancer Patients","REctal Organ Preservation With a BOost Approach Using CBCT-based Online Adaptive radioTherapy","REBOOT","Inclusion Criteria:\n\n* Age ≥18 years\n* Eastern cooperative oncology group (ECOG) performance status ≤2\n* Histologically confirmed rectal adenocarcinoma\n* Non-locally advanced rectal cancer, defined as (magnetic resonance imaging (MRI)-based) T1-3, N0\u002FN1 (≤3 positive mesorectal lymph nodes), MX\u002FM0\n* Indication for curative treatment with organ preservation\n* Discussed in the multidisciplinary tumor board (MTB)\n* Written informed consent\n\nExclusion Criteria:\n\n* Previous radiotherapy in the pelvic area\n* Other malignancies, except for adequately treated basal cell carcinoma (BCC), at time of inclusion or within 3 years prior to inclusion\n* Contra-indications for (chemo)radiotherapy or surgery\n* Presence of lateral lymph nodes, cN2 status, extramural vascular invasion (EMVI) or mesorectal fascia involvement as seen on MRI\n* Mucinous defined tumor on MRI\n* Prior local excision of the primary tumor\n* DPD (dihydropyrimidine dehydrogenase) deficiency\n* Unable to understand the requirements of the study and to give written informed consent, as determined by the treating physician","ALL","18 Years",{"count":20,"type":21},25,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this prospective study is to evaluate if a higher radiation dose to the tumor can increase the organ preservation rate in non-locally advanced rectal cancer.",[27,28],"Rectal Cancer","Radiation Oncology",[28,30,31],"Rectal cancer","Organ Preservation","RECRUITING","2026-05-29",{"date":35,"type":36},"2026-06-01","ACTUAL",{"date":38,"type":36},"2026-01-27",{"date":40,"type":21},"2030-08-01",{"name":42,"class":43},"Claudia Schuurhuizen","OTHER",""]